{"id":"https://openalex.org/W7052339670","doi":null,"title":"The Role of Tissue Stiffening on Meningeal Lymphatic Function","display_name":"The Role of Tissue Stiffening on Meningeal Lymphatic Function","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W7052339670"},"language":"en","primary_location":{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/68429","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2292/68429","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2292/68429","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hitpass Romero, Kate","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hitpass Romero, Kate","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11929","display_name":"Cerebral Venous Sinus Thrombosis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meningeal-lymphatic-system","display_name":"meningeal lymphatic system","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glymphatic-system","display_name":"glymphatic system","score":0.9919999837875366},{"id":"https://openalex.org/keywords/meningeal-fibrosis","display_name":"meningeal fibrosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/dura-mater","display_name":"dura mater","score":0.8579999804496765},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8629999756813049},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.7549999952316284},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tgf-beta-type-i-receptor","display_name":"TGF-beta type I receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-drainage","display_name":"cerebrospinal fluid drainage","score":0.7820000052452087},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8190000057220459},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nintedanib","display_name":"nintedanib","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pirfenidone","display_name":"pirfenidone","score":1.0},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C101054994","wikidata":"https://www.wikidata.org/wiki/Q15474254","display_name":"Glymphatic system","level":3,"score":0.8385999798774719},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.7368000149726868},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6815000176429749},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5985000133514404},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5939000248908997},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.5853000283241272},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5138999819755554},{"id":"https://openalex.org/C2778987889","wikidata":"https://www.wikidata.org/wiki/Q1394389","display_name":"Dura mater","level":2,"score":0.510200023651123},{"id":"https://openalex.org/C2776403516","wikidata":"https://www.wikidata.org/wiki/Q268930","display_name":"Meninges","level":2,"score":0.45010000467300415},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4489000141620636},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30820000171661377},{"id":"https://openalex.org/C2779822359","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Interstitial fluid","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.29600000381469727},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C2779265215","wikidata":"https://www.wikidata.org/wiki/Q1647118","display_name":"Pia mater","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C2780171596","wikidata":"https://www.wikidata.org/wiki/Q15149723","display_name":"Nintedanib","level":4,"score":0.2824000120162964},{"id":"https://openalex.org/C2780965494","wikidata":"https://www.wikidata.org/wiki/Q11238641","display_name":"Lymphatic vessel","level":4,"score":0.26170000433921814},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.25920000672340393}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/68429","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2292/68429","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/68429","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2292/68429","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409530052","https://openalex.org/W4362692201","https://openalex.org/W4390199818","https://openalex.org/W6958629053","https://openalex.org/W6977517369","https://openalex.org/W7018727418","https://openalex.org/W4394767449","https://openalex.org/W2883628966","https://openalex.org/W4413111343","https://openalex.org/W4319296716"],"abstract_inverted_index":{"Aging":[0],"is":[1,40,135],"a":[2,43,215],"significant":[3],"risk":[4],"factor":[5],"for":[6,64,303],"the":[7,26,47,57,88,102,112,117,140,152,181,187,279,293],"development":[8],"of":[9,49,73,119,144,189,214,281,295],"neurological":[10],"disorders,":[11],"including":[12,172],"Alzheimer\u2019s":[13],"disease":[14],"and":[15,61,115,124,142,159,176,238,249,298,315],"Parkinson\u2019s":[16],"disease,":[17],"which":[18],"are":[19,76,178],"characterised":[20],"by":[21,200],"abnormal":[22],"protein":[23],"accumulation":[24],"in":[25,67,101,111,137,151,168,180,204,208,221,273,276,313],"central":[27],"nervous":[28],"system":[29,60,63],"(CNS).":[30],"A":[31],"failure":[32],"to":[33,46,82,108,157,193,234,254],"effectively":[34],"clear":[35],"these":[36,50],"CNS":[37,68,84,310],"waste":[38,69,85],"proteins":[39],"believed":[41],"be":[42],"key":[44],"contributor":[45],"pathophysiology":[48],"diseases.":[51,317],"Recent":[52],"attention":[53],"has":[54],"focused":[55],"towards":[56],"meningeal":[58,122,305],"lymphatic":[59,123,264,285],"glymphatic":[62,125,239],"their":[65],"roles":[66],"removal.":[70],"The":[71],"function":[72,286],"both":[74],"systems":[75],"significantly":[77],"perturbed":[78],"with":[79,267],"aging,":[80,138],"leading":[81,233],"impaired":[83,235],"clearance;":[86],"however,":[87],"mechanisms":[89,312],"underlying":[90],"this":[91,120,145],"deficit":[92],"remain":[93,146],"elusive.":[94],"This":[95,290],"project":[96],"investigates":[97],"how":[98],"age-related":[99,304],"factors":[100],"meninges\u2014":[103],"particularly":[104,131],"T":[105,169,190],"cell":[106,170],"responses\u2014contribute":[107],"tissue":[109],"fibrosis":[110,150,203,226,256,275],"dura":[113],"mater":[114],"describe":[116],"impact":[118,262],"on":[121,263,284],"function.":[126,265],"Excessive":[127],"extracellular":[128],"matrix":[129],"deposition,":[130],"around":[132,227],"dural":[133,162,165,194,223],"sinuses,":[134],"observed":[136,179],"yet":[139],"cause":[141],"consequences":[143],"unclear.":[147],"To":[148],"investigate":[149],"dura,":[153,183],"I":[154],"developed":[155],"methods":[156],"culture":[158],"grow":[160],"human":[161],"fibroblasts":[163,224],"from":[164],"explants.":[166],"Changes":[167],"populations,":[171],"Th1,":[173],"Th2,":[174],"Th17":[175],"Tregs,":[177,201],"aged":[182,209],"prompting":[184],"investigation":[185],"into":[186,309],"contribution":[188],"cell-derived":[191],"cytokines":[192],"fibrosis.":[195],"Notably,":[196],"TGF\u03b2,":[197],"predominantly":[198],"secreted":[199],"induced":[202,225],"vitro,":[205],"mirroring":[206],"observations":[207],"meninges.":[210],"Further,":[211],"AAV-mediated":[212],"overexpression":[213],"constitutively":[216],"active":[217],"TGF\u03b2":[218],"receptor":[219],"1":[220],"mouse":[222],"critical":[228],"CSF":[229,236],"access":[230],"points,":[231],"potentially":[232],"drainage":[237],"function,":[240],"mimicking":[241],"aging-related":[242],"pathology.":[243],"Investigating":[244],"potential":[245,253,300],"anti-fibrotic":[246,269],"agents,":[247],"nintedanib":[248],"pirfenidone,":[250],"revealed":[251],"nintedanib's":[252],"mitigate":[255],"but":[257],"raised":[258],"concerns":[259],"regarding":[260],"its":[261],"Pirfenidone,":[266],"multifaceted":[268],"mechanisms,":[270],"demonstrated":[271],"promise":[272],"attenuating":[274],"vitro.":[277],"However,":[278],"complexities":[280],"drug":[282],"effects":[283],"warrant":[287],"further":[288],"investigation.":[289],"study":[291],"underscores":[292],"significance":[294],"tissue-specific":[296],"responses":[297],"highlights":[299],"therapeutic":[301],"avenues":[302],"fibrosis,":[306],"providing":[307],"insights":[308],"clearance":[311],"aging":[314],"neurodegenerative":[316]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}