{"id":"https://openalex.org/W7066103514","doi":null,"title":"Epigeneettisen ik\u00e4\u00e4ntymisnopeuden yhteys liikkumiskykyyn","display_name":"Epigeneettisen ik\u00e4\u00e4ntymisnopeuden yhteys liikkumiskykyyn","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W7066103514"},"language":"fi","primary_location":{"id":"pmh:oai:jyx.jyu.fi:123456789/76245","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-202106043470","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-202106043470","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.fi/URN:NBN:fi:jyu-202106043470","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050134299","display_name":"Hannamari Lankila","orcid":"https://orcid.org/0000-0002-5600-0064","observed_orcids":["https://orcid.org/0000-0002-5600-0064"]},"institutions":[{"id":"https://openalex.org/I94722563","display_name":"University of Jyv\u00e4skyl\u00e4","ror":"https://ror.org/05n3dz165","country_code":"FI","type":"education","lineage":["https://openalex.org/I94722563"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Lankila, Hannamari","raw_affiliation_strings":["Faculty of Sport and Health Sciences , University of Jyv\u00e4skyl\u00e4 ,","Jyv\u00e4skyl\u00e4n yliopisto Kev\u00e4t 2021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Sport and Health Sciences , University of Jyv\u00e4skyl\u00e4 ,","institution_ids":["https://openalex.org/I94722563"]},{"raw_affiliation_string":"Jyv\u00e4skyl\u00e4n yliopisto Kev\u00e4t 2021","institution_ids":["https://openalex.org/I94722563"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050134299"],"corresponding_institution_ids":["https://openalex.org/I94722563"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.043699998408555984,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-aging","display_name":"epigenetic aging","score":0.8140000104904175},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":0.753000020980835},{"id":"https://openalex.org/keywords/mobility-physical-function","display_name":"mobility (physical function)","score":0.7369999885559082},{"id":"https://openalex.org/keywords/functional-independence","display_name":"functional independence","score":0.6169999837875366},{"id":"https://openalex.org/keywords/biological-age","display_name":"biological age","score":0.4830000102519989},{"id":"https://openalex.org/keywords/chronological-age","display_name":"chronological age","score":0.6330000162124634},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.43299999833106995},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.640999972820282},{"id":"https://openalex.org/keywords/lower-limb-muscle-strength","display_name":"lower limb muscle strength","score":0.5230000019073486},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.48100000619888306},{"id":"https://openalex.org/keywords/twin-studies","display_name":"twin studies","score":0.503000020980835},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.32199999690055847},{"id":"https://openalex.org/keywords/functional-decline-prediction","display_name":"functional decline prediction","score":0.4909999966621399},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.6050000190734863},{"id":"https://openalex.org/keywords/environmental-factors-in-aging","display_name":"environmental factors in aging","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C144251240","wikidata":"https://www.wikidata.org/wiki/Q7068229","display_name":"Nucleofection","level":4,"score":0.3197000026702881},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.23759999871253967},{"id":"https://openalex.org/C2777738910","wikidata":"https://www.wikidata.org/wiki/Q3790542","display_name":"Sulfinpyrazone","level":3,"score":0.20399999618530273},{"id":"https://openalex.org/C133074676","wikidata":"https://www.wikidata.org/wiki/Q428729","display_name":"Fusible alloy","level":2,"score":0.19869999587535858},{"id":"https://openalex.org/C2781032047","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Articular cartilage damage","level":5,"score":0.19689999520778656},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.19439999759197235},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.19130000472068787},{"id":"https://openalex.org/C2779645999","wikidata":"https://www.wikidata.org/wiki/Q1858477","display_name":"Frugality","level":2,"score":0.19040000438690186},{"id":"https://openalex.org/C2777158700","wikidata":"https://www.wikidata.org/wiki/Q1419356","display_name":"Hyporeflexia","level":3,"score":0.18860000371932983},{"id":"https://openalex.org/C18743360","wikidata":"https://www.wikidata.org/wiki/Q1208096","display_name":"Diafiltration","level":4,"score":0.18369999527931213}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:jyx.jyu.fi:123456789/76245","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-202106043470","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-202106043470","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"}],"best_oa_location":{"id":"pmh:oai:jyx.jyu.fi:123456789/76245","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-202106043470","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-202106043470","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7066103514.pdf","grobid_xml":"https://content.openalex.org/works/W7066103514.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1564119855","https://openalex.org/W2022152889","https://openalex.org/W2050016813","https://openalex.org/W2080644309","https://openalex.org/W2125734753","https://openalex.org/W2290343632","https://openalex.org/W2505539351","https://openalex.org/W2618782736","https://openalex.org/W2917601557","https://openalex.org/W2990428470","https://openalex.org/W3083144484","https://openalex.org/W3093199589","https://openalex.org/W3096317657","https://openalex.org/W3106296722","https://openalex.org/W3213055265"],"related_works":["https://openalex.org/W6981563020","https://openalex.org/W7065542624","https://openalex.org/W7062503248","https://openalex.org/W7200438935","https://openalex.org/W7005536537","https://openalex.org/W6981576536","https://openalex.org/W2793953667","https://openalex.org/W2354105971","https://openalex.org/W7139219420","https://openalex.org/W7163704682"],"abstract_inverted_index":{"Riitt\u00e4v\u00e4":[0],"liikkumiskyky":[1,305],"on":[2,54,371,376],"v\u00e4ltt\u00e4m\u00e4t\u00f6n":[3],"edellytys":[4],"itsen\u00e4iselle":[5],"el\u00e4m\u00e4lle.":[6],"K\u00e4velynopeutta":[7],"ja":[8,35,40,90,158,264,325,345,373],"liikkumiskyky\u00e4":[9],"ylip\u00e4\u00e4ns\u00e4":[10],"pidet\u00e4\u00e4n":[11],"t\u00e4rkein\u00e4":[12],"toiminnallisen":[13],"itsen\u00e4isyyden":[14],"m\u00e4\u00e4ritt\u00e4jin\u00e4":[15],"ik\u00e4\u00e4ntyvill\u00e4":[16,117],"henkil\u00f6ill\u00e4,":[17,226],"sill\u00e4":[18],"heikentynyt":[19,257],"k\u00e4velykyky":[20],"ennustaa":[21,36],"toimintakyvyn":[22],"laskua.":[23],"Epigeneettinen":[24,61,153,207,333],"ik\u00e4":[25,98,151],"kuvastaa":[26],"henkil\u00f6n":[27],"biologista":[28],"ik\u00e4\u00e4,":[29],"jonka":[30],"avulla":[31],"voidaan":[32,361],"mahdollisesti":[33],"tunnistaa":[34,363],"vanhenemiseen":[37],"liittyvi\u00e4":[38],"sairauksia":[39],"toiminnanvajauksia.":[41],"Epigeneettisell\u00e4":[42],"kellolla":[43],"tarkoitetaan":[44],"biologisen":[45,327,357],"ik\u00e4\u00e4ntymisen":[46,330,353],"mittaria,":[47],"joka":[48,56],"perustuu":[49],"DNA:n":[50],"metylaatiotasojen":[51],"muutoksiin.":[52],"Kello":[53],"laskenta-algoritmi,":[55],"tuottaa":[57],"arvion":[58],"i\u00e4st\u00e4":[59],"vuosina.":[60],"ik\u00e4\u00e4ntymisnopeus":[62,81,154,208,218],"saadaan,":[63],"kun":[64,282],"epigeneettist\u00e4":[65],"ik\u00e4\u00e4":[66],"eli":[67],"DNA-metylaatioik\u00e4\u00e4":[68],"verrataan":[69],"kronologiseen":[70],"ik\u00e4\u00e4n.":[71],"T\u00e4m\u00e4n":[72,139],"pro":[73,295],"gradu":[74,296],"-tutkielman":[75],"tarkoituksena":[76],"oli":[77,219,236,267,303],"selvitt\u00e4\u00e4,":[78],"onko":[79],"epigeneettinen":[80,97,150,217],"yhteydess\u00e4":[82,211,220],"liikkumiskykyyn,":[83],"sek\u00e4":[84,112,167,180,202,247,318],"selitt\u00e4v\u00e4tk\u00f6":[85],"polven":[86,181,243],"ojennusvoima,":[87],"fyysinen":[88],"aktiivisuus":[89],"painoindeksi":[91],"mahdollista":[92],"yhteytt\u00e4.":[93],"Lis\u00e4ksi":[94],"tutkittiin,":[95],"ennustaako":[96],"liikkumiskyvyn":[99,368],"heikkenemist\u00e4":[100],"kolmen":[101,168,258,291],"vuoden":[102,169,259,292],"seurannassa.":[103,260,293],"T\u00e4ss\u00e4":[104,294],"tutkielmassa":[105],"k\u00e4ytettiin":[106,195],"FITSA":[107],"-aineistoa,":[108],"jossa":[109],"tutkittiin":[110],"geneettisten,":[111],"ymp\u00e4rist\u00f6tekij\u00f6iden":[113],"osuutta":[114],"toiminnanvajauksien":[115],"synnyss\u00e4":[116],"naisilla.":[118],"Tutkimukseen":[119],"osallistui":[120],"413":[121],"kaksosnaista,":[122],"jotka":[123,227],"olivat":[124,228],"i\u00e4lt\u00e4\u00e4n":[125,230,299],"63\u201376-vuotiaita.":[126],"L\u00e4ht\u00f6tilanteessa":[127],"vuonna":[128],"2000":[129],"tutkittavien":[130],"kokoverest\u00e4":[131],"saadusta":[132],"DNA-n\u00e4ytteest\u00e4":[133],"analysoitiin":[134],"aluksi":[135],"metylaatiotasot":[136],"EPIC-mikrosiruanalyysi\u00e4":[137],"k\u00e4ytt\u00e4en.":[138],"j\u00e4lkeen":[140,250],"metylaatiodata":[141],"sy\u00f6tettiin":[142],"vapaasti":[143],"verkossa":[144],"saatavilla":[145],"olevaan":[146],"laskenta-algoritmiin,":[147],"josta":[148],"saatiin":[149],"GrimAge.":[152],"m\u00e4\u00e4ritettiin":[155],"kronologisen":[156],"i\u00e4n":[157,328,358],"DNA-metylaatioi\u00e4n":[159],"lineaarisen":[160],"regression":[161],"j\u00e4\u00e4nn\u00f6ksist\u00e4.":[162],"Laboratoriomittauksissa":[163],"tutkittavilta":[164],"testattiin":[165],"l\u00e4ht\u00f6tilanteessa,":[166],"seurannassa":[170],"10":[171],"metrin":[172],"maksimaalinen":[173,182],"k\u00e4velynopeus,":[174],"Timed":[175],"Up":[176],"and":[177],"Go":[178],"(TUG)-testi,":[179],"isometrinen":[183],"ojennusvoima":[184],"dynamometrin":[185],"avulla.":[186],"Fyysisen":[187],"aktiivisuuden":[188],"taso":[189],"arvioitiin":[190],"validoidulla":[191],"kyselyll\u00e4.":[192],"Tilastollisina":[193],"analyysimenetelmin\u00e4":[194],"Pearsonin":[196],"korrelaatiotarkastelua,":[197],"lineaarista":[198],"regressioanalyysi\u00e4,":[199],"toistomittausten":[200],"varianssianalyysi\u00e4":[201],"Mann-Whitneyn":[203],"U":[204],"-testi\u00e4":[205],"katoanalyysissa.":[206],"ei":[209,256,308],"ollut":[210],"k\u00e4velynopeuteen":[212,313],"(\u03b2=0,062;":[213],"p=0,220).":[214],"Sen":[215,261],"sijaan":[216,262],"TUG-testin":[221,234],"tulokseen":[222],"siten,":[223,272],"ett\u00e4":[224,273],"niill\u00e4":[225],"epigeneettiselt\u00e4":[229,298],"kronologista":[231,300],"ik\u00e4\u00e4ns\u00e4":[232,301],"vanhempia,":[233],"tulos":[235],"huonompi":[237],"(\u03b2=0,156;":[238],"p=0,002).":[239],"Yhteys":[240],"s\u00e4ilyi":[241],"my\u00f6s":[242],"ojennusvoimalla,":[244],"fyysisell\u00e4":[245],"aktiivisuudella":[246],"painoindeksill\u00e4":[248],"vakioinnin":[249],"tilastollisesti":[251,268],"merkitsev\u00e4n\u00e4":[252],"(\u03b2=0,094;":[253],"p=0,039).":[254],"Liikkumiskyky":[255],"ajalla":[263],"epigeneettisell\u00e4":[265],"i\u00e4ll\u00e4":[266],"merkitsev\u00e4":[269],"yhdysvaikutus":[270],"(p=0,009)":[271],"useammalla":[274],"epigeneettisesti":[275,284],"yli":[276],"65":[277,286],"-vuotiaalla":[278],"k\u00e4velynopeus":[279,288],"hidastui":[280],"seurannassa,":[281],"taas":[283],"alle":[285],"-vuotiailla":[287],"useammin":[289],"parani":[290],"-tutkielmassa":[297],"vanhemmilla":[302],"heikompi":[304],"TUG-testin,":[306],"mutta":[307],"k\u00e4velynopeuden":[309],"osalta.":[310],"TUG-testi":[311],"vaatii":[312],"verrattuna":[314],"enemm\u00e4n":[315],"tasapainoa,":[316],"lihasvoimaa":[317],"voimantuottotehoa,":[319],"joten":[320,347],"se":[321],"saattaa":[322],"olla":[323],"monipuolisempi":[324],"luotettavampi":[326],"mittari":[329],"ilmiasujen":[331],"tarkastelussa.":[332],"kello":[334],"mittaa":[335],"ainoastaan":[336],"metylaatiomuutoksia":[337],"ik\u00e4riippuvaisissa":[338],"CpG-kohdissa.":[339],"Ik\u00e4\u00e4ntymismuutoksia":[340],"tapahtuu":[341],"kuitenkin":[342],"solutasolla,":[343],"ilmiasuissa":[344],"toiminnallisuudessa,":[346],"jatkossa":[348],"olisi":[349],"tarpeen":[350],"tarkastella":[351],"epigeneettisen":[352],"yhteytt\u00e4":[354],"liikkumiskykyyn":[355],"monipuolisilla":[356],"mittareilla,":[359],"jotta":[360],"paremmin":[362],"ne":[364],"henkil\u00f6t,":[365],"joiden":[366],"riski":[367],"ennenaikaiseen":[369],"heikkenemiseen":[370],"kohonnut":[372],"toiminnallinen":[374],"itsen\u00e4isyys":[375],"vaarassa":[377],"heikenty\u00e4.":[378]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}