{"id":"https://openalex.org/W7065397477","doi":null,"title":"Development and Technological Characterization of Novel Nanomicellar Formulations for the Ocular Delivery of Cyclosporine A","display_name":"Development and Technological Characterization of Novel Nanomicellar Formulations for the Ocular Delivery of Cyclosporine A","publication_year":2018,"publication_date":"2018-03-02","ids":{"openalex":"https://openalex.org/W7065397477"},"language":"en","primary_location":{"id":"pmh:oai:etd.adm.unipi.it:etd-02152018-121225","doi":null,"is_oa":false,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-02152018-121225/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-02152018-121225/","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"CALAMIA, GIULIA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"CALAMIA, GIULIA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nanomicelles","display_name":"nanomicelles","score":0.7950000166893005},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.8389999866485596},{"id":"https://openalex.org/keywords/chronic-uveitis","display_name":"chronic uveitis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8999999761581421},{"id":"https://openalex.org/keywords/vitamin-e-tpgs","display_name":"vitamin E TPGS","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cloud-point","display_name":"cloud point","score":0.796999990940094},{"id":"https://openalex.org/keywords/thermal-dissociation","display_name":"thermal dissociation","score":0.609000027179718},{"id":"https://openalex.org/keywords/ocular-biocompatibility","display_name":"ocular biocompatibility","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6349999904632568},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.6262999773025513},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5648999810218811},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5400000214576721},{"id":"https://openalex.org/C128489963","wikidata":"https://www.wikidata.org/wiki/Q1187724","display_name":"Filtration (mathematics)","level":2,"score":0.510699987411499},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.46299999952316284},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.43799999356269836},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.43630000948905945},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.4300000071525574},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.42239999771118164},{"id":"https://openalex.org/C4863142","wikidata":"https://www.wikidata.org/wiki/Q907920","display_name":"Solubilization","level":2,"score":0.42179998755455017},{"id":"https://openalex.org/C72918618","wikidata":"https://www.wikidata.org/wiki/Q1993211","display_name":"Niosome","level":4,"score":0.4032000005245209},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3856000006198883},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35249999165534973},{"id":"https://openalex.org/C22673317","wikidata":"https://www.wikidata.org/wiki/Q490222","display_name":"Cloud point","level":3,"score":0.33149999380111694},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3301999866962433},{"id":"https://openalex.org/C3020728648","wikidata":"https://www.wikidata.org/wiki/Q1058795","display_name":"Biological fluids","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.32350000739097595},{"id":"https://openalex.org/C84199377","wikidata":"https://www.wikidata.org/wiki/Q723912","display_name":"Freeze-drying","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29760000109672546},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C2776174307","wikidata":"https://www.wikidata.org/wiki/Q416312","display_name":"Methyl cellulose","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C2994508507","wikidata":"https://www.wikidata.org/wiki/Q1751537","display_name":"Membrane filter","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.2515000104904175},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:etd.adm.unipi.it:etd-02152018-121225","doi":null,"is_oa":false,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-02152018-121225/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-02152018-121225/","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7046060248","https://openalex.org/W3126182284","https://openalex.org/W3010915761","https://openalex.org/W7134113733","https://openalex.org/W4236618043","https://openalex.org/W4392006870","https://openalex.org/W311930526","https://openalex.org/W3195769723","https://openalex.org/W2909487578","https://openalex.org/W7208818079"],"abstract_inverted_index":{"The":[0,67,167,187,279,339,554,589,615,649,672,739],"aim":[1],"of":[2,11,22,37,73,76,85,89,112,117,164,174,189,202,231,282,294,309,325,354,356,372,384,447,455,461,493,497,507,515,518,537,547,568,591,599,631,643,652,675,684,708,722,727,753,761,770,779,818],"the":[3,7,20,34,54,103,106,114,145,150,156,159,165,175,179,193,203,212,216,220,229,232,236,253,263,267,283,295,301,310,323,382,385,389,399,445,452,456,494,498,501,505,513,545,548,557,573,582,592,597,600,605,629,632,635,653,661,667,676,702,709,720,723,728,751,768,771,777,780,792],"present":[4],"study":[5,364,433],"was":[6,65,96,109,120,195,246,277,314,365,425,434,471,594,664,733,744,799],"development":[8],"and":[9,30,80,93,98,126,132,148,170,182,214,242,259,262,300,319,333,345,404,416,466,484,490,552,563,603,625,646,660,699,750,784,803],"characterization":[10,116],"new":[12,459],"nanomicellar":[13,47,151,312],"formulations":[14,616,654,731,782],"containing":[15,71],"cyclosporine":[16],"A":[17],"(CyA)":[18],"for":[19,184,609,657],"treatment":[21],"ocular":[23,146,185,401,644,658,793],"diseases,":[24],"such":[25],"as":[26,587],"dry":[27],"eye":[28],"syndrome":[29],"chronic":[31],"uveitis.":[32],"In":[33,234,451],"first":[35],"part":[36,454],"this":[38],"thesis,":[39,457],"starting":[40,520],"from":[41,53,521],"a":[42,45,74,83,135,249,352,412,419,437,458,508,522,533,566,788,795,815],"previous":[43,574],"study,":[44,575],"promising":[46],"formulation,":[48],"prepared":[49,579],"by":[50,122,197,248,321,336,375,411,418,504,580,746,763],"taking":[51],"advantage":[52,475],"surfactants":[55,77,559],"ability":[56,100,383,395,479],"to":[57,101,142,154,210,227,266,269,291,348,380,387,396,427,473,480,512,532,607,627,666,693,700,735,766,775,786],"self-assembling":[58],"in":[59,82,158,178,219,256,467,500,544,565,572,641,679,704,807],"an":[60,206,360],"aqueous":[61],"medium":[62],"at":[63,238,271,286,297,317,328,343,444,688],"50\u00b0C,":[64],"evaluated.":[66,110],"selected":[68,535,558,734],"formulation":[69,119,176,204,296,499,593],"(Nano1HAB-CyA),":[70],"1.0%w/w":[72],"mixture":[75],"(Vitamin":[78,561],"E-TPGS":[79,562],"OPEE":[81,564],"ratio":[84,567,717],"2.25:1),":[86],"0.01%":[87],"w/w":[88],"hyaluronic":[90,407],"acid":[91,408],"(HA),":[92],"CyA":[94,355,737],"(0.1%w/w)":[95],"characterized":[97,417,619],"its":[99],"transport":[102],"drug":[104,157,190,217,326,742,754],"across":[105],"scleral":[107,370,390],"tissue":[108,371],"First":[111],"all,":[113],"technological":[115,650],"Nano1HAB-CyA":[118,284],"performed":[121,226,435],"measuring":[123,322,620],"pH,":[124,168,621],"osmolality":[125,169],"size":[127,171,623,640],"distribution":[128,624],"immediately":[129,690],"after":[130,200,691,706],"preparation":[131,590,692,772],"filtration":[133],"through":[134,487],"0.22":[136],"\u03bcm":[137],"cellulose":[138],"acetate":[139],"membrane":[140],"filter":[141],"assess:":[143],"a)":[144,477],"biocompatibility":[147],"b)":[149,491],"dimensions":[152],"suitability":[153],"deliver":[155],"anterior":[160],"and/or":[161],"posterior":[162],"segment":[163],"eye.":[166],"(10-12":[172,670],"nm)":[173],"were":[177,225,530,578,618,686],"physiological":[180],"range":[181],"suitable":[183,656],"administration.":[186],"amount":[188,517,752],"loaded":[191],"into":[192,634,801],"nanomicelles":[194,240,386,430,465,478,555,633,662,685,802],"detected":[196],"RP-HPLC":[198],"analysis":[199,251,440,765],"dilution":[201,707],"with":[205,351,398,436,596,712],"organic":[207],"solvent":[208],"able":[209],"disrupt":[211],"nanostructure":[213],"promote":[215],"solubilization":[218],"surrounding":[221],"environment.":[222],"Further":[223],"characterizations":[224],"evaluate":[228,381,701],"stability":[230,293,308],"nanomicelles.":[233],"particular,":[235],"temperature":[237,273,289,299],"which":[239],"dissociate":[241],"lose":[243],"their":[244,639,647,804],"structure":[245],"evaluated":[247,316,809],"turbidimetric":[250],"detecting":[252],"cloud":[254],"point":[255],"both":[257],"unloaded":[258],"drug-loaded":[260,462],"nanomicelles,":[261],"time":[264,330,496,806],"required":[265],"micelles":[268],"self-regenerate":[270],"room":[272,298],"(regeneration":[274],"time,":[275],"RT)":[276],"measured.":[278],"thermal":[280],"dissociation":[281],"occurred":[285],"enough":[287],"high":[288],"(32\u00b0C)":[290],"provide":[292],"RT":[302],"resulted":[303,341,655],"approximately":[304],"11":[305],"minutes.":[306],"Short-term":[307],"CyA-loaded":[311],"solution":[313],"also":[315],"4":[318,344],"20\u00b0C":[320,346],"percentage":[324],"recovered":[327],"predetermined":[329],"intervals":[331],"(1,2,7,14,":[332],"30":[334,349],"days)":[335],"HPLC":[337,764],"analysis.":[338],"Nano1HAB\u2013CyA":[340,394,669],"stable":[342],"up":[347],"days":[350],"recovery":[353],"about":[357],"95%.":[358],"Moreover,":[359],"ex":[361],"vivo":[362,808],"permeation":[363,449],"carried":[366],"out":[367],"on":[368,441,757,791,810],"excised":[369],"rabbit":[373],"eyes":[374],"using":[376,581],"horizontal":[377],"diffusion":[378],"cells":[379],"penetrate":[388],"barrier.":[391],"To":[392],"investigate":[393],"interact":[397],"external":[400],"tissues":[402,443],"(cornea":[403],"sclera)":[405],"fluorescein-labelled":[406],"(HA-FITC),":[409],"obtained":[410,724],"conjugate":[413],"addition":[414],"reaction":[415],"differential":[420],"scanning":[421],"calorimetry":[422],"(DSC)":[423],"analysis,":[424],"used":[426,571],"produce":[428,787],"labelled":[429],"(Nano1HABFITC-CyA).":[431],"This":[432],"microscopic":[438],"imaging":[439],"fixed":[442],"end":[446],"ex-vivo":[448],"study.":[450],"second":[453],"combination":[460],"non-ionic":[463],"surfactant":[464,697],"situ":[468],"gelling":[469],"system":[470],"developed":[472,730],"take":[474],"of:":[476],"incorporate":[481],"insoluble":[482],"drugs":[483],"carry":[485],"it":[486],"biological":[488],"barriers":[489],"improvement":[492],"residence":[495,805],"precorneal":[502],"area":[503],"formation":[506],"viscoelastic":[509],"gel":[510,606,636],"due":[511],"presence":[514,630,680],"specific":[516],"ions,":[519],"sol-gel":[523],"dispersion.":[524],"Three":[525],"different":[526,759],"calcium":[527],"ion":[528],"concentrations":[529],"added":[531],"previously":[534],"dispersion":[536,586,602],"0.1%w/w":[538],"gellan":[539,584],"gum":[540,585],"without":[541],"any":[542,613,695],"variation":[543],"concentration":[546],"monovalent":[549],"cations":[550],"(Na+":[551],"K*).":[553],"having":[556],"composition":[560],"2.25:1,":[569],"1%w/w)":[570],"(without":[576],"HA)":[577],"polymeric":[583,677,710,789],"solvent.":[588],"completed":[595],"centrifugation":[598],"surfactant/polymeric":[601],"leaving":[604],"stabilize":[608],"12":[610],"hours":[611],"before":[612],"use.":[614],"(NanoG1-3)":[617],"osmolality,":[622],"clarity,":[626],"assess":[628,776],"system,":[637],"analyse":[638],"view":[642],"administration,":[645],"stability.":[648],"parameters":[651],"administration":[659],"diameter":[663],"comparable":[665],"original":[668],"nm).":[671],"rheological":[673],"behaviour":[674],"dispersions":[678,711],"or":[681],"absence":[682],"(reference)":[683],"measured":[687,756],"32\u00b0C":[689],"verify":[694,767],"possible":[696],"influence":[698],"increase":[703],"viscosity":[705],"Artificial":[713],"Tear":[714],"Fluid":[715],"(ATF,":[716],"3:0.7).":[718],"On":[719],"basis":[721],"data,":[725],"one":[726],"three":[729,758],"(NanoG-2)":[732],"load":[736],"(NanoG-2CyA).":[738],"effective":[740],"successful":[741],"encapsulation":[743],"checked":[745],"dynamic":[747],"light":[748],"scattering":[749],"encapsulated":[755,800],"batches":[760],"NanoG-2CyA":[762],"reproducibility":[769],"method.":[773],"Finally,":[774],"capacity":[778],"studied":[781],"(Nano1HAB":[783],"NanoG-2)":[785],"film":[790],"surface,":[794],"fluorescent":[796],"probe":[797],"(Coumarin-6),":[798],"New":[811],"Zealand":[812],"rabbits":[813],"under":[814],"wavelength":[816],"excitation":[817],"366nm.":[819]},"counts_by_year":[],"updated_date":"2026-09-14T07:18:48.979198","created_date":"2025-10-10T00:00:00"}