{"id":"https://openalex.org/W7095949567","doi":null,"title":"A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell 118:649\u2013663","display_name":"A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell 118:649\u2013663","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W7095949567"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.621.1930","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.621.1930","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://download.cell.com/mmcs/journals/0092-8674/piis0092867404007871.mmc1.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111675571","display_name":"Ching-Pin Chang","orcid":"https://orcid.org/0000-0001-8790-3445","observed_orcids":["https://orcid.org/0000-0001-8790-3445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ching-pin Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088524809","display_name":"Joel R. Neilson","orcid":"https://orcid.org/0000-0002-3408-608X","observed_orcids":["https://orcid.org/0000-0002-3408-608X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel R. Neilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079896846","display_name":"J. Henri Bayle","orcid":"https://orcid.org/0000-0002-9829-2499","observed_orcids":["https://orcid.org/0000-0002-9829-2499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Henri Bayle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067529915","display_name":"Jason E. Gestwicki","orcid":"https://orcid.org/0000-0002-6125-3154","observed_orcids":["https://orcid.org/0000-0002-6125-3154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason E. Gestwicki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109197894","display_name":"Ann Kuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Kuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009213852","display_name":"Kryn Stankunas","orcid":"https://orcid.org/0000-0001-6206-0365","observed_orcids":["https://orcid.org/0000-0001-6206-0365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kryn Stankunas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054884352","display_name":"Isabella A. Graef","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabella A. Graef","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082977812","display_name":"Gerald R. Crabtree","orcid":"https://orcid.org/0000-0001-9685-7911","observed_orcids":["https://orcid.org/0000-0001-9685-7911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald R. Crabtree","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Figure S","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Figure S","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tissue-specifi Disruption","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tissue-specifi Disruption","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Endocardial Cnb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Endocardial Cnb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33681605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nfatc1","display_name":"NFATc1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endocardium","display_name":"endocardium","score":0.9430000185966492},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.6159999966621399},{"id":"https://openalex.org/keywords/nfat-signaling","display_name":"NFAT signaling","score":0.49900001287460327},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.46799999475479126},{"id":"https://openalex.org/keywords/mouse-mutants","display_name":"mouse mutants","score":0.44200000166893005},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cardiac-outflow-tract","display_name":"cardiac outflow tract","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C85378888","wikidata":"https://www.wikidata.org/wiki/Q721856","display_name":"Endocardium","level":2,"score":0.9168999791145325},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7450000047683716},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.6550999879837036},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6256999969482422},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5863000154495239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5552999973297119},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5523999929428101},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.46389999985694885},{"id":"https://openalex.org/C129119232","wikidata":"https://www.wikidata.org/wiki/Q2879939","display_name":"Atrioventricular cushions","level":3,"score":0.39570000767707825},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.38960000872612},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37389999628067017},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.35339999198913574},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.3425999879837036},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.32600000500679016},{"id":"https://openalex.org/C2777837822","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Embryonic heart","level":4,"score":0.29660001397132874},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.2750999927520752},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.27149999141693115},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.26930001378059387}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.621.1930","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.621.1930","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://download.cell.com/mmcs/journals/0092-8674/piis0092867404007871.mmc1.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W100863163","https://openalex.org/W2021554725","https://openalex.org/W2081480709","https://openalex.org/W7095625040","https://openalex.org/W2157780291","https://openalex.org/W1606727311","https://openalex.org/W1509578353","https://openalex.org/W2031894700","https://openalex.org/W7098204837","https://openalex.org/W7098696777"],"abstract_inverted_index":{"(A)":[0,185],"NFATc1":[1,10,95,127,136,154,245],"immunostaining":[2],"(green)":[3],"of":[4,7,21,29,45,51,70,86,94,153,173,188,207,244,253],"sagittal":[5],"sections":[6],"E10":[8,55,101,193,215],"embryos.":[9],"is":[11,138],"expressed":[12],"in":[13,35,57,60,72,82,96,103,106,155,230,246],"the":[14,36,46,73,83,97,118,123,134,142,147,156,247,250],"endocardium":[15,37,63,74,112,248],"(arrows).":[16],"(\u0392)":[17,204],"\u03b2-galactosidase":[18],"whole-mount":[19],"staining":[20],"Tie2Cre,":[22,87,157],"ROSA26RLacZ":[23],"embryos":[24,53,89,99,159,191,208,219],"at":[25,54,90,100,160,232],"E8.":[26],"(C)":[27,225],"Immunostaining":[28,69,93,152],"Cnb1":[30,71,178,211],"(Chang":[31],"et":[32],"al.,":[33],"2004)":[34],"(arrow),":[38,75],"mesenchyme":[39,76],"(double":[40,77,149],"arrow),":[41,78],"and":[42,64,79,113,131,202,223,237,240],"myocardium":[43,65,80,114],"(asterisk)":[44,81],"atrio-ventricular":[47],"canal":[48],"(AVC)":[49],"cushion":[50,85,148],"wild-type":[52,98],"(proteins":[56,102],"green,":[58,104],"DNA":[59,105],"red).":[61,107],"Cushion":[62,111],"are":[66,115,129],"outlined.":[67,116],"(D)":[68],"AVC":[84],"Cnb1F/\u0394":[88,158],"E10.":[91,161],"(E)":[92],"Arrows,":[108],"endocardial":[109,119,210],"cells.":[110],"As":[117],"cells":[120,144],"delaminate":[121],"from":[122,192,214],"surface":[124],"during":[125],"EMT,":[126],"proteins":[128],"inactivated":[130],"exported":[132],"to":[133,181,194,216,228],"cytoplasm.":[135],"expression":[137,243],"rapidly":[139],"repressed":[140],"as":[141],"mesenchymal":[143],"migrate":[145],"into":[146],"arrow).":[150],"(F)":[151],"AVC,":[162],"atrioventricular":[163],"canal.":[164],"OFT,":[165],"outfl":[166],"ow":[167],"tract.":[168],"Figure":[169],"S2.":[170],"Embryonic":[171],"Lethality":[172],"Embryos":[174,226],"Lacking":[175],"NFATc1,":[176],"Endocardial":[177],"or":[179],"Exposed":[180],"Cyclosporine":[182],"In":[183],"Utero":[184,231],"Observed":[186,205],"frequency":[187,206],"NFATc1\u2212/":[189,196,254],"\u2212":[190,197,255],"E18.":[195,217],"mutants":[198],"died":[199,220,234],"between":[200,221,235],"E13":[201,222,236],"E14.":[203,224,238],"lacking":[209,260],"(Tie2Cre,":[212],"Cnb1F/\u0394)":[213],"Mutant":[218],"exposed":[227],"CsA":[229],"E11":[233],"(D":[239],"E)":[241],"Transgenic":[242],"rescued":[249],"embryonic":[251],"lethality":[252],"mice":[256,259],"but":[257],"not":[258],"endo-":[261]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-27T00:00:00"}
