{"id":"https://openalex.org/W70527527","doi":"https://doi.org/10.1152/ajpendo.1981.241.4.e328","title":"Importance of glucagon in mediating epinephrine-induced hyperglycemia in alloxan-diabetic dogs","display_name":"Importance of glucagon in mediating epinephrine-induced hyperglycemia in alloxan-diabetic dogs","publication_year":1981,"publication_date":"1981-10-01","ids":{"openalex":"https://openalex.org/W70527527","doi":"https://doi.org/10.1152/ajpendo.1981.241.4.e328","mag":"70527527","pmid":"https://pubmed.ncbi.nlm.nih.gov/7032319"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.1981.241.4.e328","doi":"https://doi.org/10.1152/ajpendo.1981.241.4.e328","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1981.241.4.e328","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108232170","display_name":"G. Perez","orcid":"https://orcid.org/0000-0002-3467-4674","observed_orcids":["https://orcid.org/0000-0002-3467-4674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Perez","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026675050","display_name":"Friedrich W. Kemmer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. W. Kemmer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016546490","display_name":"H.Lavina A. Lickley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. L. Lickley","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109700396","display_name":"M. Vrani\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Vranic","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0779,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.72864797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"241","issue":"4","first_page":"E328","last_page":"E335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.968999981880188},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9419999718666077},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.8309999704360962},{"id":"https://openalex.org/keywords/glucose-production","display_name":"glucose production","score":0.7940000295639038},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6269999742507935},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.7770000100135803},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.6690000295639038},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.8897572159767151},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.8885732889175415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8748743534088135},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8371975421905518},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.7725459337234497},{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.6967715620994568},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5501143336296082},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4231227934360504},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.40544530749320984}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000496","descriptor_name":"Alloxan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpendo.1981.241.4.e328","doi":"https://doi.org/10.1152/ajpendo.1981.241.4.e328","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1981.241.4.e328","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:7032319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7032319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1983777004","https://openalex.org/W2009741645","https://openalex.org/W2041748125","https://openalex.org/W2043558929","https://openalex.org/W2066154192","https://openalex.org/W2075325328","https://openalex.org/W2096017546","https://openalex.org/W2103557599","https://openalex.org/W2104131411","https://openalex.org/W2132548645","https://openalex.org/W2133884882","https://openalex.org/W2142730388","https://openalex.org/W2151836253","https://openalex.org/W2155530276","https://openalex.org/W2156549131","https://openalex.org/W2171055934","https://openalex.org/W4251407012","https://openalex.org/W4301972348"],"related_works":["https://openalex.org/W2395088559","https://openalex.org/W2094099111","https://openalex.org/W2460584456","https://openalex.org/W2132548645","https://openalex.org/W2142730388","https://openalex.org/W2410759335","https://openalex.org/W2056539723","https://openalex.org/W38296339","https://openalex.org/W2461016652","https://openalex.org/W2057364295"],"abstract_inverted_index":{"In":[0,49,159],"normal":[1,167],"dogs":[2,35],"epinephrine":[3,20,82,121,154,169],"stimulates":[4],"glucose":[5,98,177],"production":[6,102,180],"(Ra)":[7],"independently":[8],"of":[9,15,41,87,97,106,153,157,185],"glucagon.":[10,158],"To":[11],"investigate":[12],"the":[13,37,85,150],"role":[14],"this":[16],"interaction":[17],"in":[18,32,36,63,130,144,161,164,176],"diabetes,":[19],"(0.1":[21,43],"micrograms":[22,44],".":[23,25,45,47,115,117],"kg-1":[24,46,116],"min-1)":[26,118],"was":[27,79,92,108,142,155],"infused":[28,80],"for":[29],"90":[30],"min":[31],"five":[33,125],"alloxan-diabetic":[34,127],"presence":[38],"or":[39],"absence":[40],"somatostatin":[42,78,107,123],"min-1).":[48],"response":[50],"to":[51,69,83,166],"epinephrine,":[52],"glycemia":[53],"rose":[54,68],"by":[55,110],"40%":[56],"reflecting":[57],"a":[58,94,171,183],"near":[59],"maximal":[60],"(122%)":[61],"increase":[62,96,141,175],"Ra.":[64],"Plasma":[65],"glucagon":[66,112],"(IRG)":[67],"953":[70],"pg/ml,":[71],"whereas":[72],"insulin":[73],"(IRI)":[74],"increased":[75],"minimally.":[76],"When":[77],"with":[81,120],"prevent":[84],"rise":[86],"IRG":[88,186],"and":[89,101,122,133,173,179],"IRI,":[90],"there":[91],"only":[93],"marginal":[95],"concentration":[99,178],"(12%)":[100],"(38%).":[103],"The":[104],"effect":[105,152],"reversed":[109],"infusing":[111],"(10":[113],"ng":[114],"together":[119],"into":[124],"additional":[126],"dogs.":[128],"Increments":[129],"IRG,":[131],"glycemia,":[132],"Ra":[134],"were":[135],"fully":[136],"reestablished.":[137],"A":[138],"100%":[139],"FFA":[140],"observed":[143],"all":[145],"three":[146],"groups,":[147],"indicating":[148],"that":[149],"lipolytic":[151],"independent":[156],"conclusion,":[160],"diabetic":[162],"dogs,":[163,168],"contrast":[165],"induced":[170],"marked":[172],"prolonged":[174],"mostly":[181],"through":[182],"stimulation":[184],"secretion.":[187]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
