{"id":"https://openalex.org/W7065123071","doi":null,"title":"Context-Dependent Acquisition of Antimicrobial Resistance Mechanisms","display_name":"Context-Dependent Acquisition of Antimicrobial Resistance Mechanisms","publication_year":2024,"publication_date":"2024-01-24","ids":{"openalex":"https://openalex.org/W7065123071"},"language":"en","primary_location":{"id":"pmh:oai:ore.exeter.ac.uk:10871/135117","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10871/135117","pdf_url":"https://ore.exeter.ac.uk/articles/thesis/Context-Dependent_Acquisition_of_Antimicrobial_Resistance_Mechanisms/29807615/1/files/56853644.pdf","source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ore.exeter.ac.uk/articles/thesis/Context-Dependent_Acquisition_of_Antimicrobial_Resistance_Mechanisms/29807615/1/files/56853644.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Winter (10645931)","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M Winter (10645931)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.39579999446868896,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-transformation","display_name":"natural transformation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bacterial-competence","display_name":"bacterial competence","score":0.906000018119812},{"id":"https://openalex.org/keywords/antimicrobial-resistance-genes","display_name":"antimicrobial resistance genes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/horizontal-gene-transfer","display_name":"horizontal gene transfer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/transformation-frequency","display_name":"transformation frequency","score":0.6349999904632568},{"id":"https://openalex.org/keywords/acinetobacter","display_name":"Acinetobacter","score":0.8209999799728394},{"id":"https://openalex.org/keywords/species-interactions","display_name":"species interactions","score":0.8090000152587891},{"id":"https://openalex.org/keywords/environmental-bacteria","display_name":"environmental bacteria","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.5809999704360962},{"id":"https://openalex.org/keywords/antimicrobial-resistance-dissemination","display_name":"antimicrobial resistance dissemination","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.24410000443458557},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.21580000221729279},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.2134999930858612},{"id":"https://openalex.org/C2781462825","wikidata":"https://www.wikidata.org/wiki/Q7363205","display_name":"Romidepsin","level":5,"score":0.18700000643730164},{"id":"https://openalex.org/C144251240","wikidata":"https://www.wikidata.org/wiki/Q7068229","display_name":"Nucleofection","level":4,"score":0.18160000443458557},{"id":"https://openalex.org/C13376991","wikidata":"https://www.wikidata.org/wiki/Q587698","display_name":"Ectotherm","level":2,"score":0.17589999735355377},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.17020000517368317},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.1687999963760376},{"id":"https://openalex.org/C80114427","wikidata":"https://www.wikidata.org/wiki/Q634260","display_name":"Circumstantial evidence","level":2,"score":0.16850000619888306}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ore.exeter.ac.uk:10871/135117","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10871/135117","pdf_url":"https://ore.exeter.ac.uk/articles/thesis/Context-Dependent_Acquisition_of_Antimicrobial_Resistance_Mechanisms/29807615/1/files/56853644.pdf","source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},{"id":"pmh:oai:figshare.com:article/29807615","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Context-Dependent_Acquisition_of_Antimicrobial_Resistance_Mechanisms/29807615","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:ore.exeter.ac.uk:10871/135117","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10871/135117","pdf_url":"https://ore.exeter.ac.uk/articles/thesis/Context-Dependent_Acquisition_of_Antimicrobial_Resistance_Mechanisms/29807615/1/files/56853644.pdf","source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7065123071.pdf","grobid_xml":"https://content.openalex.org/works/W7065123071.grobid-xml"},"referenced_works_count":302,"referenced_works":["https://openalex.org/W233486025","https://openalex.org/W1557375532","https://openalex.org/W1563553297","https://openalex.org/W1630377861","https://openalex.org/W1641873288","https://openalex.org/W1762520094","https://openalex.org/W1763857691","https://openalex.org/W1843353849","https://openalex.org/W1849979647","https://openalex.org/W1869380658","https://openalex.org/W1941252177","https://openalex.org/W1947817766","https://openalex.org/W1951724000","https://openalex.org/W1964601681","https://openalex.org/W1966549106","https://openalex.org/W1967600116","https://openalex.org/W1969080858","https://openalex.org/W1970243284","https://openalex.org/W1970815880","https://openalex.org/W1972350167","https://openalex.org/W1972848138","https://openalex.org/W1975744481","https://openalex.org/W1979587114","https://openalex.org/W1980962947","https://openalex.org/W1982579644","https://openalex.org/W1984820585","https://openalex.org/W1985106082","https://openalex.org/W1985716049","https://openalex.org/W1989985563","https://openalex.org/W1991035349","https://openalex.org/W1992897511","https://openalex.org/W1992915534","https://openalex.org/W1993279122","https://openalex.org/W1994507967","https://openalex.org/W1995108431","https://openalex.org/W1995865334","https://openalex.org/W1997025720","https://openalex.org/W1997097621","https://openalex.org/W1997152162","https://openalex.org/W1998157707","https://openalex.org/W1998485402","https://openalex.org/W1999652407","https://openalex.org/W2000930830","https://openalex.org/W2003894319","https://openalex.org/W2005548481","https://openalex.org/W2006716355","https://openalex.org/W2006882996","https://openalex.org/W2007698318","https://openalex.org/W2008502080","https://openalex.org/W2008821578","https://openalex.org/W2011130342","https://openalex.org/W2012926197","https://openalex.org/W2015402183","https://openalex.org/W2017433972","https://openalex.org/W2018368953","https://openalex.org/W2018672567","https://openalex.org/W2018883772","https://openalex.org/W2020346914","https://openalex.org/W2020934585","https://openalex.org/W2026393639","https://openalex.org/W2027333720","https://openalex.org/W2031853598","https://openalex.org/W2033121562","https://openalex.org/W2033205630","https://openalex.org/W2033623058","https://openalex.org/W2034302623","https://openalex.org/W2035270506","https://openalex.org/W2036256965","https://openalex.org/W2036775991","https://openalex.org/W2039940889","https://openalex.org/W2040539560","https://openalex.org/W2041949408","https://openalex.org/W2041977733","https://openalex.org/W2043272858","https://openalex.org/W2043889890","https://openalex.org/W2047394015","https://openalex.org/W2047893579","https://openalex.org/W2047902191","https://openalex.org/W2051905420","https://openalex.org/W2052205040","https://openalex.org/W2052419566","https://openalex.org/W2053806531","https://openalex.org/W2057168828","https://openalex.org/W2059291404","https://openalex.org/W2060737229","https://openalex.org/W2061092522","https://openalex.org/W2061817985","https://openalex.org/W2063588175","https://openalex.org/W2065857450","https://openalex.org/W2066839192","https://openalex.org/W2067108995","https://openalex.org/W2067713285","https://openalex.org/W2068111303","https://openalex.org/W2068811953","https://openalex.org/W2069200382","https://openalex.org/W2070611680","https://openalex.org/W2073095327","https://openalex.org/W2080449796","https://openalex.org/W2080777238","https://openalex.org/W2081376007","https://openalex.org/W2081794308","https://openalex.org/W2084128457","https://openalex.org/W2086569686","https://openalex.org/W2087928701","https://openalex.org/W2089219693","https://openalex.org/W2089333639","https://openalex.org/W2090611703","https://openalex.org/W2092643722","https://openalex.org/W2095048146","https://openalex.org/W2096093282","https://openalex.org/W2097162882","https://openalex.org/W2099399157","https://openalex.org/W2102586400","https://openalex.org/W2104282009","https://openalex.org/W2104750596","https://openalex.org/W2104837454","https://openalex.org/W2106183672","https://openalex.org/W2106265368","https://openalex.org/W2106629677","https://openalex.org/W2107676192","https://openalex.org/W2108417711","https://openalex.org/W2109810382","https://openalex.org/W2110065044","https://openalex.org/W2110105435","https://openalex.org/W2110398313","https://openalex.org/W2110760916","https://openalex.org/W2112396377","https://openalex.org/W2113196837","https://openalex.org/W2113730525","https://openalex.org/W2113787438","https://openalex.org/W2116686857","https://openalex.org/W2117044460","https://openalex.org/W2118168447","https://openalex.org/W2122095711","https://openalex.org/W2125340293","https://openalex.org/W2126974038","https://openalex.org/W2127546816","https://openalex.org/W2127860293","https://openalex.org/W2128077684","https://openalex.org/W2128379749","https://openalex.org/W2130271218","https://openalex.org/W2131765021","https://openalex.org/W2132396121","https://openalex.org/W2133990749","https://openalex.org/W2133991766","https://openalex.org/W2134708296","https://openalex.org/W2136309448","https://openalex.org/W2137046453","https://openalex.org/W2137654430","https://openalex.org/W2138952930","https://openalex.org/W2139216324","https://openalex.org/W2141149764","https://openalex.org/W2141281036","https://openalex.org/W2142654521","https://openalex.org/W2142775912","https://openalex.org/W2143445148","https://openalex.org/W2143669599","https://openalex.org/W2144729818","https://openalex.org/W2146971797","https://openalex.org/W2148070193","https://openalex.org/W2148844472","https://openalex.org/W2150404256","https://openalex.org/W2150468607","https://openalex.org/W2150975376","https://openalex.org/W2151208862","https://openalex.org/W2151817333","https://openalex.org/W2151895705","https://openalex.org/W2153820933","https://openalex.org/W2155661155","https://openalex.org/W2155707781","https://openalex.org/W2156382695","https://openalex.org/W2157177676","https://openalex.org/W2158310753","https://openalex.org/W2161327252","https://openalex.org/W2162152219","https://openalex.org/W2163240067","https://openalex.org/W2166084943","https://openalex.org/W2169982343","https://openalex.org/W2170540506","https://openalex.org/W2172253900","https://openalex.org/W2178386765","https://openalex.org/W2180542330","https://openalex.org/W2220587087","https://openalex.org/W2245214327","https://openalex.org/W2268029186","https://openalex.org/W2279413689","https://openalex.org/W2289628470","https://openalex.org/W2305704688","https://openalex.org/W2318461667","https://openalex.org/W2322275362","https://openalex.org/W2335061041","https://openalex.org/W2406493898","https://openalex.org/W2414602945","https://openalex.org/W2470630337","https://openalex.org/W2519431925","https://openalex.org/W2522067171","https://openalex.org/W2528989351","https://openalex.org/W2552038980","https://openalex.org/W2556738030","https://openalex.org/W2564273069","https://openalex.org/W2588469766","https://openalex.org/W2590055450","https://openalex.org/W2595335272","https://openalex.org/W2596539719","https://openalex.org/W2604271274","https://openalex.org/W2608025219","https://openalex.org/W2609312731","https://openalex.org/W2611046756","https://openalex.org/W2620530413","https://openalex.org/W2621864691","https://openalex.org/W2623616105","https://openalex.org/W2626499425","https://openalex.org/W2640475594","https://openalex.org/W2744322705","https://openalex.org/W2766085454","https://openalex.org/W2769809746","https://openalex.org/W2770248449","https://openalex.org/W2773152443","https://openalex.org/W2786358356","https://openalex.org/W2789738056","https://openalex.org/W2791117778","https://openalex.org/W2791790671","https://openalex.org/W2792021903","https://openalex.org/W2793222991","https://openalex.org/W2799524357","https://openalex.org/W2804100011","https://openalex.org/W2806047877","https://openalex.org/W2808202553","https://openalex.org/W2808352813","https://openalex.org/W2809200741","https://openalex.org/W2809340773","https://openalex.org/W2822938647","https://openalex.org/W2892616109","https://openalex.org/W2912648735","https://openalex.org/W2918023152","https://openalex.org/W2924059685","https://openalex.org/W2940709722","https://openalex.org/W2941444136","https://openalex.org/W2943811991","https://openalex.org/W2950465364","https://openalex.org/W2950891420","https://openalex.org/W2951002266","https://openalex.org/W2951060192","https://openalex.org/W2951636116","https://openalex.org/W2952167528","https://openalex.org/W2967346752","https://openalex.org/W2969461414","https://openalex.org/W2981670863","https://openalex.org/W2982961097","https://openalex.org/W2986925300","https://openalex.org/W2994920686","https://openalex.org/W2999584161","https://openalex.org/W2999645725","https://openalex.org/W3015156515","https://openalex.org/W3018128986","https://openalex.org/W3020582710","https://openalex.org/W3025403080","https://openalex.org/W3035719236","https://openalex.org/W3042844352","https://openalex.org/W3046991652","https://openalex.org/W3049714474","https://openalex.org/W3083562604","https://openalex.org/W3091268297","https://openalex.org/W3092988325","https://openalex.org/W3094052059","https://openalex.org/W3103319439","https://openalex.org/W3108381610","https://openalex.org/W3124585283","https://openalex.org/W3124999219","https://openalex.org/W3129095230","https://openalex.org/W3133224161","https://openalex.org/W3138779402","https://openalex.org/W3157810833","https://openalex.org/W3164332865","https://openalex.org/W3170550153","https://openalex.org/W3192525342","https://openalex.org/W3197194830","https://openalex.org/W3197782746","https://openalex.org/W3205413018","https://openalex.org/W3210722906","https://openalex.org/W4206677002","https://openalex.org/W4206972777","https://openalex.org/W4211156702","https://openalex.org/W4220666462","https://openalex.org/W4221122284","https://openalex.org/W4232591682","https://openalex.org/W4235712850","https://openalex.org/W4238527420","https://openalex.org/W4239761226","https://openalex.org/W4241106416","https://openalex.org/W4245793468","https://openalex.org/W4280521782","https://openalex.org/W4281483243","https://openalex.org/W4281683320","https://openalex.org/W4282025803","https://openalex.org/W4282935284","https://openalex.org/W4288074275","https://openalex.org/W4296229564","https://openalex.org/W4321481198","https://openalex.org/W4321493189","https://openalex.org/W4385442993","https://openalex.org/W4402640799"],"related_works":["https://openalex.org/W3210722906","https://openalex.org/W2983926668","https://openalex.org/W2912648735","https://openalex.org/W7082854920","https://openalex.org/W818750498","https://openalex.org/W6910765861","https://openalex.org/W161774245","https://openalex.org/W4321493189","https://openalex.org/W1991050563","https://openalex.org/W2123886059"],"abstract_inverted_index":{"Natural":[0,62],"transformation":[1,63,106,130,163,225,274],"is":[2,24,50,64,113,275],"a":[3,17,53,147,196,248,254,260],"process":[4],"whereby":[5],"bacteria":[6,160,173,222,229,292],"actively":[7],"take":[8],"up":[9],"free":[10],"DNA":[11,23,252],"from":[12,253],"the":[13,28,70,83,93,101,129,144,162,169,184,202,212,224,234,270,312],"environment":[14],"while":[15],"in":[16,59,150,175,281,295],"physiological":[18],"state":[19],"termed":[20],"competence.":[21],"Uptaken":[22],"then":[25],"recombined":[26],"into":[27,33],"recipient\u2019s":[29],"genome":[30],"or":[31],"reconverted":[32],"extra-chromosomal":[34],"genetic":[35],"elements.":[36],"The":[37],"inducing":[38],"stimuli":[39],"for":[40,69,201,233,237,262,280],"competence":[41,48],"vary":[42],"widely":[43],"between":[44,79,318],"transformable":[45,133,166,228],"species":[46,258],"and":[47,78,251,278,290,298,306],"induction":[49],"affected":[51],"by":[52,243],"host":[54],"of":[55,72,96,104,115,132,146,165,186,198,211,227,256,288,314],"abiotic":[56],"factors":[57],"found":[58],"bacterial":[60],"environments.":[61],"recognised":[65],"to":[66,82,123,154,182,194,207,217,230,304,310],"be":[67],"responsible":[68],"dissemination":[71],"antimicrobial":[73,85,187,315],"resistance":[74,86,188,316],"genes":[75,317],"both":[76,276,296],"within":[77],"species,":[80],"contributing":[81],"global":[84],"crisis":[87],"threatening":[88],"modern":[89],"medicine.":[90],"Despite":[91],"being":[92],"first":[94],"mechanism":[95],"horizontal":[97],"gene":[98],"transfer":[99],"discovered,":[100],"evolutionary":[102],"benefits":[103],"natural":[105,177,191,238,297],"are":[107],"still":[108],"under":[109,171,272],"debate.":[110],"This":[111,135,240],"thesis":[112],"comprised":[114],"four":[116],"standalone":[117],"research":[118],"chapters":[119,266],"which":[120,139,172,273],"aimed":[121],"1)":[122],"determine":[124,155,218],"if":[125,156,219],"chemotherapeutic":[126],"compounds":[127],"affect":[128,161,223],"frequencies":[131,164,226],"bacteria.":[134,167,319],"provides":[136],"important":[137],"information":[138,200,268],"can":[140,179,301],"have":[141],"implications":[142],"on":[143],"contraction":[145],"life-threatening":[148],"infection":[149],"cancer":[151],"patients.":[152],"2)":[153],"other":[157],"environmentally":[158,220],"relevant":[159,221],"Understanding":[168],"contexts":[170,271],"transform":[174],"their":[176],"environments":[178],"help":[180,302],"us":[181,303],"predict":[183],"spread":[185,313],"mechanisms":[189],"via":[190],"transformation.":[192,239,263],"3)":[193],"produce":[195],"resource":[197],"genomic":[199],"scientific":[203],"community,":[204],"allowing":[205],"researchers":[206],"improve":[208],"our":[209,286],"understanding":[210,287],"Acinetobacter":[213],"genus.":[214],"And":[215],"4)":[216],"find":[231],"evidence":[232],"sex":[235],"hypothesis":[236],"was":[241],"performed":[242],"using":[244],"biotic":[245],"interactions":[246],"as":[247,259],"selection":[249],"pressure":[250],"range":[255],"related":[257],"substrate":[261],"Together,":[264],"these":[265],"provide":[267],"about":[269],"regulated":[277],"selected":[279],"realistic":[282],"environmental":[283],"contexts.":[284],"Enhancing":[285],"how":[289],"when":[291],"naturally":[293],"transform,":[294],"clinical":[299],"environments,":[300],"monitor":[305],"establish":[307],"preventative":[308],"measures":[309],"limit":[311]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}