{"id":"https://openalex.org/W7060848672","doi":null,"title":"Oxidative stress and neuronal changes associated with prenatal ethanol exposure in human and monkey brains","display_name":"Oxidative stress and neuronal changes associated with prenatal ethanol exposure in human and monkey brains","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W7060848672"},"language":"en","primary_location":{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/30346","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1993/30346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076060303","display_name":"Duaa A. Basalah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Basalah, Duaa Ali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076060303"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenatal-alcohol-exposure","display_name":"prenatal alcohol exposure","score":0.9919999837875366},{"id":"https://openalex.org/keywords/fetal-alcohol-spectrum-disorders","display_name":"fetal alcohol spectrum disorders","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.8080000281333923},{"id":"https://openalex.org/keywords/parvalbumin","display_name":"parvalbumin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/glutamatergic-neurons","display_name":"glutamatergic neurons","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8040000200271606},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9660000205039978},{"id":"https://openalex.org/keywords/temporal-cortex","display_name":"temporal cortex","score":0.9940000176429749},{"id":"https://openalex.org/keywords/monkey-brain","display_name":"monkey brain","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.7576000094413757},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.678600013256073},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6735000014305115},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.6377999782562256},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6086000204086304},{"id":"https://openalex.org/C141547260","wikidata":"https://www.wikidata.org/wiki/Q2720322","display_name":"Parvalbumin","level":2,"score":0.5774999856948853},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5748999714851379},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.49070000648498535},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4758000075817108},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46129998564720154},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4440000057220459},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.4410000145435333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43860000371932983},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4320000112056732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4115000069141388},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4049000144004822},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.3711000084877014},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3569999933242798},{"id":"https://openalex.org/C2993858690","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal cortex","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.2782999873161316},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.2782000005245209},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27160000801086426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25600001215934753}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/30346","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1993/30346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070726583","https://openalex.org/W2138954300","https://openalex.org/W2073811030","https://openalex.org/W2171635745","https://openalex.org/W2091079457","https://openalex.org/W2526040297","https://openalex.org/W2982165420","https://openalex.org/W2002289637","https://openalex.org/W2330618614","https://openalex.org/W2078937978"],"abstract_inverted_index":{"Background:":[0],"Prenatal":[1],"ethanol":[2],"exposure":[3],"(PNEE)":[4],"causes":[5],"irreversible":[6],"intellectual":[7],"and":[8,40,59,65,81,98,103,122,125,144],"behavioral":[9],"disabilities,":[10],"clinically":[11],"known":[12,50],"as":[13],"fetal":[14],"alcohol":[15],"spectrum":[16],"disorder.":[17],"Few":[18],"neuropathologic":[19],"studies":[20],"of":[21,28],"human":[22,89,138],"brain":[23,46],"exist.":[24],"Hypotheses:":[25],"First,":[26],"markers":[27,68],"oxidative":[29,85],"stress":[30,64,86],"persist":[31],"following":[32,139],"PNEE.":[33],"Second,":[34],"PNEE":[35,51,82,90,140],"is":[36],"associated":[37],"with":[38,49],"inhibitory":[39],"excitatory":[41],"neuron":[42,135],"changes.":[43],"Methods:":[44],"Human":[45],"autopsies":[47],"(153)":[48],"were":[52,61,69,75,94,112],"reviewed;":[53],"18":[54],"cases":[55],"(fetus":[56],"to":[57],"adult)":[58],"controls":[60],"selected.":[62],"Oxidative":[63],"neuronal":[66],"differentiation":[67],"used":[70],"for":[71,110],"immunohistochemistry.":[72],"Results:":[73],"There":[74],"no":[76],"obvious":[77],"differences":[78],"between":[79],"control":[80],"brains":[83],"using":[84],"markers.":[87],"In":[88],"brains,":[91],"glutamatergic":[92],"neurons":[93,108],"reduced":[95,113],"15.96":[96],"%":[97],"18.03%":[99],"in":[100,114,129,137,147],"dentate":[101],"gyrus":[102],"temporal":[104,126],"cortex,":[105],"respectively.":[106],"GABAergic":[107,134],"reactive":[109],"parvalbumin":[111],"all":[115,130],"hippocampal":[116],"regions":[117],"(CA1=":[118],"57.86%,":[119],"CA3=":[120],"65.15%,":[121],"DG=":[123],"53.39%)":[124],"cortex":[127],"(44.13%)":[128],"age":[131],"groups.":[132],"Conclusion:":[133],"reduction":[136],"could":[141],"explain":[142],"motor":[143],"behavior":[145],"distractibility":[146],"FASD":[148],"individuals.":[149]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}
