{"id":"https://openalex.org/W7062480485","doi":null,"title":"In vitro studies on the impact of irradiated head and neck squamous cell carcinoma cells on the differentiation of human monocytes to macrophages","display_name":"In vitro studies on the impact of irradiated head and neck squamous cell carcinoma cells on the differentiation of human monocytes to macrophages","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W7062480485"},"language":"en","primary_location":{"id":"pmh:oai:ub.uni-erlangen.de-opus:12506","doi":null,"is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/12506","pdf_url":"https://opus4.kobv.de/opus4-fau/files/12506/Dissertation_kristinawild_03122019.pdf","source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opus4.kobv.de/opus4-fau/files/12506/Dissertation_kristinawild_03122019.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wild, Kristina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wild, Kristina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9559999704360962},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7609999775886536},{"id":"https://openalex.org/keywords/m1-m2-phenotype","display_name":"M1/M2 phenotype","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7070000171661377},{"id":"https://openalex.org/keywords/hpv-status","display_name":"HPV status","score":0.6370000243186951},{"id":"https://openalex.org/keywords/radiation-induced-senescence","display_name":"radiation-induced senescence","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tumor-cell-supernatant","display_name":"tumor cell supernatant","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tumor-immune-interactions","display_name":"tumor-immune interactions","score":0.5249999761581421},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6019999980926514},{"id":"https://openalex.org/keywords/macrophage-plasticity","display_name":"macrophage plasticity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.6025000214576721},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6004999876022339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5371999740600586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5101000070571899},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.461899995803833},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.4465999901294708},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.43970000743865967},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43650001287460327},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.39239999651908875},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.3903999924659729},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.3792000114917755},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.3237999975681305},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3228999972343445},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C2780312720","wikidata":"https://www.wikidata.org/wiki/Q5689100","display_name":"Head (geology)","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29409998655319214},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26489999890327454}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ub.uni-erlangen.de-opus:12506","doi":null,"is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/12506","pdf_url":"https://opus4.kobv.de/opus4-fau/files/12506/Dissertation_kristinawild_03122019.pdf","source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"}],"best_oa_location":{"id":"pmh:oai:ub.uni-erlangen.de-opus:12506","doi":null,"is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/12506","pdf_url":"https://opus4.kobv.de/opus4-fau/files/12506/Dissertation_kristinawild_03122019.pdf","source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7062480485.pdf","grobid_xml":"https://content.openalex.org/works/W7062480485.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W239602587","https://openalex.org/W1262485082","https://openalex.org/W1594464537","https://openalex.org/W1608047736","https://openalex.org/W1900044428","https://openalex.org/W1967201796","https://openalex.org/W1970916793","https://openalex.org/W1971468934","https://openalex.org/W1977780721","https://openalex.org/W1979254677","https://openalex.org/W1981989535","https://openalex.org/W1987423317","https://openalex.org/W1991129425","https://openalex.org/W1993614010","https://openalex.org/W1995177733","https://openalex.org/W1996145004","https://openalex.org/W1997219075","https://openalex.org/W2001733842","https://openalex.org/W2001816519","https://openalex.org/W2004273407","https://openalex.org/W2005145546","https://openalex.org/W2005145657","https://openalex.org/W2005334224","https://openalex.org/W2012024423","https://openalex.org/W2017558201","https://openalex.org/W2024592737","https://openalex.org/W2028169108","https://openalex.org/W2037489902","https://openalex.org/W2039183048","https://openalex.org/W2041428167","https://openalex.org/W2043522520","https://openalex.org/W2044152887","https://openalex.org/W2047330128","https://openalex.org/W2050852029","https://openalex.org/W2052313621","https://openalex.org/W2054472394","https://openalex.org/W2055374705","https://openalex.org/W2058375382","https://openalex.org/W2058648826","https://openalex.org/W2060274331","https://openalex.org/W2060763328","https://openalex.org/W2061449596","https://openalex.org/W2065210647","https://openalex.org/W2066201797","https://openalex.org/W2067616322","https://openalex.org/W2069154921","https://openalex.org/W2069797572","https://openalex.org/W2070198274","https://openalex.org/W2070855360","https://openalex.org/W2074942026","https://openalex.org/W2075145927","https://openalex.org/W2077814905","https://openalex.org/W2081787619","https://openalex.org/W2082814058","https://openalex.org/W2084188360","https://openalex.org/W2088481746","https://openalex.org/W2093705034","https://openalex.org/W2095114292","https://openalex.org/W2095537212","https://openalex.org/W2108387330","https://openalex.org/W2109951379","https://openalex.org/W2110934787","https://openalex.org/W2114119309","https://openalex.org/W2115852450","https://openalex.org/W2117246760","https://openalex.org/W2117692326","https://openalex.org/W2119194984","https://openalex.org/W2121424792","https://openalex.org/W2121626779","https://openalex.org/W2123469465","https://openalex.org/W2124167732","https://openalex.org/W2127605299","https://openalex.org/W2132087081","https://openalex.org/W2141778744","https://openalex.org/W2141859344","https://openalex.org/W2142026162","https://openalex.org/W2143321586","https://openalex.org/W2143523733","https://openalex.org/W2145485696","https://openalex.org/W2146171603","https://openalex.org/W2148771747","https://openalex.org/W2148818765","https://openalex.org/W2153024386","https://openalex.org/W2157962067","https://openalex.org/W2158924977","https://openalex.org/W2159875818","https://openalex.org/W2160483166","https://openalex.org/W2162229546","https://openalex.org/W2171635244","https://openalex.org/W2333031609","https://openalex.org/W2555377421","https://openalex.org/W2593915210","https://openalex.org/W2600219441","https://openalex.org/W2758358084"],"related_works":["https://openalex.org/W3207890355","https://openalex.org/W3193304256","https://openalex.org/W7037422392","https://openalex.org/W4307634455","https://openalex.org/W2942765569","https://openalex.org/W1986273757","https://openalex.org/W4412328705","https://openalex.org/W2889346777","https://openalex.org/W6945700973","https://openalex.org/W6958151368"],"abstract_inverted_index":{"BackgroundHead":[0],"and":[1,19,66,164,187,197,212,261,267,277,291,322,329,347],"neck":[2],"squamous":[3],"cell":[4,74,98,251,345],"carcinoma":[5],"(HNSCC)":[6],"is":[7,48,68,104,203],"one":[8],"of":[9,64,69,97,128,130,159,167,176,253,283,342],"the":[10,39,55,62,85,111,122,126,142,160,174,180,221,228,258,304,320,326,330,340,348],"most":[11],"common":[12],"tumor":[13,77,132,143,305,331,344,349],"diseases":[14],"worldwide.Risk":[15],"factors":[16],"are":[17,43,157,192,207,217,256,263],"alcohol":[18],"tobacco":[20],"consume":[21],"or":[22,273],"infection":[23],"with":[24,30,50,179,199,247,269],"a":[25,94,200],"high-risk":[26],"human":[27,249],"papillomavirus":[28],"(HPV)-type.Patients":[29],"HPV+":[31],"status":[32],"respond":[33],"better":[34],"to":[35,71,89,106,115,134,148,188,220,309,333],"radiotherapy":[36],"(RT),":[37],"but":[38,53],"causal":[40],"biological":[41],"processes":[42],"not":[44],"yet":[45],"fully":[46],"understood.HNSCC":[47],"treated":[49,131,268],"normofractionated":[51],"RT,":[52,83,103,284],"in":[54,120,152,173,300,303,318],"last":[56,281],"decade":[57],"hypofractionated":[58,82,274],"RT":[59],"came":[60],"into":[61,336],"focus":[63],"research":[65],"therapy.It":[67],"interest":[70],"determine":[72],"which":[73,254,307],"death":[75],"forms":[76],"cells":[78,133,178,285,350],"undergo":[79],"after":[80,102,280],"normo-or":[81],"as":[84,223,233],"latter":[86],"can":[87],"lead":[88],"different":[90,321],"immunological":[91],"responses.Also,":[92],"senescence,":[93],"stressinduced":[95],"form":[96],"cycle":[99],"arrest,":[100],"also":[101,315],"predicted":[105],"have":[107,225,297,332],"high":[108,226,298],"influence":[109],"on":[110,136,352],"immune":[112,155,162,181,327],"system.In":[113],"addition":[114],"that,":[116],"we":[117],"were":[118,244,265,286],"interested":[119],"how":[121],"HPV-status":[123],"impacts":[124],"this.Furthermore,":[125],"potential":[127],"supernatants":[129],"impact":[135,341],"macrophage":[137,353],"phenotype":[138,229,302],"was":[139],"examined,":[140],"since":[141],"microenvironment":[144],"has":[145],"been":[146],"demonstrated":[147],"be":[149,231,310,334,356],"strongly":[150],"involved":[151],"therapy-induced":[153],"anti-tumor":[154],"reactions.Macrophages":[156],"part":[158],"innate":[161],"system":[163,328],"develop":[165],"out":[166,246],"monocytes.They":[168],"play":[169],"an":[170,234],"important":[171],"role":[172],"interaction":[175],"tumors":[177],"system.Tumors":[182],"utilize":[183],"macrophages":[184,191,224,296],"for":[185,237],"angiogenesis":[186],"expand.These":[189],"infiltrating":[190],"called":[193],"\"tumor-associated":[194],"macrophages\"":[195],"(TAM)":[196],"correlate":[198],"poor":[201],"outcome.It":[202],"known":[204],"that":[205,295,317],"there":[206],"more":[208,213,218],"pro-inflammatory":[209],"phenotypes":[210,215],"(M1)":[211],"anti-inflammatory":[214,239],"(M2).TAMs":[216],"similar":[219],"M2-phenotype.But":[222],"plasticity,":[227],"should":[230,355],"regarded":[232],"indication":[235],"only":[236],"pro-or":[238],"reactions.":[240],"MethodsIn":[241],"vitro":[242],"experiments":[243,339],"carried":[245],"four":[248],"HNSCC":[250,319],"lines":[252],"two":[255,262],"bearing":[257],"HP":[259],"virus":[260],"not.Cells":[264],"seeded":[266],"X-Rays":[270],"either":[271],"normo-(5x2Gy)":[272],"(2x5Gy).Two":[275],"days":[276,279],"six":[278],"fraction":[282],"analyzed":[287],"regarding":[288],"their":[289,301],"Conclusion":[290],"outlookOur":[292],"results":[293],"confirm":[294],"plasticity":[299],"microenvironment,":[306],"seems":[308],"individually":[311],"influenced":[312],"by":[313],"RT.This":[314],"confirms":[316],"individual":[323],"interactions":[324],"between":[325],"taken":[335],"account.In":[337],"future":[338],"both,":[343],"supernatant":[346],"themselves":[351],"phenotype,":[354],"examined.":[357]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}