{"id":"https://openalex.org/W7095463574","doi":null,"title":"Histone deacetylase 6 AC","display_name":"Histone deacetylase 6 AC","publication_year":2014,"publication_date":"2014-12-18","ids":{"openalex":"https://openalex.org/W7095463574"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.487.812","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.487.812","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://download.thelancet.com/flatcontentassets/H1N1-flu/pathogenesis/pathogenesis-15.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51360213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.5981000065803528,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.5981000065803528,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.3889000117778778,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":0.9610000252723694},{"id":"https://openalex.org/keywords/caspase-3-cleavage","display_name":"caspase-3 cleavage","score":0.8999999761581421},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.9139999747276306},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.4480000138282776},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6019999980926514},{"id":"https://openalex.org/keywords/tubulin-acetylation","display_name":"tubulin acetylation","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C23681527","wikidata":"https://www.wikidata.org/wiki/Q18034953","display_name":"HDAC6","level":5,"score":0.8187000155448914},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.5238000154495239},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5189999938011169},{"id":"https://openalex.org/C45946802","wikidata":"https://www.wikidata.org/wiki/Q18033449","display_name":"SAP30","level":5,"score":0.5180000066757202},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.510200023651123},{"id":"https://openalex.org/C142354902","wikidata":"https://www.wikidata.org/wiki/Q18047334","display_name":"HDAC10","level":5,"score":0.5077000260353088},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5044999718666077},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.4964999854564667},{"id":"https://openalex.org/C58793620","wikidata":"https://www.wikidata.org/wiki/Q21173206","display_name":"HDAC4","level":5,"score":0.48669999837875366},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.44119998812675476},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.41780000925064087},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.37130001187324524},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.3630000054836273},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.3531000018119812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3458999991416931},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3257000148296356},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.3199000060558319},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30550000071525574},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.2906999886035919},{"id":"https://openalex.org/C2781462825","wikidata":"https://www.wikidata.org/wiki/Q7363205","display_name":"Romidepsin","level":5,"score":0.2791000008583069},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.27639999985694885},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.2754000127315521},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.487.812","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.487.812","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://download.thelancet.com/flatcontentassets/H1N1-flu/pathogenesis/pathogenesis-15.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090375806","https://openalex.org/W7099539892","https://openalex.org/W4311445151","https://openalex.org/W1980125414","https://openalex.org/W4385760882","https://openalex.org/W3000316316","https://openalex.org/W2610493049","https://openalex.org/W7125769061","https://openalex.org/W2123036936","https://openalex.org/W4312768748"],"abstract_inverted_index":{"its":[0,64],"r":[1],"spa":[2],"con":[3],"e":[4],"cl":[5],"hich":[6],"h":[7],"are":[8],"div":[9],"d":[10],"class":[11,16],"lass,":[12],"w":[13],"ises":[14],"th":[15],"[1].":[17],"HDAC6":[18,40,58],"regulates":[19],"the":[20,25,44,54],"HIV-1":[21],"infection":[22],"by":[23],"altering":[24],"acetyla-tion":[26],"status":[27],"of":[28,39,57],"cortical":[29],"a-tubulin":[30],"[2].":[31],"In":[32,49],"human":[33],"T-cell":[34],"leukemia":[35],"virus-infected":[36],"cells":[37,61,80],"inhibition":[38],"activity":[41],"leads":[42],"to":[43,94],"H5N1":[45],"pathogenesis":[46],"in":[47,59,83],"humans.":[48],"this":[50],"study":[51],"we":[52],"demonstrate":[53],"caspase-3-mediated":[55],"cleavage":[56],"IAV-infected":[60],"and":[62,68,73],"discuss":[63],"significance.":[65],"2.":[66],"Materials":[67],"methods":[69],"2.1.":[70],"Cells,":[71],"virus,":[72],"plasmids":[74],"Madin-Darby":[75],"canine":[76],"kidney":[77],"(MDCK)":[78],"epithelial":[79],"were":[81],"grown":[82],"minimum":[84],"essential":[85],"medium":[86],"(MEM)":[87],"supplemented":[88],"with":[89],"10%":[90],"Abbreviations:":[91],"BUZ,":[92],"bound":[93],"ubiquitin":[95],"zinc":[96],"finger;":[97],"HDAC,":[98],"histone":[99],"deacetylase;":[100],"hsp90,":[101],"heat-shock":[102],"protein":[103],"90;":[104],"IAV,":[105],"influenza":[106],"A":[107],"virus;":[108],"INF,":[109],"infected;":[110],"M1,":[111],"matrix":[112]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-27T00:00:00"}
