{"id":"https://openalex.org/W7053491065","doi":null,"title":"Voluntary exercise can ameliorate insulin resistance by reducing iNOS-mediated S-nitrosylation of Akt in the liver in obese rats","display_name":"Voluntary exercise can ameliorate insulin resistance by reducing iNOS-mediated S-nitrosylation of Akt in the liver in obese rats","publication_year":2016,"publication_date":"2016-03-16","ids":{"openalex":"https://openalex.org/W7053491065"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01305:0006293181","doi":null,"is_oa":true,"landing_page_url":"https://jair.repo.nii.ac.jp/records/2003246","pdf_url":"https://jair.repo.nii.ac.jp/record/2003246/files/SDK0038-zenbunpu.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://jair.repo.nii.ac.jp/record/2003246/files/SDK0038-zenbunpu.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"\u90fd\u7bc9, \u5b5d\u5141","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u90fd\u7bc9, \u5b5d\u5141","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"\u30c4\u30c5\u30ad, \u30bf\u30ab\u30de\u30b5","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u30c4\u30c5\u30ad, \u30bf\u30ab\u30de\u30b5","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.3668999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.3668999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.19619999825954437,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.10300000011920929,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voluntary-exercise","display_name":"voluntary exercise","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9610000252723694},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9940000176429749},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7699999809265137},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oletf-rats","display_name":"OLETF rats","score":0.8939999938011169},{"id":"https://openalex.org/keywords/wheel-running","display_name":"wheel running","score":0.6970000267028809},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6899999976158142},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8073999881744385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7351999878883362},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6326000094413757},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5756999850273132},{"id":"https://openalex.org/C3019424981","wikidata":"https://www.wikidata.org/wiki/Q12834857","display_name":"Resistance training","level":2,"score":0.4465000033378601},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.427700012922287},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3847000002861023},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.29499998688697815},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.27129998803138733},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2603999972343445}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01305:0006293181","doi":null,"is_oa":true,"landing_page_url":"https://jair.repo.nii.ac.jp/records/2003246","pdf_url":"https://jair.repo.nii.ac.jp/record/2003246/files/SDK0038-zenbunpu.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"pmh:oai:jair.repo.nii.ac.jp:02003132","doi":null,"is_oa":true,"landing_page_url":"https://jair.repo.nii.ac.jp/records/2003132","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"VoR"},{"id":"pmh:oai:jair.repo.nii.ac.jp:02003246","doi":null,"is_oa":true,"landing_page_url":"https://jair.repo.nii.ac.jp/records/2003246","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"VoR"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01305:0006293181","doi":null,"is_oa":true,"landing_page_url":"https://jair.repo.nii.ac.jp/records/2003246","pdf_url":"https://jair.repo.nii.ac.jp/record/2003246/files/SDK0038-zenbunpu.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5167305754","display_name":"\u904b\u52d5\u306b\u3088\u308b\uff12\u578b\u7cd6\u5c3f\u75c5\u306e\u4e88\u9632\u30fb\u6539\u5584\u52b9\u679c\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e","funder_award_id":"13J10819","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6295106038","display_name":"The role of S-nitrosylation for pathological mechanisms of metabolic syndrome.","funder_award_id":"25860231","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6780553493","display_name":null,"funder_award_id":"S1101008","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322319","display_name":"Kato Memorial Bioscience Foundation","ror":"https://ror.org/054n63512"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7053491065.pdf","grobid_xml":"https://content.openalex.org/works/W7053491065.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1505427848","https://openalex.org/W1542372173","https://openalex.org/W1594524304","https://openalex.org/W1964739304","https://openalex.org/W1968441550","https://openalex.org/W1984422410","https://openalex.org/W1985325808","https://openalex.org/W1994246552","https://openalex.org/W1996271130","https://openalex.org/W1997692317","https://openalex.org/W2001996801","https://openalex.org/W2005178032","https://openalex.org/W2005342581","https://openalex.org/W2007078899","https://openalex.org/W2024362121","https://openalex.org/W2026796986","https://openalex.org/W2047029494","https://openalex.org/W2047090731","https://openalex.org/W2058267560","https://openalex.org/W2064871936","https://openalex.org/W2068788911","https://openalex.org/W2069307303","https://openalex.org/W2070219820","https://openalex.org/W2076123854","https://openalex.org/W2077991556","https://openalex.org/W2082916190","https://openalex.org/W2085397620","https://openalex.org/W2089250607","https://openalex.org/W2089794052","https://openalex.org/W2093969963","https://openalex.org/W2094054841","https://openalex.org/W2099622909","https://openalex.org/W2100794345","https://openalex.org/W2103575153","https://openalex.org/W2108678340","https://openalex.org/W2112105248","https://openalex.org/W2113562305","https://openalex.org/W2118332512","https://openalex.org/W2136325267","https://openalex.org/W2154052663","https://openalex.org/W2163615450","https://openalex.org/W2165047367","https://openalex.org/W2168649610","https://openalex.org/W4255025501"],"related_works":["https://openalex.org/W7095905157","https://openalex.org/W1542372173","https://openalex.org/W2007650925","https://openalex.org/W2170833826","https://openalex.org/W2042111590","https://openalex.org/W2463694722","https://openalex.org/W2144153442","https://openalex.org/W2119682497","https://openalex.org/W4246743490","https://openalex.org/W2138266804"],"abstract_inverted_index":{"Voluntary":[0],"exercise":[1,47,99,110,125,139,169],"can":[2],"ameliorate":[3],"insulin":[4,30,49,171],"resistance.The":[5],"underlying":[6],"mechanism,":[7],"however,":[8],"remains":[9],"to":[10,41,94,102,156],"be":[11],"elucidated.We":[12],"previously":[13],"demonstrated":[14],"that":[15,45,167],"inducible":[16],"nitric":[17],"oxide":[18],"synthase":[19],"(iNOS)":[20],"in":[21,28,32,66,119,132,135,146,152,159,194,197],"the":[22,33,53,67,113,120,124,127,133,136,141,147,153,160,178,190,198],"liver":[23,134],"plays":[24],"an":[25],"important":[26],"role":[27],"hepatic":[29],"resistance":[31,50],"setting":[34],"of":[35,55,60,63,77,129,143,184,189],"obesity.In":[36],"this":[37],"study,":[38],"we":[39],"tried":[40],"verify":[42],"our":[43,165],"hypothesis":[44,166],"voluntary":[46,103,109,168],"improves":[48,170],"by":[51,176],"reducing":[52],"expression":[54,180],"iNOS":[56,130,179],"and":[57,82,117,181],"subsequent":[58,182],"S-nitrosylation":[59,183],"key":[61,187],"molecules":[62],"glucose":[64,116,195],"metabolism":[65,196],"liver.Twenty-one":[68],"Otsuka":[69,88],"Long-Evans":[70,86],"Tokushima":[71,87],"Fatty":[72],"(OLETF)":[73],"rats,":[74,155],"a":[75,95,186],"model":[76],"type":[78],"2":[79],"diabetes":[80],"mellitus,":[81],"18":[83],"non-diabetic":[84],"control":[85],"(LETO)":[89],"rats":[90],"were":[91,150],"randomly":[92],"assigned":[93],"sedentary":[96],"group":[97,100],"or":[98],"subjected":[101],"wheel":[104],"running":[105],"for":[106],"20":[107],"weeks.The":[108],"significantly":[111],"reduced":[112,140],"fasting":[114],"blood":[115],"HOMA-IR":[118],"OLETF":[121,137,154],"rats.In":[122],"addition,":[123],"decreased":[126],"amount":[128],"mRNA":[131],"rats.Moreover,":[138],"levels":[142],"S-nitrosylated":[144],"Akt":[145],"liver,":[148],"which":[149],"increased":[151],"those":[157],"observed":[158],"LETO":[161],"rats.These":[162],"findings":[163],"support":[164],"resistance,":[172],"at":[173],"least":[174],"partly,":[175],"suppressing":[177],"Akt,":[185],"molecule":[188],"signal":[191],"transduction":[192],"pathways":[193],"liver.":[199]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
