{"id":"https://openalex.org/W7058034524","doi":null,"title":"Mechanisms underlying endolysosomal deficits mediated by the Parkinson\u00bfs disease-related kinase LRRK2","display_name":"Mechanisms underlying endolysosomal deficits mediated by the Parkinson\u00bfs disease-related kinase LRRK2","publication_year":2019,"publication_date":"2019-03-25","ids":{"openalex":"https://openalex.org/W7058034524"},"language":"en","primary_location":{"id":"pmh:oai:digibug.ugr.es:10481/74032","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/74032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10481/74032","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rivero R\u00edos, Mar\u00eda del Pilar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rivero R\u00edos, Mar\u00eda del Pilar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.1923000067472458,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/endolysosomal-trafficking","display_name":"endolysosomal trafficking","score":0.8759999871253967},{"id":"https://openalex.org/keywords/rab8a","display_name":"Rab8a","score":0.8679999709129333},{"id":"https://openalex.org/keywords/rab7","display_name":"Rab7","score":0.9710000157356262},{"id":"https://openalex.org/keywords/rab4","display_name":"Rab4","score":0.9829999804496765},{"id":"https://openalex.org/keywords/egfr-degradation","display_name":"EGFR degradation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/endocytic-recycling","display_name":"endocytic recycling","score":0.8119999766349792},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/kinase-phosphorylation","display_name":"kinase phosphorylation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/endocytic-compartments","display_name":"endocytic compartments","score":0.43299999833106995},{"id":"https://openalex.org/keywords/membrane-trafficking","display_name":"membrane trafficking","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.9394999742507935},{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.833299994468689},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7824000120162964},{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.7799000144004822},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6438000202178955},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.5710999965667725},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5576000213623047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5465999841690063},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5148000121116638},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4952000081539154},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.492900013923645},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4875999987125397},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.40310001373291016},{"id":"https://openalex.org/C161478664","wikidata":"https://www.wikidata.org/wiki/Q901955","display_name":"Phagosome","level":3,"score":0.38830000162124634},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.385699987411499},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.359499990940094},{"id":"https://openalex.org/C145458877","wikidata":"https://www.wikidata.org/wiki/Q7317044","display_name":"Retromer","level":4,"score":0.3206999897956848},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3012999892234802},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C191141034","wikidata":"https://www.wikidata.org/wiki/Q3087369","display_name":"Cell physiology","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.27239999175071716},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.25380000472068787}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digibug.ugr.es:10481/74032","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/74032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:digital.csic.es:10261/213678","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/213678","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_db06"}],"best_oa_location":{"id":"pmh:oai:digibug.ugr.es:10481/74032","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/74032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2912069022","https://openalex.org/W7024563873","https://openalex.org/W3043088877","https://openalex.org/W2115337444","https://openalex.org/W3033972556","https://openalex.org/W3092006859","https://openalex.org/W3011983387","https://openalex.org/W2163296752","https://openalex.org/W4280593294","https://openalex.org/W7164802481"],"abstract_inverted_index":{"Mutations":[0],"in":[1,75,84,185,209,221,244,247,251,257],"the":[2,53,87,103,126,137,152,164,188,213,217,222,226,285],"gene":[3],"encoding":[4],"for":[5],"leucine-rich":[6],"repeat":[7],"kinase":[8,82],"2":[9],"(LRRK2)":[10],"are":[11,80],"a":[12,69,191,207,252],"common":[13],"cause":[14],"of":[15,71,89,92,116,136,154,168,176,182,187,219,233,266,280,287],"hereditary":[16],"Parkinson\u00b4s":[17],"disease":[18],"(PD),":[19],"and":[20,48,77,159,225,255,277,294],"some":[21],"variants":[22,124],"also":[23,143,205],"confer":[24],"risk":[25],"to":[26,34,61,212],"develop":[27],"sporadic":[28],"PD.":[29],"LRRK2":[30,81,170,179,290],"has":[31],"been":[32],"reported":[33],"regulate":[35],"various":[36],"intracellular":[37],"vesicular":[38],"trafficking":[39,97,110,146],"pathways,":[40],"including":[41],"autophagy,":[42],"retromer-mediated":[43],"trafficking,":[44],"synaptic":[45],"vesicle":[46],"dynamics":[47],"endolysosomal":[49,131,292],"degradative":[50],"events,":[51],"although":[52],"precise":[54],"molecular":[55],"mechanism(s)":[56],"underlying":[57],"these":[58,93,145,271],"alterations":[59],"remain":[60,98],"be":[62],"elucidated.":[63],"\\nRecent":[64],"studies":[65],"have":[66],"revealed":[67],"that":[68,114,151,239,274],"subset":[70],"Rab":[72],"proteins":[73],"involved":[74],"secretory":[76],"endocytic":[78,193,201,295],"recycling":[79,211,227,296],"substrates":[83,94],"vivo.":[85],"However,":[86],"effects":[88,129],"LRRK2-mediated":[90,128,275],"phosphorylation":[91,276],"on":[95,130,171],"membrane":[96,132],"unknown.":[99],"Here,":[100],"by":[101,200,206],"studying":[102],"well-characterized":[104],"epidermal":[105],"growth":[106],"factor":[107],"receptor":[108],"(EGFR)":[109],"pathway,":[111],"we":[112,149,237],"report":[113],"expression":[115,175,232,242,265],"active":[117,234,267],"or":[118,180],"phospho-deficient,":[119],"but":[120,204],"not":[121,198],"phospho-mimetic,":[122],"RAB8A":[123,155,183,281],"rescues":[125],"G2019S":[127,178],"trafficking.":[133,173],"Similarly,":[134],"upregulation":[135],"RAB11-Rabin8-RAB8A":[138],"cascade,":[139],"which":[140,195,260],"activates":[141],"RAB8A,":[142],"reverted":[144],"deficits.":[147],"Strikingly,":[148],"found":[150],"loss":[153,181],"delayed":[156],"EGFR":[157,172,189,210,220,258],"degradation":[158,202],"decreased":[160],"RAB7A":[161,241],"activity,":[162],"mimicking":[163],"previously":[165],"described":[166],"effect":[167],"pathogenic":[169,177,289],"\\nMoreover,":[174],"resulted":[184,243],"mistargeting":[186],"into":[190],"RAB4-positive":[192,223],"compartment,":[194,254],"was":[196],"accompanied":[197],"only":[199],"defects,":[203],"deficit":[208],"plasma":[214],"membrane.":[215],"Both":[216],"accumulation":[218,250],"compartment":[224],"deficits":[228,256],"were":[229,261],"rescued":[230,263],"upon":[231,264],"RAB7A.":[235],"\\nFinally,":[236],"showed":[238],"dominant-negative":[240],"similar":[245],"defects":[246],"EGF":[248],"degradation,":[249],"RAB4":[253],"recycling,":[259],"all":[262],"RAB8A.":[268],"\\nTaken":[269],"together,":[270],"findings":[272],"suggest":[273],"subsequent":[278],"impairment":[279],"function":[282],"may":[283],"form":[284],"basis":[286],"how":[288],"deregulates":[291],"transport":[293],"events.":[297]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}