{"id":"https://openalex.org/W7054800447","doi":null,"title":"An\u00e1lise das altera\u00e7\u00f5es transcricionais sexo-espec\u00edficas do transtorno depressivo maior","display_name":"An\u00e1lise das altera\u00e7\u00f5es transcricionais sexo-espec\u00edficas do transtorno depressivo maior","publication_year":2022,"publication_date":"2022-07-08","ids":{"openalex":"https://openalex.org/W7054800447"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.ufrn.br:123456789/49190","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/handle/123456789/49190","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFRN","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.ufrn.br/handle/123456789/49190","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082654135","display_name":"Iara Dantas de Souza","orcid":"https://orcid.org/0000-0002-2550-6150","observed_orcids":["https://orcid.org/0000-0002-2550-6150"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Souza, Iara Dantas de","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082654135"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":1.0},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9829999804496765},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6100000143051147},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7710000276565552},{"id":"https://openalex.org/keywords/differential-transcript-expression","display_name":"differential transcript expression","score":0.8999999761581421},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ddx39b","display_name":"DDX39B","score":0.8709999918937683},{"id":"https://openalex.org/keywords/auditory-brainstem-response","display_name":"auditory brainstem response","score":0.8130000233650208},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.7789999842643738},{"id":"https://openalex.org/keywords/orbitofrontal-cortex","display_name":"orbitofrontal cortex","score":0.9570000171661377},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.8050000071525574},{"id":"https://openalex.org/keywords/sex-specific-biomarkers","display_name":"sex-specific biomarkers","score":0.7710000276565552},{"id":"https://openalex.org/keywords/rna-processing","display_name":"RNA processing","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.30059999227523804},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.24449999630451202},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.23659999668598175},{"id":"https://openalex.org/C2777855551","wikidata":"https://www.wikidata.org/wiki/Q12310021","display_name":"Subject (documents)","level":2,"score":0.23019999265670776},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.22439999878406525},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.21809999644756317},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.20880000293254852},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.2029999941587448},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.19910000264644623},{"id":"https://openalex.org/C108170787","wikidata":"https://www.wikidata.org/wiki/Q3951828","display_name":"Agency (philosophy)","level":2,"score":0.19550000131130219}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repositorio.ufrn.br:123456789/49190","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/handle/123456789/49190","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFRN","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:repositorio.ufrn.br:123456789/49190","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/handle/123456789/49190","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFRN","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402533767","https://openalex.org/W2793970618","https://openalex.org/W4387951485","https://openalex.org/W2746917316","https://openalex.org/W4293242033","https://openalex.org/W2945575224","https://openalex.org/W4414652724","https://openalex.org/W4377287102","https://openalex.org/W7166858593","https://openalex.org/W3120679015"],"abstract_inverted_index":{"Major":[0],"depressive":[1],"disorder":[2,8],"(MDD)":[3],"is":[4,29,50,78,255,308,320],"an":[5,285],"important":[6],"neuropsychiatric":[7],"with":[9],"high":[10],"prevalence":[11],"in":[12,47,53,56,86,99,115,148,170,182,212,240,246,268,275,292,310,322],"Brazil,":[13],"characterized":[14],"by":[15,111],"persistent":[16],"depressed":[17],"mood":[18],"and/or":[19],"loss":[20],"of":[21,96,146,165,173,179,186,203,218,233,279,296,314,326],"pleasure":[22],"for":[23,113,333],"at":[24,126,183,224,348,356],"least":[25,184],"two":[26],"weeks.":[27],"MDD":[28,49,83,104,147,251,341],"a":[30,230],"disabling":[31],"condition":[32],"that":[33,250,304,339],"predisposes":[34],"to":[35,141],"other":[36],"complex":[37],"pathologies,":[38],"such":[39],"as":[40,90,92,130,352,354],"cardiovascular":[41],"diseases,":[42],"and":[43,58,64,71,88,150,163,242,261,272,298,316],"may":[44,134],"even":[45],"result":[46],"suicide.":[48],"more":[51],"prevalent":[52],"women":[54,149,297,315],"than":[55],"men":[57,87,151,241],"there":[59,77],"are":[60],"anatomical,":[61],"immunological,":[62],"neuronal":[63],"hormonal":[65],"differences,":[66],"which":[67,196],"reflect":[68],"different":[69,293],"prognoses":[70],"symptoms":[72],"between":[73,235],"the":[74,82,93,100,108,127,143,187,198,213,219,225,236,243,259,262,269,276,282,305,317,340],"sexes.":[75],"However,":[76,119],"no":[79],"consensus":[80],"regarding":[81],"transcriptional":[84,105,144,200,220,252],"alterations":[85,98,145,267],"women,":[89],"well":[91,353],"functional":[94],"implications":[95],"these":[97],"cellular":[101],"metabolism.":[102],"Most":[103],"studies":[106],"explain":[107],"disease\u2019s":[109],"pathophysiology":[110],"looking":[112],"changes":[114,122,221],"global":[116,349],"gene":[117,120,154,307,319,342,350],"expression.":[118,358],"expression":[121,155,160,343,351],"can":[123],"also":[124],"occur":[125],"transcript":[128,159,226],"level,":[129],"RNA":[131,270,286],"splicing":[132,287],"pathways":[133,274],"be":[135],"altered.":[136],"The":[137,177],"present":[138],"work":[139,337],"seeks":[140],"investigate":[142],"through":[152,346],"differential":[153,158,166],"(DGE)":[156],"analysis,":[157],"(DTE)":[161],"analysis":[162,164],"isoform":[167],"use":[168],"(DTU)":[169],"post-mortem":[171],"samples":[172],"six":[174],"brain":[175,294,312,324],"regions.":[176],"set":[178],"genes":[180,194,238],"identified":[181,210,239,245],"one":[185],"three":[188],"approaches":[189],"was":[190,290],"called":[191],"transcriptionally":[192],"altered":[193,237,291,309,321],"(TAGs),":[195],"represent":[197],"comprehensive":[199],"alteration":[201,253,347,355],"profile":[202,254],"MDD.":[204,334],"At":[205],"total,":[206],"1075":[207],"TAGs":[208],"were":[209],"mainly":[211],"prefrontal":[214],"cortex.":[215],"Approximately":[216],"half":[217],"occurred":[222],"only":[223],"level.":[227],"We":[228,265],"found":[229],"near":[231],"absence":[232],"overlap":[234],"ones":[244],"women.":[247,280],"This":[248],"indicates":[249],"sex-specific,":[256],"considering":[257],"both":[258],"gene-":[260],"transcript-level":[263],"alterations.":[264],"verified":[266],"processing":[271],"export":[273],"orbitofrontal":[277],"cortex":[278],"Additionally":[281],"DDX39B":[283],"gene,":[284],"machinery":[288],"member,":[289],"regions":[295,313,325],"men,":[299,327],"respectively.":[300],"Furthermore,":[301],"we":[302],"showed":[303],"ATAT1":[306],"multiple":[311,323],"ABR":[318],"constituting":[328],"potential":[329],"sex-specific":[330],"molecular":[331],"biomarkers":[332],"Therefore,":[335],"our":[336],"shows":[338],"perturbation":[344],"occurs":[345],"isoform-level":[357]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}