{"id":"https://openalex.org/W7052406294","doi":null,"title":"Renal sympathetic nerve ablation in moderate to severe chronic renal failure: A short term safety and efficacy pilot study","display_name":"Renal sympathetic nerve ablation in moderate to severe chronic renal failure: A short term safety and efficacy pilot study","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W7052406294"},"language":"en","primary_location":{"id":"pmh:oai:researchbank.swinburne.edu.au:2b298d1b-0901-4a28-a2db-78d00cfd2a27/1","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.3/436647","pdf_url":null,"source":{"id":"https://openalex.org/S4306401157","display_name":"Swinburne figshare (Swinburne University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57093077","host_organization_name":"Swinburne University of Technology","host_organization_lineage":["https://openalex.org/I57093077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"The 33rd Annual Scientific Meeting of the High Blood Pressure Research Council of Australia, Perth, Western Australia, Australia, 6-9 December 2011","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066976658","display_name":"Dagmara Hering","orcid":"https://orcid.org/0000-0003-4649-9524","observed_orcids":["https://orcid.org/0000-0003-4649-9524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hering, Dagmara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Walton, A. S.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walton, A. S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Krum, H.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krum, H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lambert, Gavin W.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lambert, Gavin W.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014744580","display_name":"\u00c9lisabeth Lambert","orcid":"https://orcid.org/0000-0002-2232-9048","observed_orcids":["https://orcid.org/0000-0002-2232-9048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lambert, Elisabeth A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041016234","display_name":"Murray D. Esler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esler, Murray D.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Schlaich, Markus P.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schlaich, Markus P.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58837209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-denervation","display_name":"renal denervation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/resistant-hypertension","display_name":"resistant hypertension","score":0.9229999780654907},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure","display_name":"ambulatory blood pressure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/nocturnal-blood-pressure-decline","display_name":"nocturnal blood pressure dipping","score":0.800000011920929},{"id":"https://openalex.org/keywords/catheter-ablation","display_name":"catheter ablation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.328000009059906},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9550999999046326},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7177000045776367},{"id":"https://openalex.org/C2780177628","wikidata":"https://www.wikidata.org/wiki/Q2186707","display_name":"Renal sympathetic denervation","level":4,"score":0.7148000001907349},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6129000186920166},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.5856000185012817},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5493000149726868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5166000127792358},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.47099998593330383},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.3959999978542328},{"id":"https://openalex.org/C2776634560","wikidata":"https://www.wikidata.org/wiki/Q707540","display_name":"Renal artery","level":3,"score":0.3781000077724457},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.3749000132083893},{"id":"https://openalex.org/C2993356106","wikidata":"https://www.wikidata.org/wiki/Q736715","display_name":"Chronic renal failure","level":2,"score":0.3736000061035156},{"id":"https://openalex.org/C2779190097","wikidata":"https://www.wikidata.org/wiki/Q6128790","display_name":"Sympathectomy","level":2,"score":0.3628000020980835},{"id":"https://openalex.org/C3020789104","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic activity","level":4,"score":0.34470000863075256},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33809998631477356},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3208000063896179},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.31540000438690186},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.2985000014305115},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2671999931335449},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.2590000033378601},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C2909994101","wikidata":"https://www.wikidata.org/wiki/Q41861","display_name":"Chronic hypertension","level":4,"score":0.2540000081062317},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.251800000667572},{"id":"https://openalex.org/C79752029","wikidata":"https://www.wikidata.org/wiki/Q808732","display_name":"Baroreceptor","level":4,"score":0.25},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.2460000067949295},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.243599995970726},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.23989999294281006},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.23559999465942383},{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.22589999437332153},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.22509999573230743},{"id":"https://openalex.org/C3018127138","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Cardiovascular event","level":3,"score":0.22290000319480896},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.20829999446868896},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.2070000022649765},{"id":"https://openalex.org/C2779740467","wikidata":"https://www.wikidata.org/wiki/Q4826772","display_name":"Autonomic nerve","level":2,"score":0.20649999380111694},{"id":"https://openalex.org/C2992203999","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean blood pressure","level":4,"score":0.20170000195503235},{"id":"https://openalex.org/C2992467569","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nerve","level":3,"score":0.19589999318122864}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:researchbank.swinburne.edu.au:2b298d1b-0901-4a28-a2db-78d00cfd2a27/1","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.3/436647","pdf_url":null,"source":{"id":"https://openalex.org/S4306401157","display_name":"Swinburne figshare (Swinburne University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57093077","host_organization_name":"Swinburne University of Technology","host_organization_lineage":["https://openalex.org/I57093077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"The 33rd Annual Scientific Meeting of the High Blood Pressure Research Council of Australia, Perth, Western Australia, Australia, 6-9 December 2011","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970534969","https://openalex.org/W2099897414","https://openalex.org/W2065121034","https://openalex.org/W4310944870","https://openalex.org/W2025314542","https://openalex.org/W2313379550","https://openalex.org/W1972801163","https://openalex.org/W2083250996","https://openalex.org/W2156976867","https://openalex.org/W2009956979"],"abstract_inverted_index":{"Introduction:":[0],"Sympathetic":[1],"activation":[2],"contributes":[3],"to":[4,27],"the":[5,140],"progression":[6],"of":[7,20,109,125,142,183,194,205],"chronic":[8,213],"renal":[9,21,42,72,214],"failure":[10,215],"(CRF)":[11],"and":[12,32,40,50,67,81,89,94,100,148,200,216],"is":[13,47],"associated":[14],"with":[15,37,54,78,210],"adverse":[16],"cardiovascular":[17],"outcomes.":[18],"Ablation":[19],"sympathetic":[22,29],"nerves":[23],"has":[24,62],"been":[25,65],"demonstrated":[26],"lower":[28],"nerve":[30],"activity":[31],"blood":[33,91,171,201],"pressure":[34,92,172,202],"in":[35,52,75,181,208],"patients":[36,53,77,209],"resistant":[38,79,217],"hypertension":[39,80],"preserved":[41],"function.":[43],"Whether":[44],"this":[45],"approach":[46],"also":[48],"safe":[49],"effective":[51],"an":[55],"estimated":[56],"glomerular":[57],"filtration":[58],"rate":[59],"(eGFR)":[60],"<45ml/min./1.73m2":[61],"not":[63],"yet":[64],"explored.\\nMethods":[66],"Results:":[68],"We":[69],"performed":[70],"bilateral":[71],"denervation":[73],"(RDN)":[74],"14":[76],"stage":[82,211],"3-4":[83,212],"CRF":[84],"(mean":[85],"eGFR":[86],"30.4\u00b18.3ml/min/1.73m2).":[87],"Office":[88,146],"ambulatory":[90],"(BP)":[93],"serum":[95],"biochemistry":[96],"were":[97,114],"obtained":[98],"before":[99],"at":[101,158],"1,":[102,159],"3,":[103,160],"6,":[104,161],"12-month":[105],"follow-up.":[106],"An":[107],"average":[108],"4.9\u00b10.8":[110],"ablations":[111],"per":[112],"artery":[113],"delivered":[115],"without":[116],"complications.":[117],"Angiographic":[118],"evaluation":[119],"after":[120,132],"RDN":[121,207],"revealed":[122],"no":[123],"compromise":[124],"treated":[126],"arteries.":[127],"Estimated":[128],"GFR":[129],"remained":[130],"unchanged":[131],"RDN.":[133],"Mean":[134],"baseline":[135],"BP":[136,150],"was":[137,173],"174\u00b122/91\u00b116mmHg":[138],"despite":[139],"use":[141],"5.6\u00b11.4":[143],"antihypertensive":[144],"drugs.":[145],"systolic":[147],"diastolic":[149],"decreased":[151],"by":[152,176],"-34\u00b113/-14\u00b113,":[153],"-26\u00b121/-11\u00b110,":[154],"-31\u00b120/-13\u00b112,":[155],"-36\u00b150/-29\u00b143":[156],"mmHg":[157,178],"12":[162],"month":[163],"follow-up,":[164],"respectively":[165],"(P":[166],"for":[167],"all":[168],"<0.001).":[169],"Night-time":[170],"significantly":[174],"reduced":[175],"-9":[177],"(P<0.05)":[179],"resulting":[180],"restoration":[182],"a":[184,195],"more":[185],"physiologic":[186],"dipping":[187],"pattern.\\nConclusion:":[188],"Our":[189],"findings":[190],"provide":[191],"first":[192],"evidence":[193],"favourable":[196],"short-term":[197],"safety":[198],"profile":[199],"lowering":[203],"effects":[204],"catheter-based":[206],"hypertension.":[218]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}