{"id":"https://openalex.org/W7061278397","doi":null,"title":"Probiotics mediate neuroprotection against ad through cns and ens crosstalk: modulation of neurotransmitters, neuropeptides and gut hormones / Muhammad Syukri Noor Azman","display_name":"Probiotics mediate neuroprotection against ad through cns and ens crosstalk: modulation of neurotransmitters, neuropeptides and gut hormones / Muhammad Syukri Noor Azman","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W7061278397"},"language":"en","primary_location":{"id":"pmh:oai:ir.uitm.edu.my:53599","doi":null,"is_oa":false,"landing_page_url":"https://ir.uitm.edu.my/id/eprint/53599/1/53599.pdf","pdf_url":"https://ir.uitm.edu.my/id/eprint/53599/1/53599.pdf","source":{"id":"https://openalex.org/S4306402285","display_name":"UiTM Institutional Repositories (Universiti Teknologi MARA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82724352","host_organization_name":"Universiti Teknologi MARA","host_organization_lineage":["https://openalex.org/I82724352"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023236687","display_name":"Muhammad Syukri Noor Azman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Noor Azman, Muhammad Syukri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023236687"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.41530001163482666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lps-challenge","display_name":"lipopolysaccharide challenge","score":0.8769999742507935},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.597000002861023},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.6430000066757202},{"id":"https://openalex.org/keywords/firmicutes-bacteroidetes-ratio","display_name":"Firmicutes/Bacteroidetes ratio","score":0.8349999785423279},{"id":"https://openalex.org/keywords/lactic-acid-bacteria","display_name":"lactic acid bacteria","score":0.6290000081062317},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.4569999873638153},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.675000011920929},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.46399998664855957},{"id":"https://openalex.org/keywords/gastrointestinal-hormones","display_name":"gastrointestinal hormones","score":0.3310000002384186},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.8569999933242798},{"id":"https://openalex.org/keywords/16s-rrna-gene-sequencing","display_name":"16S rRNA gene sequencing","score":0.5669999718666077},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9075000286102295},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7202000021934509},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6352999806404114},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6078000068664551},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.522599995136261},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5049999952316284},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.5044000148773193},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.5006999969482422},{"id":"https://openalex.org/C138906646","wikidata":"https://www.wikidata.org/wiki/Q7507668","display_name":"Sickness behavior","level":3,"score":0.47769999504089355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.435699999332428},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.427700012922287},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.41940000653266907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4011000096797943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3946000039577484},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3944000005722046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38029998540878296},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.3571000099182129},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.3411000072956085},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3328999876976013},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.30730000138282776},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3003999888896942},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2994000017642975},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2745000123977661}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ir.uitm.edu.my:53599","doi":null,"is_oa":false,"landing_page_url":"https://ir.uitm.edu.my/id/eprint/53599/1/53599.pdf","pdf_url":"https://ir.uitm.edu.my/id/eprint/53599/1/53599.pdf","source":{"id":"https://openalex.org/S4306402285","display_name":"UiTM Institutional Repositories (Universiti Teknologi MARA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82724352","host_organization_name":"Universiti Teknologi MARA","host_organization_lineage":["https://openalex.org/I82724352"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7010920931","https://openalex.org/W7220665203","https://openalex.org/W7143760973","https://openalex.org/W2895806190","https://openalex.org/W4392123262","https://openalex.org/W4415062856","https://openalex.org/W4321257278","https://openalex.org/W4382725788","https://openalex.org/W4390103343","https://openalex.org/W7125690581"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1,22],"(AD)":[2],"is":[3,23],"the":[4,38,72,82,96,100,131,169,192,211,237,247,306,362,366,420,441,485,488],"commonest":[5],"form":[6],"of":[7,12,37,59,81,88,109,224,249,255,292,308,346,378,409,492,499],"dementia":[8],"characterised":[9,118],"by":[10,119,204],"aggregation":[11],"amyloid":[13],"beta":[14],"(A\u03b2)":[15],"plaque":[16],"and":[17,41,54,105,144,162,297,313,328,353,397,462,470,487,496],"Tau":[18],"protein.":[19],"This":[20,241],"neurodegenerative":[21],"now":[24],"linked":[25],"to":[26,45,66,130,174,191,210,236,245,277,282,303,330,334,372,404,424,445],"altered":[27],"gut":[28,39,110,256,311,438,494,500],"microbiota":[29,139,312,501],"composition":[30,108],"which":[31,63],"could":[32,479],"result":[33],"in":[34,107,168,187,222,271,365,391,419,440,467],"increased":[35,232,275,361,386,414,432],"permeability":[36],"barrier":[40],"immune":[42],"activation,":[43],"leading":[44],"systemic":[46],"inflammation,":[47],"impaired":[48],"blood-brain":[49],"barrier,":[50],"neuroinflammation,":[51],"neural":[52],"injury,":[53],"ultimately":[55],"neurodegeneration.":[56],"The":[57,79,126,338,427,472],"limitations":[58],"current":[60],"AD":[61,123],"therapy,":[62],"mainly":[64],"aims":[65],"alleviate":[67],"symptoms":[68],"rather":[69],"than":[70],"curing":[71],"disease,":[73],"have":[74],"called":[75],"for":[76],"alternative":[77],"approach.":[78],"emergence":[80],"Gut-Brain":[83],"Axis":[84],"concept":[85],"raises":[86],"possibility":[87],"using":[89,267],"probiotics":[90],"as":[91,220,370],"neuroprotective":[92],"agents.":[93],"As":[94],"such,":[95],"present":[97,473],"study":[98,242],"investigated":[99],"correlation":[101],"between":[102,295,484],"probiotic-induced":[103],"neuroprotection":[104,478],"changes":[106,454],"microbiota.":[111,257],"For":[112],"this":[113],"purpose,":[114],"lipopolysaccharide":[115],"(LPS)-challenged":[116],"rats":[117,127,149,179,228,317],"neuroinflammation":[120],"that":[121,359,476],"mimic":[122,331],"were":[124,128,180,318,340,383],"used.":[125],"subjected":[129],"Morris":[132],"Water":[133],"Maze":[134],"(MWM)":[135],"Test,":[136],"immunohistochemistry":[137],"(IHC),":[138],"diversity":[140],"analyses,":[141],"biochemical":[142],"analyses":[143],"mitochondrial":[145,379],"enzymatic":[146],"analyses.":[147],"LPS-challenged":[148,178,227,316],"pre-treated":[150,226],"with":[151,182,197,321,385],"either":[152],"LAB6":[153],"or":[154],"LAB12":[155,296],"exhibited":[156],"significantly":[157,183,199,230,273,413,431],"(p<0.05)":[158],"reduced":[159,185],"escape":[160,163],"latency":[161],"distance.":[164],"They":[165],"remained":[166],"longer":[167],"platform":[170,367],"quadrant":[171],"when":[172,189,208,234,280,402,422,443],"compared":[173,190,209,235,281,403,423,444],"control.":[175,284],"In":[176,301,376,407],"IHC,":[177],"presented":[181,384],"(p<0.001)":[184,274],"5-HT":[186,202,221,415],"hippocampi":[188,398,421,442,469],"wild":[193],"type":[194],"group.":[195,214,240,406,426],"Pre-treatment":[196],"LAB":[198,225,250,309,477],"(p<0.01)":[200,231],"restored":[201],"level":[203,416,434],"at":[205],"least":[206],"37%":[207],"LPS":[212,238,283,298,348],"control":[213,239,299],"A":[215],"similar":[216],"trend":[217],"was":[218,229,265,357],"observed":[219],"colons":[223],"(+59%)":[233],"went":[243],"on":[244,252,310],"explore":[246],"impact":[248],"pre-treatment":[251],"compositional":[253,497],"shift":[254,498],"Bacterial":[258],"16S":[259],"rRNA":[260],"gene":[261],"from":[262],"caecal":[263],"content":[264],"amplified":[266],"515F-806R":[268],"primers.":[269],"LAB12,":[270],"particular,":[272],"Bacteroidetes":[276],"Firmicutes":[278],"ratio":[279],"Principal":[285],"Component":[286],"Analysis":[287],"plot":[288],"showed":[289],"clear":[290],"separation":[291],"bacteria":[293],"community":[294],"groups.":[300],"order":[302],"further":[304],"understand":[305],"role":[307],"cognitive":[314],"function,":[315],"being":[319],"administered":[320],"antibiotic":[322],"cocktails":[323],"(imipenem,":[324],"vancomycin,":[325],"ampicillin,":[326],"ciprofloxacin":[327],"metronidazole)":[329],"a":[332,437],"close":[333],"germ":[335],"free":[336],"condition.":[337],"rodents":[339],"divided":[341],"into":[342],"groups":[343],"(n=8/":[344],"group)":[345],"wild-type,":[347],"control,":[349],"LAB12+LPS,":[350],"ABX":[351,374,405,425],"(antibiotics+LPS)":[352],"ABXL":[354,360,381,411,428,448],"(ABX+LAB12).":[355],"It":[356],"found":[358],"time":[363],"spent":[364],"zone":[368],"(+16%)":[369],"opposed":[371],"their":[373,392],"counterparts.":[375],"terms":[377,408],"enzymes,":[380],"group":[382,412,429],"Complex":[387],"III":[388],"enzyme":[389],"activities":[390],"cortices":[393],"(+57":[394],"%;":[395,400],"p<0.05)":[396,418],"(+33":[399],"p<0.01)":[401],"neurotransmitters,":[410],"(+32%,":[417],"also":[430],"GHRL":[433],"(+85%,":[435],"p<0.05),":[436],"hormone,":[439],"ABXL.":[446],"Nevertheless,":[447],"did":[449],"not":[450],"bring":[451],"about":[452],"significant":[453],"against":[455],"neuropeptides":[456],"[neurotensin":[457],"(NT),":[458],"neuropeptide":[459],"Y":[460],"(NPY)":[461],"vasoactive":[463],"intestestinal":[464],"peptide":[465],"(VIP)]":[466],"both":[468],"colons.":[471],"findings":[474],"indicated":[475],"be":[480],"mediated":[481],"via":[482],"crosstalk":[483],"CNS":[486],"ENS":[489],"through":[490],"modulation":[491],"neurotransmitter,":[493],"hormone":[495]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}