{"id":"https://openalex.org/W7053513162","doi":null,"title":"Varia\u00e7\u00e3o na composi\u00e7\u00e3o de g\u00eaneros probi\u00f3ticos nos diferentes est\u00e1gios da COVID-19: uma abordagem in silico","display_name":"Varia\u00e7\u00e3o na composi\u00e7\u00e3o de g\u00eaneros probi\u00f3ticos nos diferentes est\u00e1gios da COVID-19: uma abordagem in silico","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W7053513162"},"language":"en","primary_location":{"id":"pmh:oai:www.lume.ufrgs.br:10183/289709","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/289709","pdf_url":"https://lume.ufrgs.br/bitstream/10183/289709/1/001244245.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lume.ufrgs.br/bitstream/10183/289709/1/001244245.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072828461","display_name":"Clarissa Reginato Taufer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Taufer, Clarissa Reginato","raw_affiliation_strings":["Porto Alegre , novembro de 2024"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Porto Alegre , novembro de 2024","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072828461"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9430000185966492},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8190000057220459},{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/lachnospiraceae","display_name":"Lachnospiraceae","score":0.871999979019165},{"id":"https://openalex.org/keywords/bacteroides","display_name":"Bacteroides","score":0.8100000023841858},{"id":"https://openalex.org/keywords/akkermansia","display_name":"Akkermansia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/faecalibacterium","display_name":"Faecalibacterium","score":0.8339999914169312},{"id":"https://openalex.org/keywords/roseburia","display_name":"Roseburia","score":0.550000011920929},{"id":"https://openalex.org/keywords/ruminococcus","display_name":"Ruminococcus","score":0.8299999833106995},{"id":"https://openalex.org/keywords/blautia","display_name":"Blautia","score":0.7770000100135803},{"id":"https://openalex.org/keywords/coprococcus","display_name":"Coprococcus","score":0.7760000228881836},{"id":"https://openalex.org/keywords/oscillospira","display_name":"Oscillospira","score":0.9279999732971191},{"id":"https://openalex.org/keywords/differential-abundance-analysis","display_name":"differential abundance","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2776706654","wikidata":"https://www.wikidata.org/wiki/Q3941444","display_name":"Roseburia","level":4,"score":0.7026000022888184},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.6190000176429749},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.5346999764442444},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.5343999862670898},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5116999745368958},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.43709999322891235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3571999967098236},{"id":"https://openalex.org/C2908643440","wikidata":"https://www.wikidata.org/wiki/Q132809","display_name":"Clostridiales","level":4,"score":0.3409999907016754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3345000147819519},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.314300000667572},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29919999837875366},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.lume.ufrgs.br:10183/289709","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/289709","pdf_url":"https://lume.ufrgs.br/bitstream/10183/289709/1/001244245.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:www.lume.ufrgs.br:10183/289709","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/289709","pdf_url":"https://lume.ufrgs.br/bitstream/10183/289709/1/001244245.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2823776494","display_name":null,"funder_award_id":"88887","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G3498291812","display_name":null,"funder_award_id":"88887.798411/2022-00","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G4392815463","display_name":null,"funder_award_id":"88887.513461/2020-00","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G47252533","display_name":null,"funder_award_id":"2020-00","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7053513162.pdf","grobid_xml":"https://content.openalex.org/works/W7053513162.grobid-xml"},"referenced_works_count":229,"referenced_works":["https://openalex.org/W1575273264","https://openalex.org/W1616226146","https://openalex.org/W1692592874","https://openalex.org/W1948723230","https://openalex.org/W1948774627","https://openalex.org/W1965027165","https://openalex.org/W1965175897","https://openalex.org/W1966556896","https://openalex.org/W1966641706","https://openalex.org/W1971073599","https://openalex.org/W1984869424","https://openalex.org/W1987184081","https://openalex.org/W1992144919","https://openalex.org/W1996453022","https://openalex.org/W1998335236","https://openalex.org/W1999376421","https://openalex.org/W1999820650","https://openalex.org/W2003342633","https://openalex.org/W2005771364","https://openalex.org/W2006404454","https://openalex.org/W2013470122","https://openalex.org/W2017614891","https://openalex.org/W2029262201","https://openalex.org/W2031431575","https://openalex.org/W2032230795","https://openalex.org/W2034285706","https://openalex.org/W2041506403","https://openalex.org/W2041633812","https://openalex.org/W2045745337","https://openalex.org/W2059282351","https://openalex.org/W2060185417","https://openalex.org/W2081653606","https://openalex.org/W2083089709","https://openalex.org/W2084057318","https://openalex.org/W2085284704","https://openalex.org/W2086021468","https://openalex.org/W2086804952","https://openalex.org/W2089876932","https://openalex.org/W2097936419","https://openalex.org/W2098181141","https://openalex.org/W2102119566","https://openalex.org/W2103088074","https://openalex.org/W2103503670","https://openalex.org/W2105315699","https://openalex.org/W2106829739","https://openalex.org/W2108281900","https://openalex.org/W2108589639","https://openalex.org/W2108718991","https://openalex.org/W2110840202","https://openalex.org/W2110934836","https://openalex.org/W2111731663","https://openalex.org/W2114574400","https://openalex.org/W2117065897","https://openalex.org/W2120321064","https://openalex.org/W2121635719","https://openalex.org/W2125826054","https://openalex.org/W2128769815","https://openalex.org/W2132113202","https://openalex.org/W2133856765","https://openalex.org/W2136758227","https://openalex.org/W2138955399","https://openalex.org/W2139334262","https://openalex.org/W2141878383","https://openalex.org/W2142586702","https://openalex.org/W2143197985","https://openalex.org/W2145520421","https://openalex.org/W2147790901","https://openalex.org/W2150366828","https://openalex.org/W2151277589","https://openalex.org/W2155413133","https://openalex.org/W2159008215","https://openalex.org/W2161667744","https://openalex.org/W2161868263","https://openalex.org/W2162088497","https://openalex.org/W2162228100","https://openalex.org/W2162396392","https://openalex.org/W2167826411","https://openalex.org/W2170241563","https://openalex.org/W2170325206","https://openalex.org/W2222621726","https://openalex.org/W2236332835","https://openalex.org/W2294867081","https://openalex.org/W2299913967","https://openalex.org/W2311812208","https://openalex.org/W2343175653","https://openalex.org/W2343758687","https://openalex.org/W2344149427","https://openalex.org/W2398894736","https://openalex.org/W2434410662","https://openalex.org/W2461582275","https://openalex.org/W2482354067","https://openalex.org/W2511184432","https://openalex.org/W2513506562","https://openalex.org/W2558803112","https://openalex.org/W2566680380","https://openalex.org/W2573938105","https://openalex.org/W2589381355","https://openalex.org/W2594894350","https://openalex.org/W2603346833","https://openalex.org/W2603546255","https://openalex.org/W2607879065","https://openalex.org/W2615273341","https://openalex.org/W2616825195","https://openalex.org/W2690365708","https://openalex.org/W2754424039","https://openalex.org/W2754579667","https://openalex.org/W2758005814","https://openalex.org/W2762425175","https://openalex.org/W2763540102","https://openalex.org/W2775086803","https://openalex.org/W2776033757","https://openalex.org/W2791877316","https://openalex.org/W2792451891","https://openalex.org/W2794108373","https://openalex.org/W2797413896","https://openalex.org/W2800093403","https://openalex.org/W2883529746","https://openalex.org/W2885662829","https://openalex.org/W2886322630","https://openalex.org/W2889208646","https://openalex.org/W2889616411","https://openalex.org/W2899470865","https://openalex.org/W2900850632","https://openalex.org/W2907048060","https://openalex.org/W2913097383","https://openalex.org/W2945318499","https://openalex.org/W2952437732","https://openalex.org/W2952564192","https://openalex.org/W2953371386","https://openalex.org/W2990223293","https://openalex.org/W2990249310","https://openalex.org/W2996149432","https://openalex.org/W2998420978","https://openalex.org/W3001118548","https://openalex.org/W3001897055","https://openalex.org/W3003217347","https://openalex.org/W3003224476","https://openalex.org/W3004280078","https://openalex.org/W3004318991","https://openalex.org/W3004699161","https://openalex.org/W3005444990","https://openalex.org/W3006354146","https://openalex.org/W3008071129","https://openalex.org/W3008827533","https://openalex.org/W3009825169","https://openalex.org/W3009912996","https://openalex.org/W3011605790","https://openalex.org/W3013152614","https://openalex.org/W3016016792","https://openalex.org/W3017488767","https://openalex.org/W3017491718","https://openalex.org/W3021655800","https://openalex.org/W3024312732","https://openalex.org/W3024363132","https://openalex.org/W3027658010","https://openalex.org/W3033735761","https://openalex.org/W3037771764","https://openalex.org/W3042305844","https://openalex.org/W3045398725","https://openalex.org/W3049250265","https://openalex.org/W3084276692","https://openalex.org/W3085845631","https://openalex.org/W3087096410","https://openalex.org/W3097721345","https://openalex.org/W3102967988","https://openalex.org/W3107994581","https://openalex.org/W3118579072","https://openalex.org/W3126104798","https://openalex.org/W3128867972","https://openalex.org/W3130940832","https://openalex.org/W3132450255","https://openalex.org/W3132617495","https://openalex.org/W3133699935","https://openalex.org/W3135195291","https://openalex.org/W3148433444","https://openalex.org/W3152763731","https://openalex.org/W3157150475","https://openalex.org/W3157484867","https://openalex.org/W3176015444","https://openalex.org/W3184130481","https://openalex.org/W3186747227","https://openalex.org/W3189929141","https://openalex.org/W3202352160","https://openalex.org/W3206650634","https://openalex.org/W3208090959","https://openalex.org/W3211693276","https://openalex.org/W3213684687","https://openalex.org/W4206750902","https://openalex.org/W4210302563","https://openalex.org/W4211008136","https://openalex.org/W4212930378","https://openalex.org/W4213326723","https://openalex.org/W4220860247","https://openalex.org/W4220917877","https://openalex.org/W4225127463","https://openalex.org/W4225650845","https://openalex.org/W4254002263","https://openalex.org/W4280522904","https://openalex.org/W4283369143","https://openalex.org/W4283780414","https://openalex.org/W4285387785","https://openalex.org/W4296284875","https://openalex.org/W4297265218","https://openalex.org/W4307269790","https://openalex.org/W4307847181","https://openalex.org/W4308968337","https://openalex.org/W4317042796","https://openalex.org/W4319296547","https://openalex.org/W4353055797","https://openalex.org/W4362525665","https://openalex.org/W4362588840","https://openalex.org/W4376133613","https://openalex.org/W4382776560","https://openalex.org/W4384820308","https://openalex.org/W4385430151","https://openalex.org/W4385497394","https://openalex.org/W4385617043","https://openalex.org/W4385660922","https://openalex.org/W4385982398","https://openalex.org/W4386332247","https://openalex.org/W4391917671","https://openalex.org/W4392518483","https://openalex.org/W4392712371","https://openalex.org/W4394913177","https://openalex.org/W4395701860","https://openalex.org/W4396518737","https://openalex.org/W4398202715","https://openalex.org/W4398211668","https://openalex.org/W4399971342"],"related_works":["https://openalex.org/W4404483079","https://openalex.org/W4413983939","https://openalex.org/W4214849431","https://openalex.org/W4308968337","https://openalex.org/W3116233421","https://openalex.org/W4200020168","https://openalex.org/W4404832731","https://openalex.org/W4284891254","https://openalex.org/W4212930378","https://openalex.org/W4387607800"],"abstract_inverted_index":{"O":[0],"desequil\u00edbrio":[1],"da":[2,47,64,187,199,216,235,245,259,276,322,337,367,377,384,465],"microbiota":[3,48,93,165,200,439,466],"foi":[4],"identificado":[5],"em":[6,10,80,134,201,208,308,468],"pacientes":[7,95,202,469],"com":[8,96,173,203,297,334,470],"COVID-19":[9,204,392],"amostras":[11],"de":[12,23,26,31,43,70,84,94,106,126,128,130,136,176,185,195,243,300,363,397,426,428,455,457],"orofaringe,":[13],"nasofaringe":[14],"e":[15,29,52,61,79,161,167,205,233,247,282,290,307,330,390,393,410,422,441,447],"fezes,":[16],"sendo":[17],"associado":[18],"a":[19,41,68,98,104,110,178,325,382,387,391,394,417,423,434,438,442,452,471],"infec\u00e7\u00f5es":[20],"bacterianas,":[21],"redu\u00e7\u00e3o":[22,333],"probi\u00f3ticos,":[24],"aumento":[25,336],"bact\u00e9rias":[27],"patog\u00eanicas":[28],"diminui\u00e7\u00e3o":[30],"simbiontes":[32],"ben\u00e9ficos.":[33],"Para":[34,116,324],"compreender":[35],"mais":[36,401,461],"profundamente":[37],"essas":[38],"altera\u00e7\u00f5es,":[39],"avaliamos":[40,148],"rela\u00e7\u00e3o":[42,385,436],"dois":[44],"g\u00eaneros":[45,56,74,150,181,209,229,234,319],"importantes":[46,222],"intestinal":[49,132,166,440,467],"humana:":[50],"Bifidobacterium":[51,238],"Lactobacillus.":[53],"Ambos":[54],"os":[55,145,228,274,407,411],"estiveram":[57],"relacionados":[58,168],"\u00e0":[59,62,169,214,257],"doen\u00e7a":[60,246,260],"severidade":[63,186,244,321],"COVID-19.":[65,188,277,323,357,378],"Al\u00e9m":[66,358],"disso,":[67,359],"administra\u00e7\u00e3o":[69],"probi\u00f3ticos":[71],"contendo":[72],"esses":[73],"demonstrou":[75],"melhora":[76],"nos":[77,182],"sintomas":[78],"par\u00e2metros":[81],"laboratoriais.":[82],"Apesar":[83],"muitos":[85],"estudos":[86],"j\u00e1":[87],"terem":[88],"avaliado":[89],"as":[90,118,197,374,463],"mudan\u00e7as":[91,207,221,269],"na":[92,164,223,271,320,356],"COVID-19,":[97,443],"varia\u00e7\u00e3o":[99],"dos":[100],"m\u00e9todos":[101],"dispon\u00edveis":[102,133],"para":[103,143,227,305,312,348,373],"an\u00e1lise":[105,141,415],"dados":[107,129,137,380,429],"biol\u00f3gicos":[108],"prejudica":[109],"compara\u00e7\u00e3o":[111],"direta":[112],"entre":[113,273,386,406,437],"diferentes":[114,183,375],"trabalhos.":[115,146],"mitigar":[117],"limita\u00e7\u00f5es":[119],"metodol\u00f3gicas,":[120],"este":[121],"trabalho":[122,311],"realizou":[123],"uma":[124,140,315,360],"rean\u00e1lise":[125,219],"conjuntos":[127],"microbioma":[131],"bancos":[135,427],"p\u00fablicos,":[138],"seguindo":[139],"padronizada":[142],"todos":[144],"Especificamente,":[147],"dez":[149],"bacterianos":[151],"(Akkermansia,":[152],"Bacteroides,":[153,231],"Bifidobacterium,":[154,230],"Blautia,":[155],"Coprococcus,":[156],"Faecalibacterium,":[157],"Lactobacillus,":[158],"Oscillospira,":[159,306],"Roseburia":[160,331],"Ruminococcus)":[162],"presentes":[163],"sa\u00fade":[170],"do":[171,419],"hospedeiro,":[172],"o":[174,335],"objetivo":[175],"identificar":[177],"din\u00e2mica":[179],"desses":[180,318],"graus":[184],"Por":[189,278,339],"meio":[190],"dessa":[191],"abordagem,":[192],"fomos":[193],"capazes":[194],"observar":[196],"altera\u00e7\u00f5es":[198,464],"como":[206,264,451],"espec\u00edficos":[210],"poderiam":[211],"estar":[212],"relacionadas":[213],"gravidade":[215],"doen\u00e7a.":[217,472],"A":[218],"identificou":[220],"abund\u00e2ncia":[224,272],"diferencial,":[225],"especialmente":[226],"Lactobacillus":[232,267],"fam\u00edlia":[236,326,368,388,400],"Lachnospiraceae.":[237],"mostrou-se":[239],"um":[240,252,310,349],"potencial":[241],"biomarcador":[242],"alvo":[248],"terap\u00eautico.":[249],"Bacteroides":[250],"apresentou":[251,343],"padr\u00e3o":[253],"complexo,":[254],"possivelmente":[255],"relacionado":[256],"inflama\u00e7\u00e3o":[258],"ou":[261],"ao":[262],"crescimento":[263],"pat\u00f3genos":[265],"oportunistas.":[266],"mostrou":[268],"significativas":[270],"est\u00e1gios":[275],"outro":[279,340],"lado,":[280,341],"Akkermansia":[281],"Faecalibacterium":[283],"n\u00e3o":[284,365],"demonstraram":[285],"diferen\u00e7as":[286,404],"significativas,":[287],"enquanto":[288],"Oscillospira":[289],"Ruminococcus":[291],"apresentaram":[292,332],"resultados":[293,344,408],"estatisticamente":[294,345],"significativos,":[295],"mas":[296],"baixo":[298],"valor":[299],"LDA":[301],"(linear":[302],"discriminant":[303],"analysis)":[304],"apenas":[309,347],"Ruminococcus,":[313],"sugerindo":[314,351],"relev\u00e2ncia":[316],"limitada":[317],"Lachnospiraceae,":[327],"Coprococcus":[328],"Lachnospira":[329],"gravidade.":[338],"Blautia":[342],"significativos":[346],"trabalho,":[350],"baixa":[352],"influ\u00eancia":[353],"deste":[354],"g\u00eanero":[355],"grande":[361],"diversidade":[362],"representantes":[364],"classificados":[366],"Lachnospiraceae":[369,389],"pode":[370],"ser":[371],"observada":[372],"gravidades":[376],"Esses":[379],"ressaltam":[381],"import\u00e2ncia":[383,418],"necessidade":[395,424,453],"urgente":[396],"explorar":[398],"essa":[399],"profundamente.":[402],"As":[403],"encontradas":[405],"originais":[409],"obtidos":[412],"pela":[413],"nossa":[414],"destacam":[416,433],"rigor":[420],"metodol\u00f3gico":[421],"cr\u00edtica":[425],"atualizados.":[430],"Nossos":[431],"achados":[432],"complexa":[435],"evidenciando":[444],"potenciais":[445],"biomarcadores":[446],"alvos":[448],"terap\u00eauticos,":[449],"bem":[450],"cont\u00ednua":[454],"compreender,":[456],"maneira":[458],"cada":[459],"vez":[460],"aprofundada,":[462]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}