{"id":"https://openalex.org/W7070980969","doi":null,"title":"A Proposed Study to Investigate the Relationship Between Telomere Length and Chronic Traumatic Encephalopathy","display_name":"A Proposed Study to Investigate the Relationship Between Telomere Length and Chronic Traumatic Encephalopathy","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W7070980969"},"language":"en","primary_location":{"id":"pmh:oai:scholarship.claremont.edu:cmc_theses-4347","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.claremont.edu/cmc_theses/3106","pdf_url":null,"source":{"id":"https://openalex.org/S4377196412","display_name":"Scholarship - Claremont (Claremont Colleges)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I872248612","host_organization_name":"Claremont Colleges","host_organization_lineage":["https://openalex.org/I872248612"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CMC Senior Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Matckie, Mackenzie R.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matckie, Mackenzie R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.11919999867677689,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-traumatic-encephalopathy","display_name":"chronic traumatic encephalopathy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hyperphosphorylated-tau","display_name":"hyperphosphorylated tau","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9919999837875366},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.8479999899864197},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9535999894142151},{"id":"https://openalex.org/C2911139526","wikidata":"https://www.wikidata.org/wiki/Q5114004","display_name":"Chronic traumatic encephalopathy","level":5,"score":0.6873999834060669},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5874999761581421},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46889999508857727},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.43149998784065247},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.42399999499320984},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4075999855995178},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.40400001406669617},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.4011000096797943},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3634999990463257},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3603000044822693},{"id":"https://openalex.org/C2780553607","wikidata":"https://www.wikidata.org/wiki/Q684868","display_name":"Attrition","level":2,"score":0.34290000796318054},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29739999771118164},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C2991747559","wikidata":"https://www.wikidata.org/wiki/Q4915075","display_name":"Biological age","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2775000035762787},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2687000036239624},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2549000084400177},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:scholarship.claremont.edu:cmc_theses-4347","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.claremont.edu/cmc_theses/3106","pdf_url":null,"source":{"id":"https://openalex.org/S4377196412","display_name":"Scholarship - Claremont (Claremont Colleges)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I872248612","host_organization_name":"Claremont Colleges","host_organization_lineage":["https://openalex.org/I872248612"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CMC Senior Theses","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2501558674","https://openalex.org/W7117259612","https://openalex.org/W3154126962","https://openalex.org/W2208667142","https://openalex.org/W4379745831","https://openalex.org/W2084706926","https://openalex.org/W2041011865","https://openalex.org/W2113546897","https://openalex.org/W2760665136","https://openalex.org/W4385665983"],"abstract_inverted_index":{"Chronic":[0],"traumatic":[1],"encephalopathy":[2],"(CTE)":[3],"is":[4,10,17,51,98,215,222],"a":[5,52,83,103,119,260],"progressive":[6],"neurodegenerative":[7],"disease":[8],"that":[9,58,67,212],"linked":[11],"to":[12,100,107,116,144,153,207,235,265],"repetitive":[13],"brain":[14,136,174,188],"trauma":[15],"and":[16,48,76,97,125,150,164,179,192,195,198,218,254,256],"pathologically":[18],"characterized":[19],"by":[20,37,127],"the":[21,108,159,226,249],"widespread":[22],"deposition":[23],"of":[24,105,161,228],"hyperphosphorylated":[25],"tau":[26],"as":[27,82,102,259],"neurofibrillary":[28],"tangles.":[29],"At":[30],"present,":[31],"CTE":[32,62,87,126,162,178,194,208,233],"can":[33,59,71,90],"only":[34],"be":[35,72,91],"diagnosed":[36,231],"post-mortem":[38,134],"neuropathological":[39],"examination,":[40],"severely":[41],"limiting":[42],"research":[43,264],"on":[44],"risk":[45],"factors,":[46],"epidemiology,":[47],"treatment.":[49],"There":[50],"critical":[53],"need":[54],"for":[55,74,86,262,269],"novel":[56],"biomarkers":[57,268],"accurately":[60],"diagnose":[61],"in":[63,94,133,158,225],"living":[64,95],"people":[65],"so":[66],"effective":[68],"therapeutic":[69],"strategies":[70],"developed":[73],"treatment":[75],"prevention.":[77],"Telomere":[78],"length":[79,124,132,203,221,253],"shows":[80],"promise":[81],"potential":[84],"biomarker":[85],"because":[88],"it":[89],"safely":[92],"assayed":[93],"subjects":[96,163,229],"thought":[99],"decrease":[101],"result":[104],"damage":[106],"central":[109],"nervous":[110],"system.":[111],"This":[112],"proposed":[113,242],"study":[114,243],"seeks":[115],"establish":[117],"whether":[118],"relationship":[120,250],"exists":[121],"between":[122,177,193,251],"telomere":[123,131,156,175,184,202,213,220,252],"directly":[128],"examining":[129],"cerebral":[130],"human":[135],"tissue.":[137],"In":[138],"this":[139,241],"initial":[140],"phase,":[141],"we":[142],"propose":[143],"use":[145],"well-established":[146],"quantitative":[147],"PCR":[148],"techniques":[149],"TRF":[151],"analysis":[152],"measure":[154],"regional":[155],"lengths":[157,176,185],"brains":[160,227],"neurologically":[165],"normal":[166],"matched":[167,236],"controls.":[168,237],"We":[169,210],"will":[170,244],"(1)":[171],"compare":[172],"whole":[173],"control":[180,196],"subjects,":[181,197],"(2)":[182],"examine":[183],"across":[186],"different":[187],"regions":[189],"within":[190],"individuals":[191],"(3)":[199],"analyze":[200],"how":[201],"varies":[204],"with":[205,232],"respect":[206],"severity.":[209],"hypothesize":[211],"attrition":[214],"faster":[216],"-":[217,224],"therefore":[219],"shorter":[223],"neuropathologically":[230],"compared":[234],"Confirmatory":[238],"results":[239],"from":[240],"give":[245],"us":[246],"insight":[247],"into":[248],"CTE,":[255],"may":[257],"serve":[258],"springboard":[261],"future":[263],"identify":[266],"suitable":[267],"CTE.":[270]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}