{"id":"https://openalex.org/W7096009291","doi":null,"title":"ORIGINAL CONTRIBUTION JAMA-EXPRESS Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer The Women\u2019s Health Study: A Randomized Controlled Trial","display_name":"ORIGINAL CONTRIBUTION JAMA-EXPRESS Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer The Women\u2019s Health Study: A Randomized Controlled Trial","publication_year":2014,"publication_date":"2014-12-30","ids":{"openalex":"https://openalex.org/W7096009291"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.505.8535","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.505.8535","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.brainlife.org/reprint/2005/lee_im050706.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037910706","display_name":"I-min M Lee","orcid":"https://orcid.org/0000-0002-1083-6907","observed_orcids":["https://orcid.org/0000-0002-1083-6907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I-min Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084857746","display_name":"Nancy R. Cook","orcid":"https://orcid.org/0000-0002-9705-0842","observed_orcids":["https://orcid.org/0000-0002-9705-0842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy R. Cook","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J. Michael Gaziano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Michael Gaziano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David Gordon Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Gordon Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544276","display_name":"Paul M. Ridker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul M Ridker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049411008","display_name":"JoAnn Elisabeth Manson","orcid":"https://orcid.org/0000-0002-9426-7595","observed_orcids":["https://orcid.org/0000-0002-9426-7595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joann E. Manson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006554574","display_name":"Charles H. Hennekens","orcid":"https://orcid.org/0000-0003-1214-1663","observed_orcids":["https://orcid.org/0000-0003-1214-1663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles H. Hennekens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090744975","display_name":"Julie E. Buring","orcid":"https://orcid.org/0000-0003-2648-8692","observed_orcids":["https://orcid.org/0000-0003-2648-8692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie E. Buring","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45435209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9670000076293945},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7490000128746033},{"id":"https://openalex.org/keywords/women-s-health-study","display_name":"Women's Health Study","score":0.8019999861717224},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.7139999866485596},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ldl-oxidation","display_name":"LDL oxidation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ischemic-heart-disease-mortality","display_name":"ischemic heart disease mortality","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8708999752998352},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.8345999717712402},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.65420001745224},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.6080999970436096},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5936999917030334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.571399986743927},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5291000008583069},{"id":"https://openalex.org/C2993857929","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Primary prevention","level":3,"score":0.4878000020980835},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.47110000252723694},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4471000134944916},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.43970000743865967},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4187999963760376},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.37720000743865967},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.37369999289512634},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.3594000041484833},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3260999917984009},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.3255000114440918},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3116999864578247},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.3037000000476837},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.25870001316070557},{"id":"https://openalex.org/C3019417119","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Secondary prevention","level":2,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.505.8535","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.505.8535","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.brainlife.org/reprint/2005/lee_im050706.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995731966","https://openalex.org/W2532943901","https://openalex.org/W4240714710","https://openalex.org/W2164667256","https://openalex.org/W2162270378","https://openalex.org/W2006538351","https://openalex.org/W1522980946","https://openalex.org/W2138588047","https://openalex.org/W2277001260","https://openalex.org/W1512272756"],"abstract_inverted_index":{"FREE":[0],"RADICALS":[1],"CAN":[2],"CAUSE":[3],"LIPIDperoxidation":[4],"and":[5,16,71,146],"DNA":[6],"dam-age,":[7],"contributing":[8],"to":[9,34],"the":[10,35,138,153],"devel-opment":[11],"of":[12,25,27,100,112,117,123,141,155],"cardiovascular":[13],"dis-ease":[14],"(CVD)":[15],"cancer.1-5":[17],"Vitamin":[18],"E":[19,53,69,102],"has":[20],"antioxidant":[21,124],"properties,":[22],"including":[23],"inhibition":[24],"oxidation":[26],"low-density":[28],"lipoprotein":[29],"cholesterol":[30],"in":[31,78,80],"plasma,":[32],"leading":[33],"hypothesis":[36],"that":[37],"it":[38],"can":[39],"prevent":[40],"these":[41],"chronic":[42],"diseases.5":[43],"In":[44,57],"some,":[45],"but":[46],"not":[47],"all,":[48],"basic":[49],"research":[50],"reports,":[51],"vitamin":[52,101,127],"supplementation":[54],"retarded":[55],"atherogenesis.6":[56],"descriptive":[58],"data,":[59],"investigators":[60],"noted":[61],"a":[62,110],"strong":[63],"inverse":[64],"relation":[65],"between":[66],"plasma":[67],"vita-min":[68],"concentrations":[70],"death":[72],"rates":[73,92],"from":[74],"ischemic":[75],"heart":[76],"disease":[77],"men":[79],"several":[81,85],"European":[82],"countries.7":[83],"Addi-tionally,":[84],"large":[86],"cohort":[87],"studies":[88],"observed":[89],"decreased":[90],"CVD":[91],"among":[93],"individuals":[94],"who":[95,133],"self-selected":[96],"for":[97,137],"higher":[98],"intakes":[99],"through":[103],"diet":[104],"and/or":[105],"supplements.8-10":[106],"By":[107],"1997,":[108],"despite":[109],"lack":[111],"randomized":[113],"trials,":[114],"44":[115],"%":[116,132],"US":[118],"cardiologists":[119],"reported":[120],"rou-tine":[121],"use":[122],"supplements,":[125],"primarily":[126],"E,":[128],"compared":[129],"with":[130],"42":[131],"routinely":[134],"used":[135],"aspirin":[136],"primary":[139],"prevention":[140],"CVD.11See":[142],"also":[143],"pp":[144],"47":[145],"105.":[147],"Author":[148],"Affiliations":[149],"are":[150],"listed":[151],"at":[152],"end":[154],"this":[156],"article.":[157]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-27T00:00:00"}
