{"id":"https://openalex.org/W7054534032","doi":null,"title":"Aging, immortality and persistence produced by phenotypic heterogeneity in bacterial populations","display_name":"Aging, immortality and persistence produced by phenotypic heterogeneity in bacterial populations","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W7054534032"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt33h5k4dd","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/33h5k4dd","pdf_url":"https://escholarship.org/uc/item/33h5k4dd","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/33h5k4dd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Menegaz Proenca, Audrey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Menegaz Proenca, Audrey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.1648000031709671,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-aging","display_name":"bacterial aging","score":0.9670000076293945},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.8100000023841858},{"id":"https://openalex.org/keywords/rejuvenation","display_name":"rejuvenation","score":0.781000018119812},{"id":"https://openalex.org/keywords/phenotypic-heterogeneity","display_name":"phenotypic heterogeneity","score":0.878000020980835},{"id":"https://openalex.org/keywords/bacterial-persistence","display_name":"bacterial persistence","score":0.6539999842643738},{"id":"https://openalex.org/keywords/antibiotic-tolerance","display_name":"antibiotic tolerance","score":0.7490000128746033},{"id":"https://openalex.org/keywords/age-structure","display_name":"age structure","score":0.49000000953674316},{"id":"https://openalex.org/keywords/deterministic-population-dynamics","display_name":"deterministic population dynamics","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8295999765396118},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.6334999799728394},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5647000074386597},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5034000277519226},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4505999982357025},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.439300000667572},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.38989999890327454},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3750999867916107},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C2780902518","wikidata":"https://www.wikidata.org/wiki/Q6033780","display_name":"Inheritance (genetic algorithm)","level":3,"score":0.3447999954223633},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.3418000042438507},{"id":"https://openalex.org/C86792732","wikidata":"https://www.wikidata.org/wiki/Q1416338","display_name":"Creatures","level":3,"score":0.326200008392334},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.32580000162124634},{"id":"https://openalex.org/C548578009","wikidata":"https://www.wikidata.org/wiki/Q44595","display_name":"Cannibalism","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.29829999804496765},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.2815999984741211},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.27869999408721924},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2669999897480011},{"id":"https://openalex.org/C131892835","wikidata":"https://www.wikidata.org/wiki/Q770985","display_name":"Intraspecific competition","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.26100000739097595},{"id":"https://openalex.org/C11710620","wikidata":"https://www.wikidata.org/wiki/Q680054","display_name":"Microevolution","level":3,"score":0.25949999690055847}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt33h5k4dd","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/33h5k4dd","pdf_url":"https://escholarship.org/uc/item/33h5k4dd","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt33h5k4dd","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/33h5k4dd","pdf_url":"https://escholarship.org/uc/item/33h5k4dd","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320313550","display_name":"Society for the Study of Evolution","ror":"https://ror.org/057kr0a20"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320336557","display_name":"Ci\u00eancia sem Fronteiras","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7054534032.pdf","grobid_xml":"https://content.openalex.org/works/W7054534032.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W58805225","https://openalex.org/W1517607432","https://openalex.org/W1528273806","https://openalex.org/W1576430955","https://openalex.org/W1899580745","https://openalex.org/W1964422431","https://openalex.org/W1964464000","https://openalex.org/W1966062610","https://openalex.org/W1968726044","https://openalex.org/W1970924670","https://openalex.org/W1976144868","https://openalex.org/W1977066402","https://openalex.org/W1978459962","https://openalex.org/W1984571004","https://openalex.org/W1985002373","https://openalex.org/W1993488597","https://openalex.org/W1996666978","https://openalex.org/W2003028136","https://openalex.org/W2009311326","https://openalex.org/W2013830587","https://openalex.org/W2018659819","https://openalex.org/W2022664428","https://openalex.org/W2023985059","https://openalex.org/W2026799761","https://openalex.org/W2033360893","https://openalex.org/W2036367528","https://openalex.org/W2045825103","https://openalex.org/W2053704624","https://openalex.org/W2055792599","https://openalex.org/W2055926450","https://openalex.org/W2064107535","https://openalex.org/W2064300165","https://openalex.org/W2067972708","https://openalex.org/W2069250280","https://openalex.org/W2075551125","https://openalex.org/W2077651691","https://openalex.org/W2083581925","https://openalex.org/W2090363184","https://openalex.org/W2094535446","https://openalex.org/W2098018866","https://openalex.org/W2099614390","https://openalex.org/W2101366952","https://openalex.org/W2102585177","https://openalex.org/W2103650497","https://openalex.org/W2106233470","https://openalex.org/W2111967267","https://openalex.org/W2114123456","https://openalex.org/W2115446988","https://openalex.org/W2118904810","https://openalex.org/W2119178925","https://openalex.org/W2120545407","https://openalex.org/W2121020843","https://openalex.org/W2126525177","https://openalex.org/W2138505529","https://openalex.org/W2148323109","https://openalex.org/W2149181149","https://openalex.org/W2150269770","https://openalex.org/W2155335606","https://openalex.org/W2156684470","https://openalex.org/W2159620582","https://openalex.org/W2160182641","https://openalex.org/W2162984257","https://openalex.org/W2168606178","https://openalex.org/W2168997454","https://openalex.org/W2216677116","https://openalex.org/W2238393164","https://openalex.org/W2321819616","https://openalex.org/W2325399027","https://openalex.org/W2566432881","https://openalex.org/W2591498398","https://openalex.org/W2785178156","https://openalex.org/W2800451751","https://openalex.org/W2889285236","https://openalex.org/W2891967605","https://openalex.org/W2940117744","https://openalex.org/W2951214849","https://openalex.org/W2952566017"],"related_works":["https://openalex.org/W2891967605","https://openalex.org/W2945020868","https://openalex.org/W4407843655","https://openalex.org/W6889309643","https://openalex.org/W2071219742","https://openalex.org/W2018659819","https://openalex.org/W2119178925","https://openalex.org/W1993488597","https://openalex.org/W2087078675","https://openalex.org/W2288331675"],"abstract_inverted_index":{"Senescence,":[0],"the":[1,14,18,37,57,69,104,126,157,168,189,194,209,221],"process":[2],"of":[3,6,16,20,60,71,106,121,128,133,138,159,196,211,223,231],"age-specific":[4],"decrease":[5],"fitness,":[7],"has":[8],"puzzled":[9],"evolutionary":[10],"biologists":[11],"ever":[12],"since":[13],"publication":[15],"On":[17],"Origin":[19],"Species.":[21],"How":[22],"ubiquitous":[23],"among":[24],"living":[25],"creatures":[26],"is":[27],"this":[28,139,232],"phenotypic":[29,169],"decline":[30],"that":[31,77,114,147],"arises":[32],"with":[33,46,68],"age?":[34],"Up":[35],"until":[36],"last":[38],"decade":[39],"aging":[40,97,115,160,192],"seemed":[41],"limited":[42],"to":[43,82,156,177],"multicellular":[44],"organisms":[45],"a":[47,86,107,129,181,228,235],"clear":[48],"separation":[49],"between":[50,191],"soma":[51],"and":[52,116,193,226],"germline,":[53],"as":[54],"stated":[55],"by":[56,152,172],"Evolutionary":[58],"Theory":[59],"Aging.":[61],"Bacteria":[62,84],"were":[63],"considered":[64],"functionally":[65],"immortal.":[66,166],"However,":[67],"improvement":[70],"single-cell":[72],"microscopy":[73],"techniques,":[74],"studies":[75],"revealed":[76],"prokaryotes":[78],"are,":[79],"indeed,":[80],"susceptible":[81],"aging.":[83],"inheriting":[85],"conserved":[87],"cell":[88],"pole,":[89],"harboring":[90],"larger":[91],"non-genetic":[92],"damage":[93,109,174],"loads,":[94],"display":[95],"an":[96],"phenotype,":[98],"while":[99,162],"its":[100,218],"sibling":[101],"rejuvenates":[102],"through":[103],"inheritance":[105],"reduced":[108],"load.":[110],"My":[111],"research":[112,233],"shows":[113],"rejuvenation":[117],"represent":[118],"deterministic":[119,212],"aspects":[120],"bacterial":[122,182,197,216],"physiology,":[123],"deriving":[124],"from":[125],"stabilization":[127],"population":[130],"around":[131],"states":[132],"growth":[134],"equilibrium.":[135],"The":[136],"maintenance":[137,222],"equilibrium":[140,148],"allows":[141],"for":[142,188,220,234],"proliferative":[143],"immortality.":[144],"I":[145,185],"demonstrate":[146],"can":[149],"be":[150],"disrupted":[151],"extrinsic":[153],"damage,":[154],"leading":[155],"mortality":[158,179],"lineages":[161,164],"rejuvenating":[163],"remain":[165],"Thus,":[167],"heterogeneity":[170],"produced":[171],"asymmetric":[173],"partitioning":[175],"leads":[176],"differential":[178],"in":[180,215],"population.":[183],"Finally,":[184],"offer":[186],"evidence":[187],"connection":[190],"phenotype":[195],"persistence,":[198],"where":[199],"transiently":[200],"dormant":[201],"cells":[202],"survive":[203],"antibiotic":[204],"treatments.":[205],"This":[206],"work":[207],"demonstrates":[208],"emergence":[210],"age":[213],"structures":[214],"populations,":[217],"relevance":[219],"cellular":[224],"proliferation,":[225],"offers":[227],"potential":[229],"application":[230],"pressing":[236],"public":[237],"health":[238],"concern.":[239]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}