{"id":"https://openalex.org/W70522370","doi":"https://doi.org/10.1152/jn.1989.61.2.233","title":"Long-lasting reduction of excitability by a sodium-dependent potassium current in cat neocortical neurons","display_name":"Long-lasting reduction of excitability by a sodium-dependent potassium current in cat neocortical neurons","publication_year":1989,"publication_date":"1989-02-01","ids":{"openalex":"https://openalex.org/W70522370","doi":"https://doi.org/10.1152/jn.1989.61.2.233","mag":"70522370","pmid":"https://pubmed.ncbi.nlm.nih.gov/2918352"},"language":"en","primary_location":{"id":"doi:10.1152/jn.1989.61.2.233","doi":"https://doi.org/10.1152/jn.1989.61.2.233","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.1989.61.2.233","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W70522370"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113595895","display_name":"Peter C. Schwindt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. C. Schwindt","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Washington, School of Medicine, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Washington, School of Medicine, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103199363","display_name":"William J. Spain","orcid":"https://orcid.org/0000-0001-9213-7335","observed_orcids":["https://orcid.org/0000-0001-9213-7335","https://orcid.org/0000-0002-7528-5261"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. J. Spain","raw_affiliation_strings":["Department of Physiology and Biophysics, University of WashingtonSchool of Medicine, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of WashingtonSchool of Medicine, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109906004","display_name":"W. E. Crill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. E. Crill","raw_affiliation_strings":["Department of Physiology and Biophysics, University of WashingtonSchool of Medicine, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of WashingtonSchool of Medicine, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":3.2306,"has_fulltext":false,"cited_by_count":272,"citation_normalized_percentile":{"value":0.93770268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"61","issue":"2","first_page":"233","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/persistent-sodium-current","display_name":"persistent sodium current","score":0.9300000071525574},{"id":"https://openalex.org/keywords/spike-frequency-adaptation","display_name":"spike frequency adaptation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/slow-afterhyperpolarization","display_name":"slow afterhyperpolarization","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.5979999899864197},{"id":"https://openalex.org/keywords/sensorimotor-cortex","display_name":"sensorimotor cortex","score":0.9330000281333923},{"id":"https://openalex.org/keywords/potassium-channel-blockers","display_name":"potassium channel blockers","score":0.6480000019073486},{"id":"https://openalex.org/keywords/muscarine","display_name":"muscarine","score":0.7829999923706055},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tetraethylammonium","display_name":"tetraethylammonium","score":0.9470000267028809},{"id":"https://openalex.org/keywords/dantrolene","display_name":"dantrolene","score":0.8220000267028809},{"id":"https://openalex.org/keywords/repetitive-firing","display_name":"repetitive firing","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.7527223825454712},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6934283375740051},{"id":"https://openalex.org/C93872552","wikidata":"https://www.wikidata.org/wiki/Q4690722","display_name":"Afterhyperpolarization","level":3,"score":0.6733026504516602},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6202627420425415},{"id":"https://openalex.org/C101404756","wikidata":"https://www.wikidata.org/wiki/Q5038336","display_name":"Cardiac transient outward potassium current","level":4,"score":0.599532961845398},{"id":"https://openalex.org/C2777151030","wikidata":"https://www.wikidata.org/wiki/Q146870","display_name":"Current clamp","level":4,"score":0.5913941860198975},{"id":"https://openalex.org/C2778071365","wikidata":"https://www.wikidata.org/wiki/Q3089249","display_name":"Reversal potential","level":4,"score":0.5851578712463379},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.5759530067443848},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.5644994378089905},{"id":"https://openalex.org/C2776919887","wikidata":"https://www.wikidata.org/wiki/Q417260","display_name":"Apamin","level":3,"score":0.5242036581039429},{"id":"https://openalex.org/C2780841807","wikidata":"https://www.wikidata.org/wiki/Q407952","display_name":"Muscarine","level":4,"score":0.5002233982086182},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.49488943815231323},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.49298450350761414},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.49109983444213867},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.47947320342063904},{"id":"https://openalex.org/C2781295685","wikidata":"https://www.wikidata.org/wiki/Q410728","display_name":"Tetraethylammonium","level":3,"score":0.4770890176296234},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4692756235599518},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4367600083351135},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.39485180377960205},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.21712571382522583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12674054503440857},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08137822151184082},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013757","descriptor_name":"Tetraethylammonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019789","descriptor_name":"Tetraethylammonium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jn.1989.61.2.233","doi":"https://doi.org/10.1152/jn.1989.61.2.233","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.1989.61.2.233","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmid:2918352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2918352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2070881896","display_name":"SEIZURE MECHANISMS IN NEOCORTEX","funder_award_id":"K08NS001166","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6902253503","display_name":"MEMBRANE PROPERTIES OF NEOCORTICAL NEURONS","funder_award_id":"R01NS016792","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2084647496","https://openalex.org/W2403611111","https://openalex.org/W1566881515","https://openalex.org/W2396331417","https://openalex.org/W2034290434","https://openalex.org/W2055086631","https://openalex.org/W2287398345","https://openalex.org/W2409130336","https://openalex.org/W1827142872","https://openalex.org/W2032846178"],"abstract_inverted_index":{"1.":[0],"The":[1,109,179,216],"function":[2],"and":[3,28,86,158,197,208,233,259,276],"ionic":[4],"mechanism":[5],"of":[6,18,42,69,93,95,104,130,149,162,170,186,254,263,270,280,289,301],"a":[7,38,56,74,91,154,159,187,242],"slow":[8,39,110,132,155,274],"outward":[9,43,82,101,111,134,283],"current":[10,44,68,83,103,112,135,152,176,182,217,247,255,284,312],"were":[11],"studied":[12],"in":[13,24,88,241,268],"large":[14],"layer":[15],"V":[16],"neurons":[17],"cat":[19],"sensorimotor":[20],"cortex":[21],"using":[22],"an":[23,81,290],"vitro":[25],"slice":[26],"preparation":[27],"single":[29],"microelectrode":[30],"voltage":[31,60],"clamp.":[32],"2.":[33],"With":[34,124,295],"Ca2+":[35,125,296],"influx":[36,126,297],"blocked,":[37,127,298],"relaxation":[40],"(\"tail\")":[41],"followed":[45,107],"either":[46],"(1)":[47],"repetitive":[48,142],"firing":[49],"evoked":[50],"for":[51,168,273],"1":[52],"s":[53],"or":[54,202,314],"(2)":[55],"small":[57],"1-s":[58],"depolarizing":[59],"clamp":[61],"step":[62,251,292],"that":[63,76],"activated":[64,77],"the":[65,128,131,145,147,150,171,195,223,249,261,278,281,311,315],"persistent":[66],"Na+":[67,121],"neocortical":[70],"neurons,":[71],"INaP.":[72],"When":[73],"depolarization":[75],"INaP":[78],"was":[79,113,166,200,219],"maintained,":[80],"gradually":[84],"developed":[85],"increased":[87,193],"amplitude":[89,199],"over":[90],"period":[92],"tens":[94],"seconds":[96],"to":[97,173],"several":[98],"minutes.":[99],"An":[100],"tail":[102,181,198,218,313],"similar":[105],"duration":[106],"repolarization.":[108],"abolished":[114],"by":[115,204,222],"TTX,":[116],"indicating":[117],"it":[118],"depended":[119],"on":[120,310],"influx.":[122],"3.":[123],"onset":[129,279],"Na+-dependent":[133,151,180,282],"caused":[136,153],"spike":[137],"frequency":[138],"adaptation":[139],"during":[140,194,248],"current-evoked":[141],"firing.":[143],"Following":[144],"firing,":[146],"decay":[148],"afterhyperpolarization":[156],"(sAHP)":[157],"long-lasting":[160],"reduction":[161],"excitability.":[163],"It":[164],"also":[165,239],"responsible":[167],"habituation":[169],"response":[172],"repeated":[174],"identical":[175],"pulses.":[177],"4.":[178],"had":[183,306],"properties":[184],"expected":[185],"K+":[188,211,224],"current.":[189],"Membrane":[190],"chord":[191],"conductance":[192],"tail,":[196],"reduced":[201,220],"reversed":[203],"membrane":[205],"potential":[206],"hyperpolarization":[207],"raised":[209],"extracellular":[210,299],"concentration":[212],"[(":[213],"K+]0).":[214],"5.":[215],"reversibly":[221],"channel":[225],"blockers":[226],"TEA":[227],"(5-10":[228],"mM),":[229],"muscarine":[230],"(5-20":[231],"microM),":[232],"norepinephrine":[234],"(100":[235],"microM).":[236],"These":[237],"agents":[238,265],"resulted":[240],"larger,":[243],"more":[244],"sustained":[245],"inward":[246],"preceding":[250],"depolarization.":[252,293],"Comparison":[253],"time":[256],"course":[257],"before":[258],"after":[260],"application":[262,300],"blocking":[264],"suggested":[266],"that,":[267],"spite":[269],"its":[271],"capability":[272],"buildup":[275],"decay,":[277],"occurs":[285],"within":[286],"100":[287],"ms":[288],"adequate":[291],"6.":[294],"dantrolene":[302],"sodium":[303],"(30":[304],"microM)":[305],"no":[307],"clear":[308],"effect":[309],"corresponding":[316],"sAHP.(ABSTRACT":[317],"TRUNCATED":[318],"AT":[319],"400":[320],"WORDS)":[321]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
