{"id":"https://openalex.org/W7052328496","doi":null,"title":"Sleep Disturbance in Parkinson\u2019s Disease: Consequences for the Brain and Disease Progression \u2013 A Narrative Review","display_name":"Sleep Disturbance in Parkinson\u2019s Disease: Consequences for the Brain and Disease Progression \u2013 A Narrative Review","publication_year":2025,"publication_date":"2025-06-01","ids":{"openalex":"https://openalex.org/W7052328496"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:f58e61047e07408d8de00b59185fc266","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f58e61047e07408d8de00b59185fc266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature and Science of Sleep, Vol Volume 17, Iss Issue 1, Pp 1521-1537 (2025)","raw_type":"article"},"volume":null,"type":"review","indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/f58e61047e07408d8de00b59185fc266","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124266846","display_name":"Anderson KN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anderson KN","raw_affiliation_strings":["Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032286909","display_name":"Michael John Keogh","orcid":"https://orcid.org/0000-0001-7594-7379","observed_orcids":["https://orcid.org/0000-0001-7594-7379"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keogh MJ","raw_affiliation_strings":["Faculty of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051368796","display_name":"Luca Gosse","orcid":"https://orcid.org/0000-0003-2574-9272","observed_orcids":["https://orcid.org/0000-0003-2574-9272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gosse L","raw_affiliation_strings":["Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25438596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12569","display_name":"Restless Legs Syndrome Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.9520000219345093},{"id":"https://openalex.org/keywords/rem-sleep-behavior-disorder","display_name":"REM sleep behavior disorder","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sleep-disordered-breathing","display_name":"sleep-disordered breathing","score":0.8230000138282776},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.996999979019165},{"id":"https://openalex.org/keywords/restless-legs-syndrome","display_name":"restless legs syndrome","score":0.8889999985694885},{"id":"https://openalex.org/keywords/periodic-limb-movements","display_name":"periodic limb movements","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nightmare-disorder","display_name":"nightmare disorder","score":0.9319999814033508},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/non-motor-symptoms","display_name":"non-motor symptoms","score":0.8009999990463257},{"id":"https://openalex.org/keywords/prodromal-parkinson-s-disease","display_name":"prodromal Parkinson's disease","score":0.8230000138282776},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6610000133514404},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.9710000157356262},{"id":"https://openalex.org/keywords/sleep-therapy","display_name":"sleep therapy","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.7049000263214111},{"id":"https://openalex.org/C3020390432","wikidata":"https://www.wikidata.org/wiki/Q1425428","display_name":"Newcastle upon tyne","level":2,"score":0.5730000138282776},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5602999925613403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4927000105381012},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48010000586509705},{"id":"https://openalex.org/C2778116459","wikidata":"https://www.wikidata.org/wiki/Q327082","display_name":"Newcastle disease","level":3,"score":0.4643999934196472},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4616999924182892},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4244000017642975},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.4059000015258789},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38999998569488525},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3528999984264374},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.3391000032424927},{"id":"https://openalex.org/C2780317758","wikidata":"https://www.wikidata.org/wiki/Q3339235","display_name":"Neurological disorder","level":3,"score":0.33239999413490295},{"id":"https://openalex.org/C188394188","wikidata":"https://www.wikidata.org/wiki/Q744029","display_name":"Sleep medicine","level":4,"score":0.29420000314712524},{"id":"https://openalex.org/C2778910407","wikidata":"https://www.wikidata.org/wiki/Q1778620","display_name":"Sleep diary","level":4,"score":0.2935999929904938},{"id":"https://openalex.org/C2776750294","wikidata":"https://www.wikidata.org/wiki/Q916280","display_name":"Restless legs syndrome","level":3,"score":0.25999999046325684}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:f58e61047e07408d8de00b59185fc266","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f58e61047e07408d8de00b59185fc266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature and Science of Sleep, Vol Volume 17, Iss Issue 1, Pp 1521-1537 (2025)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/104310","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/sleep-disturbance-in-parkinsons-disease-consequences-for-the-brain-and-peer-reviewed-fulltext-article-NSS","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:f58e61047e07408d8de00b59185fc266","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f58e61047e07408d8de00b59185fc266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature and Science of Sleep, Vol Volume 17, Iss Issue 1, Pp 1521-1537 (2025)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.43425923585891724}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Kirstie":[0,53],"N":[1,54],"Anderson,1,2":[2],"Michael":[3],"J":[4],"Keogh,2,3":[5],"Luca":[6],"Gosse4":[7],"1Institute":[8],"of":[9,20,33,57,84,154,175,205,216,231,243,254],"Neuroscience,":[10],"Newcastle":[11,15,22,28,36,38,47,49,65],"University":[12],"Medical":[13,34],"School,":[14],"Upon":[16,23],"Tyne,":[17,30,40,51,67],"UK;":[18,31,41],"2Department":[19],"Neurology,":[21,58],"Tyne":[24],"NHS":[25],"Foundation":[26],"Trust,":[27],"upon":[29,39,50,66,169],"3Faculty":[32],"Sciences,":[35],"University,":[37,48],"4Translational":[42],"and":[43,100,109,144,172,214,246],"Clinical":[44],"Research":[45],"Institute,":[46],"UKCorrespondence:":[52],"Anderson,":[55],"Department":[56],"Royal":[59],"Victoria":[60,63],"Infirmary,":[61],"Queen":[62],"Road,":[64],"NE1":[68],"4LP,":[69],"UK,":[70],"Email":[71],"kirstieanderson@nhs.netAbstract:":[72],"Sleep":[73],"disturbance":[74,245],"in":[75,113,125,183,186,191,222],"Parkinson\u2019s":[76,128,176,206,233,256,263],"disease":[77,93,104,129,207,257],"(PD)":[78],"is":[79,163,236],"recognized":[80],"to":[81,123,238],"be":[82,111],"one":[83],"the":[85,103,114,155,170,211,223,229,241,251],"most":[86],"common":[87],"non-motor":[88,173],"complications.":[89],"It":[90,235],"occurs":[91],"before":[92],"onset":[94],"as":[95,197],"a":[96,198],"prodromal":[97],"symptom,":[98],"during":[99],"then":[101],"throughout":[102],"course.":[105],"Causes":[106],"are":[107,121],"multifactorial":[108],"can":[110],"multiple":[112],"same":[115],"patient.":[116],"Specific":[117],"sleep":[118,132,135,140,166,189,194,220,244,248,261,266],"disorders":[119,167,221,249],"that":[120],"known":[122],"occur":[124],"those":[126,202],"with":[127],"include":[130],"REM":[131,193],"behavior":[133,195],"disorder,":[134,149,196],"disordered":[136],"breathing":[137],"including":[138],"obstructive":[139],"apnea,":[141],"restless":[142],"legs":[143],"periodic":[145],"limb":[146],"movements,":[147],"nightmare":[148],"insomnia":[150],"alongside":[151],"direct":[152],"side-effects":[153],"medication":[156],"used":[157],"for":[158,201],"therapy.":[159],"One":[160],"key":[161],"question":[162],"whether":[164,240],"these":[165],"impact":[168],"motor":[171],"symptoms":[174],"disease.":[177,234],"There":[178],"has":[179],"been":[180],"significant":[181],"interest":[182],"recent":[184],"years":[185],"using":[187],"certain":[188],"disorders,":[190,262],"particular,":[192],"biomarker":[199],"both":[200],"at":[203],"risk":[204,230,253],"but":[208],"also":[209,227],"influencing":[210],"subsequent":[212],"severity":[213],"speed":[215],"progression.":[217],"However,":[218],"other":[219],"general":[224],"population":[225],"may":[226],"increase":[228],"developing":[232,255],"important":[237],"understand":[239],"treatment":[242],"specific":[247],"modifies":[250],"long-term":[252],"or":[258],"its":[259],"progression.Keywords:":[260],"disease,":[264],"REMBD,":[265],"therapies":[267]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}