{"id":"https://openalex.org/W7076791","doi":null,"title":"Mise en \u00e9vidence d'un courant calcium \u00e0 bas potentiel d'activation sur les cellules auriculaires isol\u00e9es de grenouille","display_name":"Mise en \u00e9vidence d'un courant calcium \u00e0 bas potentiel d'activation sur les cellules auriculaires isol\u00e9es de grenouille","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W7076791","mag":"7076791"},"language":"fr","primary_location":{"id":"mag:7076791","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/1989LYO10009","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017144366","display_name":"Robert Bonvallet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert Bonvallet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017144366"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.25270000100135803,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-threshold-calcium-current","display_name":"low-threshold calcium current","score":0.9399999976158142},{"id":"https://openalex.org/keywords/atrial-cells","display_name":"atrial cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/slow-calcium-current","display_name":"slow calcium current","score":0.765999972820282},{"id":"https://openalex.org/keywords/dihydropyridines","display_name":"dihydropyridines","score":0.8939999938011169},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9160000085830688},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.984000027179718},{"id":"https://openalex.org/keywords/sodium-ions","display_name":"sodium ions","score":0.7799999713897705},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5202801823616028},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.5031363368034363},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4481302499771118},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35084787011146545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11622574925422668}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:7076791","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/1989LYO10009","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W829560888","https://openalex.org/W768909787","https://openalex.org/W8956578","https://openalex.org/W191297851","https://openalex.org/W1781879957","https://openalex.org/W2067220672","https://openalex.org/W1870987572","https://openalex.org/W574790459","https://openalex.org/W372090930","https://openalex.org/W7064536215"],"abstract_inverted_index":{"Les":[0,230],"mouvements":[1],"transmembranaires":[2],"de":[3,23,69,72,110,129,135,176,208,227],"ca,":[4,27,102],"lies":[5],"au":[6],"potentiel,":[7,119],"ont":[8,240],"ete":[9,34,160,200,241],"etudies":[10],"en":[11,36,101,106,202],"voltage":[12],"impose":[13],"avec":[14],"la":[15,52,88,98,211],"technique":[16],"du":[17,29,118,131,171,246],"patch-clamp,":[18],"sur":[19,204],"les":[20,84,156,205,235],"cellules":[21],"atriales":[22],"grenouille.":[24],"Un":[25,193],"courant":[26,30,43,109,132,139,150,162,172,178,209,247],"distinct":[28],"calcique":[31],"lent,":[32],"a":[33,56,77,87,159,164,199,249],"mis":[35,201],"evidence":[37,203],"dans":[38,93],"un":[39,57,80],"milieu":[40],"physiologique.":[41],"Ce":[42,149],"entrant,":[44],"s'activant":[45],"vers":[46],"60":[47],"mv,":[48],"est":[49,54,105,179,186,253],"present":[50],"si":[51],"cellule":[53],"maintenue":[55],"potentiel":[58],"plus":[59,114],"negatif":[60],"que":[61,97,137,217],"80":[62],"mv.":[63],"Il":[64],"n'est":[65,152],"pas":[66,153],"affecte":[67],"par":[68,83,141,155,181,188],"fortes":[70],"concentrations":[71],"tetrodotoxine":[73],"(ttx)":[74],"ce":[75,103,138,177],"qui":[76,104,151],"permis":[78],"d'exclure":[79],"passage":[81],"d'ions":[82],"canaux":[85,143,146],"sensibles":[86],"ttx.":[89],"Son":[90],"amplitude":[91],"varie":[92],"le":[94,169,189,219],"meme":[95],"sens":[96],"concentration":[99],"externe":[100],"faveur":[107],"d'un":[108],"nature":[111],"calcique.":[112],"De":[113],"sa":[115],"sensibilite":[116],"vis-a-vis":[117],"des":[120,126,142,145,196,213,237],"calci-bloqueurs":[121],"inorganiques":[122],"(ni,":[123],"cd)":[124],"et":[125],"dihydropyridines,":[127],"differente":[128],"celle":[130],"lent":[133],"permet":[134],"penser":[136],"passe":[140],"distincts":[144],"calciques":[147],"lents.":[148],"module":[154],"agonistes":[157],"adrenergiques":[158],"appele":[161],"ca":[163,173],"bas":[165,250],"seuil":[166,251],"d'activation":[167,252],"pour":[168],"differencier":[170],"lent.":[174],"L'amplitude":[175],"augmentee":[180],"l'angiotensine":[182],"ii":[183],"alors":[184],"qu'elle":[185],"diminuee":[187],"facteur":[190],"atrial":[191],"natriuretique.":[192],"role":[194,244],"important":[195],"ions":[197,214,238],"na":[198,215,239],"deux":[206],"types":[207],"calcium:":[210],"suppression":[212],"(quel":[216],"soit":[218],"substituant)":[220],"s'accompagne":[221],"toujours":[222],"d'une":[223],"tres":[224],"forte":[225],"diminution":[226],"leur":[228],"amplitude.":[229],"differents":[231],"mecanismes":[232],"susceptibles":[233],"d'expliquer":[234],"effets":[236],"testes.":[242],"Le":[243],"physiologique":[245],"calcium":[248],"discute":[254]},"counts_by_year":[],"updated_date":"2026-08-08T07:41:36.138363","created_date":"2016-06-24T00:00:00"}