{"id":"https://openalex.org/W7075329552","doi":"https://doi.org/10.1101/gr.202648.115","title":"Control of fluxes in metabolic networks","display_name":"Control of fluxes in metabolic networks","publication_year":2016,"publication_date":"2016-05-19","ids":{"openalex":"https://openalex.org/W7075329552","doi":"https://doi.org/10.1101/gr.202648.115","pmid":"https://pubmed.ncbi.nlm.nih.gov/27197218","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4937563"},"language":"en","primary_location":{"id":"doi:10.1101/gr.202648.115","doi":"https://doi.org/10.1101/gr.202648.115","is_oa":false,"landing_page_url":"https://doi.org/10.1101/gr.202648.115","pdf_url":null,"source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4937563","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076124302","display_name":"Georg Basler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092123","display_name":"Estaci\u00f3n Experimental del Zaid\u00edn","ror":"https://ror.org/00drcz023","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210092123"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Georg Basler","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, USA; Department of Environmental Protection, Estaci\u00f3n Experimental del Zaid\u00edn CSIC, Granada, 18008 Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, USA; Department of Environmental Protection, Estaci\u00f3n Experimental del Zaid\u00edn CSIC, Granada, 18008 Spain;","institution_ids":["https://openalex.org/I4210092123","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059658943","display_name":"Zoran Nikoloski","orcid":"https://orcid.org/0000-0003-2671-6763","observed_orcids":["https://orcid.org/0000-0003-2671-6763"]},"institutions":[{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zoran Nikoloski","raw_affiliation_strings":["Systems Biology and Mathematical Modeling, Max Planck Institute of Molecular Plant Physiology, Potsdam, 14476 Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology and Mathematical Modeling, Max Planck Institute of Molecular Plant Physiology, Potsdam, 14476 Germany;","institution_ids":["https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041552051","display_name":"Abdelhalim Larhlimi","orcid":"https://orcid.org/0000-0002-1709-2648","observed_orcids":["https://orcid.org/0000-0002-1709-2648"]},"institutions":[{"id":"https://openalex.org/I4210165258","display_name":"Laboratoire d'informatique de Nantes Atlantique","ror":"https://ror.org/05487pd16","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I205703379","https://openalex.org/I4210127572","https://openalex.org/I4210159245","https://openalex.org/I4210165258","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Abdelhalim Larhlimi","raw_affiliation_strings":["Laboratoire d'Informatique de Nantes Atlantique, Universit\u00e9 de Nantes, Nantes, 44322 France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Informatique de Nantes Atlantique, Universit\u00e9 de Nantes, Nantes, 44322 France;","institution_ids":["https://openalex.org/I4210165258","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038976962","display_name":"Albert-\u0139aszl\u00f3 Barab\u00e1si","orcid":"https://orcid.org/0000-0002-4028-3522","observed_orcids":["https://orcid.org/0000-0002-4028-3522"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert-L\u00e1szl\u00f3 Barab\u00e1si","raw_affiliation_strings":["Center for Complex Network Research and Departments of Physics, Computer Science, and Biology, Northeastern University, Boston, Massachusetts 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Complex Network Research and Departments of Physics, Computer Science, and Biology, Northeastern University, Boston, Massachusetts 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I12912129","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yang-Yu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang-Yu Liu","raw_affiliation_strings":["Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"7","first_page":"956","last_page":"968"},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.061900001019239426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-networks","display_name":"metabolic networks","score":0.722000002861023},{"id":"https://openalex.org/keywords/flux-control","display_name":"flux control","score":0.8560000061988831},{"id":"https://openalex.org/keywords/metabolic-control-analysis","display_name":"metabolic control analysis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7089999914169312},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.8183000087738037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7671999931335449},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6162999868392944},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.5382000207901001},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.44359999895095825},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.4250999987125397},{"id":"https://openalex.org/C70818257","wikidata":"https://www.wikidata.org/wiki/Q502671","display_name":"Metabolic control analysis","level":3,"score":0.4212999939918518},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4018999934196472},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.3968999981880188},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35760000348091125},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3546999990940094},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.3379000127315521},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.337799996137619},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.33649998903274536},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.32010000944137573},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.30169999599456787},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2551000118255615},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.25459998846054077}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1101/gr.202648.115","doi":"https://doi.org/10.1101/gr.202648.115","is_oa":false,"landing_page_url":"https://doi.org/10.1101/gr.202648.115","pdf_url":null,"source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4937563","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4937563","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Res","raw_type":"Text"},{"id":"pmid:27197218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27197218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01658343v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01658343","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Research, 2016, 26 (7), pp.956 - 968. ⟨10.1101/gr.202648.115⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:escidoc.org:escidoc:2321201","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002B-0E43-8","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:genome:26/7/956","doi":null,"is_oa":false,"landing_page_url":"http://genome.cshlp.org/cgi/content/short/26/7/956","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pure.mpg.de:item_2321201","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002B-0E43-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Research","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4937563","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4937563","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Res","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1022204393","display_name":null,"funder_award_id":"PFI-777","funder_id":"https://openalex.org/F4320306193","funder_display_name":"John Templeton Foundation"},{"id":"https://openalex.org/G1221413972","display_name":null,"funder_award_id":"51977","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2797176860","display_name":"Integrative Modeling and Engineering of Pseudomonas putida for Green Chemistry","funder_award_id":"329682","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2973790809","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3676855405","display_name":"Integrative Genomics of Acute Asthma Control","funder_award_id":"R01HL118455","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4809929516","display_name":"The control principles of complex systems","funder_award_id":"51977","funder_id":"https://openalex.org/F4320306193","funder_display_name":"John Templeton Foundation"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7191832816","display_name":null,"funder_award_id":"329682","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G8106039593","display_name":"Genomic Analysis of Network Perturbations in Human Disease","funder_award_id":"P50HG004233","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306193","display_name":"John Templeton Foundation","ror":"https://ror.org/035tnyy05"},{"id":"https://openalex.org/F4320315721","display_name":"Max Kade Foundation","ror":"https://ror.org/02tn5vs15"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320338285","display_name":"Krell Institute","ror":"https://ror.org/02pas9b60"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1484198052","https://openalex.org/W1505130887","https://openalex.org/W1543819126","https://openalex.org/W1686433163","https://openalex.org/W1870717075","https://openalex.org/W1931084385","https://openalex.org/W1972731253","https://openalex.org/W1980222019","https://openalex.org/W1986647193","https://openalex.org/W1989061197","https://openalex.org/W1992117451","https://openalex.org/W1998711816","https://openalex.org/W1998777096","https://openalex.org/W1999124942","https://openalex.org/W1999938932","https://openalex.org/W2009044337","https://openalex.org/W2015399172","https://openalex.org/W2015668518","https://openalex.org/W2015751324","https://openalex.org/W2017986168","https://openalex.org/W2020356832","https://openalex.org/W2022012525","https://openalex.org/W2024850003","https://openalex.org/W2029931619","https://openalex.org/W2036298713","https://openalex.org/W2037614307","https://openalex.org/W2039420810","https://openalex.org/W2055280476","https://openalex.org/W2057312785","https://openalex.org/W2059546521","https://openalex.org/W2062245653","https://openalex.org/W2063828920","https://openalex.org/W2072095756","https://openalex.org/W2072708674","https://openalex.org/W2073429274","https://openalex.org/W2074880157","https://openalex.org/W2076262841","https://openalex.org/W2077854294","https://openalex.org/W2077919059","https://openalex.org/W2082019892","https://openalex.org/W2082382448","https://openalex.org/W2089713346","https://openalex.org/W2090495875","https://openalex.org/W2097259163","https://openalex.org/W2098493765","https://openalex.org/W2098573723","https://openalex.org/W2100838748","https://openalex.org/W2102140136","https://openalex.org/W2103554498","https://openalex.org/W2104108767","https://openalex.org/W2110355460","https://openalex.org/W2111264907","https://openalex.org/W2111421616","https://openalex.org/W2113634596","https://openalex.org/W2117474489","https://openalex.org/W2120167281","https://openalex.org/W2121365413","https://openalex.org/W2123863402","https://openalex.org/W2124737787","https://openalex.org/W2131848047","https://openalex.org/W2135473716","https://openalex.org/W2137667844","https://openalex.org/W2140418591","https://openalex.org/W2143424137","https://openalex.org/W2144589197","https://openalex.org/W2146064872","https://openalex.org/W2148141042","https://openalex.org/W2149505266","https://openalex.org/W2156185846","https://openalex.org/W2157635835","https://openalex.org/W2166665154","https://openalex.org/W2166817392","https://openalex.org/W2223549218","https://openalex.org/W2488483130","https://openalex.org/W4235169531","https://openalex.org/W4245225949"],"related_works":["https://openalex.org/W1236177649","https://openalex.org/W2156150709","https://openalex.org/W3132803234","https://openalex.org/W7133049145","https://openalex.org/W2586192494","https://openalex.org/W2912099272","https://openalex.org/W1607122574","https://openalex.org/W2039251116","https://openalex.org/W2193677026","https://openalex.org/W4382935817"],"abstract_inverted_index":{"Understanding":[0],"the":[1,36,62,143],"control":[2,66,86],"of":[3,57,67,74,85,134,139,145],"large-scale":[4,58],"metabolic":[5,69],"networks":[6,70],"is":[7],"central":[8],"to":[9],"biology":[10],"and":[11,41,119,136,149],"medicine.":[12],"However,":[13],"existing":[14],"approaches":[15],"either":[16],"require":[17,50,81],"specifying":[18],"a":[19,82],"cellular":[20,52,95,106],"objective":[21,53],"or":[22],"can":[23],"only":[24],"be":[25],"used":[26],"for":[27,54],"small":[28],"networks.":[29],"We":[30,60,76],"introduce":[31],"new":[32],"coupling":[33],"types":[34],"describing":[35],"relations":[37],"between":[38],"reaction":[39],"activities,":[40],"develop":[42],"an":[43],"efficient":[44],"computational":[45],"framework,":[46],"which":[47],"does":[48],"not":[49],"any":[51],"systematic":[55],"studies":[56],"metabolism.":[59,150],"identify":[61],"driver":[63,112],"reactions":[64,91,113],"facilitating":[65,105],"23":[68],"from":[71],"all":[72],"kingdoms":[73],"life.":[75],"find":[77],"that":[78],"unicellular":[79],"organisms":[80],"smaller":[83],"degree":[84],"than":[87],"multicellular":[88],"organisms.":[89],"Driver":[90],"are":[92],"under":[93],"complex":[94],"regulation":[96],"in":[97,104,117],"Escherichia":[98],"coli,":[99],"indicating":[100],"their":[101],"preeminent":[102],"role":[103],"control.":[107],"In":[108],"human":[109],"cancer":[110],"cells,":[111],"play":[114],"pivotal":[115],"roles":[116],"malignancy":[118],"represent":[120],"potential":[121],"therapeutic":[122],"targets.":[123],"The":[124],"developed":[125],"framework":[126],"helps":[127],"us":[128],"gain":[129],"insights":[130],"into":[131],"regulatory":[132],"principles":[133],"diseases":[135],"facilitates":[137],"design":[138],"engineering":[140],"strategies":[141],"at":[142],"interface":[144],"gene":[146],"regulation,":[147],"signaling,":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}