{"id":"https://openalex.org/W7056530035","doi":null,"title":"Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation","display_name":"Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation","publication_year":2023,"publication_date":"2023-03-20","ids":{"openalex":"https://openalex.org/W7056530035"},"language":"en","primary_location":{"id":"pmh:oai:openarchive.ki.se:10616/48490","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/48490","pdf_url":"https://openarchive.ki.se/articles/thesis/Evaluating_antitumoral_lymphocytes_for_adoptive_cell_therapy_oxidative_stress_neoantigen_processing_and_co-stimulation/26917531/1/files/48961837.pdf","source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://openarchive.ki.se/articles/thesis/Evaluating_antitumoral_lymphocytes_for_adoptive_cell_therapy_oxidative_stress_neoantigen_processing_and_co-stimulation/26917531/1/files/48961837.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070595483","display_name":"Stefanie Renken","orcid":"https://orcid.org/0000-0002-2743-5886","observed_orcids":["https://orcid.org/0000-0002-2743-5886"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stefanie Renken (18669079)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070595483"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cytotoxic-lymphocytes","display_name":"cytotoxic lymphocytes","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8149999976158142},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nrf2-signaling-pathway","display_name":"Nrf2 signaling","score":0.8460000157356262},{"id":"https://openalex.org/keywords/auranofin","display_name":"auranofin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8230000138282776},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.8740000128746033},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/immunoproteasome","display_name":"immunoproteasome","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mesothelin","display_name":"mesothelin","score":0.7490000128746033},{"id":"https://openalex.org/keywords/4-1bb-costimulation","display_name":"4-1BB costimulation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cd28-costimulation","display_name":"CD28 costimulation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7641000151634216},{"id":"https://openalex.org/C2776243873","wikidata":"https://www.wikidata.org/wiki/Q421230","display_name":"Auranofin","level":3,"score":0.5795000195503235},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5692999958992004},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5530999898910522},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5382000207901001},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49390000104904175},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.47600001096725464},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4758000075817108},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.47279998660087585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4375},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4345000088214874},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.42239999771118164},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4187999963760376},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37950000166893005},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.36899998784065247},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3634999990463257},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3596999943256378},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.3465000092983246},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3431999981403351},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3278000056743622},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30309998989105225},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28040000796318054},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25279998779296875}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:openarchive.ki.se:10616/48490","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/48490","pdf_url":"https://openarchive.ki.se/articles/thesis/Evaluating_antitumoral_lymphocytes_for_adoptive_cell_therapy_oxidative_stress_neoantigen_processing_and_co-stimulation/26917531/1/files/48961837.pdf","source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:figshare.com:article/26917531","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Evaluating_antitumoral_lymphocytes_for_adoptive_cell_therapy_oxidative_stress_neoantigen_processing_and_co-stimulation/26917531","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/48490","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/48490","pdf_url":"https://openarchive.ki.se/articles/thesis/Evaluating_antitumoral_lymphocytes_for_adoptive_cell_therapy_oxidative_stress_neoantigen_processing_and_co-stimulation/26917531/1/files/48961837.pdf","source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7056530035.pdf","grobid_xml":"https://content.openalex.org/works/W7056530035.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097626107","https://openalex.org/W2178151738","https://openalex.org/W4401876151","https://openalex.org/W4408995762","https://openalex.org/W4285708672","https://openalex.org/W3159483406","https://openalex.org/W3024706376","https://openalex.org/W2424335548","https://openalex.org/W2911334107","https://openalex.org/W2946028346"],"abstract_inverted_index":{"Rapid":[0],"advancement":[1],"in":[2,81,89,93,115,124,165,180,210,300],"the":[3,9,16,46,64,73,102,106,122,132,159,166,176,236,250,264,328,409,419,429],"field":[4],"of":[5,12,18,26,33,48,55,75,105,121,135,162,227,235,252,333,368,382,408,411,422,431,438,459,479,506,524],"immunotherapy":[6],"has":[7],"changed":[8],"treatment":[10,222],"landscape":[11],"cancer,":[13],"especially":[14],"with":[15,72,342,373],"approval":[17],"immune":[19,49],"checkpoint":[20],"inhibitors":[21],"for":[22,97,149,396,477],"a":[23,30,224,301,394,405],"wide":[24],"range":[25],"cancer":[27,254,370],"types.":[28],"However,":[29,91],"large":[31,53],"proportion":[32],"patients":[34],"does":[35],"not":[36],"benefit":[37],"from":[38],"this":[39,125,185],"treatment.":[40],"Adoptive":[41],"cell":[42,146,260,272,278,371,399,435,557],"therapy":[43],"(ACT)":[44],"describes":[45],"infusion":[47,74],"cells,":[50,212,215,467],"such":[51],"as":[52,223,256,293],"numbers":[54],"tumor-reactive":[56],"cytotoxic":[57,136,163,423],"lymphocytes":[58,87,137,164,238,424,516],"that":[59,157,174,220,282,355,380],"can":[60,426],"control":[61],"and":[62,101,130,143,188,203,216,239,267,311,314,321,330,366,388,391,415,425,433,469,509,517,550],"eliminate":[63],"tumor.":[65],"Remarkable":[66],"clinical":[67,228,241],"responses":[68,112,463],"have":[69],"been":[70],"achieved":[71],"CD19-":[76],"targeting":[77],"CAR":[78,98,213,360,397,470,555],"T":[79,99,214,334,361,398,471,519,556],"cells":[80,100,182,255,291,335,362,472,520],"hematological":[82],"cancers":[83],"or":[84,286,347],"tumor":[85,107,167,259,265,290,514],"infiltrating":[86,515],"(TIL)":[88],"melanoma.":[90],"limitations":[92],"identifying":[94],"suitable":[95],"antigens":[96],"immunosuppressive":[103,412],"features":[104],"microenvironment":[108,266],"contribute":[109,403],"to":[110,113,128,138,198,248,275,317,358,385,404],"insufficient":[111],"ACT":[114],"most":[116],"solid":[117],"tumors.":[118],"The":[119],"goal":[120],"studies":[123],"thesis":[126],"was":[127,304],"evaluate":[129],"optimize":[131],"antitumoral":[133,233,420,462],"efficacy":[134],"elicit":[139],"their":[140],"full":[141],"potential":[142],"thereby":[144,427],"improve":[145,232],"products":[147],"used":[148],"ACT.":[150],"Reactive":[151],"oxygen":[152],"species":[153],"(ROS)":[154],"are":[155,268],"radicals":[156],"impair":[158],"effector":[160,205],"functions":[161,206,421],"microenvironment.":[168],"In":[169,243,323],"paper":[170,244],"I,":[171,447,536],"we":[172,246,326,378],"hypothesized":[173],"activating":[175],"Nrf2":[177,193,460],"antioxidant":[178],"pathway":[179],"these":[181],"could":[183,231],"overcome":[184],"limitation.":[186],"Auranofin":[187],"two":[189],"other":[190],"compounds":[191],"induced":[192],"target":[194],"gene":[195],"expression,":[196],"leading":[197],"reduced":[199],"intracellular":[200],"ROS":[201],"accumulation":[202],"improved":[204,434],"during":[207,473],"oxidative":[208,474],"stress":[209],"NK":[211,466],"TIL.":[217],"We":[218,280,353],"propose":[219],"auranofin":[221],"last":[225],"step":[226],"expansion":[229],"protocols":[230],"activity":[234],"infused":[237],"thus":[240,315],"outcomes.":[242],"II,":[245],"aimed":[247],"understand":[249],"impact":[251],"culturing":[253],"spheroids,":[257],"on":[258,306,418],"immunogenicity.":[261],"Spheroids":[262],"resemble":[263],"therefore":[269,392],"an":[270],"advantageous":[271],"culture":[273,523],"model":[274],"study":[276],"immune-cancer":[277],"interactions.":[279],"found":[281,354],"TIL,":[283],"either":[284,343],"unsorted":[285],"neoantigen-specific,":[287],"recognized":[288],"autologous":[289],"cultured":[292,299],"spheroids":[294,372],"more":[295],"efficiently":[296],"than":[297],"those":[298],"monolayer.":[302],"This":[303],"dependent":[305],"TCR-MHC":[307],"class":[308],"I":[309],"interaction":[310],"immunoproteasome":[312],"activity,":[313],"due":[316],"altered":[318],"antigen":[319,389,416],"processing":[320,417],"presentation.":[322],"Paper":[324],"III,":[325],"studied":[327],"functional":[329],"phenotypic":[331],"characteristics":[332],"expressing":[336],"mesothelin":[337,375,383],"directed,":[338],"second":[339],"generation":[340],"CARs":[341],"CD28":[344],"(M28z":[345],"CAR)":[346,350],"4-1BB":[348],"(MBBz":[349],"co-stimulatory":[351],"domain.":[352],"M28z,":[356],"compared":[357],"MBBz,":[359],"showed":[363,379],"higher":[364],"infiltration":[365],"killing":[367,387,552],"ovarian":[369],"varying":[374],"expression.":[376],"Further,":[377],"trogocytosis":[381],"leads":[384],"fratricide":[386,551],"loss":[390],"presents":[393],"limitation":[395],"therapy.":[400],"These":[401],"findings":[402],"better":[406],"understanding":[407],"influence":[410],"mediators,":[413],"co-stimulation,":[414],"support":[428],"development":[430],"new":[432],"therapies.":[436],"List":[437],"scientific":[439],"papers":[440],"I.":[441,548],"Renken":[442,485,532],"S,":[443,486,533],"Nakajima":[444],"T,":[445,540],"Magalhaes":[446,547],"Mattsson":[448,545],"J,":[449,546],"Lundqvist":[450],"A,":[451,494,498],"Arn\u00e9r":[452],"ESJ,":[453],"Kiessling":[454,499,541],"R,":[455,492,500,542],"Wickstr\u00f6m":[456,503,543],"SL.":[457,504],"Targeting":[458],"improves":[461],"by":[464,512],"human":[465],"TIL":[468],"stress.":[475],"Journal":[476],"ImmunoTherapy":[478],"Cancer.":[480],"2022;":[481,560],"10:e004458.":[482],"https://doi.org/10.1136/jitc-2021-004458":[483],"II.":[484],"Panella":[487],"D,":[488],"T\u00e1borsk\u00e1":[489],"P,":[490,502,538],"England":[491],"Bergqvist":[493],"Skoglund":[495],"C,":[496],"Etl":[497],"D\u2019arcy":[501],"Upregulation":[505],"immunoproteasome-specific":[507],"subunits":[508],"increased":[510],"recognition":[511],"autologous,":[513],"neoantigen-specific":[518],"following":[521],"3D":[522],"patient-derived":[525],"melanoma":[526],"cells.":[527],"[Manuscript]":[528],"III.":[529],"Schoutrop":[530],"E,":[531],"Micallef":[534],"Nilsson":[535],"Hahn":[537],"Poiret":[539],"SL,":[544],"Trogocytosis":[549],"impede":[553],"MSLN-directed":[554],"functionality.":[558],"Oncoimmunology.":[559],"11":[561],"(1):":[562],"e2093426.":[563],"https://doi.org/10.1080/2162402X.2022.2093426":[564]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}