{"id":"https://openalex.org/W7061736688","doi":null,"title":"Retinoic acid receptor (Phosphorylation and dynamic control of association/dissociation of protein complexes)","display_name":"Retinoic acid receptor (Phosphorylation and dynamic control of association/dissociation of protein complexes)","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W7061736688"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/867889","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/867889","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110826873","display_name":"S\u00e9bastien Lalev\u00e9e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LALEVEE, S\u00e9bastien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039471250","display_name":"C\u00e9cile Rochette\u2010Egly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EGLY, C\u00e9cile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid-receptor","display_name":"retinoic acid receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.6790000200271606},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cyclin-h","display_name":"cyclin H","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cdk7","display_name":"CDK7","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tfiih","display_name":"TFIIH","score":0.9660000205039978},{"id":"https://openalex.org/keywords/sug1","display_name":"SUG1","score":0.6579999923706055},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.781000018119812},{"id":"https://openalex.org/keywords/proline-rich-motif","display_name":"proline-rich motif","score":0.781000018119812},{"id":"https://openalex.org/keywords/sh3-domain","display_name":"SH3 domain","score":0.7919999957084656},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.609000027179718},{"id":"https://openalex.org/keywords/rare-elements","display_name":"rare elements","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6647999882698059},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5171999931335449},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4961000084877014},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3714999854564667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30570000410079956},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.2913999855518341},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.25189998745918274},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2517000138759613},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.24549999833106995}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:hdl:10068/867889","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/867889","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W407246246","https://openalex.org/W7030401645","https://openalex.org/W436780079","https://openalex.org/W596674400","https://openalex.org/W7042609534","https://openalex.org/W2730231716","https://openalex.org/W7033252398","https://openalex.org/W7134659085","https://openalex.org/W91358179","https://openalex.org/W7144268663"],"abstract_inverted_index":{"Les":[0],"r\u00e9tino\u00efdes":[1],"(d\u00e9riv\u00e9s":[2],"actifs":[3],"de":[4,12,47,59,77,92,141,144,149,161,168,177,179,192,204,224,237,260,266,271,288,334,352,360,370,383],"la":[5,155,162,169,180,193,198,211,218,255,264,267,279,313,335,350,353],"vitamine":[6],"A)":[7],"agissent":[8],"via":[9,278],"deux":[10,80],"familles":[11],"r\u00e9cepteurs":[13],"nucl\u00e9aires":[14],":":[15],"les":[16,22,126],"RAR(a,":[17],"b":[18,25,355],"et":[19,21,26,53,89,97,133,273,328,356],"g)":[20,134],"RXR":[23],"(a,":[24],"g).":[27],"In":[28],"vivo,":[29],"le":[30,84,90,115,147,190,286,294,322,330,358],"signal":[31],"r\u00e9tino\u00efque":[32],"est":[33,209,242,325],"transmis":[34],"par":[35,50,220],"des":[36,45,57,67,75,82,106,112,117,130,159,184,257,306,343,365,367],"h\u00e9t\u00e9rodim\u00e8res":[37],"du":[38,65,94,164,175,201,222,246,281,300,345,390],"type":[39],"RAR/RXR":[40],"qui":[41,241],"se":[42,54],"comportent":[43],"comme":[44],"facteurs":[46],"transcription":[48,205,256,268],"inductibles":[49],"leur":[51,142],"ligand":[52,95],"lient":[55],"\u00e0":[56,124,154,173,197,210,217,230,339,387],"\u00e9l\u00e9ments":[58],"r\u00e9ponse":[60,338],"(RARE)":[61],"situ\u00e9s":[62],"au":[63,166,363],"niveau":[64,167,364],"promoteur":[66],"g\u00e8nes":[68,258,368],"cibles.":[69],"L":[70],"\u00e9quipe":[71],"a":[72,318],"d\u00e9montr\u00e9":[73,292],"que":[74,293],"processus":[76],"phosphorylation":[78,163,188,219],"ciblent":[79],"domaines":[81,307],"RAR,":[83,118],"domaine":[85,91,176],"N":[86],"terminal":[87],"(NTD)":[88],"liaison":[93],"(LBD),":[96],"jouent":[98],"un":[99,234,251,305],"r\u00f4le":[100,252],"cl\u00e9":[101],"dans":[102,254],"l":[103,110,231,340,371,388],"activit\u00e9":[104],"transcriptionnelle":[105],"r\u00e9cepteurs.":[107],"Pour":[108],"comprendre":[109],"impact":[111],"phosphorylations":[113],"sur":[114],"fonctionnement":[116],"je":[119],"me":[120],"suis":[121],"particuli\u00e8rement":[122],"int\u00e9ress\u00e9":[123],"\u00e9tudier":[125],"dynamiques":[127],"d":[128,213,233,309],"association/dissociation":[129],"RAR":[131],"(a":[132],"avec":[135,304],"diff\u00e9rents":[136],"partenaires":[137],"prot\u00e9iques":[138],"en":[139,157,262,269,274,297,332],"fonction":[140],"\u00e9tat":[143],"phosphorylation.":[145],"Dans":[146,285,373],"cas":[148,287],"RARa,":[150,238],"j":[151,290,376],"ai":[152,227,291,377],"particip\u00e9":[153,229],"mise":[156],"\u00e9vidence":[158],"cons\u00e9quences":[160],"LBD":[165],"s\u00e9rine":[170],"369,":[171],"localis\u00e9e":[172],"proximit\u00e9":[174],"fixation":[178],"cycline":[181,194],"H.":[182],"Via":[183],"changements":[185],"conformationnels,":[186],"cette":[187],"am\u00e9liore":[189],"recrutement":[191,359],"H":[195],"associ\u00e9e":[196],"kinase":[199],"cdk7":[200,221],"facteur":[202],"g\u00e9n\u00e9ral":[203],"TFIIH.":[206],"Cet":[207],"effet":[208],"base":[212],"une":[214,243,310,342,380],"cascade":[215],"aboutissant":[216],"NTD":[223,301],"RARa.":[225],"J":[226],"aussi":[228],"\u00e9tude":[232],"autre":[235],"partenaire":[236],"SUG":[239,248],"1,":[240],"sous":[244],"unit\u00e9":[245],"prot\u00e9asome.":[247],"1":[249],"joue":[250],"double":[253],"cibles":[259,369],"RARa":[261],"r\u00e9gulant":[263],"dynamique":[265],"absence":[270],"prot\u00e9olyse,":[272],"signalisant":[275],"sa":[276],"fin":[277],"d\u00e9gradation":[280],"coactivateur":[282],"SRC":[283],"3.":[284],"RARg,":[289],"motif":[295],"riche":[296],"prolines":[298],"(MRP)":[299],"interagit":[302],"directement":[303],"SH3":[308],"prot\u00e9ine":[311],"adaptatrice,":[312],"Vinexine":[314,354],"b.":[315],"Cette":[316],"association":[317],"lieu":[319],"uniquement":[320],"lorsque":[321],"MRP":[323,346],"n":[324],"pas":[326],"phosphoryl\u00e9":[327,362],"maintient":[329],"r\u00e9cepteur":[331],"dehors":[333],"chromatine.":[336],"En":[337],"AR,":[341],"s\u00e9rines":[344],"devient":[347],"phosphoryl\u00e9e,":[348],"induisant":[349],"dissociation":[351],"finalement":[357],"RARg":[361],"promoteurs":[366],"AR.":[372],"ce":[374],"contexte,":[375],"\u00e9galement":[378],"effectu\u00e9":[379],"recherche":[381],"bioinformatique":[382],"nouveaux":[384],"RARE":[385],"fonctionnels":[386],"\u00e9chelle":[389],"g\u00e9nome.":[391]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
