{"id":"https://openalex.org/W7062524893","doi":null,"title":"Understanding the Role of Locus Coeruleus Norepinephrine on Perceptual Representations and Behavior","display_name":"Understanding the Role of Locus Coeruleus Norepinephrine on Perceptual Representations and Behavior","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W7062524893"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt0qf2g6z1","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0qf2g6z1","pdf_url":"https://escholarship.org/content/qt0qf2g6z1/qt0qf2g6z1.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/content/qt0qf2g6z1/qt0qf2g6z1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053599563","display_name":"Kimia C. Yaghoubi","orcid":"https://orcid.org/0000-0002-6806-2617","observed_orcids":["https://orcid.org/0000-0002-6806-2617"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yaghoubi, Kimia Claudia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053599563"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.16500000655651093,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":1.0},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/perceptual-processing","display_name":"perceptual processing","score":0.7289999723434448},{"id":"https://openalex.org/keywords/sensory-processing","display_name":"sensory processing","score":0.8889999985694885},{"id":"https://openalex.org/keywords/attention","display_name":"attention","score":0.824999988079071},{"id":"https://openalex.org/keywords/decision-making","display_name":"decision-making","score":0.9309999942779541},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.48899999260902405},{"id":"https://openalex.org/keywords/stimulus-response-function","display_name":"stimulus-response function","score":0.6859999895095825},{"id":"https://openalex.org/keywords/sensory-cortex","display_name":"sensory cortex","score":0.7889999747276306},{"id":"https://openalex.org/keywords/brainstem-arousal","display_name":"brainstem arousal","score":0.46000000834465027},{"id":"https://openalex.org/keywords/cognitive-modulation","display_name":"cognitive modulation","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.7906000018119812},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.7080000042915344},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.7003999948501587},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6966000199317932},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6008999943733215},{"id":"https://openalex.org/C2776861996","wikidata":"https://www.wikidata.org/wiki/Q241849","display_name":"Sensory processing","level":3,"score":0.5286999940872192},{"id":"https://openalex.org/C2779508121","wikidata":"https://www.wikidata.org/wiki/Q7451122","display_name":"Sensory cortex","level":3,"score":0.4959999918937683},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.46299999952316284},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4603999853134155},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4496000111103058},{"id":"https://openalex.org/C36951298","wikidata":"https://www.wikidata.org/wiki/Q379784","display_name":"Arousal","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.4133000075817108},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.39340001344680786},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.3686999976634979},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.26489999890327454},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.2563000023365021}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt0qf2g6z1","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0qf2g6z1","pdf_url":"https://escholarship.org/content/qt0qf2g6z1/qt0qf2g6z1.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt0qf2g6z1","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0qf2g6z1","pdf_url":"https://escholarship.org/content/qt0qf2g6z1/qt0qf2g6z1.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7062524893.pdf","grobid_xml":"https://content.openalex.org/works/W7062524893.grobid-xml"},"referenced_works_count":294,"referenced_works":["https://openalex.org/W11575409","https://openalex.org/W90604466","https://openalex.org/W153187294","https://openalex.org/W183063296","https://openalex.org/W349504017","https://openalex.org/W1053287285","https://openalex.org/W1481663104","https://openalex.org/W1500891748","https://openalex.org/W1502160784","https://openalex.org/W1535038405","https://openalex.org/W1601100579","https://openalex.org/W1608244379","https://openalex.org/W1608952396","https://openalex.org/W1670352010","https://openalex.org/W1860512920","https://openalex.org/W1897972863","https://openalex.org/W1932385070","https://openalex.org/W1954301870","https://openalex.org/W1964309132","https://openalex.org/W1964491687","https://openalex.org/W1964843067","https://openalex.org/W1965112813","https://openalex.org/W1968461602","https://openalex.org/W1968783051","https://openalex.org/W1970928383","https://openalex.org/W1973521302","https://openalex.org/W1974064384","https://openalex.org/W1974244275","https://openalex.org/W1974537497","https://openalex.org/W1974975426","https://openalex.org/W1975180379","https://openalex.org/W1976606839","https://openalex.org/W1977294321","https://openalex.org/W1977574579","https://openalex.org/W1979364392","https://openalex.org/W1980129559","https://openalex.org/W1981337227","https://openalex.org/W1981382083","https://openalex.org/W1981723438","https://openalex.org/W1985117964","https://openalex.org/W1985431179","https://openalex.org/W1985883097","https://openalex.org/W1986098871","https://openalex.org/W1986256882","https://openalex.org/W1986964933","https://openalex.org/W1988863819","https://openalex.org/W1990038183","https://openalex.org/W1991695937","https://openalex.org/W1992587397","https://openalex.org/W1992694071","https://openalex.org/W1993208680","https://openalex.org/W1995833317","https://openalex.org/W1996626332","https://openalex.org/W1997319821","https://openalex.org/W1997599315","https://openalex.org/W1997822886","https://openalex.org/W1997823461","https://openalex.org/W1998721922","https://openalex.org/W1999869847","https://openalex.org/W2004293194","https://openalex.org/W2004606702","https://openalex.org/W2005084287","https://openalex.org/W2006096283","https://openalex.org/W2007311340","https://openalex.org/W2007497655","https://openalex.org/W2007581301","https://openalex.org/W2009104998","https://openalex.org/W2010450314","https://openalex.org/W2010716926","https://openalex.org/W2011597937","https://openalex.org/W2011868904","https://openalex.org/W2013045879","https://openalex.org/W2013313898","https://openalex.org/W2013740545","https://openalex.org/W2014737057","https://openalex.org/W2015340885","https://openalex.org/W2015509669","https://openalex.org/W2016378735","https://openalex.org/W2016898417","https://openalex.org/W2018644390","https://openalex.org/W2019361862","https://openalex.org/W2020315242","https://openalex.org/W2020320000","https://openalex.org/W2020696485","https://openalex.org/W2020779246","https://openalex.org/W2020957587","https://openalex.org/W2023088704","https://openalex.org/W2023555571","https://openalex.org/W2024708682","https://openalex.org/W2025009638","https://openalex.org/W2028167167","https://openalex.org/W2028569155","https://openalex.org/W2030138801","https://openalex.org/W2030191470","https://openalex.org/W2030325164","https://openalex.org/W2031583388","https://openalex.org/W2032165309","https://openalex.org/W2034431198","https://openalex.org/W2035473397","https://openalex.org/W2036592327","https://openalex.org/W2038008568","https://openalex.org/W2039365471","https://openalex.org/W2039409559","https://openalex.org/W2041336675","https://openalex.org/W2043615144","https://openalex.org/W2044057824","https://openalex.org/W2044073424","https://openalex.org/W2044584315","https://openalex.org/W2047331899","https://openalex.org/W2047704070","https://openalex.org/W2048886673","https://openalex.org/W2048897426","https://openalex.org/W2052644075","https://openalex.org/W2052908314","https://openalex.org/W2057594895","https://openalex.org/W2057602178","https://openalex.org/W2058420610","https://openalex.org/W2059590710","https://openalex.org/W2061231754","https://openalex.org/W2062503636","https://openalex.org/W2062815868","https://openalex.org/W2063495321","https://openalex.org/W2063652896","https://openalex.org/W2065206478","https://openalex.org/W2067945948","https://openalex.org/W2068461290","https://openalex.org/W2068793916","https://openalex.org/W2070165661","https://openalex.org/W2070201885","https://openalex.org/W2070372815","https://openalex.org/W2070949043","https://openalex.org/W2074895886","https://openalex.org/W2082127589","https://openalex.org/W2082986442","https://openalex.org/W2083956595","https://openalex.org/W2085315793","https://openalex.org/W2086009204","https://openalex.org/W2086916134","https://openalex.org/W2087809804","https://openalex.org/W2087963213","https://openalex.org/W2089289079","https://openalex.org/W2089549991","https://openalex.org/W2089632738","https://openalex.org/W2090305817","https://openalex.org/W2090363503","https://openalex.org/W2092122238","https://openalex.org/W2095688342","https://openalex.org/W2099401565","https://openalex.org/W2101135654","https://openalex.org/W2101448784","https://openalex.org/W2103406492","https://openalex.org/W2103481737","https://openalex.org/W2105466163","https://openalex.org/W2109406833","https://openalex.org/W2109558179","https://openalex.org/W2109682741","https://openalex.org/W2109939890","https://openalex.org/W2110175860","https://openalex.org/W2110745711","https://openalex.org/W2111275492","https://openalex.org/W2111293376","https://openalex.org/W2111968444","https://openalex.org/W2112696849","https://openalex.org/W2113619522","https://openalex.org/W2115095583","https://openalex.org/W2116190393","https://openalex.org/W2116483429","https://openalex.org/W2116679324","https://openalex.org/W2117104656","https://openalex.org/W2117340355","https://openalex.org/W2119090916","https://openalex.org/W2119093605","https://openalex.org/W2119306020","https://openalex.org/W2123773443","https://openalex.org/W2124109469","https://openalex.org/W2124402513","https://openalex.org/W2126712529","https://openalex.org/W2128762423","https://openalex.org/W2129882844","https://openalex.org/W2129928127","https://openalex.org/W2133602205","https://openalex.org/W2138595310","https://openalex.org/W2138728119","https://openalex.org/W2139886607","https://openalex.org/W2140741071","https://openalex.org/W2143620016","https://openalex.org/W2144214580","https://openalex.org/W2144267571","https://openalex.org/W2145875022","https://openalex.org/W2146882598","https://openalex.org/W2147167623","https://openalex.org/W2148276911","https://openalex.org/W2148726987","https://openalex.org/W2150632992","https://openalex.org/W2151130155","https://openalex.org/W2153635508","https://openalex.org/W2154562678","https://openalex.org/W2155705846","https://openalex.org/W2157643754","https://openalex.org/W2158466023","https://openalex.org/W2160654481","https://openalex.org/W2162634115","https://openalex.org/W2166114254","https://openalex.org/W2166584229","https://openalex.org/W2171024980","https://openalex.org/W2171225607","https://openalex.org/W2189676241","https://openalex.org/W2198169527","https://openalex.org/W2210396547","https://openalex.org/W2263173111","https://openalex.org/W2275229234","https://openalex.org/W2276238108","https://openalex.org/W2308051861","https://openalex.org/W2349375992","https://openalex.org/W2397257824","https://openalex.org/W2401304507","https://openalex.org/W2408532247","https://openalex.org/W2409049622","https://openalex.org/W2417521627","https://openalex.org/W2479376018","https://openalex.org/W2502534556","https://openalex.org/W2512138671","https://openalex.org/W2525193599","https://openalex.org/W2528361202","https://openalex.org/W2551360963","https://openalex.org/W2577513788","https://openalex.org/W2586044158","https://openalex.org/W2588166475","https://openalex.org/W2594002025","https://openalex.org/W2594638981","https://openalex.org/W2604427212","https://openalex.org/W2611597219","https://openalex.org/W2737320535","https://openalex.org/W2738782983","https://openalex.org/W2756421372","https://openalex.org/W2757253955","https://openalex.org/W2763252886","https://openalex.org/W2765507708","https://openalex.org/W2766247218","https://openalex.org/W2776257264","https://openalex.org/W2778536001","https://openalex.org/W2782386660","https://openalex.org/W2788770082","https://openalex.org/W2801667518","https://openalex.org/W2803227434","https://openalex.org/W2806020332","https://openalex.org/W2806914683","https://openalex.org/W2877442110","https://openalex.org/W2887925139","https://openalex.org/W2889548240","https://openalex.org/W2890112730","https://openalex.org/W2897780572","https://openalex.org/W2903971524","https://openalex.org/W2904104018","https://openalex.org/W2918456385","https://openalex.org/W2920510990","https://openalex.org/W2921392007","https://openalex.org/W2922077153","https://openalex.org/W2922232063","https://openalex.org/W2949921015","https://openalex.org/W2951583631","https://openalex.org/W2952451491","https://openalex.org/W2953649774","https://openalex.org/W2964104722","https://openalex.org/W2970560145","https://openalex.org/W2971036596","https://openalex.org/W2980532222","https://openalex.org/W2996470202","https://openalex.org/W3001557906","https://openalex.org/W3014634065","https://openalex.org/W3037385322","https://openalex.org/W3045329796","https://openalex.org/W3047624096","https://openalex.org/W3081934577","https://openalex.org/W3087194547","https://openalex.org/W3096985350","https://openalex.org/W3122272320","https://openalex.org/W3146442847","https://openalex.org/W3155821888","https://openalex.org/W3207557865","https://openalex.org/W4206038759","https://openalex.org/W4211186612","https://openalex.org/W4213443529","https://openalex.org/W4223899320","https://openalex.org/W4224216943","https://openalex.org/W4225357290","https://openalex.org/W4241074797","https://openalex.org/W4243962542","https://openalex.org/W4251844988","https://openalex.org/W4286638073","https://openalex.org/W4292745309","https://openalex.org/W4293082421","https://openalex.org/W4307208844","https://openalex.org/W4385814092"],"related_works":["https://openalex.org/W7071271097","https://openalex.org/W2953649774","https://openalex.org/W2889548240","https://openalex.org/W1998825004","https://openalex.org/W2989585341","https://openalex.org/W4396578424","https://openalex.org/W3165921463","https://openalex.org/W2297642558","https://openalex.org/W2807886502","https://openalex.org/W4300962378"],"abstract_inverted_index":{"Perceptual":[0],"processes":[1,207],"are":[2],"significantly":[3],"modulated":[4],"by":[5],"the":[6,12,14,21,24,31,76,84,92,118,127,179,200,232],"primary":[7],"neurotransmitter,":[8],"Norepinephrine":[9],"(NE).":[10],"In":[11,87],"brain,":[13],"Locus":[15],"Coeruleus":[16],"(LC)":[17],"nucleus":[18],"located":[19],"in":[20,50,83,111,123,168,185,199,221],"pons":[22],"of":[23,37,79,105,130,182,196,202,205,212,227],"brainstem":[25],"houses":[26],"NE":[27],"production":[28],"and":[29,59,68,100,108,135,144,157,163,208,217,223,240],"serves":[30],"brain":[32],"as":[33],"its":[34,63],"sole":[35],"source":[36],"NE.":[38],"The":[39],"LC-NE":[40],"circuit":[41],"has":[42],"been":[43],"shown":[44],"to":[45,74,97,148,174],"play":[46],"a":[47,103,141],"critical":[48],"role":[49,82,122],"modulating":[51,124],"various":[52],"cognitive":[53],"functions,":[54],"including":[55],"sensory":[56,98,180,187,238],"processing,":[57],"perception,":[58],"perceptual":[60,134,183,206,241],"behavior.":[61,242],"However,":[62],"complex":[64],"circuitry,":[65],"features,":[66],"size,":[67],"location,":[69],"have":[70],"challenged":[71],"our":[72],"ability":[73],"understand":[75],"underlying":[77],"mechanisms":[78],"LC\u2019s":[80,121,151],"modulatory":[81],"human":[85,154],"brain.":[86],"this":[88],"dissertation,":[89],"I":[90],"investigate":[91],"relationship":[93,132],"linking":[94],"LC":[95,177,197,203,213,233],"activity":[96,234],"processing":[99,181],"perception":[101],"through":[102],"series":[104],"behavioral,":[106,142],"neuroimaging,":[107],"physiological":[109],"studies":[110],"healthy":[112],"young":[113],"adults.":[114],"Chapter":[115,138],"1":[116],"reviews":[117],"literature":[119,198],"on":[120,153,215,237],"cognition,":[125],"emphasizing":[126],"predominant":[128],"models":[129],"LC's":[131],"with":[133,170],"memory":[136],"processes.":[137,159],"2":[139],"reports":[140],"physiological,":[143],"neuroimaging":[145],"study":[146],"designed":[147],"facilitate":[149],"understanding":[150],"influence":[152],"perceptual,":[155],"attentional,":[156],"decision-making":[158],"More":[160],"specifically,":[161],"behavioral":[162,216],"fMRI":[164],"paradigms":[165],"were":[166],"investigated":[167],"conjunction":[169],"suitable":[171],"analytical":[172],"approaches":[173,229],"address":[175],"how":[176],"affects":[178],"stimuli":[184],"relevant":[186],"cortex":[188],"areas.":[189],"Together,":[190],"these":[191],"chapters":[192],"highlight":[193],"key":[194],"findings":[195],"context":[201],"modulation":[204],"behavior,":[209],"examine":[210],"influences":[211,236],"engagement":[214],"neural":[218],"stimulus-response":[219],"function":[220],"humans,":[222],"provide":[224],"an":[225],"overview":[226],"current":[228],"for":[230],"evaluating":[231],"related":[235],"representations":[239]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}