{"id":"https://openalex.org/W7066185252","doi":null,"title":"The impact of correct and efficient oral hygiene manoeuvres on markers of systemic inflammation and overall well-being","display_name":"The impact of correct and efficient oral hygiene manoeuvres on markers of systemic inflammation and overall well-being","publication_year":2022,"publication_date":"2022-03-29","ids":{"openalex":"https://openalex.org/W7066185252"},"language":"en","primary_location":{"id":"pmh:oai:etd.adm.unipi.it:etd-03212022-193827","doi":null,"is_oa":false,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-03212022-193827/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-03212022-193827/","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017069116","display_name":"Marina Peri\u0107","orcid":"https://orcid.org/0000-0002-9817-816X","observed_orcids":["https://orcid.org/0000-0002-9817-816X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"PERIC, MARINA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017069116"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-hygiene","display_name":"oral hygiene","score":0.7099999785423279},{"id":"https://openalex.org/keywords/gingivitis","display_name":"gingivitis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9300000071525574},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9559999704360962},{"id":"https://openalex.org/keywords/powered-toothbrushes","display_name":"powered toothbrushes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/dental-plaque-reduction","display_name":"plaque reduction","score":0.6359999775886536},{"id":"https://openalex.org/keywords/gingival-bleeding","display_name":"gingival bleeding","score":0.925000011920929},{"id":"https://openalex.org/keywords/oral-health-related-quality-of-life","display_name":"oral health-related quality of life","score":0.9120000004768372},{"id":"https://openalex.org/keywords/well-being","display_name":"well-being","score":0.8519999980926514},{"id":"https://openalex.org/keywords/periodontal-treatment","display_name":"periodontal treatment","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9262999892234802},{"id":"https://openalex.org/C515851188","wikidata":"https://www.wikidata.org/wiki/Q13445028","display_name":"Oral hygiene","level":2,"score":0.7329999804496765},{"id":"https://openalex.org/C2909956956","wikidata":"https://www.wikidata.org/wiki/Q673083","display_name":"Gingival inflammation","level":3,"score":0.6247000098228455},{"id":"https://openalex.org/C2777892068","wikidata":"https://www.wikidata.org/wiki/Q134205","display_name":"Toothbrush","level":3,"score":0.6043999791145325},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5769000053405762},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4767000079154968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38850000500679016},{"id":"https://openalex.org/C2780791200","wikidata":"https://www.wikidata.org/wiki/Q673083","display_name":"Gingivitis","level":2,"score":0.38339999318122864},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.3801000118255615},{"id":"https://openalex.org/C2779914569","wikidata":"https://www.wikidata.org/wiki/Q143504","display_name":"Dental plaque","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C547646559","wikidata":"https://www.wikidata.org/wiki/Q162297","display_name":"Hygiene","level":2,"score":0.33550000190734863},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.33320000767707825},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.3246000111103058},{"id":"https://openalex.org/C2777084678","wikidata":"https://www.wikidata.org/wiki/Q15646788","display_name":"Chlorhexidine","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C2781460226","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antiseptic","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2705000042915344},{"id":"https://openalex.org/C2778013446","wikidata":"https://www.wikidata.org/wiki/Q6840355","display_name":"Microstomia","level":2,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:etd.adm.unipi.it:etd-03212022-193827","doi":null,"is_oa":false,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-03212022-193827/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-03212022-193827/","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4283658625","https://openalex.org/W2071694400","https://openalex.org/W4400526848","https://openalex.org/W3181506135","https://openalex.org/W7120467760","https://openalex.org/W3203834016","https://openalex.org/W7162848872","https://openalex.org/W3007031595","https://openalex.org/W2297051562","https://openalex.org/W3138414752"],"abstract_inverted_index":{"Aim:":[0],"This":[1,47],"study":[2,227],"aimed":[3],"to":[4,41,65,271,432,436,533],"evaluate":[5],"the":[6,22,29,226,231,267,300,315,323,338,347,371,377,393,409,417,421,424,437,447,459,472,541,544,549,552,557],"impact":[7,412],"of":[8,24,31,35,67,75,92,103,110,276,310,374,405,423,471,483,517,551],"oral":[9,32,80,87,161,402,514],"hygiene":[10,81,88,162],"changes":[11],"resulting":[12],"in":[13,148,248,256,266,286,299,308,337,397,401,446,469,494,501,513,519,561],"a":[14,49,93,97,101,272,282,304,319,360,398,491],"drastic":[15,484],"plaque":[16,261,485],"and":[17,27,37,62,107,126,144,166,169,177,185,202,206,213,218,224,262,289,382,435,486,503,554],"gingival":[18,263,487],"inflammation":[19,26,488,496],"reduction":[20,255,265,489,500],"on":[21,28],"markers":[23],"systemic":[25,495],"indicators":[30],"health-related":[33,403,515],"quality":[34,404,516],"life":[36,518],"other":[38],"aspects":[39],"related":[40],"overall":[42,178,425,448],"well-being.":[43],"Materials":[44],"&":[45],"Methods:":[46],"was":[48,246,296,312,387],"randomized":[50],"clinical":[51,258,274],"trial":[52],"with":[53,96,128,318,408,524,540],"one-month":[54,186,208,441,477,506],"follow-up,":[55],"including":[56],"patients":[57,77,119,154,221,522],"affected":[58,523],"by":[59],"generalized":[60,525],"gingivitis,":[61],"randomly":[63],"allocated":[64],"one":[66,293,327,429,452],"two":[68,108,316],"treatment":[69,245,546],"arms.":[70],"The":[71,114,132,151,278,480],"test":[72,133,152,268,324,339,418],"group":[73,116,134,153,269,325,340,349,419,439,461],"comprised":[74],"70":[76,118],"receiving":[78,121],"intense":[79],"instructions":[82],"(OHI)":[83],"as":[84,86,172,174],"well":[85,173],"(OH)":[89],"tools,":[90],"consisting":[91],"powered":[94],"toothbrush":[95],"rotation":[98],"oscillation":[99],"action,":[100],"tube":[102],"stannous":[104],"fluoride":[105],"dentifrice,":[106],"dispensers":[109],"waxed":[111],"interdental":[112],"floss.":[113],"control":[115,301,348,438,460],"involved":[117],"not":[120,297,455],"OHI":[122,137],"or":[123,534],"OH":[124],"tools":[125],"continuing":[127],"their":[129],"routine":[130],"habits.":[131],"received":[135],"intensive":[136],"at":[138,183,193,207,242,292,326,335,428,440,451,476,505],"baseline":[139,184,194,336,433],"when":[140],"professional":[141],"supragingival":[142],"scaling":[143],"polishing":[145],"were":[146,155,181,191,222,236,341],"performed":[147],"both":[149,249],"groups.":[150],"seen":[156],"again":[157],"every":[158],"week":[159],"for":[160,195,211,230,238,322,362,369,458],"reinforcement":[163],"(T7,":[164],"T14,":[165],"T21).":[167],"Periodontal":[168,244],"anthropometric":[170],"measurements,":[171],"vital":[175],"signs":[176],"well-being-related":[179],"parameters,":[180],"collected":[182],"follow-up":[187,209,442],"visit.":[188],"Serum":[189],"samples":[190],"drawn":[192],"high-sensitivity":[196],"C-reactive":[197],"protein":[198],"(hs-CRP),":[199],"interleukin-6":[200],"(IL-6),":[201],"vitamin":[203],"D":[204,331],"(25(OH)D3)":[205],"visit":[210],"hs-CRP":[212,287,311,502,553],"IL-6.":[214],"Results:":[215],"One":[216],"hundred":[217],"forty":[219],"consecutive":[220],"enrolled":[223],"completed":[225],"providing":[228],"data":[229],"final":[232],"analysis.":[233],"Both":[234],"groups":[235,250],"comparable":[237],"all":[239],"measured":[240,257],"characteristics":[241],"baseline.":[243],"successful":[247],"that":[251,543],"exhibited":[252,497],"an":[253,467,562],"important":[254],"parameters.":[259],"Drastic":[260],"bleeding":[264,364,530],"led":[270],"complete":[273],"resolution":[275],"gingivitis.":[277,526],"tested":[279,394,481],"protocol":[280,395,482],"elicited":[281,490],"significant":[283,306,399,492,511],"intragroup":[284],"decrease":[285,321,493],"(p<0.01)":[288,291],"IL-6":[290,383,504,555],"month,":[294],"which":[295,370],"observed":[298,313,457,466,560],"group.":[302],"Moreover,":[303,508],"statistically":[305],"difference":[307],"levels":[309,333,550],"between":[314],"groups,":[317],"higher":[320],"month":[328,430,453],"(p<0.05).":[329],"Vitamin":[330],"serum":[332,499],"assessed":[334,473],"24.65":[342],"\u00b1":[343,352,389],"4.90":[344],"\u03bcg/L,":[345],"while":[346],"had":[350,420],"25.25":[351],"4.79":[353],"\u03bcg/L.":[354],"Logistic":[355],"multivariate":[356],"regression":[357],"model":[358],"identified":[359],"threshold":[361,559],"full-mouth":[363],"score":[365,427,450,531],"(FMBS)":[366],"\u2264":[367,379,384],"8%,":[368],"odds":[372],"ratio":[373],"having":[375],"both,":[376,548],"CRP":[378],"0.3":[380],"mg/dL":[381],"6.4":[385],"pg/mL":[386],"23.48":[388],"9.37":[390],"(p<0.01).":[391],"Additionally,":[392],"resulted":[396],"improvement":[400,422,468],"life,":[406],"evaluated":[407],"Oral":[410],"health":[411],"profile-14":[413],"questionnaire":[414],"(OHIP-14).":[415],"Indeed,":[416],"OHIP-14":[426,449],"compared":[431],"(p<0.0001),":[434],"(p<0.001).":[443],"These":[444],"improvements":[445,512],"could":[454,464],"be":[456,465],"(p=0.11),":[462],"neither":[463],"any":[470],"14":[474],"questions":[475],"follow-up.":[478,507],"Conclusions:":[479],"through":[498],"it":[509],"produced":[510],"healthy,":[520],"adult":[521],"A":[527],"full":[528],"mouth":[529],"equal":[532],"less":[535],"than":[536],"8%":[537],"is":[538],"associated":[539],"probabilities":[542],"periodontal":[545],"reduced":[547],"below":[556],"reference":[558],"adult,":[563],"healthy":[564],"population.":[565]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}