{"id":"https://openalex.org/W7078698564","doi":"https://doi.org/10.7912/8gce-m198","title":"Predictive Molecular Biomarkers for Human Health Risk","display_name":"Predictive Molecular Biomarkers for Human Health Risk","publication_year":2025,"publication_date":"2025-08-29","ids":{"openalex":"https://openalex.org/W7078698564","doi":"https://doi.org/10.7912/8gce-m198"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/42797","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/42797","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/a7f53acd-18f4-4652-8b10-3737a6bc5b09/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/a7f53acd-18f4-4652-8b10-3737a6bc5b09/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002316061","display_name":"Guanglong Jiang","orcid":"https://orcid.org/0000-0002-9233-052X","observed_orcids":["https://orcid.org/0000-0002-9233-052X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiang, Guanglong","raw_affiliation_strings":["Indiana University Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Indianapolis","institution_ids":["https://openalex.org/I4388446366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002316061"],"corresponding_institution_ids":["https://openalex.org/I4388446366"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.11299999803304672,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"molecular biomarkers","score":0.8220000267028809},{"id":"https://openalex.org/keywords/mirna-isomirs","display_name":"miRNA isomiRs","score":0.7710000276565552},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8849999904632568},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.902999997138977},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.7929999828338623},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9620000123977661},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.6869999766349792},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6525999903678894},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6492999792098999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6195999979972839},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4643000066280365},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.45680001378059387},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45179998874664307},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4359999895095825},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42969998717308044},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4043000042438507},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.39719998836517334},{"id":"https://openalex.org/C3019646584","wikidata":"https://www.wikidata.org/wiki/Q2311855","display_name":"Molecular biomarkers","level":2,"score":0.3763999938964844},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3361000120639801},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3154999911785126},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.29339998960494995},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2734000086784363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26989999413490295},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2637999951839447},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25679999589920044},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.25360000133514404}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/42797","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/42797","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/a7f53acd-18f4-4652-8b10-3737a6bc5b09/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"doi:10.7912/8gce-m198","doi":"https://doi.org/10.7912/8gce-m198","is_oa":true,"landing_page_url":"https://doi.org/10.7912/8gce-m198","pdf_url":null,"source":{"id":"https://openalex.org/S7407051850","display_name":"IU Indianapolis University Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/42797","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/42797","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/a7f53acd-18f4-4652-8b10-3737a6bc5b09/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7539884448051453,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320310263","display_name":"Indiana University-Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08"},{"id":"https://openalex.org/F4320310931","display_name":"Capital Normal University","ror":"https://ror.org/005edt527"},{"id":"https://openalex.org/F4320311345","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28"},{"id":"https://openalex.org/F4320332961","display_name":"School of Medicine, Indiana University","ror":null},{"id":"https://openalex.org/F4320337380","display_name":"Division of Mathematical Sciences","ror":"https://ror.org/051fftw81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7078698564.pdf","grobid_xml":"https://content.openalex.org/works/W7078698564.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Molecular":[0],"biomarkers":[1,24,98,230,312,338],"play":[2],"vital":[3],"roles":[4,335],"in":[5,33,54,66,75,99,135,144,216,241,325,339],"disease":[6,100,237,249,326],"risk":[7,239],"assessment,":[8],"personalized":[9,352],"treatment":[10,174,329],"selection":[11],"and":[12,36,52,56,114,149,164,192,211,278,290,296,321,328,343,353],"therapy":[13,159],"response":[14,138,219],"monitoring.":[15],"This":[16],"thesis":[17],"explores":[18],"the":[19,26,71,106,126,137,206,226,232,301,307,334,348],"use":[20],"of":[21,28,49,73,108,111,118,129,157,202,209,228,234,254,263,285,309,336],"diverse":[22,310,337],"molecular":[23,229,311],"for":[25,238,306],"assessment":[27,208,233],"human":[29,358],"health":[30,359],"risks,":[31],"primarily":[32],"cancers.":[34,146],"MiRNAs":[35],"their":[37,46,95],"isoforms":[38],"(isomiR)":[39],"are":[40],"promising":[41],"biomarker":[42],"candidates":[43],"due":[44],"to":[45,90,139,220,231,356],"comprehensive":[47],"regulation":[48,110],"gene":[50],"expression":[51],"involvement":[53],"physiology":[55],"pathological":[57],"processes.":[58],"The":[59,102,283],"first":[60],"study":[61],"demonstrates":[62],"that":[63,197],"genetic":[64,109],"variations":[65],"miRNA":[67,119,315],"precursor":[68],"regions":[69],"influence":[70],"biogenesis":[72],"isomiRs":[74],"95":[76],"SNP-isomiR":[77],"pairs.":[78],"Notably,":[79],"we":[80,124,224,346],"identified":[81],"a":[82,260],"SNP":[83],"(rs6505162)":[84],"impacting":[85],"hsa-miR-423":[86],"isomiRs,":[87],"potentially":[88],"linked":[89],"breast":[91,244],"cancer":[92,245,341],"pathogenesis,":[93],"suggesting":[94],"potential":[96],"as":[97],"assessment.":[101,331],"findings":[103],"also":[104],"highlight":[105],"mechanism":[107],"isomiR":[112],"generation":[113],"advance":[115],"our":[116],"understanding":[117],"mediated":[120],"post-transcriptional":[121],"regulation.":[122],"Secondly,":[123],"explored":[125],"predictive":[127],"capacity":[128],"aberrant":[130],"intron-retention":[131],"neoantigen":[132,319],"burden":[133,152],"(INB)":[134],"predicting":[136,217,340],"immune":[140],"checkpoint":[141],"inhibitors":[142],"(ICI)":[143],"metastatic":[145],"Both":[147],"INB":[148,179,191,210],"tumor":[150,203,256,287,323],"mutation":[151],"(TMB)":[153],"were":[154,194],"strong":[155],"predictors":[156],"ICI":[158,221],"duration":[160],"(p":[161,187,269,275,280],"=":[162,188,270,276,281],"0.019":[163],"0.038,":[165],"respectively),":[166],"with":[167,177,247],"patients":[168],"exhibiting":[169],"elevated":[170],"levels":[171],"demonstrating":[172],"exceptional":[173],"duration.":[175],"Patients":[176],"high":[178],"or":[180],"TMB":[181,193,212],"had":[182],"improved":[183,214],"overall":[184],"survival":[185,267,273],"(OS)":[186],"1.1\u00d710-4).":[189],"Importantly,":[190],"uncorrelated,":[195],"indicating":[196],"they":[198],"capture":[199],"distinct":[200],"aspects":[201],"neoantigen.":[204],"Together,":[205],"combined":[207],"offers":[213],"accuracy":[215],"clinical":[218],"therapies.":[222],"Finally,":[223],"extend":[225],"application":[227],"minimal":[235],"residual":[236,248],"stratification":[240],"triple":[242],"negative":[243],"(TNBC)":[246],"after":[250],"neoadjuvant":[251],"chemotherapy.":[252],"Detection":[253],"circulating":[255,286,322],"DNA":[257,324],"(ctDNA)":[258],"was":[259],"significant":[261],"predictor":[262],"inferior":[264],"distant":[265],"disease-free":[266,272],"(DDFS)":[268],"0.006),":[271],"(DFS)":[274],"0.009)":[277],"OS":[279],"0.002).":[282],"combination":[284],"cell":[288],"(CTC)":[289],"ctDNA":[291],"markers":[292],"provided":[293],"superior":[294],"sensitivity":[295],"prognostic":[297],"value.":[298],"In":[299],"conclusion,":[300],"studies":[302],"provide":[303],"compelling":[304],"evidence":[305],"utility":[308],"\u2013":[313],"including":[314],"isoforms,":[316],"abnormal":[317],"splicing-based":[318],"metrics":[320],"prediction":[327],"efficacy":[330],"By":[332],"elucidating":[333],"pathogenesis":[342],"therapeutic":[344],"response,":[345],"pave":[347],"way":[349],"towards":[350],"more":[351],"effective":[354],"approaches":[355],"managing":[357],"risks.":[360]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}