{"id":"https://openalex.org/W7093340692","doi":"https://doi.org/10.5281/zenodo.17399930","title":"Spatial Dependence and Heterogeneity in Molecular Imaging: Imaging Mass Spectrometry Datasets","display_name":"Spatial Dependence and Heterogeneity in Molecular Imaging: Imaging Mass Spectrometry Datasets","publication_year":2025,"publication_date":"2025-10-20","ids":{"openalex":"https://openalex.org/W7093340692","doi":"https://doi.org/10.5281/zenodo.17399930"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.17399930","doi":"https://doi.org/10.5281/zenodo.17399930","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17399930","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.17399930","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086031908","display_name":"L\u00e9onore E. M. Tideman","orcid":"https://orcid.org/0000-0001-7405-3146","observed_orcids":["https://orcid.org/0000-0001-7405-3146"]},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tideman, L\u00e9onore","raw_affiliation_strings":["Delft University of Technology"],"raw_orcid":"https://orcid.org/0000-0001-7405-3146","affiliations":[{"raw_affiliation_string":"Delft University of Technology","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059275651","display_name":"Jeffrey M. Spraggins","orcid":"https://orcid.org/0000-0001-9198-5498","observed_orcids":["https://orcid.org/0000-0001-9198-5498"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Spraggins, Jeffrey","raw_affiliation_strings":["Vanderbilt University Medical Center","Vanderbilt University"],"raw_orcid":"https://orcid.org/0000-0001-9198-5498","affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133088220","display_name":"Raf Van de Plas","orcid":"https://orcid.org/0000-0002-2232-7130","observed_orcids":["https://orcid.org/0000-0002-2232-7130"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Van de Plas, Raf","raw_affiliation_strings":["Delft University of Technology","Vanderbilt University"],"raw_orcid":"https://orcid.org/0000-0002-2232-7130","affiliations":[{"raw_affiliation_string":"Delft University of Technology","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Skaar, Eric","orcid":"https://orcid.org/0000-0001-5094-8105","observed_orcids":["https://orcid.org/0000-0001-5094-8105"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Skaar, Eric","raw_affiliation_strings":["Vanderbilt University"],"raw_orcid":"https://orcid.org/0000-0001-5094-8105","affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071480547","display_name":"Jacquelyn Spathies","orcid":"https://orcid.org/0000-0002-7731-1363","observed_orcids":["https://orcid.org/0000-0002-7731-1363"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Spathies, Jacquelyn","raw_affiliation_strings":["Vanderbilt University Medical Center"],"raw_orcid":"https://orcid.org/0000-0002-7731-1363","affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11911","display_name":"Spatial and Panel Data Analysis","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maldi-mass-spectrometry-imaging","display_name":"MALDI mass spectrometry imaging","score":0.9340000152587891},{"id":"https://openalex.org/keywords/spatial-autocorrelation","display_name":"spatial autocorrelation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.8270000219345093},{"id":"https://openalex.org/keywords/spatial-heterogeneity","display_name":"spatial heterogeneity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.5059999823570251},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9679999947547913},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.8759999871253967},{"id":"https://openalex.org/keywords/zebrafish-embryos","display_name":"zebrafish embryos","score":0.7760000228881836},{"id":"https://openalex.org/keywords/spatial-proteomics","display_name":"spatial proteomics","score":0.49900001287460327},{"id":"https://openalex.org/keywords/spatial-statistics","display_name":"spatial statistics","score":0.4169999957084656},{"id":"https://openalex.org/keywords/anndata","display_name":"AnnData","score":0.40700000524520874},{"id":"https://openalex.org/keywords/umap","display_name":"UMAP","score":0.5770000219345093},{"id":"https://openalex.org/keywords/pca","display_name":"PCA","score":0.4429999887943268},{"id":"https://openalex.org/keywords/ion-images","display_name":"ion images","score":0.3440000116825104},{"id":"https://openalex.org/keywords/2-5-dihydroxyacetophenone","display_name":"2,5-dihydroxyacetophenone","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C24066741","wikidata":"https://www.wikidata.org/wiki/Q3796564","display_name":"Mass spectrometry imaging","level":3,"score":0.7526999711990356},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5580999851226807},{"id":"https://openalex.org/C159620131","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Spatial analysis","level":2,"score":0.5482000112533569},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5311999917030334},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.4830000102519989},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.47690001130104065},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46700000762939453},{"id":"https://openalex.org/C101092202","wikidata":"https://www.wikidata.org/wiki/Q6714252","display_name":"MALDI imaging","level":5,"score":0.44279998540878296},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4099999964237213},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.36469998955726624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33629998564720154},{"id":"https://openalex.org/C2780639617","wikidata":"https://www.wikidata.org/wiki/Q6516972","display_name":"Quadrant (abdomen)","level":2,"score":0.33320000767707825},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C159078339","wikidata":"https://www.wikidata.org/wiki/Q959005","display_name":"Hyperspectral imaging","level":2,"score":0.30230000615119934},{"id":"https://openalex.org/C51432778","wikidata":"https://www.wikidata.org/wiki/Q1259145","display_name":"Independent component analysis","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.2922999858856201},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C138695830","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Spatial dependence","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C2776853492","wikidata":"https://www.wikidata.org/wiki/Q3138539","display_name":"Hypotaurine","level":4,"score":0.2712000012397766},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C15213710","wikidata":"https://www.wikidata.org/wiki/Q904207","display_name":"Ion-mobility spectrometry","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.25940001010894775},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.2556999921798706},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C40325409","wikidata":"https://www.wikidata.org/wiki/Q2360668","display_name":"Mass spectrum","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.5281/zenodo.17399930","doi":"https://doi.org/10.5281/zenodo.17399930","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17399930","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.17399931","doi":"https://doi.org/10.5281/zenodo.17399931","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17399931","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.21838150","doi":"https://doi.org/10.5281/zenodo.21838150","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21838150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.21861029","doi":"https://doi.org/10.5281/zenodo.21861029","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21861029","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.23135988","doi":"https://doi.org/10.5281/zenodo.23135988","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23135988","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.5281/zenodo.17399930","doi":"https://doi.org/10.5281/zenodo.17399930","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17399930","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1033138463","display_name":null,"funder_award_id":"1RF1NS129735","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2033189609","display_name":"Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue Mapping","funder_award_id":"U54DK120058","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2280314020","display_name":null,"funder_award_id":"1RF1NS130334","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3052236605","display_name":"Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye","funder_award_id":"U54EY032442","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3425492262","display_name":null,"funder_award_id":"2021-240339","funder_id":"https://openalex.org/F4320315474","funder_display_name":"Chan Zuckerberg Initiative"},{"id":"https://openalex.org/G4160050819","display_name":"Defining the impact of host factors on the molecular architecture and bacterial physiology of Staphylococcus aureus abscesses","funder_award_id":"R01AI145992","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7425993560","display_name":"MRI: Development of a next-generation MALDI ion mobility mass spectrometry platform for molecular imaging and training","funder_award_id":"1828299","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8310475262","display_name":null,"funder_award_id":"2022-309518","funder_id":"https://openalex.org/F4320315474","funder_display_name":"Chan Zuckerberg Initiative"},{"id":"https://openalex.org/G9000883729","display_name":"Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human Kidney","funder_award_id":"U54DK134302","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000885883","display_name":"Molecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometry","funder_award_id":"R01AI138581","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000891784","display_name":"Elucidating Molecular Drivers of Aging and Alzheimer's Disease via Multimodal Imaging Mass Spectrometry","funder_award_id":"R01AG078803","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000900554","display_name":"Multimodal Imaging Mass Spectrometry and Spatial Omics for the Human Kidney","funder_award_id":"U01DK133766","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320315474","display_name":"Chan Zuckerberg Initiative","ror":"https://ror.org/02qenvm24"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415626572","https://openalex.org/W2332972329","https://openalex.org/W7212816159","https://openalex.org/W2334419113","https://openalex.org/W2112523116","https://openalex.org/W6999869347","https://openalex.org/W4319294043","https://openalex.org/W7125502837","https://openalex.org/W1968280571","https://openalex.org/W97000267"],"abstract_inverted_index":{"You":[0],"will":[1],"find":[2],"the":[3,63,70,229,256,265,275,290,295,302,312,353,358,371,406,410,418,439,466,470,475,483,496,525,769,820,839,845,854,975,1092],"following":[4],"datasets":[5,112],"in":[6,87,119,174,264,398,524,563,660,716,836,879,895,965,1061],"our":[7],"Zenodo":[8],"repository:":[9],"Demo_rat_brain_data.pickle":[10],"is":[11,45,81,137,242,271,294,453,458,478],"a":[12,46,162,235,245,272,280,324,335,344,367,377,399,415,454,531,601,612,623,638,646,717,890,896,956,971,982,986,1012,1028,1050,1066],"subset":[13,47],"of":[14,18,33,48,52,228,247,258,274,282,286,301,307,323,357,405,409,414,428,465,566,616,627,641,648,719,768,772,828,850,857,861,865,974,1009,1014,1069,1091,1095],"100":[15],"ion":[16,50,77],"images":[17,51,597,635],"MALDI-IMS":[19,53,82,143,761,810,1084],"dataset":[20,54,83,144,762,811,1085],"no1":[21],"(rat":[22],"brain).":[23],"It":[24,58,90],"was":[25,59,159,341,349,374,385,420,435,506,522,653,909,940,979,1016,1025,1046],"used":[26,60,342,375,878],"to":[27,61,74,114,317,331,363,445,469,481,557,643,710,723,765,778,912,1039,1088],"demonstrate":[28,62],"exporatory":[29],"spatial":[30,41,101,178,613,664,1067],"data":[31,36,704],"analysis":[32],"molecular":[34,634],"imaging":[35,190,657,676,725,780],"with":[37,100,388,391,422,493,584,611,645,838,937],"local":[38],"and":[39,95,105,108,117,170,184,202,255,396,412,473,501,513,540,561,588,622,670,712,728,738,751,783,793,806,824,848,872,886,918,994],"global":[40],"autocorrelation":[42],"statistics.":[43],"Zebra_fish_8_clusters_dataset.pickle":[44],"174":[49],"no2":[55,84],"(zebra":[56,85],"fish).":[57],"Moran-HOG":[64],"clustering":[65],"workflow,":[66],"which":[67,68,278],"uses":[69],"Moran":[71,122],"quadrant":[72],"map":[73],"perform":[75],"colocalization-based":[76],"image":[78,1024],"clustering.":[79],"Zebra_fish_anndata.h5ad":[80],"fish)":[86],"AnnData":[88],"format.":[89],"has":[91],"1,005,524":[92],"mass":[93,186,191,604,624,672,677,726,781,1055],"spectra":[94],"1,636":[96],"m/z":[97,631,639],"features,":[98],"together":[99],"coordinates,":[102],"acquisition":[103],"metadata,":[104],"precomputed":[106],"PCA":[107],"UMAP":[109],"representations.":[110],"These":[111],"relate":[113],"\"Spatial":[115],"Dependence":[116],"Heterogeneity":[118],"Molecular":[120],"Imaging:":[121],"Quadrant":[123],"Maps":[124],"Enable":[125],"Advanced":[126],"Spatial-Statistical":[127],"Analysis\"":[128],"by":[129,196,208,215,244,495,682,741,796,819,970],"Tideman":[130,773,1096],"et":[131,198,217,684,743,746,774,798,801,1097],"al.":[132,199,218,685,744,775,799,1098],"(October":[133],"2025).":[134],"The":[135,147,224,268,305,320,338,346,633,651,875,931],"preprint":[136],"available":[138],"on":[139,637,844,889,1027,1049],"bioRxiv:":[140],"https://www.biorxiv.org/content/10.1101/2025.10.27.684518v1.":[141],"About":[142,809],"no1:":[145],"Materials:":[146,915],"MALDI":[148,188,595,674,1040,1052],"matrix":[149,932],"2,5-dihydroxyacetphenone":[150],"(DHA,":[151],"Sigma-Aldrich":[152,927],"Chemical":[153],"CO.,":[154],"St.":[155],"Louis,":[156,929],"MO,":[157],"USA)":[158,169,539,610],"applied":[160,1017],"using":[161,510,530,600,955,985,1018],"TM":[163],"Sprayer":[164],"(HTX":[165],"Technologies,":[166,550,1003],"Carrboro,":[167],"NC,":[168],"rehydrated":[171],"as":[172,343,351,376,482,658],"described":[173,659],"\"Next-generation":[175,661],"technologies":[176,662],"for":[177,193,205,655,663,679,702,734,754,789],"proteomics:":[179,665],"Integrating":[180,666],"ultra-high":[181,667],"speed":[182,668],"MALDI-TOF":[183,669],"high":[185,671],"resolution":[187,615,673,1068],"FTICR":[189,675],"spectrometry":[192,678,727,782],"protein":[194,262,656,680],"analysis\"":[195,681,740,795],"Spraggins":[197,683],"(Proteomics,":[200,686],"2016)":[201],"\"Matrix":[203],"Sublimation/Recrystallization":[204],"Imaging":[206,592,1042],"Proteins":[207,750,805],"Mass":[209,593,1043],"Spectrometry":[210],"at":[211,515,528,630,981,1011,1065,1074],"High":[212],"Spatial":[213],"Resolution\"":[214],"Yang":[216],"(Analytical":[219],"Chemistry,":[220],"2011).":[221],"Sample":[222,947],"Preparation:":[223],"brain":[225,327,520],"tissue":[226,505,521],"sections":[227],"case":[230],"study":[231,881],"were":[232,329,361,491,555,598,692,708,817,887,924,953,962],"collected":[233,599,1026],"from":[234,920,926,942,1105],"rat":[236,347,384],"Parkinson's":[237],"disease":[238,241],"model.":[239],"Parkinson\u2019s":[240],"characterized":[243],"degeneration":[246],"dopaminergic":[248,308,321,355,449],"neurons":[249,251,309,322,356],"(i.e.,":[250,261,284,298],"that":[252],"synthesize":[253],"dopamine)":[254],"formation":[257],"Lewy":[259],"bodies":[260],"aggregates)":[263],"substantia":[266,269,440],"nigra.":[267],"nigra":[270,441],"region":[273],"basal":[276,303],"ganglia,":[277],"are":[279],"group":[281],"nuclei":[283],"clusters":[285],"neurons)":[287],"located":[288],"beneath":[289],"cerebral":[291],"cortex.":[292],"Dopamine":[293],"primary":[296],"neurotransmitter":[297],"chemical":[299],"messenger)":[300],"ganglia.":[304],"loss":[306],"severely":[310],"impairs":[311],"brain\u2019s":[313],"motor":[314],"function,":[315],"leading":[316],"movement":[318],"disorders.":[319],"rat\u2019s":[325],"left":[326,359],"hemisphere":[328,340,360,373],"destroyed":[330,362],"make":[332,364],"it":[333,365,457],"resemble":[334,366],"diseased":[336,368],"brain.":[337],"right":[339,372],"control.":[345,378],"model":[348],"obtained":[350],"follows:":[352],"nigrostriatal":[354,448],"brain,":[369],"whereas":[370],"An":[379],"adult":[380,950],"male":[381,907,951],"Sprague":[382],"Dawley":[383],"deeply":[386],"anesthetized":[387],"isoflurane,":[389],"pretreated":[390],"desmethylimipramine":[392],"(12.5":[393],"mg/kg,":[394],"ip)":[395],"placed":[397],"stereotaxic":[400],"frame.":[401],"After":[402],"an":[403,883,1019],"incision":[404],"dorsal":[407],"surface":[408],"skull":[411],"placement":[413],"burr":[416],"hole,":[417],"animal":[419,489,873],"injected":[421,437],"despramine.":[423],"10":[424],"min":[425],"later":[426],"1.5:L":[427],"6-hydroxydopamine":[429],"HBr":[430],"(6-OHDA;":[431],"4.0:g/\u03bcL,":[432],"free":[433],"base)":[434],"unilaterally":[436],"into":[438,694],"(AP:-5.4;":[442],"L:2.3;":[443],"DV:-8.4)":[444],"selectively":[446],"destroy":[447],"neurons.":[450],"Although":[451],"there":[452],"crossed-nigrostriatal":[455],"pathway,":[456],"quite":[459],"small,":[460],"contributing":[461],"well":[462],"under":[463,853],"5%":[464],"dopamine":[467],"content":[468],"contralateral":[471,476],"striatum,":[472],"thus":[474],"striatum":[477],"usually":[479],"referred":[480],"intact":[484],"(control)":[485],"side.":[486],"All":[487],"in-house":[488,1020],"experiments":[490],"performed":[492],"approval":[494],"Vanderbilt":[497,829,1106],"Institutional":[498,821],"Animal":[499,822,867],"Care":[500,823,847],"Use":[502,825,849],"Committee.":[503],"Brain":[504],"harvested,":[507],"snap":[508],"frozen":[509,954],"liquid":[511],"nitrogen,":[512],"stored":[514],"-80\u00b0C":[516],"until":[517],"use.":[518],"Frozen":[519],"sectioned":[523],"coronal":[526],"plane":[527],"10\u03bcm":[529,983,1070],"cryostat":[532,989],"(-20\u00b0C,":[533],"Leica":[534],"CM3050S;":[535],"Buffalo":[536],"Grove,":[537],"IL,":[538],"thaw":[541],"mounted":[542,995],"onto":[543,996],"conductive":[544],"Indium-tin-oxide":[545],"coated":[546],"glass":[547,1000],"slides":[548,1001],"(Delta":[549,1002],"Loveland,":[551,1004],"CO,":[552,1005],"USA).":[553,1006],"Samples":[554,961],"washed":[556],"remove":[558],"interfering":[559],"lipids":[560],"salts":[562],"sequential":[564],"washes":[565],"70%":[567],"ethanol":[568,571,581,590],"(30s),":[569,572,582,587],"100%":[570,580,589],"Carnoy's":[573],"fluid":[574],"(6:3:1":[575],"ethanol:chloroform:":[576],"acetic":[577],"acid)":[578],"(2min),":[579],"water":[583,922],"0.2%":[585],"TFA":[586],"(30s).":[591],"Spectrometry:":[594,1044],"IMS":[596],"15T":[602],"FT-ICR":[603],"spectrometer":[605,1056],"(Bruker":[606,1057],"Daltonics,":[607,1058],"Billerica,":[608],"MA,":[609],"sampling":[614],"75\u03bcm(laser":[617],"spot":[618],"size":[619],"50":[620],"\u03bcm)":[621],"resolving":[625],"power":[626,1073],"50,000":[628],"(m/FWHM)":[629],"5000.":[632],"focused":[636],"range":[640],"1300":[642],"23,000":[644],"total":[647,718],"20,000":[649],"pixels.":[650],"instrument":[652],"tuned":[654],"April":[687],"2016).":[688],"Data":[689,691],"Processing:":[690],"imported":[693],"MATLAB":[695],"2015b":[696],"(The":[697],"Mathworks":[698],"Inc.,":[699],"Natick,":[700],"MA)":[701],"further":[703],"analysis,":[705],"where":[706],"they":[707],"normalized":[709],"TIC":[711],"peak":[713],"picked,":[714],"resulting":[715],"2611":[720],"peaks.":[721],"Refer":[722],"\"Connecting":[724,779],"magnetic":[729,784],"resonance":[730,785],"imaging-based":[731,786],"anatomical":[732,736,787,791],"atlases":[733,788],"automated":[735,790],"interpretation":[737,792],"differential":[739,794],"Verbeeck":[742,797],"(Biochimica":[745,800],"Biophysica":[747,802],"Acta":[748,803],"-":[749,804],"Proteomics,":[752,807],"2017)":[753],"additional":[755],"information.":[756],"For":[757,1080],"more":[758,1081],"information":[759,1082],"about":[760,1083],"no1,":[763],"refer":[764,777,1087],"Section":[766,1089],"4.1":[767],"Supplementary":[770,1093],"Material":[771,1094],"and/or":[776,1099],"2017).":[808],"no2:":[812],"Ethics":[813],"statement:":[814],"Zebrafish":[815,870],"studies":[816],"approved":[818],"Committees":[826],"(IACUC)":[827],"University":[830,1107],"Medical":[831,1108],"Center":[832],"(protocol":[833],"number":[834],"M2200064)":[835],"accordance":[837],"Public":[840],"Health":[841,862],"Service":[842],"Policy":[843],"Human":[846],"Laboratory":[851,866],"Animals":[852],"United":[855],"States":[856],"America":[858],"National":[859],"Institutes":[860],"(NIH)":[863],"Office":[864],"Welfare":[868],"(OLAW).":[869],"husbandry":[871],"work:":[874],"zebrafish":[876,908,952],"line":[877],"this":[880],"had":[882],"AB":[884],"background":[885],"maintained":[888],"14:10":[891],"h":[892],"light:dark":[893],"cycle":[894],"recirculating":[897],"aquaculture":[898],"system.":[899],"A":[900],"single":[901],"Adult":[902],"(>90":[903],"days":[904],"post":[905],"fertilization)":[906],"euthanized":[910],"according":[911],"IACUC":[913],"protocol.":[914],"Acetonitrile,":[916],"isopentane,":[917],"gelatin":[919],"cold":[921],"fish":[923,967],"purchased":[925],"(St.":[928],"MO).":[930],"4-(dimethylamino)":[933],"cinnamic":[934],"acid":[935],"(DMACA)":[936],"99%":[938],"purity":[939],"bought":[941],"Thermo":[943],"Scientific":[944],"(Waltham,":[945],"MA).":[946],"preparation:":[948],"Whole-body":[949],"dry":[957],"ice/isopentane":[958],"freezing":[959],"method.":[960],"then":[963],"embedded":[964],"10%":[966],"gelatine":[968],"followed":[969],"second":[972],"embedding":[973],"swim":[976],"bladders.":[977],"Cryosectioning":[978],"done":[980],"thickness":[984],"CM3050":[987],"S":[988],"(Leica":[990],"Biosystems,":[991],"Wetzlar,":[992],"Germany)":[993,1037,1060],"indium":[997],"tin":[998],"oxide-coated":[999],"Matrix":[1007],"application":[1008],"DMACA":[1010],"concentration":[1013],"2mg/mL":[1015],"sublimation":[1021],"apparatus.":[1022],"Autofluorescence":[1023],"Zeiss":[1029,1033],"Axio":[1030],"Scan.Z1":[1031],"(Carl":[1032],"Microscopy":[1034],"GmbH,":[1035],"Oberkochen,":[1036],"prior":[1038],"imaging.":[1041],"Experiment":[1045],"carried":[1047],"out":[1048],"prototype":[1051],"timsTOF":[1053],"Pro":[1054],"Bremen,":[1059],"positive":[1062],"ionization":[1063],"mode":[1064],"(30%":[1071],"laser":[1072],"10kHz,":[1075],"200":[1076],"shots":[1077],"per":[1078],"pixel).":[1079],"no2,":[1086],"4.3":[1090],"contact":[1100],"Jacquelyn":[1101],"Spathies":[1102],"(data":[1103],"collector)":[1104],"Center.":[1109]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-10-24T00:00:00"}
