{"id":"https://openalex.org/W7055836267","doi":null,"title":"Developing safe and efficient cellular reprogramming approaches for the amelioration of age-associated phenotypes","display_name":"Developing safe and efficient cellular reprogramming approaches for the amelioration of age-associated phenotypes","publication_year":2024,"publication_date":"2024-12-17","ids":{"openalex":"https://openalex.org/W7055836267"},"language":"en","primary_location":{"id":"pmh:oai:serval.unil.ch:BIB_FC57D5AA2E51","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_FC57D5AA2E51","pdf_url":"https://iris.unil.ch/bitstreams/c4c25c4d-0a3b-48d4-b3f4-bc725d87b4ab/download","source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.unil.ch/bitstreams/c4c25c4d-0a3b-48d4-b3f4-bc725d87b4ab/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084248361","display_name":"Lucas Schoenfeldt","orcid":"https://orcid.org/0000-0003-1487-0747","observed_orcids":["https://orcid.org/0000-0003-1487-0747"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Schoenfeldt, Lucas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084248361"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.9319999814033508},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8999999761581421},{"id":"https://openalex.org/keywords/partial-reprogramming","display_name":"partial reprogramming","score":0.8529999852180481},{"id":"https://openalex.org/keywords/small-molecule-reprogramming","display_name":"small molecule reprogramming","score":0.6460000276565552},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7059999704360962},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/healthspan-extension","display_name":"healthspan extension","score":0.7279999852180481},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.9829999804496765},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.6140000224113464},{"id":"https://openalex.org/keywords/oskm-transcription-factors","display_name":"OSKM transcription factors","score":0.6510000228881836},{"id":"https://openalex.org/keywords/somatic-cell-nuclear-transfer","display_name":"somatic cell nuclear transfer","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.9309999942779541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7644000053405762},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6022999882698059},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.585099995136261},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5360999703407288},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5349000096321106},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5322999954223633},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5289999842643738},{"id":"https://openalex.org/C2910790502","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Totipotent","level":4,"score":0.4941999912261963},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4629000127315521},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44190001487731934},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.3725999891757965},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36570000648498535},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34689998626708984},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.32659998536109924},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25760000944137573},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.2572999894618988},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.2529999911785126},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:serval.unil.ch:BIB_FC57D5AA2E51","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_FC57D5AA2E51","pdf_url":"https://iris.unil.ch/bitstreams/c4c25c4d-0a3b-48d4-b3f4-bc725d87b4ab/download","source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:iris.unil.ch:iris/260168","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/260168","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:serval.unil.ch:BIB_FC57D5AA2E51","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_FC57D5AA2E51","pdf_url":"https://iris.unil.ch/bitstreams/c4c25c4d-0a3b-48d4-b3f4-bc725d87b4ab/download","source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7055836267.pdf","grobid_xml":"https://content.openalex.org/works/W7055836267.grobid-xml"},"referenced_works_count":178,"referenced_works":["https://openalex.org/W36881043","https://openalex.org/W1485430712","https://openalex.org/W1572421661","https://openalex.org/W1861832246","https://openalex.org/W1869763094","https://openalex.org/W1966132436","https://openalex.org/W1967210596","https://openalex.org/W1971800922","https://openalex.org/W1972298775","https://openalex.org/W1972646376","https://openalex.org/W1977466283","https://openalex.org/W1982481909","https://openalex.org/W1982602899","https://openalex.org/W1983673827","https://openalex.org/W1984556350","https://openalex.org/W1985647060","https://openalex.org/W1987449859","https://openalex.org/W1992525863","https://openalex.org/W2001971523","https://openalex.org/W2002698073","https://openalex.org/W2005842414","https://openalex.org/W2012895159","https://openalex.org/W2012956466","https://openalex.org/W2014408660","https://openalex.org/W2022152889","https://openalex.org/W2022487205","https://openalex.org/W2023605251","https://openalex.org/W2030299771","https://openalex.org/W2030795773","https://openalex.org/W2032195707","https://openalex.org/W2032747284","https://openalex.org/W2034090560","https://openalex.org/W2034278983","https://openalex.org/W2035375803","https://openalex.org/W2035941409","https://openalex.org/W2039551265","https://openalex.org/W2042986568","https://openalex.org/W2046989794","https://openalex.org/W2047015004","https://openalex.org/W2048376025","https://openalex.org/W2049956841","https://openalex.org/W2051454588","https://openalex.org/W2053493267","https://openalex.org/W2054059225","https://openalex.org/W2058521801","https://openalex.org/W2059223857","https://openalex.org/W2059971436","https://openalex.org/W2062168762","https://openalex.org/W2065197926","https://openalex.org/W2068549027","https://openalex.org/W2069519394","https://openalex.org/W2072810104","https://openalex.org/W2077436902","https://openalex.org/W2077450385","https://openalex.org/W2078291208","https://openalex.org/W2080605611","https://openalex.org/W2082603625","https://openalex.org/W2082669279","https://openalex.org/W2084097442","https://openalex.org/W2084562248","https://openalex.org/W2089411743","https://openalex.org/W2090595204","https://openalex.org/W2091279754","https://openalex.org/W2092476887","https://openalex.org/W2096083625","https://openalex.org/W2096587251","https://openalex.org/W2101512588","https://openalex.org/W2101569447","https://openalex.org/W2104654275","https://openalex.org/W2111092938","https://openalex.org/W2112365416","https://openalex.org/W2114840727","https://openalex.org/W2115852450","https://openalex.org/W2121739926","https://openalex.org/W2125987139","https://openalex.org/W2126525177","https://openalex.org/W2127773387","https://openalex.org/W2129326379","https://openalex.org/W2130458932","https://openalex.org/W2133425142","https://openalex.org/W2133452708","https://openalex.org/W2138138136","https://openalex.org/W2138977668","https://openalex.org/W2139384923","https://openalex.org/W2139697647","https://openalex.org/W2145200068","https://openalex.org/W2150748567","https://openalex.org/W2151220680","https://openalex.org/W2151522898","https://openalex.org/W2156416784","https://openalex.org/W2159914115","https://openalex.org/W2160279897","https://openalex.org/W2164500590","https://openalex.org/W2167265200","https://openalex.org/W2168909179","https://openalex.org/W2169187183","https://openalex.org/W2189937132","https://openalex.org/W2265145455","https://openalex.org/W2266290735","https://openalex.org/W2273566024","https://openalex.org/W2315512556","https://openalex.org/W2421283105","https://openalex.org/W2491494855","https://openalex.org/W2553534905","https://openalex.org/W2565424224","https://openalex.org/W2587087824","https://openalex.org/W2597775634","https://openalex.org/W2600452401","https://openalex.org/W2605674430","https://openalex.org/W2733273049","https://openalex.org/W2796559433","https://openalex.org/W2800157131","https://openalex.org/W2883525804","https://openalex.org/W2889841620","https://openalex.org/W2898185647","https://openalex.org/W2899014762","https://openalex.org/W2911555896","https://openalex.org/W2922632336","https://openalex.org/W2947488007","https://openalex.org/W2953131601","https://openalex.org/W2954437651","https://openalex.org/W2990520546","https://openalex.org/W3013381082","https://openalex.org/W3023347551","https://openalex.org/W3041534707","https://openalex.org/W3087037618","https://openalex.org/W3090831677","https://openalex.org/W3094243271","https://openalex.org/W3108896277","https://openalex.org/W3111404439","https://openalex.org/W3125259346","https://openalex.org/W3165546848","https://openalex.org/W3172486167","https://openalex.org/W3174549668","https://openalex.org/W3200536900","https://openalex.org/W3200928356","https://openalex.org/W3210347436","https://openalex.org/W4200628108","https://openalex.org/W4205735067","https://openalex.org/W4211089624","https://openalex.org/W4224046406","https://openalex.org/W4225270242","https://openalex.org/W4229002207","https://openalex.org/W4242396764","https://openalex.org/W4245403460","https://openalex.org/W4281756708","https://openalex.org/W4281775870","https://openalex.org/W4288427183","https://openalex.org/W4289028880","https://openalex.org/W4289545008","https://openalex.org/W4306643244","https://openalex.org/W4308688003","https://openalex.org/W4311446096","https://openalex.org/W4313531093","https://openalex.org/W4315705280","https://openalex.org/W4378952896","https://openalex.org/W4384922902","https://openalex.org/W4385302610","https://openalex.org/W4386122826","https://openalex.org/W4386244897","https://openalex.org/W4386499275","https://openalex.org/W4387969325","https://openalex.org/W4388313784","https://openalex.org/W4388344123","https://openalex.org/W4389268741","https://openalex.org/W4389781037","https://openalex.org/W4390144018","https://openalex.org/W4391138234","https://openalex.org/W4391515326","https://openalex.org/W4392017897","https://openalex.org/W4394786854","https://openalex.org/W4396634355","https://openalex.org/W4399848805","https://openalex.org/W4401007872","https://openalex.org/W4401679667","https://openalex.org/W4402480335","https://openalex.org/W4406804161","https://openalex.org/W6944127214"],"related_works":["https://openalex.org/W4411807169","https://openalex.org/W4394991142","https://openalex.org/W7123610734","https://openalex.org/W4394811007","https://openalex.org/W2565424224","https://openalex.org/W7139113897","https://openalex.org/W4387969502","https://openalex.org/W7118064670","https://openalex.org/W4220929361","https://openalex.org/W4416852394"],"abstract_inverted_index":{"Aging":[0],"is":[1],"the":[2,16,73,129,137,148,155,249],"major":[3],"risk":[4,121],"factor":[5],"for":[6,154],"most":[7],"human":[8],"chronic":[9],"diseases.":[10],"During":[11],"development,":[12],"cellular":[13,211],"reprogramming":[14,97,135,153,167,199],"initiates":[15],"formation":[17],"of":[18,55,76,101,107,122,132,139,150,157,172,180,197,203,207,218,228,230,251,254],"zygotic":[19],"and":[20,33,48,112,120,136,185,213,233,235,256],"primordial":[21],"germ":[22],"cells,":[23],"accompanied":[24],"by":[25],"significant":[26],"chromatin":[27],"reorganization.":[28],"This":[29,53],"process":[30],"generates":[31],"totipotent":[32],"pluripotent":[34],"cells":[35],"that":[36,44,93,165],"are":[37],"free":[38],"from":[39],"age-related":[40],"molecular":[41,105],"defects,":[42],"illustrating":[43],"both":[45,128],"cell":[46,56,69],"identity":[47,57],"age":[49],"can":[50,103,176],"be":[51],"reversed.":[52],"alteration":[54],"has":[58],"been":[59],"successfully":[60],"replicated":[61],"in":[62,94,115,188,222,242],"vitro":[63],"through":[64],"various":[65],"methods,":[66],"including":[67,182,210],"somatic":[68],"nuclear":[70],"transfer":[71],"(SCNT),":[72],"forced":[74],"expression":[75],"transcription":[77],"factors":[78],"(OSKM),":[79],"and,":[80],"more":[81],"recently,":[82],"treatment":[83],"with":[84],"small":[85,140,173],"molecules":[86,174,200],"(7c).":[87],"While":[88],"several":[89],"groups":[90],"have":[91],"shown":[92],"vivo":[95],"partial":[96,134,152,166,261],"via":[98,259],"transient":[99],"application":[100,217],"OSKM":[102,133],"rejuvenate":[104],"hallmarks":[106],"aging,":[108,231],"restore":[109],"tissue":[110],"function,":[111],"extend":[113,240],"lifespan":[114,241,257],"mice,":[116],"inefficient":[117],"gene":[118],"delivery":[119],"oncogenesis":[123],"hinders":[124],"clinical":[125],"development.":[126],"Considering":[127],"rejuvenating":[130],"effects":[131],"ability":[138],"molecule":[141],"cocktails":[142],"to":[143,238],"induce":[144],"pluripotency,":[145],"I":[146,163,192],"propose":[147],"use":[149],"chemical-induced":[151,260],"amelioration":[156,227],"aging":[158,181,208,255],"phenotypes.":[159],"In":[160,190],"this":[161,219],"thesis,":[162],"demonstrated":[164],"using":[168],"a":[169,264],"defined":[170],"cocktail":[171,221],"(7c)":[175],"improve":[177],"key":[178,252],"drivers":[179,253],"genomic":[183],"instability":[184],"epigenetic":[186],"alterations":[187],"vitro.":[189],"addition,":[191],"identified":[193],"an":[194],"optimized":[195],"combination":[196],"two":[198],"(2c)":[201],"capable":[202],"inducing":[204],"additional":[205],"improvements":[206],"phenotypes":[209],"senescence":[212],"oxidative":[214],"stress.":[215],"Importantly,":[216],"reduced":[220],"C.":[223],"elegans":[224],"induced":[225],"multiparameter":[226],"markers":[229],"stress-resistance,":[232],"healthspan,":[234],"was":[236],"able":[237],"significantly":[239],"vivo.":[243],"Taken":[244],"together,":[245],"these":[246],"data":[247],"demonstrate":[248],"improvement":[250],"extension":[258],"reprogramming,":[262],"opening":[263],"path":[265],"towards":[266],"future":[267],"translational":[268],"applications.":[269]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
