{"id":"https://openalex.org/W7071340683","doi":null,"title":"Safety and therapeutical efficacy of the anti-ageing protein klotho for treating age-associated deficits and increasing longevity","display_name":"Safety and therapeutical efficacy of the anti-ageing protein klotho for treating age-associated deficits and increasing longevity","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W7071340683"},"language":"ca","primary_location":{"id":"pmh:oai:ddd.uab.cat:292608","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/292608","pdf_url":"https://ddd.uab.cat/pub/tesis/2023/hdl_10803_690938/jrs1de1.pdf","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesi doctoral"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ddd.uab.cat/pub/tesis/2023/hdl_10803_690938/jrs1de1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033054576","display_name":"Joan Roig-Soriano","orcid":"https://orcid.org/0000-0002-6134-3141","observed_orcids":["https://orcid.org/0000-0002-6134-3141"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Roig Soriano, Joan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology , Institut de Neuroci\u00e8nces (INc) , Universitat Aut\u00f2noma Barcelona , Bellaterra , Spain","Institut de Neuroci\u00e8nces (INc) , Department of Biochemistry and Molecular Biology , Universitat Aut\u00f2noma Barcelona , Bellaterra , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology , Institut de Neuroci\u00e8nces (INc) , Universitat Aut\u00f2noma Barcelona , Bellaterra , Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Institut de Neuroci\u00e8nces (INc) , Department of Biochemistry and Molecular Biology , Universitat Aut\u00f2noma Barcelona , Bellaterra , Spain","institution_ids":["https://openalex.org/I123044942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033054576"],"corresponding_institution_ids":["https://openalex.org/I123044942"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klotho","display_name":"Klotho","score":0.9229999780654907},{"id":"https://openalex.org/keywords/anti-aging-treatment","display_name":"anti-aging therapy","score":0.890999972820282},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/samp8-mice","display_name":"SAMP8 mice","score":0.6790000200271606},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.7049999833106995},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mineral-and-bone-metabolism","display_name":"bone mineral metabolism","score":0.5},{"id":"https://openalex.org/keywords/insulin-igf-1-signaling","display_name":"insulin/IGF-1 signaling","score":0.5860000252723694},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7239999771118164},{"id":"https://openalex.org/keywords/inflammatory-stress","display_name":"inflammatory stress","score":0.8569999933242798},{"id":"https://openalex.org/keywords/aav9-vector","display_name":"AAV9 vector","score":0.6710000038146973},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.3400000035762787},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4000000059604645},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.4429999887943268},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.5410000085830688},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.47200000286102295},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4763999879360199},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4526999890804291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.353300005197525},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.33309999108314514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.329800009727478},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.31470000743865967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2987000048160553},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.2150000035762787},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.19679999351501465},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.1931000053882599},{"id":"https://openalex.org/C62692923","wikidata":"https://www.wikidata.org/wiki/Q493630","display_name":"Petrochemistry","level":2,"score":0.1914999932050705},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.17550000548362732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16850000619888306},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.16030000150203705},{"id":"https://openalex.org/C3019497199","wikidata":"https://www.wikidata.org/wiki/Q853516","display_name":"Skin color","level":2,"score":0.15600000321865082},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.15309999883174896},{"id":"https://openalex.org/C2776842983","wikidata":"https://www.wikidata.org/wiki/Q581319","display_name":"Production system (computer science)","level":3,"score":0.147599995136261},{"id":"https://openalex.org/C3018122547","wikidata":"https://www.wikidata.org/wiki/Q5690813","display_name":"Health benefits","level":2,"score":0.1436000019311905},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.14339999854564667},{"id":"https://openalex.org/C2983413640","wikidata":"https://www.wikidata.org/wiki/Q1080794","display_name":"Public education","level":2,"score":0.1387999951839447},{"id":"https://openalex.org/C3018907156","wikidata":"https://www.wikidata.org/wiki/Q7785058","display_name":"Third generation","level":2,"score":0.13570000231266022},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.13510000705718994},{"id":"https://openalex.org/C9832595","wikidata":"https://www.wikidata.org/wiki/Q414050","display_name":"Klotho","level":3,"score":0.1265999972820282},{"id":"https://openalex.org/C52130261","wikidata":"https://www.wikidata.org/wiki/Q39825","display_name":"Census","level":3,"score":0.12600000202655792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.125900000333786},{"id":"https://openalex.org/C2994510176","wikidata":"https://www.wikidata.org/wiki/Q1080794","display_name":"National education","level":2,"score":0.1257999986410141},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.12430000305175781},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.11760000139474869},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11559999734163284},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11500000208616257},{"id":"https://openalex.org/C2994573606","wikidata":"https://www.wikidata.org/wiki/Q2781245","display_name":"Fetal death","level":4,"score":0.11469999700784683},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.10890000313520432},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10809999704360962},{"id":"https://openalex.org/C3018875020","wikidata":"https://www.wikidata.org/wiki/Q1441305","display_name":"Signs and symptoms","level":2,"score":0.10589999705553055},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.10520000010728836},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.10379999876022339},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.10379999876022339},{"id":"https://openalex.org/C3018697994","wikidata":"https://www.wikidata.org/wiki/Q191089","display_name":"Elderly people","level":2,"score":0.10360000282526016},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10270000249147415}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ddd.uab.cat:292608","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/292608","pdf_url":"https://ddd.uab.cat/pub/tesis/2023/hdl_10803_690938/jrs1de1.pdf","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesi doctoral"},{"id":"pmh:oai:www.tdx.cat:10803/690938","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/690938","pdf_url":"https://www.tdx.cat/bitstream/10803/690938/1/jrs1de1.pdf","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:ddd.uab.cat:292608","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/292608","pdf_url":"https://ddd.uab.cat/pub/tesis/2023/hdl_10803_690938/jrs1de1.pdf","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesi doctoral"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1512873207","display_name":null,"funder_award_id":"PID2020-116735RB-I00","funder_id":"https://openalex.org/F4320326262","funder_display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a"},{"id":"https://openalex.org/G1661095267","display_name":null,"funder_award_id":"2017 SGR 106","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G2262748287","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3005324705","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G3288897321","display_name":null,"funder_award_id":"2017-SGR","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G3480869486","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G425668148","display_name":null,"funder_award_id":".13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G451917667","display_name":null,"funder_award_id":"13039/501100011033","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G5347533872","display_name":null,"funder_award_id":"SAF2016-33307","funder_id":"https://openalex.org/F4320326262","funder_display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a"},{"id":"https://openalex.org/G5554424168","display_name":null,"funder_award_id":"2017SGR","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G578634983","display_name":null,"funder_award_id":"2017-SGR-106","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G5852091828","display_name":null,"funder_award_id":"13039/501100011033","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G5967599077","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G669617321","display_name":null,"funder_award_id":"PCIN-2015-229","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7084143925","display_name":null,"funder_award_id":"AEI/10","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G7425137858","display_name":null,"funder_award_id":"PID2019","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G8684520763","display_name":null,"funder_award_id":"PID2019","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320322121","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230"},{"id":"https://openalex.org/F4320323428","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57"},{"id":"https://openalex.org/F4320326262","display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","ror":"https://ror.org/03sv46s19"},{"id":"https://openalex.org/F4320327451","display_name":"Fundaci\u00f3 Institut de Recerca Hospital Universitari Vall d\u2019Hebron","ror":null},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7071340683.pdf","grobid_xml":"https://content.openalex.org/works/W7071340683.grobid-xml"},"referenced_works_count":307,"referenced_works":["https://openalex.org/W11016890","https://openalex.org/W1177905050","https://openalex.org/W1495719268","https://openalex.org/W1506428037","https://openalex.org/W1509037082","https://openalex.org/W1581119831","https://openalex.org/W1585985640","https://openalex.org/W1622489609","https://openalex.org/W1640694777","https://openalex.org/W1771974095","https://openalex.org/W1964460240","https://openalex.org/W1964653796","https://openalex.org/W1967232281","https://openalex.org/W1970270883","https://openalex.org/W1970638396","https://openalex.org/W1970719549","https://openalex.org/W1971122000","https://openalex.org/W1974632191","https://openalex.org/W1977140999","https://openalex.org/W1982712041","https://openalex.org/W1983068271","https://openalex.org/W1983527841","https://openalex.org/W1983945268","https://openalex.org/W1985216157","https://openalex.org/W1985860523","https://openalex.org/W1986535251","https://openalex.org/W1987925568","https://openalex.org/W1988032328","https://openalex.org/W1991429442","https://openalex.org/W1992510938","https://openalex.org/W1993405199","https://openalex.org/W1994357518","https://openalex.org/W1994814634","https://openalex.org/W1995870693","https://openalex.org/W1996219539","https://openalex.org/W1997458597","https://openalex.org/W1998165633","https://openalex.org/W2004314923","https://openalex.org/W2004344897","https://openalex.org/W2005586848","https://openalex.org/W2005911385","https://openalex.org/W2007193535","https://openalex.org/W2011914524","https://openalex.org/W2013209686","https://openalex.org/W2016073527","https://openalex.org/W2019252920","https://openalex.org/W2019387292","https://openalex.org/W2019691840","https://openalex.org/W2020725735","https://openalex.org/W2021751747","https://openalex.org/W2022166760","https://openalex.org/W2024573448","https://openalex.org/W2027386372","https://openalex.org/W2028394784","https://openalex.org/W2028480953","https://openalex.org/W2030134966","https://openalex.org/W2033344778","https://openalex.org/W2034373988","https://openalex.org/W2034546193","https://openalex.org/W2038510075","https://openalex.org/W2040542461","https://openalex.org/W2041019818","https://openalex.org/W2045400137","https://openalex.org/W2045867494","https://openalex.org/W2045916315","https://openalex.org/W2049229440","https://openalex.org/W2049956841","https://openalex.org/W2050565170","https://openalex.org/W2051945197","https://openalex.org/W2057166126","https://openalex.org/W2057737927","https://openalex.org/W2061667272","https://openalex.org/W2063035406","https://openalex.org/W2065048683","https://openalex.org/W2065401361","https://openalex.org/W2065962214","https://openalex.org/W2068334367","https://openalex.org/W2069369322","https://openalex.org/W2071027270","https://openalex.org/W2071864606","https://openalex.org/W2072441360","https://openalex.org/W2072645006","https://openalex.org/W2073026167","https://openalex.org/W2073572813","https://openalex.org/W2073924899","https://openalex.org/W2075088231","https://openalex.org/W2076787014","https://openalex.org/W2079691799","https://openalex.org/W2083607270","https://openalex.org/W2084180690","https://openalex.org/W2084566588","https://openalex.org/W2085086344","https://openalex.org/W2085105325","https://openalex.org/W2087544898","https://openalex.org/W2088038548","https://openalex.org/W2088221930","https://openalex.org/W2092476887","https://openalex.org/W2104048619","https://openalex.org/W2106318382","https://openalex.org/W2109815592","https://openalex.org/W2111387279","https://openalex.org/W2113275211","https://openalex.org/W2114360920","https://openalex.org/W2115844104","https://openalex.org/W2118789293","https://openalex.org/W2119589283","https://openalex.org/W2121270324","https://openalex.org/W2121734692","https://openalex.org/W2123082215","https://openalex.org/W2123223518","https://openalex.org/W2125987139","https://openalex.org/W2126525177","https://openalex.org/W2127608566","https://openalex.org/W2129598053","https://openalex.org/W2132083557","https://openalex.org/W2132537604","https://openalex.org/W2132961875","https://openalex.org/W2133173731","https://openalex.org/W2133574882","https://openalex.org/W2133904980","https://openalex.org/W2136097257","https://openalex.org/W2137484110","https://openalex.org/W2137720344","https://openalex.org/W2142139309","https://openalex.org/W2142798211","https://openalex.org/W2142867403","https://openalex.org/W2150355840","https://openalex.org/W2151588047","https://openalex.org/W2152109784","https://openalex.org/W2154248702","https://openalex.org/W2157669984","https://openalex.org/W2159296038","https://openalex.org/W2159433569","https://openalex.org/W2160695627","https://openalex.org/W2161630557","https://openalex.org/W2161986963","https://openalex.org/W2165852917","https://openalex.org/W2166843798","https://openalex.org/W2168473380","https://openalex.org/W2169020430","https://openalex.org/W2169621456","https://openalex.org/W2170534823","https://openalex.org/W2171204069","https://openalex.org/W2174897251","https://openalex.org/W2176154815","https://openalex.org/W2206935564","https://openalex.org/W2214652553","https://openalex.org/W2223167867","https://openalex.org/W2255685744","https://openalex.org/W2258095556","https://openalex.org/W2263350650","https://openalex.org/W2270417683","https://openalex.org/W2305265838","https://openalex.org/W2320638839","https://openalex.org/W2321673926","https://openalex.org/W2337932523","https://openalex.org/W2418367670","https://openalex.org/W2468325590","https://openalex.org/W2491494855","https://openalex.org/W2517126981","https://openalex.org/W2532225934","https://openalex.org/W2534906898","https://openalex.org/W2537214690","https://openalex.org/W2554361415","https://openalex.org/W2556853809","https://openalex.org/W2569860947","https://openalex.org/W2577597748","https://openalex.org/W2578855353","https://openalex.org/W2594688987","https://openalex.org/W2596228608","https://openalex.org/W2597132569","https://openalex.org/W2604896367","https://openalex.org/W2605061259","https://openalex.org/W2606478035","https://openalex.org/W2608335129","https://openalex.org/W2611842385","https://openalex.org/W2726357417","https://openalex.org/W2727910262","https://openalex.org/W2734888049","https://openalex.org/W2741676308","https://openalex.org/W2742840392","https://openalex.org/W2744041459","https://openalex.org/W2750235736","https://openalex.org/W2766400005","https://openalex.org/W2766885602","https://openalex.org/W2767517408","https://openalex.org/W2768033029","https://openalex.org/W2769652680","https://openalex.org/W2770332361","https://openalex.org/W2771554318","https://openalex.org/W2779406489","https://openalex.org/W2780834529","https://openalex.org/W2783547662","https://openalex.org/W2789850150","https://openalex.org/W2789955563","https://openalex.org/W2790191085","https://openalex.org/W2791304677","https://openalex.org/W2792782460","https://openalex.org/W2795818534","https://openalex.org/W2796075038","https://openalex.org/W2799981558","https://openalex.org/W2800819396","https://openalex.org/W2803669677","https://openalex.org/W2809695658","https://openalex.org/W2809896540","https://openalex.org/W2810391611","https://openalex.org/W2884538590","https://openalex.org/W2887733344","https://openalex.org/W2889787710","https://openalex.org/W2892001713","https://openalex.org/W2894859047","https://openalex.org/W2900439582","https://openalex.org/W2901082414","https://openalex.org/W2901183439","https://openalex.org/W2901748284","https://openalex.org/W2904187571","https://openalex.org/W2905589246","https://openalex.org/W2909477364","https://openalex.org/W2913212173","https://openalex.org/W2913940235","https://openalex.org/W2914251418","https://openalex.org/W2914942665","https://openalex.org/W2921389329","https://openalex.org/W2924222341","https://openalex.org/W2925620762","https://openalex.org/W2937386865","https://openalex.org/W2939604020","https://openalex.org/W2941417604","https://openalex.org/W2948514534","https://openalex.org/W2952791314","https://openalex.org/W2955233471","https://openalex.org/W2958408897","https://openalex.org/W2959335797","https://openalex.org/W2960199440","https://openalex.org/W2974398780","https://openalex.org/W2975507539","https://openalex.org/W2981170486","https://openalex.org/W2984307536","https://openalex.org/W2987092380","https://openalex.org/W2988310131","https://openalex.org/W2989318766","https://openalex.org/W2990889969","https://openalex.org/W2994604017","https://openalex.org/W2995600606","https://openalex.org/W3004507471","https://openalex.org/W3004887743","https://openalex.org/W3014418129","https://openalex.org/W3017377629","https://openalex.org/W3027026505","https://openalex.org/W3028082975","https://openalex.org/W3032166296","https://openalex.org/W3042141026","https://openalex.org/W3044596333","https://openalex.org/W3087214315","https://openalex.org/W3088224260","https://openalex.org/W3094557333","https://openalex.org/W3096489545","https://openalex.org/W3097127970","https://openalex.org/W3097893099","https://openalex.org/W3112058737","https://openalex.org/W3119985674","https://openalex.org/W3122524813","https://openalex.org/W3126884725","https://openalex.org/W3128825549","https://openalex.org/W3130160967","https://openalex.org/W3134591300","https://openalex.org/W3136370828","https://openalex.org/W3138032810","https://openalex.org/W3146891894","https://openalex.org/W3147542109","https://openalex.org/W3156499396","https://openalex.org/W3157246869","https://openalex.org/W3163121156","https://openalex.org/W3165546848","https://openalex.org/W3188003180","https://openalex.org/W3200691584","https://openalex.org/W3205404208","https://openalex.org/W3208110623","https://openalex.org/W3212074568","https://openalex.org/W3213906603","https://openalex.org/W3215823623","https://openalex.org/W4205241023","https://openalex.org/W4211154726","https://openalex.org/W4220663938","https://openalex.org/W4220989986","https://openalex.org/W4225121116","https://openalex.org/W4229445765","https://openalex.org/W4280609519","https://openalex.org/W4282547094","https://openalex.org/W4283747762","https://openalex.org/W4283778388","https://openalex.org/W4285020331","https://openalex.org/W4292488030","https://openalex.org/W4293484733","https://openalex.org/W4302363811","https://openalex.org/W4307657098","https://openalex.org/W4308298493","https://openalex.org/W4312114044","https://openalex.org/W4312193046","https://openalex.org/W4313455295","https://openalex.org/W4313531093","https://openalex.org/W4315705280","https://openalex.org/W4322619862","https://openalex.org/W4322629656","https://openalex.org/W4323566030","https://openalex.org/W4324018519","https://openalex.org/W4324143106"],"related_works":["https://openalex.org/W4407852288","https://openalex.org/W204871396","https://openalex.org/W4307657098","https://openalex.org/W7014723759","https://openalex.org/W2617693931","https://openalex.org/W2921468732","https://openalex.org/W4220663938","https://openalex.org/W6907994381","https://openalex.org/W1984444552","https://openalex.org/W2990362935"],"abstract_inverted_index":{"Els":[0,318],"aven\u00e7os":[1],"en":[2,113,175,224,234,277,295,335,403,505,515,549,558],"l'atenci\u00f3":[3],"sanit\u00e0ria":[4],"i":[5,27,62,73,77,127,136,142,155,161,239,264,311,322,362,376,382,530],"la":[6,60,63,80,116,119,125,131,140,147,190,196,206,218,272,308,315,363,404,422,434,437,451,553],"qualitat":[7],"de":[8,20,42,50,56,70,105,118,121,133,146,150,173,195,198,200,257,259,274,297,307,314,330,358,373,389,418,421,453,458,475,477,488,513,541,552],"vida":[9],"a":[10,24,103,124,261,368,386,398,430,460,465,472,556],"les":[11,106,341,371,455,535],"societats":[12],"modernes":[13],"han":[14],"provocat":[15],"un":[16,47,88,212,312,399,483,526,544],"augment":[17,313,355,400],"del":[18,185,208,401,494],"percentatge":[19],"poblaci\u00f3":[21],"que":[22,30,189,243,268,300,350,485,510,523,537],"arriba":[23],"edats":[25],"avan\u00e7ades,":[26],"es":[28,168,249,301,448,469],"preveu":[29],"al":[31,392],"2060":[32],"el":[33,143,225,280,416,503],"25%":[34],"dels":[35,37,48,344,356,365,407,439],"ciutadans":[36],"pa\u00efsos":[38],"occidentals":[39],"tingui":[40],"m\u00e9s":[41,463],"65":[43],"anys.":[44],"L'envelliment":[45],"\u00e9s":[46,531],"factors":[49],"risc":[51],"principals":[52],"d'una":[53,255],"\u00e0mplia":[54],"gamma":[55],"patologies,":[57],"com":[58,98,115,130,370,436,522],"l'osteoporosi,":[59],"sarcop\u00e8nia":[61],"degeneraci\u00f3":[64,554],"cognitiva.":[65],"Aquestes":[66],"afeccions":[67],"van":[68,169,250,333,347,501],"acompanyades":[69],"patiment,":[71],"discapacitat":[72],"elevats":[74],"costos":[75],"econ\u00f2mics":[76],"socials,":[78],"per":[79,86,179,379,413,425,547],"qual":[81],"cosa":[82,242,267,299,509],"calen":[83],"noves":[84],"ter\u00e0pies":[85],"aconseguir":[87],"envelliment":[89],"saludable.":[90],"La":[91],"prote\u00efna":[92,275,423,533],"klotho":[93],"(KL)":[94],"ha":[95],"estat":[96],"identificada":[97],"una":[99,305,506,532],"prometedora":[100],"mol\u00e8cula":[101],"antienvelliment":[102,145],"causa":[104],"seves":[107],"accions":[108],"pleiotr\u00f2piques,":[109],"amb":[110,290,304,394,499],"efectes":[111,183,232],"prolongevitat":[112],"vies":[114],"senyalitzaci\u00f3":[117],"insulina/factor":[120],"creixement":[122],"similar":[123],"insulina":[126],"Wnt,":[128],"aix\u00ed":[129],"modulaci\u00f3":[132],"l'estr\u00e8s":[134],"inflamatori":[135],"oxidatiu.":[137],"Aqu\u00ed,":[138],"explorem":[139],"seguretat":[141,245],"potencial":[144,417],"isoforma":[148,191,197,219],"secretada":[149],"KL":[151,174,199,291],"als":[152,283,324],"ratolins":[153,262,408],"SAMP8":[154,263],"C57BL/6J,":[156],"models":[157,461],"murins":[158],"d'envelliment":[159,282],"accelerat":[160],"no":[162,221,441,479],"patol\u00f2gic,":[163],"respectivament.":[164],"\\nEn":[165],"primer":[166],"lloc,":[167],"expressar":[170],"diferents":[171,236,284],"isoformes":[172],"animals":[176,337,345,440,462,497],"joves":[177],"sans":[178],"estudiar":[180],"els":[181,235,336,496,539],"possibles":[182],"negatius":[184],"tractament.":[186],"Cal":[187],"destacar":[188],"p-KL,":[192],"forma":[193],"soluble":[194],"longitud":[201],"completa":[202],"(m-KL),":[203],"va":[204,222,229,269,292,302,351,396,449,470],"alterar":[205],"regulaci\u00f3":[207],"metabolisme":[209,226],"mineral,":[210],"generant":[211],"fort":[213],"fenotip":[214,281],"osteopor\u00f2tic.":[215],"Per":[216,467],"contra,":[217],"s-KL":[220,260,276,390,424,459,489,500,514,524,542],"interferir":[223],"mineral":[227],"ni":[228],"induir":[230],"altres":[231],"adversos":[233],"estudis":[237],"histol\u00f2gics":[238],"serol\u00f2gics":[240],"realitzats,":[241],"suggereix":[244,511],"farmacol\u00f2gica.":[246],"A":[247,339],"continuaci\u00f3,":[248],"administrar":[251,471],"vectors":[252],"AAV9":[253,484],"portadors":[254],"c\u00f2pia":[256],"l'ADNc":[258],"C57BL/6J":[265],"envellits,":[266,326],"incrementar":[270],"eficientment":[271],"concentraci\u00f3":[273],"s\u00e8rum,":[278],"millorant":[279],"\u00f2rgans":[285],"analitzats":[286],".":[287],"El":[288],"tractament":[289,393],"millorar":[293,334,502],"l'aptitud":[294],"proves":[296],"comportament,":[298],"correlacionar":[303],"reducci\u00f3":[306],"fibrosi":[309],"muscular":[310],"regeneraci\u00f3":[316],"muscular.":[317],"par\u00e0metres":[319],"microestructurals":[320],"corticals":[321],"trabeculars":[323],"ossos":[325],"mesurats":[327],"mitjan\u00e7ant":[328],"an\u00e0lisi":[329],"MicroCT,":[331],"tamb\u00e9":[332],"tractats.":[338],"m\u00e9s,":[340],"capacitats":[342],"cognitives":[343],"envellits":[346,474],"millorar,":[348],"fet":[349],"venir":[352],"acompanyat":[353],"d'un":[354],"marcadors":[357,366],"neurog\u00e8nesi":[359],"adulta":[360],"(DCX),":[361],"normalitzaci\u00f3":[364],"cel\u00b7lulars":[367],"l'hipocamp":[369],"poblacions":[372],"c\u00e8l\u00b7lules":[374],"Iba1+":[375],"GFAP+,":[377],"recolzat":[378],"l'an\u00e0lisi":[380],"histol\u00f2gica":[381],"transcripcional.":[383],"Sorprenentment,":[384],"l'expressi\u00f3":[385],"llarg":[387],"termini":[388],"degut":[391],"AAV":[395],"conduir":[397],"20%":[402],"longevitat":[405,438],"total":[406],"C57BL/6J.":[409],"Aquests":[410],"resultats":[411,446],"mostren":[412],"primera":[414],"vegada":[415],"l'augment":[419],"exogen":[420],"tractar":[426],"diversos":[427],"d\u00e8ficits":[428],"associats":[429],"l'edat,":[431],"augmentant":[432],"tant":[433],"salut":[435],"alterats":[442],"gen\u00e8ticament.":[443],"Despr\u00e9s":[444],"d'aquests":[445],"prometedors,":[447],"avaluar":[450],"possibilitat":[452],"traslladar":[454],"propietats":[456],"beneficioses":[457],"propers":[464],"l'hum\u00e0.":[466],"aix\u00f2,":[468],"individus":[473],"l'esp\u00e8cie":[476],"primat":[478],"hum\u00e0":[480],"Microcebus":[481],"murinus":[482],"expressava":[486],"ADNc":[487],"hum\u00e0.":[490],"Nou":[491],"mesos":[492],"despr\u00e9s":[493],"tractament,":[495],"tractats":[498],"rendiment":[504],"prova":[507],"cognitiva,":[508],"l'efic\u00e0cia":[512],"aquest":[516],"complex":[517],"model":[518],"animal.":[519],"\\nPer":[520],"tant,":[521],"t\u00e9":[525],"perfil":[527],"farmacol\u00f2gic":[528],"segur":[529],"secretable,":[534],"estrat\u00e8gies":[536],"augmenten":[538],"nivells":[540],"representen":[543],"enfocament":[545],"prometedor":[546],"reduir":[548],"humans":[550],"l'impacte":[551],"associada":[555],"l'edat":[557],"m\u00faltiples":[559],"\u00f2rgans.":[560]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
