{"id":"https://openalex.org/W7095418477","doi":null,"title":"The Carboxy Terminal Domain of Connexin43 From Molecular Regulation of the Gap Junction Channel to Supramolecular Organization of the Intercalated Disk","display_name":"The Carboxy Terminal Domain of Connexin43 From Molecular Regulation of the Gap Junction Channel to Supramolecular Organization of the Intercalated Disk","publication_year":2016,"publication_date":"2016-10-09","ids":{"openalex":"https://openalex.org/W7095418477"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.970.7623","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.970.7623","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circres.ahajournals.org/content/101/12/1213.full.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157864441","display_name":"Nicholas J. Severs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nicholas J. Severs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5157864441"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3580305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.996999979019165},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.8560000061988831},{"id":"https://openalex.org/keywords/gap-junction-channels","display_name":"gap junction channels","score":0.781000018119812},{"id":"https://openalex.org/keywords/intercalated-discs","display_name":"intercalated discs","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.7390000224113464},{"id":"https://openalex.org/keywords/electrical-coupling","display_name":"electrical coupling","score":0.9169999957084656},{"id":"https://openalex.org/keywords/desmosomes","display_name":"desmosomes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/adhesion-junctions","display_name":"adhesion junctions","score":0.796999990940094},{"id":"https://openalex.org/keywords/ventricular-myocardium","display_name":"ventricular myocardium","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.7301999926567078},{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.6664999723434448},{"id":"https://openalex.org/C2781175142","wikidata":"https://www.wikidata.org/wiki/Q6045608","display_name":"Intercalated disc","level":4,"score":0.5911999940872192},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5073999762535095},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.49459999799728394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4487000107765198},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.44350001215934753},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4422000050544739},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.42239999771118164},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3443000018596649},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3418000042438507},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.3084000051021576},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.970.7623","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.970.7623","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circres.ahajournals.org/content/101/12/1213.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044726736","https://openalex.org/W2035512665","https://openalex.org/W151493181","https://openalex.org/W2540056119","https://openalex.org/W4231432638","https://openalex.org/W28023560","https://openalex.org/W2031713075","https://openalex.org/W2233914319","https://openalex.org/W134169721","https://openalex.org/W2078939575"],"abstract_inverted_index":{"Cardiac":[0],"function":[1,106],"depends":[2],"fundamentally":[3],"on":[4],"gap":[5,64],"junctions,plaques":[6],"of":[7,19,29,39,44,72,102,124,132],"transmembrane":[8],"channels":[9],"constructed":[10],"from":[11,116],"connexin":[12],"proteins":[13],"that":[14,47],"bridge":[15],"the":[16,25,30,36,40,57,61,75,82,86,100,122],"plasma":[17],"membranes":[18],"adjacent":[20,125],"myocytes.":[21],"By":[22],"electrically":[23],"coupling":[24],"entire":[26],"myo-cyte":[27],"population":[28],"heart,":[31],"these":[32],"junctions":[33,65,78],"preside":[34],"over":[35],"cell-to-cell":[37,104],"passage":[38],"precisely":[41],"orchestrated":[42],"patterns":[43],"current":[45],"flow":[46],"synchronize,":[48],"coordinate,":[49],"and":[50,79],"harness":[51],"indi-vidual":[52],"cell":[53,87,117],"contractions":[54],"to":[55,118],"generate":[56],"heart":[58],"beat.":[59],"In":[60],"ventricular":[62],"myocardium,":[63],"are":[66,130],"organized,":[67],"together":[68],"with":[69],"2":[70],"types":[71],"adhesion":[73],"junction,":[74],"fasciae":[76,109],"adherentes":[77,110],"desmosomes,":[80],"at":[81],"intercalated":[83,91],"disks":[84],"where":[85],"ends":[88],"abut.1":[89],"The":[90,108],"disk":[92],"has":[93],"a":[94],"characteristic":[95],"struc-ture,":[96],"exquisitely":[97],"specialized":[98],"for":[99],"task":[101],"integrating":[103],"electromechanical":[105],"(Figure).":[107],"junctions,":[111],"which":[112],"transmit":[113],"mechanical":[114],"force":[115],"cell,":[119],"link":[120],"up":[121],"myofibrils":[123],"cells":[126],"in":[127],"series.":[128],"They":[129],"thus,":[131]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-27T00:00:00"}
