{"id":"https://openalex.org/W7071595752","doi":null,"title":"Seguran\u00e7a e tolerabilidade do canabidiol no tratamento da depress\u00e3o bipolar : relato de resultados preliminares","display_name":"Seguran\u00e7a e tolerabilidade do canabidiol no tratamento da depress\u00e3o bipolar : relato de resultados preliminares","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W7071595752"},"language":"pt","primary_location":{"id":"pmh:oai:www.lume.ufrgs.br:10183/213234","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/213234","pdf_url":"http://hdl.handle.net/10183/213234","source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Resumo publicado em evento"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/213234","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Pinto, Jairo Vin\u00edcius Merege de Mello Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pinto, Jairo Vin\u00edcius Merege de Mello Cruz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016019673","display_name":"Carlos Eduardo Santana de Oliveira","orcid":"https://orcid.org/0000-0003-4154-8323","observed_orcids":["https://orcid.org/0000-0003-4154-8323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliveira, Carlos Eduardo Santana de","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028527720","display_name":"\u00c9rico de Moura Silveira J\u00fanior","orcid":"https://orcid.org/0000-0001-6439-1627","observed_orcids":["https://orcid.org/0000-0001-6439-1627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silveira J\u00fanior, \u00c9rico de Moura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039630637","display_name":"Mir\u00e9ia Fortes Vianna Sulzbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sulzbach, Mir\u00e9ia Fortes Vianna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022459446","display_name":"Gabriel Santana da Rosa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosa, Gabriel Santana da","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011263675","display_name":"Pierre Emanuel de Freitas Gon\u00e7alves","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gon\u00e7alves, Pierre Emanuel de Freitas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066862037","display_name":"Giovana Bristot","orcid":"https://orcid.org/0000-0002-0553-9334","observed_orcids":["https://orcid.org/0000-0002-0553-9334"]},"institutions":[{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bristot, Giovana","raw_affiliation_strings":["HCPA -Hospital de Cl\u00ednicas de Porto Alegre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HCPA -Hospital de Cl\u00ednicas de Porto Alegre","institution_ids":["https://openalex.org/I4210097146"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ceres\u00e9r, Keila Maria Mendes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ceres\u00e9r, Keila Maria Mendes","raw_affiliation_strings":["HCPA -Hospital de Cl\u00ednicas de Porto Alegre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HCPA -Hospital de Cl\u00ednicas de Porto Alegre","institution_ids":["https://openalex.org/I4210097146"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Crippa, Jos\u00e9 Alexandre de Souza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Crippa, Jos\u00e9 Alexandre de Souza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Kauer-Sant'Anna, M\u00e1rcia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kauer-Sant'Anna, M\u00e1rcia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.35499998927116394,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.9240000247955322},{"id":"https://openalex.org/keywords/bipolar-depression","display_name":"bipolar depression","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bipolar-i-disorder","display_name":"bipolar I disorder","score":0.8209999799728394},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.9190000295639038},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.847000002861023},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6349999904632568},{"id":"https://openalex.org/keywords/young-mania-rating-scale","display_name":"Young Mania Rating Scale","score":0.6840000152587891},{"id":"https://openalex.org/keywords/brief-psychiatric-rating-scale","display_name":"Brief Psychiatric Rating Scale","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cannabis-derivatives","display_name":"cannabis derivatives","score":0.42399999499320984},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.45500001311302185},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6680999994277954},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.31029999256134033},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2904999852180481},{"id":"https://openalex.org/C2776882386","wikidata":"https://www.wikidata.org/wiki/Q2291130","display_name":"Hemiparesis","level":3,"score":0.25699999928474426},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.24770000576972961},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.23559999465942383},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.22949999570846558},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.22529999911785126},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.22460000216960907},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2231999933719635}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.lume.ufrgs.br:10183/213234","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/213234","pdf_url":"http://hdl.handle.net/10183/213234","source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Resumo publicado em evento"}],"best_oa_location":{"id":"pmh:oai:www.lume.ufrgs.br:10183/213234","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/213234","pdf_url":"http://hdl.handle.net/10183/213234","source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Resumo publicado em evento"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7071595752.pdf","grobid_xml":"https://content.openalex.org/works/W7071595752.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7014450701","https://openalex.org/W7061633320","https://openalex.org/W4388295980","https://openalex.org/W4312783127","https://openalex.org/W7029695738","https://openalex.org/W4402354186","https://openalex.org/W4403284383","https://openalex.org/W6981320963","https://openalex.org/W2052694761","https://openalex.org/W4411929236"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o:":[0],"Os":[1],"epis\u00f3dios":[2,158,289],"mais":[3,55],"comuns":[4],"ao":[5,256,264],"longo":[6],"do":[7,9,46,123,160,236],"curso":[8],"Transtorno":[10,161],"Bipolar":[11],"s\u00e3o":[12,340],"os":[13,36,51,157],"de":[14,23,29,94,112,139,169,180,197,231,258,328,343],"depress\u00e3o":[15,132,323],"bipolar,":[16,324],"que":[17,84,149,326,338],"est\u00e3o":[18,58],"associados":[19,59,298],"a":[20,26,60,65,118,121,131,166,200,227,322],"importantes":[21,61],"d\u00e9ficits":[22],"funcionalidade":[24],"e":[25,41,82,91,106,114,120,193,205,239,306,319],"risco":[27],"aumentado":[28],"suic\u00eddio.Entretanto,":[30],"o":[31,151,185,189,250,273,307,325],"tratamento":[32,93,128,186,317],"ainda":[33,302],"\u00e9":[34,135],"limitado:":[35],"antidepressivos":[37],"apresentam":[38],"respostas":[39],"limitadas":[40],"podem":[42],"levar":[43],"\u00e0":[44,299],"desestabiliza\u00e7\u00e3o":[45],"humor":[47],"se":[48,277],"usados":[49],"cronicamente;":[50],"antipsic\u00f3ticos":[52],"at\u00edpicos,":[53],"embora":[54],"eficazes,":[56],"tamb\u00e9m":[57],"efeitos":[62,211,295],"colaterais.Assim":[63],"sendo,":[64],"busca":[66],"por":[67,147,177,271,285],"novas":[68],"op\u00e7\u00f5es":[69],"terap\u00eauticas":[70],"faz-se":[71],"necess\u00e1ria.O":[72],"canabidiol":[73,313],"(CBD),":[74],"derivado":[75],"da":[76,216],"Cannabis":[77],"sativa,":[78],"apresenta":[79],"evid\u00eancias":[80],"cl\u00ednicas":[81],"pr\u00e9-cl\u00ednicas":[83],"sugerem":[85],"potencial":[86],"papel":[87],"positivo":[88],"na":[89],"neuroprote\u00e7\u00e3o":[90],"no":[92,99],"transtornos":[95,336],"neuropsiqui\u00e1tricos.O":[96],"CBD":[97,124,152,170],"atua":[98],"sistema":[100],"endocanabinoide,":[101],"um":[102,109,127,136,140,175,178,316,344],"promissor":[103],"alvo":[104],"terap\u00eautico,":[105],"tem":[107],"apresentado":[108],"favor\u00e1vel":[110],"perfil":[111],"seguran\u00e7a":[113,119],"tolerabilidade.Objetivo:":[115],"Objetivamos":[116],"investigar":[117],"tolerabilidade":[122],"puro":[125],"como":[126,153],"adjuvante":[129,155],"para":[130,156,321],"bipolar.M\u00e9todos:":[133],"Este":[134],"relat\u00f3rio":[137],"preliminar":[138],"ensaio":[141],"cl\u00ednico":[142],"duplo-cego,":[143],"randomizado":[144],"(ECR),":[145],"controlado":[146],"placebo,":[148],"testa":[150],"terapia":[154],"depressivos":[159],"Bipolar.Os":[162],"participantes":[163,224],"recebem":[164],"1":[165],"2":[167],"c\u00e1psulas":[168],"150mg/dia":[171],"ou":[172],"placebo":[173],"em":[174,304,334,346],"ECR":[176],"per\u00edodo":[179],"12":[181],"semanas,":[182],"permanecendo":[183],"com":[184,199,330],"usual":[187],"durante":[188],"estudo.Os":[190],"sintomas":[191,267,281],"man\u00edacos":[192],"psic\u00f3ticos":[194,290],"foram":[195,213,225],"avaliados":[196,214],"acordo":[198,329],"Young":[201],"Mania":[202],"Rating":[203,208],"Scale":[204],"Brief":[206],"Psychiatric":[207],"Scale,":[209],"respectivamente.Os":[210],"colaterais":[212,296],"atrav\u00e9s":[215],"escala":[217],"Udvalg":[218],"for":[219],"Kliniske":[220],"Undersogelserrating":[221],"Scale.Resultados:":[222],"27":[223],"inclu\u00eddos,":[226],"idade":[228],"m\u00e9dia":[229],"foi":[230,253,310],"43,9":[232],"anos,":[233],"21":[234],"eram":[235],"sexo":[237],"feminino":[238],"18":[240],"tinham":[241],"transtorno":[242],"bipolar":[243],"tipo":[244],"I.":[245],"6":[246],"pacientes":[247],"n\u00e3o":[248,309],"completaram":[249],"estudo:":[251],"uma":[252,261],"retirada":[254,262],"devido":[255,263],"desenvolvimento":[257],"rash":[259],"cut\u00e2neo;":[260],"agravamento":[265],"dos":[266,280],"depressivos;":[268,282],"dois":[269,283],"optaram":[270],"parar":[272],"estudo":[274,301,345],"porque":[275],"estavam":[276],"sentindo":[278],"melhor":[279],"desistiram":[284],"outros":[286,335],"motivos.N\u00e3o":[287],"houve":[288],"induzidos,":[291],"virada":[292],"man\u00edaca":[293],"nem":[294],"graves":[297],"interven\u00e7\u00e3o.O":[300],"est\u00e1":[303,327],"andamento":[305],"cegamento":[308],"quebrado.Conclus\u00e3o:":[311],"O":[312],"parece":[314],"ser":[315],"seguro":[318],"toler\u00e1vel":[320],"estudos":[331],"deste":[332],"f\u00e1rmaco":[333],"neuropsiqui\u00e1tricos.Destacamos":[337],"estes":[339],"resultados":[341],"preliminares":[342],"andamento.":[347]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}