{"id":"https://openalex.org/W7064581098","doi":null,"title":"Broken Circuits: How Diet and Genetics Rewire Liver and Kidney Metabolism to Fuel Disease","display_name":"Broken Circuits: How Diet and Genetics Rewire Liver and Kidney Metabolism to Fuel Disease","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W7064581098"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt6vh2w7ht","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6vh2w7ht","pdf_url":"https://escholarship.org/content/qt6vh2w7ht/qt6vh2w7ht.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/content/qt6vh2w7ht/qt6vh2w7ht.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072826857","display_name":"Cuauhtemoc B. Ramirez","orcid":"https://orcid.org/0000-0001-7182-1859","observed_orcids":["https://orcid.org/0000-0001-7182-1859"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramirez, Cuauhtemoc Blas","raw_affiliation_strings":["Field of Study University of California , Irvine University of California , Irvine University of California , Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Field of Study University of California , Irvine University of California , Irvine University of California , Irvine","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072826857"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.37790000438690186,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.37790000438690186,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.29809999465942383,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.09399999678134918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.8360000252723694},{"id":"https://openalex.org/keywords/renal-metabolism","display_name":"renal metabolism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.6890000104904175},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.765999972820282},{"id":"https://openalex.org/keywords/elovl2","display_name":"ELOVL2","score":1.0},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/metabolic-biomarkers","display_name":"metabolic biomarkers","score":0.6420000195503235},{"id":"https://openalex.org/keywords/diet-and-disease","display_name":"diet and disease","score":0.4169999957084656},{"id":"https://openalex.org/keywords/chronic-disease","display_name":"chronic disease","score":0.45899999141693115},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6829000115394592},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5860999822616577},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5684999823570251},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47780001163482666},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.47760000824928284},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.4293000102043152},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3855000138282776},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3806999921798706},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3621000051498413},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3391999900341034},{"id":"https://openalex.org/C27502469","wikidata":"https://www.wikidata.org/wiki/Q906343","display_name":"Dysfunctional family","level":2,"score":0.3361999988555908},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.334199994802475},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.3203999996185303},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.3190999925136566},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2883000075817108},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C105619462","wikidata":"https://www.wikidata.org/wiki/Q1187990","display_name":"Evolutionary medicine","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C97633540","wikidata":"https://www.wikidata.org/wiki/Q4328195","display_name":"Nutrigenomics","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.2689000070095062},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2581999897956848}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt6vh2w7ht","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6vh2w7ht","pdf_url":"https://escholarship.org/content/qt6vh2w7ht/qt6vh2w7ht.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt6vh2w7ht","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6vh2w7ht","pdf_url":"https://escholarship.org/content/qt6vh2w7ht/qt6vh2w7ht.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3968198911","display_name":null,"funder_award_id":"T32 CA009054","funder_id":"https://openalex.org/F4320332688","funder_display_name":"University of California, Irvine"},{"id":"https://openalex.org/G8388041379","display_name":null,"funder_award_id":"R25 GM055246","funder_id":"https://openalex.org/F4320332688","funder_display_name":"University of California, Irvine"},{"id":"https://openalex.org/G8812774062","display_name":"MBRS IMSD Program at the University of California, Irvine","funder_award_id":"R25GM055246","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000895599","display_name":"A Training Program for Interdisciplinary Cancer Research","funder_award_id":"T32CA009054","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7064581098.pdf","grobid_xml":"https://content.openalex.org/works/W7064581098.grobid-xml"},"referenced_works_count":266,"referenced_works":["https://openalex.org/W1503760388","https://openalex.org/W1523155649","https://openalex.org/W1829589101","https://openalex.org/W1830916533","https://openalex.org/W1859037964","https://openalex.org/W1863359215","https://openalex.org/W1884302798","https://openalex.org/W1914971985","https://openalex.org/W1942089699","https://openalex.org/W1964245978","https://openalex.org/W1966549856","https://openalex.org/W1966824235","https://openalex.org/W1967588638","https://openalex.org/W1968217511","https://openalex.org/W1971775466","https://openalex.org/W1980380307","https://openalex.org/W1982642842","https://openalex.org/W1985123658","https://openalex.org/W1985592156","https://openalex.org/W1990519172","https://openalex.org/W1996311090","https://openalex.org/W1999879148","https://openalex.org/W1999919904","https://openalex.org/W2007782047","https://openalex.org/W2009138882","https://openalex.org/W2009763836","https://openalex.org/W2009966467","https://openalex.org/W2010450923","https://openalex.org/W2011814478","https://openalex.org/W2012216316","https://openalex.org/W2017511982","https://openalex.org/W2025925905","https://openalex.org/W2027570228","https://openalex.org/W2029810183","https://openalex.org/W2031708237","https://openalex.org/W2041308494","https://openalex.org/W2047458756","https://openalex.org/W2050790870","https://openalex.org/W2054998824","https://openalex.org/W2055604801","https://openalex.org/W2060319981","https://openalex.org/W2065151741","https://openalex.org/W2066612245","https://openalex.org/W2067107606","https://openalex.org/W2068779992","https://openalex.org/W2069544265","https://openalex.org/W2069839376","https://openalex.org/W2074307869","https://openalex.org/W2074755397","https://openalex.org/W2077146968","https://openalex.org/W2078184757","https://openalex.org/W2078490695","https://openalex.org/W2086066803","https://openalex.org/W2086528604","https://openalex.org/W2089920864","https://openalex.org/W2098555833","https://openalex.org/W2105169496","https://openalex.org/W2105476490","https://openalex.org/W2105738527","https://openalex.org/W2106273529","https://openalex.org/W2114597116","https://openalex.org/W2120244696","https://openalex.org/W2121562893","https://openalex.org/W2126843509","https://openalex.org/W2126968146","https://openalex.org/W2129532016","https://openalex.org/W2130073817","https://openalex.org/W2132881158","https://openalex.org/W2134013666","https://openalex.org/W2139948451","https://openalex.org/W2140791028","https://openalex.org/W2141823673","https://openalex.org/W2147028601","https://openalex.org/W2148053098","https://openalex.org/W2148551969","https://openalex.org/W2157069918","https://openalex.org/W2157828527","https://openalex.org/W2160411684","https://openalex.org/W2172099178","https://openalex.org/W2192367232","https://openalex.org/W2204688218","https://openalex.org/W2223535266","https://openalex.org/W2263998250","https://openalex.org/W2266126951","https://openalex.org/W2275816640","https://openalex.org/W2286797029","https://openalex.org/W2289624028","https://openalex.org/W2290638097","https://openalex.org/W2296585153","https://openalex.org/W2300782953","https://openalex.org/W2322847553","https://openalex.org/W2343975196","https://openalex.org/W2419228228","https://openalex.org/W2488598394","https://openalex.org/W2507321490","https://openalex.org/W2514394434","https://openalex.org/W2516006356","https://openalex.org/W2518285528","https://openalex.org/W2521958286","https://openalex.org/W2560747241","https://openalex.org/W2565367159","https://openalex.org/W2593816418","https://openalex.org/W2594530283","https://openalex.org/W2605431828","https://openalex.org/W2605491380","https://openalex.org/W2606441315","https://openalex.org/W2607129810","https://openalex.org/W2612903807","https://openalex.org/W2617696743","https://openalex.org/W2624658421","https://openalex.org/W2763585593","https://openalex.org/W2767801219","https://openalex.org/W2768762167","https://openalex.org/W2770903823","https://openalex.org/W2772163503","https://openalex.org/W2773194338","https://openalex.org/W2787707131","https://openalex.org/W2788203274","https://openalex.org/W2788261792","https://openalex.org/W2791690656","https://openalex.org/W2794383917","https://openalex.org/W2795319633","https://openalex.org/W2801170851","https://openalex.org/W2803425795","https://openalex.org/W2808583077","https://openalex.org/W2885162827","https://openalex.org/W2890597423","https://openalex.org/W2891474997","https://openalex.org/W2893897533","https://openalex.org/W2897629267","https://openalex.org/W2897934013","https://openalex.org/W2898144712","https://openalex.org/W2898932164","https://openalex.org/W2899010137","https://openalex.org/W2899384460","https://openalex.org/W2899493958","https://openalex.org/W2899769732","https://openalex.org/W2901242178","https://openalex.org/W2907926991","https://openalex.org/W2908445461","https://openalex.org/W2913095286","https://openalex.org/W2913137771","https://openalex.org/W2924203236","https://openalex.org/W2940680843","https://openalex.org/W2944279070","https://openalex.org/W2949603991","https://openalex.org/W2952632749","https://openalex.org/W2954321663","https://openalex.org/W2964628031","https://openalex.org/W2971544885","https://openalex.org/W2971582509","https://openalex.org/W2976008845","https://openalex.org/W2977528366","https://openalex.org/W2981892954","https://openalex.org/W2983881420","https://openalex.org/W2988805363","https://openalex.org/W2992324722","https://openalex.org/W2993039085","https://openalex.org/W2994268592","https://openalex.org/W2996642684","https://openalex.org/W2998824887","https://openalex.org/W2999421965","https://openalex.org/W3002071299","https://openalex.org/W3004642442","https://openalex.org/W3005421475","https://openalex.org/W3006764495","https://openalex.org/W3009220429","https://openalex.org/W3015020891","https://openalex.org/W3015450697","https://openalex.org/W3019567338","https://openalex.org/W3028054079","https://openalex.org/W3028143303","https://openalex.org/W3032355325","https://openalex.org/W3033117194","https://openalex.org/W3033788489","https://openalex.org/W3036373725","https://openalex.org/W3043817571","https://openalex.org/W3048126708","https://openalex.org/W3067827927","https://openalex.org/W3082343303","https://openalex.org/W3084013276","https://openalex.org/W3087409627","https://openalex.org/W3093216979","https://openalex.org/W3108493784","https://openalex.org/W3109665518","https://openalex.org/W3118575215","https://openalex.org/W3123922203","https://openalex.org/W3157232612","https://openalex.org/W3175283754","https://openalex.org/W3176576117","https://openalex.org/W3177720273","https://openalex.org/W3178500894","https://openalex.org/W3183486118","https://openalex.org/W3186245679","https://openalex.org/W3192573830","https://openalex.org/W3194553971","https://openalex.org/W3194768808","https://openalex.org/W3195953296","https://openalex.org/W3198922828","https://openalex.org/W3202109875","https://openalex.org/W3209269235","https://openalex.org/W3210100509","https://openalex.org/W3215151292","https://openalex.org/W3217589610","https://openalex.org/W4200139800","https://openalex.org/W4200327636","https://openalex.org/W4205381748","https://openalex.org/W4210774372","https://openalex.org/W4211015312","https://openalex.org/W4220798004","https://openalex.org/W4220874523","https://openalex.org/W4221112683","https://openalex.org/W4224222746","https://openalex.org/W4226106494","https://openalex.org/W4226367800","https://openalex.org/W4236982618","https://openalex.org/W4247878364","https://openalex.org/W4281682725","https://openalex.org/W4281696767","https://openalex.org/W4281712898","https://openalex.org/W4282920696","https://openalex.org/W4285592482","https://openalex.org/W4291020874","https://openalex.org/W4292454784","https://openalex.org/W4293276412","https://openalex.org/W4295079178","https://openalex.org/W4296293246","https://openalex.org/W4306148650","https://openalex.org/W4306746303","https://openalex.org/W4307732897","https://openalex.org/W4309076562","https://openalex.org/W4309666883","https://openalex.org/W4311135407","https://openalex.org/W4313558770","https://openalex.org/W4319310796","https://openalex.org/W4322154777","https://openalex.org/W4322743596","https://openalex.org/W4353055686","https://openalex.org/W4361002324","https://openalex.org/W4361204548","https://openalex.org/W4367626299","https://openalex.org/W4376615879","https://openalex.org/W4378903480","https://openalex.org/W4379469747","https://openalex.org/W4382937517","https://openalex.org/W4383483388","https://openalex.org/W4385421844","https://openalex.org/W4386069873","https://openalex.org/W4386593534","https://openalex.org/W4387230320","https://openalex.org/W4388735079","https://openalex.org/W4389648838","https://openalex.org/W4391849363","https://openalex.org/W4391878282","https://openalex.org/W4392143814","https://openalex.org/W4393251590","https://openalex.org/W4393935425","https://openalex.org/W4394987921","https://openalex.org/W4399211695","https://openalex.org/W4401170954","https://openalex.org/W4401562714","https://openalex.org/W4402191150","https://openalex.org/W4402993275","https://openalex.org/W4403320694","https://openalex.org/W4405356785","https://openalex.org/W4407132594"],"related_works":["https://openalex.org/W7081549432","https://openalex.org/W4410941721","https://openalex.org/W2999155374","https://openalex.org/W7124229914","https://openalex.org/W7124979851","https://openalex.org/W2122523483","https://openalex.org/W4394710961","https://openalex.org/W4285048576","https://openalex.org/W4212935830","https://openalex.org/W7011317155"],"abstract_inverted_index":{"Metabolism":[0],"is":[1],"a":[2,68,138,210,226,233],"foundational":[3],"driver":[4],"of":[5,18,35,70,90,107,120,141,229,269],"life,":[6,230],"deeply":[7],"conserved":[8],"through":[9,67,200],"evolution":[10],"to":[11,143,213,282,297,302],"support":[12],"survival.":[13],"Yet":[14],"in":[15,30,117,125,185,237,255,300],"the":[16,31,91,104,112,121,126,130,147,154,161,186,240,259,267],"context":[17],"modern":[19],"environmental":[20],"and":[21,33,44,50,56,62,75,93,115,123,152,265,275],"dietary":[22,158],"pressures,":[23],"these":[24,58,219],"once-adaptive":[25],"systems":[26,261],"are":[27,110],"increasingly":[28],"implicated":[29],"onset":[32],"progression":[34],"chronic":[36],"diseases.":[37],"This":[38,80],"dissertation":[39],"investigates":[40],"how":[41,166,249,258],"metabolic":[42,84,99,118,253],"regulation":[43],"its":[45],"dysregulation":[46],"shapes":[47],"disease":[48,88,299],"susceptibility":[49],"progression\u2014providing":[51],"avenues":[52],"for":[53,156,291],"prevention,":[54,272],"diagnosis,":[55],"treatment.In":[57],"studies,":[59],"my":[60],"colleagues":[61],"I":[63,244],"dissect":[64],"dysfunctional":[65],"metabolism":[66,222],"combination":[69],"metabolomics,":[71],"lipidomics,":[72],"isotope":[73],"tracing,":[74],"in-vivo":[76],"genetic":[77],"mouse":[78],"modeling.":[79],"work":[81],"uncovers":[82],"context-specific":[83],"adaptations":[85],"across":[86],"diverse":[87],"settings":[89],"liver":[92,122,167],"kidney.":[94],"Further,":[95],"evolutionary":[96],"insights":[97],"into":[98],"compartmentalization":[100],"that":[101,179,191],"help":[102],"explain":[103],"systemic":[105],"impact":[106],"organ-specific":[108],"dysfunction":[109,254],"discussed\u2014emphasizing":[111],"role":[113,151],"genetics":[114],"diet":[116],"diseases":[119],"kidney":[124,193],"first":[127],"chapter.":[128],"In":[129,160,239],"second":[131],"chapter,":[132,163,188],"we":[133,164,189],"identify":[134],"circulating":[135],"glycerate":[136],"as":[137,225,232],"predictive":[139],"biomarker":[140],"resistance":[142],"fructose-induced":[144],"steatosis,":[145],"emphasizing":[146],"small":[148],"intestine's":[149],"protective":[150],"laying":[153],"groundwork":[155],"personalized":[157],"strategies.":[159],"third":[162],"reveal":[165],"tumors":[168,194],"escape":[169],"ferroptosis":[170],"by":[171],"elongating":[172],"polyunsaturated":[173],"fatty":[174],"acids":[175,198],"via":[176],"ELOVL2\u2014a":[177],"vulnerability":[178],"can":[180],"be":[181],"therapeutically":[182],"targeted.":[183],"Lastly,":[184],"fourth":[187],"demonstrate":[190],"TSC-mutated":[192],"accumulate":[195],"essential":[196],"amino":[197],"likely":[199],"enhanced":[201],"protein":[202],"degradation":[203],"rather":[204],"than":[205],"uptake":[206],"from":[207],"circulation,":[208],"offering":[209],"new":[211],"angle":[212],"disrupt":[214],"mTORC1-fueled":[215],"tumor":[216],"growth.":[217],"Together,":[218],"findings":[220],"highlight":[221],"not":[223],"only":[224],"universal":[227],"requirement":[228],"but":[231],"dynamic,":[234],"targetable":[235],"system":[236],"disease.":[238],"concluding":[241],"fifth":[242],"chapter":[243],"raise":[245],"broader":[246],"questions":[247],"about":[248],"medicine":[250],"currently":[251],"addresses":[252],"patients.":[256],"Highlighting":[257],"healthcare":[260],"prioritize":[262],"symptom":[263],"management":[264],"underscoring":[266],"urgency":[268],"shifting":[270],"toward":[271],"early":[273],"detection,":[274],"science-informed":[276],"policymaking.":[277],"The":[278],"ultimate":[279],"goal":[280],"being":[281],"bridge":[283],"scientific":[284],"insight":[285],"with":[286],"clinical":[287],"application,":[288],"improving":[289],"outcomes":[290],"today\u2019s":[292],"patients":[293],"while":[294],"informing":[295],"strategies":[296],"prevent":[298],"generations":[301],"come.":[303]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}