{"id":"https://openalex.org/W7053650127","doi":null,"title":"Yeast-derived \u03b2\u20131,3\u20131,6\u2013glucan increases DC secretion of TNF\u03b1 and IL-10","display_name":"Yeast-derived \u03b2\u20131,3\u20131,6\u2013glucan increases DC secretion of TNF\u03b1 and IL-10","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W7053650127"},"language":"en","primary_location":{"id":"pmh:oai:skemman.is:1946/46564","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1946/46564","pdf_url":"https://skemman.is/bitstream/1946/46564/1/Diplomaritgerd.Dagmar.pdf","source":{"id":"https://openalex.org/S4377196131","display_name":"Skemman","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://skemman.is/bitstream/1946/46564/1/Diplomaritgerd.Dagmar.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Dagmar Elsa J\u00f3nasd\u00f3ttir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dagmar Elsa J\u00f3nasd\u00f3ttir 1993-","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2883000075817108,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-1-3-1-6-glucan","display_name":"\u03b2-1,3/1,6-glucan","score":0.9309999942779541},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.843999981880188},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dectin-1","display_name":"Dectin-1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.7250000238418579},{"id":"https://openalex.org/keywords/tlr6","display_name":"TLR6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.8709999918937683},{"id":"https://openalex.org/keywords/annexin-a1","display_name":"annexin A1","score":0.875},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7426000237464905},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7067999839782715},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6377000212669373},{"id":"https://openalex.org/C2777726330","wikidata":"https://www.wikidata.org/wiki/Q320607","display_name":"Oligosaccharide","level":2,"score":0.5910000205039978},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5444999933242798},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.5288000106811523},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4657000005245209},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45419999957084656},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3147999942302704},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26350000500679016},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:skemman.is:1946/46564","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1946/46564","pdf_url":"https://skemman.is/bitstream/1946/46564/1/Diplomaritgerd.Dagmar.pdf","source":{"id":"https://openalex.org/S4377196131","display_name":"Skemman","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:skemman.is:1946/46564","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1946/46564","pdf_url":"https://skemman.is/bitstream/1946/46564/1/Diplomaritgerd.Dagmar.pdf","source":{"id":"https://openalex.org/S4377196131","display_name":"Skemman","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7053650127.pdf","grobid_xml":"https://content.openalex.org/works/W7053650127.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W143902200","https://openalex.org/W1641598552","https://openalex.org/W1653650310","https://openalex.org/W1964257721","https://openalex.org/W1968773176","https://openalex.org/W1978262255","https://openalex.org/W1987051998","https://openalex.org/W1994848434","https://openalex.org/W1995441274","https://openalex.org/W2002603605","https://openalex.org/W2007837848","https://openalex.org/W2013315740","https://openalex.org/W2031799130","https://openalex.org/W2034845924","https://openalex.org/W2039395562","https://openalex.org/W2053004605","https://openalex.org/W2058801589","https://openalex.org/W2062819127","https://openalex.org/W2066222426","https://openalex.org/W2072161687","https://openalex.org/W2083084591","https://openalex.org/W2104213579","https://openalex.org/W2111044557","https://openalex.org/W2111717604","https://openalex.org/W2129718739","https://openalex.org/W2130832456","https://openalex.org/W2139620037","https://openalex.org/W2143498880","https://openalex.org/W2147497666","https://openalex.org/W2148658155","https://openalex.org/W2463363721","https://openalex.org/W2565490787","https://openalex.org/W2729863621","https://openalex.org/W2913970879","https://openalex.org/W2915038597","https://openalex.org/W2943081109","https://openalex.org/W3006122165","https://openalex.org/W3013064778","https://openalex.org/W3020384843","https://openalex.org/W3095170341","https://openalex.org/W3123154095","https://openalex.org/W3133820561","https://openalex.org/W3134454558","https://openalex.org/W3179850871","https://openalex.org/W3200104592","https://openalex.org/W4206782792","https://openalex.org/W4213237806","https://openalex.org/W4224327190","https://openalex.org/W4280503388","https://openalex.org/W4293279301","https://openalex.org/W4299851340","https://openalex.org/W4321275866","https://openalex.org/W4372285937","https://openalex.org/W4391784822"],"related_works":["https://openalex.org/W2147497666","https://openalex.org/W982791403","https://openalex.org/W2314767964","https://openalex.org/W1973350726","https://openalex.org/W2399895238","https://openalex.org/W7096671945","https://openalex.org/W3013064778","https://openalex.org/W2043338946","https://openalex.org/W2062819127","https://openalex.org/W4292266514"],"abstract_inverted_index":{"The":[0,151,177,258],"insoluble":[1,35,68,108,152,237],"\u03b2\u20131,3\u20131,6\u2013glucan":[2,36,69,109,153,238,282],"derived":[3],"from":[4,37,280],"baker\u2018s":[5,38],"yeast,":[6],"the":[7,11,31,34,59,67,104,107,126,129,139,142,155,168,180,193,204,225,230,236,241,281,283,287,297,308],"main":[8],"ingredient":[9],"in":[10,47,58,103,115,128,167,192,246,253,260],"food":[12],"supplement":[13],"product":[14],"NutramunityTM,":[15],"has":[16],"been":[17],"claimed":[18],"to":[19,29,111,263,296],"improve":[20],"immune":[21,45],"function.":[22],"\\nThe":[23,219],"aim":[24],"of":[25,33,63,66,82,101,106,118,131,141,157,170,182,195,216,223],"this":[26],"study":[27],"was":[28,290],"determine":[30],"effects":[32,75],"yeast":[39],"and":[40,56,70,80,85,94,99,120,124,149,175,201,229,267,301],"its":[41,71,207],"oligosaccharide":[42,72,133,208,278],"derivatives":[43],"on":[44,76,138,213],"responses":[46],"human":[48],"dendritic":[49],"cells":[50],"(DCs).":[51],"\\nHuman":[52],"DCs":[53,102,127,158,171,183,196,274],"were":[54,88,275],"matured":[55],"stimulated":[57],"absence":[60],"or":[61],"presence":[62,105,130],"different":[64,132,304],"concentrations":[65],"derivatives.":[73],"Their":[74],"DC":[77,214,221,265],"cytokine":[78,227,232,242],"secretion":[79,117,140,222],"expression":[81,215],"surface":[83],"molecules":[84],"Annexin":[86,217],"A1":[87],"determined":[89],"using":[90],"ELISA,":[91],"flow":[92],"cytometry,":[93],"Simple":[95],"Western,":[96],"respectively.":[97],"\\nMaturation":[98],"stimulation":[100],"led":[110],"a":[112,162,187,190],"dose-dependent":[113],"increase":[114,166,268],"their":[116,269],"TNF\u03b1":[119,228],"IL-10":[121,233,250],"while":[122],"maturing":[123],"stimulating":[125],"fractions":[134,209,279],"had":[135,210],"no":[136],"effect":[137,212,284],"four":[143],"cytokines":[144],"tested":[145],"(TNF\u03b1,":[146],"IL-6,":[147],"IL-12p40,":[148],"IL-10).":[150],"increased":[154,220],"proportion":[156,169,181,194],"expressing":[159,172,184,197],"CD141":[160],"with":[161,186,235,255,277],"tendency":[163,188],"towards":[164,189],"an":[165,211],"Dectin-1,":[173],"CD14,":[174],"TLR6.":[176],"glucan":[178],"decreased":[179],"CD86":[185],"decrease":[191],"HLA-DR,":[198],"CD40,":[199],"PD-L1,":[200],"CD1c.":[202],"Neither":[203],"\u03b2-glucan":[205,259],"nor":[206],"A1.":[218],"both":[224],"pro-inflammatory":[226,256,270],"anti-inflammatory":[231],"treated":[234,276],"may":[239,293],"reflect":[240],"scenario":[243],"often":[244],"seen":[245,285],"inflammatory":[247],"diseases,":[248],"where":[249],"is":[251],"present":[252],"conjunction":[254],"cytokines.":[257],"Nutramunity":[261],"seems":[262],"diminish":[264],"maturation":[266],"activity.":[271],"However,":[272],"when":[273],"by":[286],"native":[288,309],"compound":[289],"lost,":[291],"which":[292],"be":[294],"due":[295],"oligosaccharides":[298],"being":[299],"smaller":[300],"perhaps":[302],"having":[303],"branching":[305],"structures":[306],"than":[307],"compound.":[310]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}