{"id":"https://openalex.org/W7058072295","doi":null,"title":"Modelos in vitro personalizados basados en c\u00e9lulas pluripotentes para el estudio de la toxicidad hep\u00e1tica inducida por f\u00e1rmacos de car\u00e1cter idiosincr\u00e1sico","display_name":"Modelos in vitro personalizados basados en c\u00e9lulas pluripotentes para el estudio de la toxicidad hep\u00e1tica inducida por f\u00e1rmacos de car\u00e1cter idiosincr\u00e1sico","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W7058072295"},"language":"es","primary_location":{"id":"pmh:oai:roderic.uv.es:10550/87860","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10550/87860","pdf_url":"https://roderic.uv.es/bitstreams/6641a4fa-aa04-4b65-a142-ef2df9d9b544/download","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://roderic.uv.es/bitstreams/6641a4fa-aa04-4b65-a142-ef2df9d9b544/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Pelech\u00e1 Salvador, Mar\u00eda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pelech\u00e1 Salvador, Mar\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.9620000123977661},{"id":"https://openalex.org/keywords/idiosyncratic-drug-induced-liver-injury","display_name":"idiosyncratic drug-induced liver injury","score":0.9639999866485596},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hepatocyte-like-cells","display_name":"hepatocyte-like cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/hepatotoxicity-prediction","display_name":"hepatotoxicity prediction","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hepatotoxicity-mechanisms","display_name":"hepatotoxicity mechanisms","score":0.42800000309944153},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.46000000834465027},{"id":"https://openalex.org/keywords/drug-safety-assessment","display_name":"drug safety assessment","score":0.37700000405311584},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.6380000114440918},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.5139999985694885},{"id":"https://openalex.org/keywords/xenobiotics","display_name":"xenobiotics","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5867999792098999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.490200012922287},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37049999833106995},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2994999885559082},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.19220000505447388},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13830000162124634},{"id":"https://openalex.org/C3019393901","wikidata":"https://www.wikidata.org/wiki/Q232932","display_name":"Open access publishing","level":2,"score":0.13529999554157257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13300000131130219},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.12129999697208405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.120899997651577},{"id":"https://openalex.org/C3020366717","wikidata":"https://www.wikidata.org/wiki/Q14075","display_name":"Free access","level":2,"score":0.10970000177621841},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10029999911785126},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.09200000017881393},{"id":"https://openalex.org/C129990765","wikidata":"https://www.wikidata.org/wiki/Q7508482","display_name":"Sidestream smoke","level":3,"score":0.09139999747276306},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.09130000323057175},{"id":"https://openalex.org/C2910112519","wikidata":"https://www.wikidata.org/wiki/Q4816772","display_name":"Myocardial reperfusion","level":3,"score":0.08100000023841858},{"id":"https://openalex.org/C145458877","wikidata":"https://www.wikidata.org/wiki/Q7317044","display_name":"Retromer","level":4,"score":0.08049999922513962},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.07919999957084656},{"id":"https://openalex.org/C2779867896","wikidata":"https://www.wikidata.org/wiki/Q2357007","display_name":"Fenoldopam","level":4,"score":0.0786999985575676},{"id":"https://openalex.org/C158342456","wikidata":"https://www.wikidata.org/wiki/Q587862","display_name":"Forensic toxicology","level":2,"score":0.07850000262260437},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.0754999965429306},{"id":"https://openalex.org/C2993153387","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic diagnosis","level":3,"score":0.07530000060796738},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.07509999722242355},{"id":"https://openalex.org/C2909743892","wikidata":"https://www.wikidata.org/wiki/Q81671","display_name":"Brazil nut","level":2,"score":0.07419999688863754},{"id":"https://openalex.org/C2778734912","wikidata":"https://www.wikidata.org/wiki/Q416271","display_name":"Dimethoxyethane","level":4,"score":0.07249999791383743},{"id":"https://openalex.org/C2992097611","wikidata":"https://www.wikidata.org/wiki/Q3531616","display_name":"Waste material","level":2,"score":0.07190000265836716},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.07039999961853027},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.0697999969124794},{"id":"https://openalex.org/C529618451","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasonography","level":2,"score":0.06970000267028809},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.06909999996423721},{"id":"https://openalex.org/C3018059006","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Human placenta","level":5,"score":0.06889999657869339},{"id":"https://openalex.org/C2780172944","wikidata":"https://www.wikidata.org/wiki/Q1075029","display_name":"Antennapedia","level":5,"score":0.06889999657869339},{"id":"https://openalex.org/C2993807623","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genetic data","level":3,"score":0.06830000132322311},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.06790000200271606},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.06790000200271606},{"id":"https://openalex.org/C2992598832","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Blood clotting","level":2,"score":0.06710000336170197},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.06700000166893005},{"id":"https://openalex.org/C2910636507","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular Transport Proteins","level":5,"score":0.06629999727010727},{"id":"https://openalex.org/C3018923281","wikidata":"https://www.wikidata.org/wiki/Q3639228","display_name":"Chemical agents","level":2,"score":0.06509999930858612},{"id":"https://openalex.org/C138651985","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutics","level":2,"score":0.0640999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:roderic.uv.es:10550/87860","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10550/87860","pdf_url":"https://roderic.uv.es/bitstreams/6641a4fa-aa04-4b65-a142-ef2df9d9b544/download","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:roderic.uv.es:10550/87860","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10550/87860","pdf_url":"https://roderic.uv.es/bitstreams/6641a4fa-aa04-4b65-a142-ef2df9d9b544/download","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7058072295.pdf","grobid_xml":"https://content.openalex.org/works/W7058072295.grobid-xml"},"referenced_works_count":300,"referenced_works":["https://openalex.org/W160110801","https://openalex.org/W192788113","https://openalex.org/W285943277","https://openalex.org/W1097015697","https://openalex.org/W1483835552","https://openalex.org/W1492876742","https://openalex.org/W1534392087","https://openalex.org/W1565410707","https://openalex.org/W1565605888","https://openalex.org/W1599065434","https://openalex.org/W1599568627","https://openalex.org/W1604486038","https://openalex.org/W1775749144","https://openalex.org/W1843852214","https://openalex.org/W1892168964","https://openalex.org/W1926498138","https://openalex.org/W1966988092","https://openalex.org/W1969780974","https://openalex.org/W1970023965","https://openalex.org/W1970295705","https://openalex.org/W1972086924","https://openalex.org/W1972774086","https://openalex.org/W1973405449","https://openalex.org/W1975440270","https://openalex.org/W1975631283","https://openalex.org/W1976214439","https://openalex.org/W1979099791","https://openalex.org/W1979893692","https://openalex.org/W1980455299","https://openalex.org/W1981809048","https://openalex.org/W1985342348","https://openalex.org/W1985842788","https://openalex.org/W1986595047","https://openalex.org/W1988414309","https://openalex.org/W1990506447","https://openalex.org/W1992168193","https://openalex.org/W1993113937","https://openalex.org/W1993623398","https://openalex.org/W1994736606","https://openalex.org/W1995042037","https://openalex.org/W1997086295","https://openalex.org/W1997435071","https://openalex.org/W1998416434","https://openalex.org/W1998704502","https://openalex.org/W1999954704","https://openalex.org/W2002493942","https://openalex.org/W2003268732","https://openalex.org/W2003626671","https://openalex.org/W2008332694","https://openalex.org/W2008912873","https://openalex.org/W2009222736","https://openalex.org/W2009313893","https://openalex.org/W2010268291","https://openalex.org/W2010427019","https://openalex.org/W2014313435","https://openalex.org/W2014370035","https://openalex.org/W2014484446","https://openalex.org/W2015392958","https://openalex.org/W2016772172","https://openalex.org/W2017501449","https://openalex.org/W2019590435","https://openalex.org/W2020755558","https://openalex.org/W2020886306","https://openalex.org/W2024229755","https://openalex.org/W2025569286","https://openalex.org/W2029657547","https://openalex.org/W2031364396","https://openalex.org/W2032537363","https://openalex.org/W2033295943","https://openalex.org/W2034211696","https://openalex.org/W2034383978","https://openalex.org/W2034460442","https://openalex.org/W2034745491","https://openalex.org/W2035459829","https://openalex.org/W2038747312","https://openalex.org/W2039488381","https://openalex.org/W2040470970","https://openalex.org/W2049845594","https://openalex.org/W2049863903","https://openalex.org/W2052356187","https://openalex.org/W2053355345","https://openalex.org/W2053529879","https://openalex.org/W2053549888","https://openalex.org/W2053946842","https://openalex.org/W2055473817","https://openalex.org/W2057415024","https://openalex.org/W2057767639","https://openalex.org/W2059224128","https://openalex.org/W2068185076","https://openalex.org/W2070209352","https://openalex.org/W2071385801","https://openalex.org/W2074049068","https://openalex.org/W2074884450","https://openalex.org/W2075352120","https://openalex.org/W2075976888","https://openalex.org/W2076314388","https://openalex.org/W2077732560","https://openalex.org/W2077762861","https://openalex.org/W2078881478","https://openalex.org/W2079695054","https://openalex.org/W2084172388","https://openalex.org/W2084751642","https://openalex.org/W2087527419","https://openalex.org/W2088139400","https://openalex.org/W2088788142","https://openalex.org/W2089383974","https://openalex.org/W2089676626","https://openalex.org/W2090712756","https://openalex.org/W2092593350","https://openalex.org/W2093549617","https://openalex.org/W2094689158","https://openalex.org/W2094961834","https://openalex.org/W2096502099","https://openalex.org/W2097354475","https://openalex.org/W2097840947","https://openalex.org/W2102560467","https://openalex.org/W2103259382","https://openalex.org/W2103974459","https://openalex.org/W2104243204","https://openalex.org/W2105042695","https://openalex.org/W2105782901","https://openalex.org/W2107277218","https://openalex.org/W2109061031","https://openalex.org/W2109364613","https://openalex.org/W2110335719","https://openalex.org/W2111781204","https://openalex.org/W2113183888","https://openalex.org/W2116459155","https://openalex.org/W2116826060","https://openalex.org/W2117246945","https://openalex.org/W2117502107","https://openalex.org/W2120039087","https://openalex.org/W2120052920","https://openalex.org/W2120057036","https://openalex.org/W2123743609","https://openalex.org/W2124592407","https://openalex.org/W2125525850","https://openalex.org/W2125987139","https://openalex.org/W2127284788","https://openalex.org/W2129132663","https://openalex.org/W2129222048","https://openalex.org/W2129401405","https://openalex.org/W2131635560","https://openalex.org/W2133570600","https://openalex.org/W2134520937","https://openalex.org/W2137424064","https://openalex.org/W2137658602","https://openalex.org/W2138977668","https://openalex.org/W2146012023","https://openalex.org/W2146825820","https://openalex.org/W2148240831","https://openalex.org/W2149437179","https://openalex.org/W2150031244","https://openalex.org/W2152352541","https://openalex.org/W2152426454","https://openalex.org/W2152548885","https://openalex.org/W2155663558","https://openalex.org/W2157437146","https://openalex.org/W2159632264","https://openalex.org/W2163961396","https://openalex.org/W2165659573","https://openalex.org/W2166628699","https://openalex.org/W2167527810","https://openalex.org/W2168538436","https://openalex.org/W2169471064","https://openalex.org/W2169489209","https://openalex.org/W2169996531","https://openalex.org/W2171822041","https://openalex.org/W2178993225","https://openalex.org/W2179578895","https://openalex.org/W2190678000","https://openalex.org/W2194468624","https://openalex.org/W2254528831","https://openalex.org/W2273488592","https://openalex.org/W2276921381","https://openalex.org/W2296585153","https://openalex.org/W2302134090","https://openalex.org/W2303389367","https://openalex.org/W2323758773","https://openalex.org/W2331628193","https://openalex.org/W2336238342","https://openalex.org/W2340588852","https://openalex.org/W2345415005","https://openalex.org/W2345802399","https://openalex.org/W2401396814","https://openalex.org/W2405584860","https://openalex.org/W2460134072","https://openalex.org/W2466033010","https://openalex.org/W2467235541","https://openalex.org/W2469087095","https://openalex.org/W2470369424","https://openalex.org/W2485841399","https://openalex.org/W2487643522","https://openalex.org/W2489789909","https://openalex.org/W2491929492","https://openalex.org/W2499005230","https://openalex.org/W2507334139","https://openalex.org/W2508279129","https://openalex.org/W2521142313","https://openalex.org/W2522661768","https://openalex.org/W2528806650","https://openalex.org/W2532589309","https://openalex.org/W2538201653","https://openalex.org/W2551241918","https://openalex.org/W2552776938","https://openalex.org/W2561886403","https://openalex.org/W2564084678","https://openalex.org/W2565787913","https://openalex.org/W2566203333","https://openalex.org/W2570066011","https://openalex.org/W2573810887","https://openalex.org/W2582045323","https://openalex.org/W2584193381","https://openalex.org/W2584427437","https://openalex.org/W2586353415","https://openalex.org/W2592181793","https://openalex.org/W2599336749","https://openalex.org/W2604666421","https://openalex.org/W2606888484","https://openalex.org/W2607618862","https://openalex.org/W2625348090","https://openalex.org/W2731260319","https://openalex.org/W2734640108","https://openalex.org/W2738075018","https://openalex.org/W2739935761","https://openalex.org/W2740127584","https://openalex.org/W2755692808","https://openalex.org/W2765206971","https://openalex.org/W2769935541","https://openalex.org/W2784187065","https://openalex.org/W2788261792","https://openalex.org/W2790782873","https://openalex.org/W2791017844","https://openalex.org/W2791554651","https://openalex.org/W2792692650","https://openalex.org/W2794368481","https://openalex.org/W2804922717","https://openalex.org/W2834957215","https://openalex.org/W2835694964","https://openalex.org/W2885317802","https://openalex.org/W2894811044","https://openalex.org/W2898245388","https://openalex.org/W2898277285","https://openalex.org/W2899991374","https://openalex.org/W2900958958","https://openalex.org/W2901934452","https://openalex.org/W2904473951","https://openalex.org/W2907789384","https://openalex.org/W2907885915","https://openalex.org/W2909239315","https://openalex.org/W2917076621","https://openalex.org/W2939464333","https://openalex.org/W2943811827","https://openalex.org/W2944569053","https://openalex.org/W2946842680","https://openalex.org/W2949380546","https://openalex.org/W2949844821","https://openalex.org/W2950148498","https://openalex.org/W2957275599","https://openalex.org/W2959932413","https://openalex.org/W2965788201","https://openalex.org/W2966674513","https://openalex.org/W2970156237","https://openalex.org/W2972883372","https://openalex.org/W2982386637","https://openalex.org/W2988408692","https://openalex.org/W2990152092","https://openalex.org/W2990297624","https://openalex.org/W2996376952","https://openalex.org/W2997054737","https://openalex.org/W3001847051","https://openalex.org/W3002110689","https://openalex.org/W3004094806","https://openalex.org/W3008592960","https://openalex.org/W3017979272","https://openalex.org/W3022480838","https://openalex.org/W3023443595","https://openalex.org/W3035334103","https://openalex.org/W3047204374","https://openalex.org/W3085363552","https://openalex.org/W3088351292","https://openalex.org/W3090442253","https://openalex.org/W3092088977","https://openalex.org/W3093116518","https://openalex.org/W3094295513","https://openalex.org/W3111209669","https://openalex.org/W3119866689","https://openalex.org/W3131589781","https://openalex.org/W3157282498","https://openalex.org/W3169544955","https://openalex.org/W3204613200","https://openalex.org/W3213625208","https://openalex.org/W3216140833","https://openalex.org/W4206450246","https://openalex.org/W4206651895","https://openalex.org/W4213350667","https://openalex.org/W4220850996","https://openalex.org/W4236669115","https://openalex.org/W4247878364","https://openalex.org/W4250057060"],"related_works":["https://openalex.org/W2049292734","https://openalex.org/W2108614024","https://openalex.org/W7095777659","https://openalex.org/W7206531166","https://openalex.org/W1414915499","https://openalex.org/W2625436883","https://openalex.org/W7099014797","https://openalex.org/W7134260169","https://openalex.org/W6906050298","https://openalex.org/W4402146956"],"abstract_inverted_index":{"El":[0,46],"da\u00f1o":[1,335],"hep\u00e1tico":[2,26,146,183,267],"inducido":[3],"por":[4,275,301,338],"f\u00e1rmacos":[5,38,256,276,285],"(DILI)":[6],"es":[7,29,48,70,81,121],"una":[8,18,259,280],"reacci\u00f3n":[9],"adversa":[10],"a":[11,181,191,204,252,255,262,283,297,327],"medicamentos":[12],"y":[13,28,44,85,128,188,195,218,268],"otros":[14],"xenobi\u00f3ticos":[15],"que":[16,53,69,72,200,247],"representa":[17],"de":[19,24,31,35,37,42,78,83,103,108,116,142,148,154,166,172,176,193,206,209,211,226,228,230,233,244,265,272,294,307,310,315,323,334,352,355],"las":[20,40,105,173,201,248,263,308],"causas":[21],"m\u00e1s":[22],"relevantes":[23],"fallo":[25],"agudo":[27],"uno":[30],"los":[32,59,88,231,270,284],"principales":[33],"motivos":[34],"retirada":[36],"en":[39,58,74,87],"fases":[41],"desarrollo":[43],"farmacovigilancia.":[45],"DILI":[47,66],"un":[49,75,237,311],"proceso":[50],"patol\u00f3gico":[51],"multifactorial":[52],"no":[54],"se":[55,97,137,168,179,189],"puede":[56],"recapitular":[57],"modelos":[60,89,101],"in":[61,350],"vitro":[62,351],"actuales.":[63],"Adem\u00e1s,":[64,278],"el":[65,92,125,140,160,224,287,332,339,348],"idiosincr\u00e1tico":[67],"(iDILI),":[68],"aquel":[71],"aparece":[73],"reducido":[76],"n\u00famero":[77],"pacientes":[79,109],"susceptibles,":[80],"dif\u00edcil":[82],"diagnosticar":[84],"predecir":[86],"propuestos":[90],"hasta":[91],"momento.":[93],"Por":[94,303],"esta":[95],"raz\u00f3n,":[96],"han":[98],"propuesto":[99],"nuevos":[100],"capaces":[102],"reproducir":[104],"caracter\u00edsticas":[106],"espec\u00edficas":[107],"concretos,":[110],"lo":[111,119],"suficientemente":[112],"adaptables":[113],"para":[114,124,159,292,347],"ser":[115],"aplicaci\u00f3n":[117],"pr\u00e1ctica,":[118],"cual,":[120],"particularmente":[122],"importante":[123],"diagn\u00f3stico":[126],"diferencial":[127,282],"la":[129,134,207,253,298,305],"predicci\u00f3n":[130],"del":[131,162,321],"iDILI.":[132,356],"En":[133],"presente":[135],"tesis,":[136],"ha":[138],"explorado":[139],"uso":[141],"c\u00e9lulas":[143,149,174,264],"con":[144,236,258,313,331],"fenotipo":[145,182],"derivadas":[147],"madre":[150],"pluripotentes":[151],"inducidas":[152],"(iPSC)":[153],"diferentes":[155,212],"donantes":[156,213,232],"como":[157,344],"modelo":[158,345],"estudio":[161,349],"DILI.":[163],"Las":[164],"l\u00edneas":[165],"iPSC":[167,210],"obtuvieron":[169],"mediante":[170],"reprogramaci\u00f3n":[171],"mononucleares":[175],"sangre":[177],"perif\u00e9rica,":[178],"diferenciaron":[180],"(HLC":[184],"o":[185,240],"hepatocyte-like":[186],"cells)":[187],"caracterizaron":[190],"nivel":[192,328],"expresi\u00f3n":[194],"funcionalidad.":[196],"Los":[197,242],"resultados":[198],"mostraron":[199],"HLC":[202,249,309],"obtenidas":[203],"partir":[205],"diferenciaci\u00f3n":[208],"presentan":[214],"rasgos":[215],"transcript\u00f3micos,":[216],"metabol\u00f3micos":[217],"funcionales":[219],"hep\u00e1ticos":[220],"y,":[221],"adem\u00e1s,":[222],"emulan":[223],"perfil":[225],"actividades":[227],"biotransformaci\u00f3n":[229],"origen,":[234],"aunque":[235],"estado":[238],"inmaduro":[239],"temprano.":[241],"ensayos":[243],"toxicidad":[245],"demostraron":[246],"son":[250],"sensibles":[251],"exposici\u00f3n":[254,306],"hepatot\u00f3xicos":[257],"respuesta":[260,281],"equiparable":[261],"origen":[266],"reproducen":[269],"mecanismos":[271],"hepatotoxicidad":[273,299,324],"inducidos":[274],"modelo.":[277],"exhiben":[279],"seg\u00fan":[286],"donante,":[288],"indicando":[289],"su":[290,342],"potencial":[291,343],"estudios":[293],"susceptibilidad":[295],"interindividual":[296],"inducida":[300],"f\u00e1rmacos.":[302],"\u00faltimo,":[304],"paciente":[312],"sospecha":[314],"iDILI":[316],"al":[317],"agente":[318],"supuestamente":[319],"responsable":[320],"episodio":[322],"revel\u00f3":[325],"cambios":[326],"transcripcional":[329],"compatibles":[330],"patr\u00f3n":[333],"colest\u00e1sico":[336],"mostrado":[337],"paciente,":[340],"evidenciando":[341],"personalizado":[346],"casos":[353],"concretos":[354]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}