{"id":"https://openalex.org/W7095541741","doi":null,"title":"Summary Background Diabetes","display_name":"Summary Background Diabetes","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W7095541741"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.548.7108","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.548.7108","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://archives.who.int/prioritymeds/report/append/cvd_ramipril_apx3.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57047261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.38260000944137573,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.38260000944137573,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.2685999870300293,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.2273000031709671,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ramipril","display_name":"ramipril","score":0.9070000052452087},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.5820000171661377},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.953000009059906},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9980000257492065},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8420000076293945},{"id":"https://openalex.org/keywords/vascular-protection","display_name":"vascular protection","score":0.8740000128746033},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.7300000190734863},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2779888176","wikidata":"https://www.wikidata.org/wiki/Q412666","display_name":"Ramipril","level":3,"score":0.96670001745224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9401999711990356},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6564000248908997},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6513000130653381},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6029999852180481},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5695000290870667},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5662999749183655},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5228000283241272},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4602000117301941},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.42660000920295715},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.39320001006126404},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.38420000672340393},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.36809998750686646},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.3264999985694885},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.548.7108","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.548.7108","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://archives.who.int/prioritymeds/report/append/cvd_ramipril_apx3.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1604542334","https://openalex.org/W2529012027","https://openalex.org/W2071715316","https://openalex.org/W2064349784","https://openalex.org/W2040158415","https://openalex.org/W2122966913","https://openalex.org/W2014807701","https://openalex.org/W3028683657","https://openalex.org/W61247079","https://openalex.org/W2278189061"],"abstract_inverted_index":{"mellitus":[0],"is":[1],"a":[2,47,90,108,112,135,258],"strong":[3],"risk":[4,57,146,216],"factor":[5],"for":[6,197,231,263],"cardiovascular":[7,49,56,103,170,232,242],"and":[8,68,83,130,187,205,234,260],"renal":[9],"disease.":[10],"We":[11],"investigated":[12],"whether":[13],"the":[14,34,126,145,148,198,215,218,250],"angiotensin-converting-enzyme":[15],"(ACE)":[16],"inhibitor":[17],"ramipril":[18,78,139,212],"can":[19],"lower":[20],"these":[21],"risks":[22],"in":[23,33,111,200,237,252],"patients":[24],"with":[25,30,141,239,265],"diabetes.":[26,240,266],"Methods":[27],"3577":[28],"people":[29,238,264],"diabetes":[31],"included":[32],"Heart":[35],"Outcomes":[36],"Prevention":[37],"Evaluation":[38],"study,":[39],"aged":[40],"55":[41],"years":[42],"or":[43,51,64,81,86,102],"older,":[44],"who":[45,69],"had":[46],"previous":[48],"event":[50],"at":[52],"least":[53],"one":[54],"other":[55],"factor,":[58],"no":[59],"clinical":[60],"proteinuria,":[61],"heart":[62],"failure,":[63],"low":[65],"ejection":[66],"fraction,":[67],"were":[70,75],"not":[71],"taking":[72],"ACE":[73],"inhibitors,":[74],"randomly":[76],"assigned":[77],"(10":[79],"mg/day)":[80],"placebo,":[82,87],"vitamin":[84],"E":[85],"according":[88],"to":[89,249],"two-by-two":[91],"factorial":[92],"design.":[93],"The":[94,115,241],"combined":[95,149,219],"primary":[96,150,220],"outcome":[97,110,151,221],"was":[98,107,117,229,244],"myocardial":[99,160],"infarction,":[100],"stroke,":[101],"death.":[104],"Overt":[105],"nephropathy":[106,189,236],"main":[109],"substudy.":[113],"Findings":[114],"study":[116],"stopped":[118],"6":[119],"months":[120],"early":[121],"(after":[122],"4\u00b75":[123],"years)":[124],"by":[125,152,162,167,172,178,183,190,222],"independent":[127],"data":[128],"safety":[129],"monitoring":[131],"board":[132],"because":[133],"of":[134,138,147,217],"consistent":[136],"benefit":[137,243],"compared":[140],"placebo.":[142],"Ramipril":[143,228],"lowered":[144,214],"25":[153,223],"%":[154,156,164,174,180,185,192,224],"(95":[155],"CI":[157],"12\u201336,":[158],"p=0\u00b70004),":[159],"infarction":[161],"22":[163],"(6\u201336),":[165],"stroke":[166],"33%":[168],"(10\u201350),":[169],"death":[171],"37":[173],"(21\u201351),":[175],"total":[176],"mortality":[177],"24":[179,191],"(8\u201337),":[181],"revascularisation":[182],"17":[184],"(2\u201330),":[186],"overt":[188,235],"(3\u201340,":[193],"p=0\u00b7027).":[194],"After":[195],"adjustment":[196],"changes":[199],"systolic":[201],"(2\u00b74":[202],"mm":[203,208],"Hg)":[204,209],"diastolic":[206],"(1\u00b70":[207],"blood":[210,253],"pressures,":[211],"still":[213],"(12\u201336,":[225],"p=0\u00b70004).":[226],"Interpretation":[227],"beneficial":[230],"events":[233],"greater":[245],"than":[246],"that":[247],"attributable":[248],"decrease":[251],"pressure.":[254],"This":[255],"treatment":[256],"represents":[257],"vasculoprotective":[259],"renoprotective":[261],"effect":[262]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-27T00:00:00"}