{"id":"https://openalex.org/W7057342014","doi":null,"title":"Il carico orale di glucosio:cosa si aspetta il clinico","display_name":"Il carico orale di glucosio:cosa si aspetta il clinico","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W7057342014"},"language":"en","primary_location":{"id":"pmh:oai:fair.unifg.it:11369/15646","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11369/15646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025291956","display_name":"Mauro Cignarelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CIGNARELLI, MAURO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"LAMACCHIA, OLGA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LAMACCHIA, OLGA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57191719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.9300000071525574},{"id":"https://openalex.org/keywords/impaired-fasting-glucose","display_name":"impaired fasting glucose","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oral-glucose-tolerance-test","display_name":"oral glucose tolerance test","score":0.8080000281333923},{"id":"https://openalex.org/keywords/first-phase-insulin-secretion","display_name":"first-phase insulin secretion","score":0.734000027179718},{"id":"https://openalex.org/keywords/insulinogenic-index","display_name":"insulinogenic index","score":0.7670000195503235},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6460000276565552},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.6370000243186951},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hepatic-insulin-resistance","display_name":"hepatic insulin resistance","score":0.8629999756813049},{"id":"https://openalex.org/keywords/skeletal-muscle-insulin-sensitivity","display_name":"skeletal muscle insulin sensitivity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.5740000009536743},{"id":"https://openalex.org/keywords/beta-cell-apoptosis","display_name":"beta-cell apoptosis","score":0.703000009059906},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8578000068664551},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.828000009059906},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.7836999893188477},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7379999756813049},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6807000041007996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6262999773025513},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5421000123023987},{"id":"https://openalex.org/C144855686","wikidata":"https://www.wikidata.org/wiki/Q6042245","display_name":"Insulin oscillation","level":4,"score":0.4323999881744385},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4187000095844269},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.382099986076355},{"id":"https://openalex.org/C2780833929","wikidata":"https://www.wikidata.org/wiki/Q1501412","display_name":"Glucose tolerance test","level":4,"score":0.374099999666214},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.36039999127388},{"id":"https://openalex.org/C2777185836","wikidata":"https://www.wikidata.org/wiki/Q3306264","display_name":"Impaired fasting glucose","level":5,"score":0.3571999967098236},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.3353999853134155},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.319599986076355},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.2847999930381775},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.2800999879837036},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C3017594758","wikidata":"https://www.wikidata.org/wiki/Q776862","display_name":"Insulin response","level":4,"score":0.2711000144481659},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.26030001044273376},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:fair.unifg.it:11369/15646","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11369/15646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2386235646","https://openalex.org/W4241031718","https://openalex.org/W2083313641","https://openalex.org/W2356514423","https://openalex.org/W2085542137","https://openalex.org/W2003416763","https://openalex.org/W2015790940","https://openalex.org/W2384845551","https://openalex.org/W118601237","https://openalex.org/W2369647680"],"abstract_inverted_index":{"The":[0,218,252,402],"dysfunction":[1],"of":[2,16,38,56,70,175,183,233,236,243,254,319,329,343,378,419,424,430,438,455,466,479,491],"the":[3,11,14,17,30,39,50,53,58,67,71,222,227,237,241,244,255,264,283,290,297,306,316,320,344,352,370,376,379,385,391,394,422,425,431,436,439,445,447,477,480,492,499,503,510],"\u03b2":[4,59,238,256,307],"cells":[5,41,60,239,246,257,308],"plays":[6],"an":[7,34,148,261,365],"important":[8],"role":[9],"in":[10,29,32,46,87,109,120,141,181,226,263,282,288,302,399,413,502],"development":[12],"and":[13,123,145,158,194,211,240,277,325,333,362,388,427,441,458,463,469,519],"progression":[15],"impaired":[18,107,149],"glucose":[19,93],"tolerance":[20,94],"towards":[21],"Type":[22],"2":[23],"Diabetes":[24],"Mellitus":[25],"(TD2M),":[26],"above":[27,495],"all":[28,496],"phase":[31],"which":[33,268,289,337,412],"effective":[35],"secretory":[36,61,152],"capacity":[37,62],"pancreatic":[40,228,292],"would":[42],"be":[43,273],"extremely":[44],"opportune":[45],"order":[47],"to":[48,91,127,154,205,213,260,272,296,384,390,408,444,516],"tackle":[49],"insulin-resistance.":[51],"In":[52,75],"natural":[54],"history":[55],"TD2M":[57],"is":[63,104,137,171,258,313,396],"precociously":[64],"impaired,":[65],"with":[66,78,115,143,187,201,348,356,364,381,449],"typical":[68],"reduction":[69,235,253],"early-phase":[72,88],"insulin":[73,89,100,125,151,176,184,192,197,209,216,331,335],"release.":[74],"particular,":[76],"subjects":[77,142,347,363,448],"isolated":[79],"Impaired":[80,110],"Fasting":[81],"Glucose":[82,111],"(IFG)":[83],"manifest":[84],"a":[85,138,166,172,234,247,266,285,487,506,517],"decrease":[86],"response":[90,101,153],"oral":[92,128],"test":[95],"(OGTT).":[96],"However,":[97],"late-phase":[98,124],"plasma":[99],"during":[102],"OGTT":[103],"less":[105],"severely":[106],"than":[108,351,369],"Tolerance":[112],"(IGT).":[113],"Subjects":[114,186],"IGT":[116,144,157,202],"have":[117,165,190,203],"severe":[118,214],"defects":[119,328],"both":[121,330,400],"early-":[122],"responses":[126,443],"glucose.":[129],"Thus,":[130],"reduced":[131,207],"insulinogenic":[132,358,366],"index":[133,359,367],"(\u0394I":[134],"0-30/\u0394G":[135],"0-30)":[136],"consistent":[139],"finding":[140],"IFG,":[146],"indicating":[147],"early":[150],"OGTT.":[155],"Both":[156],"IFG":[159,188],"are":[160,322,405],"also":[161],"insulin-resistant":[162,450],"states":[163],"(they":[164],"significantly":[167],"elevated":[168],"HOMA-IR,":[169],"that":[170,505],"surrogate":[173],"measure":[174],"sensitivity)":[177],"but":[178,355,494],"they":[179],"differ":[180],"site":[182],"resistance.":[185,217],"predominantly":[189],"hepatic":[191,208],"resistance":[193],"normal":[195,204,357],"muscle":[196,215],"sensitivity,":[198,336],"while":[199,393],"individuals":[200],"slightly":[206],"sensitivity":[210],"moderate":[212],"functional":[219,248],"modifications":[220,224],"reflect":[221],"histological":[223],"observed":[225],"islets":[229],"where,":[230],"as":[231],"consequence":[232],"expansion":[242],"\u03b1":[245],"endocrine":[249],"umbalance":[250],"develops.":[251],"due":[259],"increase":[262],"apoptosis,":[265],"condition":[267],"has":[269],"been":[270],"supposed":[271],"enhanced":[274],"by":[275,476],"gluco-":[276],"lipotoxicity":[278],"related":[279],"mechanisms.":[280],"Therefore,":[281,315],"T2DM":[284,321],"vicious":[286],"circle,":[287],"initial":[291],"secretion":[293,332],"defect":[294],"contributes":[295],"progressive":[298],"metabolic":[299,410,428,521],"deterioration":[300],"which,":[301],"turn,":[303],"reduces":[304],"either":[305],"mass":[309],"or":[310],"its":[311],"functionality,":[312],"hypothesized.":[314],"pathogenetic":[317,512],"mechanisms":[318],"very":[323],"heterogeneous":[324],"involve":[326],"different":[327,340,416],"tissue":[334],"account":[338],"for":[339],"clinical":[341,426],"phenotypes":[342,387,404],"disease.":[345],"Selecting":[346],"HOMA-IR":[349],"higher":[350,453,464],"75\u00b0":[353],"percentile":[354,372],"(insulin-resistant":[360],"phenotype)":[361],"lower":[368,460],"25\u00b0":[371],"(reduced":[373],"insulin-secretion":[374],"phenotype),":[375],"36%":[377],"patients":[380],"IGR":[382],"belongs":[383],"first":[386],"16%":[389],"second,":[392],"58%":[395],"simultaneously":[397],"included":[398],"categories.":[401],"respective":[403],"indeed":[406],"associated":[407],"several":[409],"profiles":[411],"turn":[414],"characterize":[415],"risk":[417],"class":[418],"complications.":[420],"From":[421],"comparison":[423],"parameters":[429],"two":[432],"groups,":[433],"distinguished":[434],"on":[435,509],"basis":[437],"glycemic":[440],"insulinemic":[442],"OGTT,":[446,481],"phenotype":[451],"present":[452],"levels":[454],"total":[456],"cholesterol":[457],"triglycerides,":[459],"cholesterol-HDL":[461],"concentrations":[462],"values":[465],"arterial":[467],"systolic":[468],"diastolic":[470],"pressure.":[471],"A":[472],"careful":[473,489],"investigation":[474],"obtained":[475],"study":[478],"could":[482,497],"therefore,":[483],"not":[484],"only":[485],"allow":[486],"more":[488],"stratification":[490],"risk,":[493],"address":[498],"pharmacological":[500],"treatment":[501],"conviction":[504],"therapy":[507],"tailored":[508],"preponderant":[511],"cause":[513],"can":[514],"contribute":[515],"better":[518],"lasting":[520],"control.":[522]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}