{"id":"https://openalex.org/W7066798085","doi":null,"title":"Influence de l\u2019hypoxie sur la susceptibilit\u00e9 des cellules tumorales \u00e0 la lyse induite par les lymphocytes T cytotoxiques","display_name":"Influence de l\u2019hypoxie sur la susceptibilit\u00e9 des cellules tumorales \u00e0 la lyse induite par les lymphocytes T cytotoxiques","publication_year":2012,"publication_date":"2012-09-28","ids":{"openalex":"https://openalex.org/W7066798085"},"language":"en","primary_location":{"id":"pmh:2012PA11T051","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2012PA11T051/document","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.theses.fr/2012PA11T051/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003314533","display_name":"Muhammad Zaeem Noman","orcid":"https://orcid.org/0000-0002-1837-3097","observed_orcids":["https://orcid.org/0000-0002-1837-3097"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Noman, Muhammad zaeem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003314533"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ctl-mediated-lysis","display_name":"CTL-mediated lysis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.921999990940094},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hydroxychloroquine","display_name":"hydroxychloroquine","score":0.8939999938011169},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6959999799728394},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7039999961853027},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.5849999785423279},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.5540000200271606},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.5600000023841858},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7383000254631042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4226999878883362},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.37369999289512634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.298799991607666},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2281000018119812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21889999508857727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1876000016927719},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.18080000579357147},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.15880000591278076},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.15719999372959137}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:2012PA11T051","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2012PA11T051/document","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"}],"best_oa_location":{"id":"pmh:2012PA11T051","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2012PA11T051/document","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7143289035","https://openalex.org/W7096534131","https://openalex.org/W2066251089","https://openalex.org/W1799143857","https://openalex.org/W108332923","https://openalex.org/W1779595676","https://openalex.org/W7147515823","https://openalex.org/W2326796800","https://openalex.org/W7144066872","https://openalex.org/W1505873322"],"abstract_inverted_index":{"L\u2019hypoxie":[0,16],"est":[1,183,359,413,432],"une":[2,97,228],"caract\u00e9ristique":[3],"commune":[4],"des":[5,10,75,132,141,152,255,381,423],"tumeurs":[6,76,96],"solides":[7],"et":[8,34,52,175,251,315,328,385,388,427,430,475],"l\u2019une":[9],"sp\u00e9cificit\u00e9s":[11],"du":[12,40,176],"micro":[13],"environnement":[14],"tumoral.":[15],"tumorale":[17,68,341,350,398,457],"joue":[18,480],"un":[19,48,121,306,481],"r\u00f4le":[20,331,482],"important":[21],"dans":[22,231,276,335,380,392,422,434,484],"l\u2019angio":[23],"g\u00e9n\u00e8se,":[24],"la":[25,32,70,73,78,82,100,125,144,150,164,172,189,201,212,219,241,248,253,260,281,299,316,319,339,348,352,393,396,400,455,459,485,488],"progression":[26],"maligne,":[27],"le":[28,277,290,330,336,347],"d\u00e9veloppement":[29],"de":[30,42,44,50,53,61,66,72,114,127,143,146,149,163,166,171,188,191,214,238,243,247,271,294,298,318,333,338,364,383,386,395,417,420,425,428,438,441,450,470,472,487],"m\u00e9tastases,":[31],"chimio/radio-r\u00e9sistance":[33],"favorise":[35],"l\u2019\u00e9chappement":[36],"au":[37,169],"syst\u00e8me":[38],"immunitaire":[39],"fait":[41],"l\u2019\u00e9mergence":[43],"variant":[45],"tumoraux":[46],"avec":[47,289],"potentiel":[49,483],"survie":[51],"r\u00e9sistance":[54,98,213,349],"\u00e0":[55,77,99,118,140,186,196,200,218,227,259,351,399,458,468],"l\u2019apoptose":[56],"augment\u00e9.":[57],"Cependant,":[58,155],"tr\u00e8s":[59,360],"peu":[60],"travaux":[62],"ont":[63],"\u00e9tudi\u00e9":[64],"l\u2019impact":[65],"l\u2019hypoxie":[67,92,119,224,314,379,453],"sur":[69,124],"r\u00e9gulation":[71,317,394,486],"susceptibilit\u00e9":[74,190,254,397,456],"lyse":[79,101,126,220,261,320,353,401,460],"induite":[80,102,203,222,262,312,321,354,402,461],"par":[81,103,131,204,223,263,273,313,322,355,363,378,403,452,462],"r\u00e9ponse":[83,489],"immune":[84,490],"cytotoxique.":[85],"Nous":[86,109,207],"nous":[87,156,367,445],"sommes":[88],"donc":[89],"demand\u00e9":[90],"si":[91],"pouvait":[93],"conf\u00e9rer":[94],"aux":[95],"les":[104,205,232,264,286,323,356,374,404,435,463],"lymphocytes":[105],"T":[106,325,406],"cytotoxiques":[107],"(CTL).":[108],"avons":[110,157,208,368,446],"d\u00e9montr\u00e9":[111,447],"que":[112,159,211,346,448,478],"l\u2019exposition":[113],"cellules":[115,129,153,192,198,215,233,256,324,357,405,424],"cibles":[116],"tumorales":[117,130,193,216,257],"poss\u00e9dait":[120],"effet":[122],"inhibiteur":[123],"ces":[128],"CTL":[133,147,221,464],"autologues.":[134],"Cette":[135],"inhibition":[136],"n\u2019est":[137],"pas":[138],"associ\u00e9e":[139,226],"alt\u00e9rations":[142],"r\u00e9activit\u00e9":[145],"ou":[148],"reconnaissance":[151],"cibles.":[154,234],"montr\u00e9":[158,210],"l\u2019induction":[160,449],"hypoxique":[161],"concomitante":[162],"phosphorylation":[165,242],"STAT3":[167,244],"(pSTAT3)":[168],"niveau":[170],"tyrosine":[173],"705":[174],"facteur":[177],"HIF-1\u03b1":[178,421],"(Hypoxia":[179],"Inducible":[180],"Factor-1":[181],"alpha)":[182],"li\u00e9e":[184],"fonctionnellement":[185],"l\u2019alt\u00e9ration":[187],"bronchiques":[194,217],"non":[195],"petites":[197],"(NSCLC)":[199],"mort":[202],"CTL.":[206,265],"aussi":[209,369],"\u00e9tait":[225],"induction":[229],"d\u2019autophagie":[230],"En":[235],"effet,":[236],"l\u2019inhibition":[237,246,268,297,469],"l\u2019autophagie":[239,272,311,334],"emp\u00eache":[240],"(via":[245],"kinase":[249],"Src)":[250],"restaure":[252],"hypoxiques":[258,437],"De":[266,443],"plus,":[267,444],"in":[269,342],"vivo":[270],"l\u2019hydroxychloroquine":[274],"(HCQ)":[275],"mod\u00e8le":[278],"murin":[279],"portant":[280],"tumeur":[282],"B16F10":[283],"and":[284],"chez":[285],"souris":[287],"vaccin\u00e9e":[288],"peptide":[291],"TRP2":[292],"augmente":[293],"fa\u00e7on":[295],"drastique":[296],"croissance":[300,340],"tumorale.":[301],"Collectivement,":[302],"cette":[303],"\u00e9tude":[304],"\u00e9tablit":[305],"nouveau":[307],"lien":[308],"fonctionnel":[309],"entre":[310],"sp\u00e9cifique":[326,407],"d\u2019antig\u00e8nes":[327],"souligne":[329],"majeur":[332],"contr\u00f4le":[337],"vivo.Finalement,":[343],"\u00e9tant":[344],"donn\u00e9":[345],"tueuses":[358],"probablement":[361],"r\u00e9gul\u00e9e":[362],"multiples":[365],"facteurs,":[366],"eu":[370],"pour":[371],"but":[372],"d\u2019identifier":[373],"micro-ARNs":[375],"(miRs)":[376],"r\u00e9gul\u00e9s":[377],"mod\u00e8les":[382],"NSCLC":[384,426],"m\u00e9lanome":[387],"leur":[389],"implication":[390],"putative":[391],"d\u2019antig\u00e8nes.":[408],"Le":[409],"micro-ARN":[410],"210":[411],"(miR-210)":[412],"ainsi":[414],"significativement":[415],"induit":[416],"mani\u00e8re":[418],"d\u00e9pendante":[419],"m\u00e9lanome,":[429],"miR-210":[431,451,479],"exprim\u00e9":[433],"zones":[436],"tissus":[439],"issus":[440],"NSCLC.":[442],"r\u00e9gule":[454],"en":[465],"partie":[466],"gr\u00e2ce":[467],"l\u2019expression":[471],"PTPN,":[473],"HOXA1":[474],"TP53I11,":[476],"indiquant":[477],"antitumorale.":[491]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2025-10-10T00:00:00"}
