{"id":"https://openalex.org/W7051995834","doi":null,"title":"Antifungal prophylaxis practices and epidemiology of fungal infections in liver transplantation","display_name":"Antifungal prophylaxis practices and epidemiology of fungal infections in liver transplantation","publication_year":2010,"publication_date":"2010-11-24","ids":{"openalex":"https://openalex.org/W7051995834"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3197450","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/9952","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.unifesp.br/handle/11600/9952","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063795201","display_name":"Michelle Zicker","orcid":"https://orcid.org/0000-0001-8825-8783","observed_orcids":["https://orcid.org/0000-0001-8825-8783"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zicker, Michelle [UNIFESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063795201"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antifungal-prophylaxis","display_name":"antifungal prophylaxis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.8690000176429749},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9940000176429749},{"id":"https://openalex.org/keywords/candida","display_name":"Candida","score":0.9039999842643738},{"id":"https://openalex.org/keywords/aspergillus","display_name":"Aspergillus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/superficial-mycoses","display_name":"superficial fungal infections","score":0.6690000295639038},{"id":"https://openalex.org/keywords/graft-loss","display_name":"graft loss","score":0.7239999771118164},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.777999997138977},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6740000247955322},{"id":"https://openalex.org/keywords/breakthrough-infection","display_name":"breakthrough infection","score":0.5270000100135803},{"id":"https://openalex.org/keywords/antifungal-therapy-duration","display_name":"antifungal therapy duration","score":0.4020000100135803},{"id":"https://openalex.org/keywords/sao-paulo","display_name":"S\u00e3o Paulo","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6945000290870667},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3158999979496002},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2418999969959259},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.22370000183582306},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2175000011920929},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.19099999964237213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18870000541210175},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18610000610351562},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.18250000476837158},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.18209999799728394}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:americanae.aecid.es:3197450","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/9952","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:repositorio.unifesp.br:11600/9952","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/9952","pdf_url":"http://repositorio.unifesp.br/handle/11600/9952","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3197450","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/9952","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7051995834.pdf","grobid_xml":"https://content.openalex.org/works/W7051995834.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404241055","https://openalex.org/W2027994717","https://openalex.org/W3171276458","https://openalex.org/W6987009345","https://openalex.org/W3160863303","https://openalex.org/W2044281840","https://openalex.org/W2022050200","https://openalex.org/W4205345215","https://openalex.org/W2405281728","https://openalex.org/W2956908502"],"abstract_inverted_index":{"Objectives:":[0],"the":[1,9,25,30,36,55,78,125,144,221,237,254,265,274,277,323,388,396,405,416,438],"aims":[2],"of":[3,13,32,38,67,81,106,153,160,171,178,223,239,267,279,292,304,339,371,398,407,421,448],"this":[4,70],"study":[5],"were":[6,110,130,143,318,341,387,437],"to":[7,20,23,46,53,273,285],"determine":[8,54],"incidence":[10,37,222,266,278,370,397],"and":[11,22,43,52,101,140,157,175,189,231,309,357,385,400,404,434],"epidemiology":[12],"fungal":[14,39,48,61,117,127,155,163,173,181,269,281,349,373,402,432],"infection":[15,49,62,156,270,374],"in":[16,112,120,135,253,276,415],"liver":[17,83,92,108],"transplant":[18,84],"recipients;":[19],"describe":[21,47],"compare":[24],"antifungal":[26,34,187,218,241,293,314,393,409,422],"prophylaxis":[27,188,219,294,315,394,423],"regimens":[28],"regarding":[29,306],"requirement":[31,238,406],"late":[33,240,408],"therapy,":[35,410],"infection,":[40],"graft":[41,310,429],"loss":[42,311],"survival":[44,308],"rates;":[45],"breakthrough":[50],"episodes":[51],"risk":[56,331,382,440],"factors":[57,332,441],"for":[58,151,158,169,176,333,442],"developing":[59,334,443],"invasive":[60,162,180,372,399],"(IFI)":[63],"within":[64,336,445],"12":[65,337,446],"months":[66,338,447],"transplantation.":[68,449],"Methods:":[69],"is":[71],"a":[72,368,377,380],"retrospective":[73],"observational":[74],"study.":[75],"We":[76],"analyzed":[77],"medical":[79],"records":[80],"all":[82,154,161,172,179,313],"recipients":[85],"above":[86],"18":[87],"years":[88],"old":[89],"who":[90,287,325],"underwent":[91],"transplantation":[93,340],"at":[94,195,208,258],"Hospital":[95],"Israelita":[96],"Albert":[97],"Einstein,":[98],"between":[99],"2002":[100],"2007.":[102],"Results:":[103],"A":[104],"total":[105],"596":[107],"transplants":[109],"performed":[111],"540":[113],"patients.":[114,123],"Overall,":[115],"106":[116,126],"infections":[118,174,403],"occurred":[119,134],"95":[121],"(18%)":[122],"Among":[124],"infections,":[128,164,282],"there":[129,366],"40":[131,214],"IFI":[132,232,320,335,444],"that":[133],"37":[136],"patients":[137,185,286,324],"(7%).":[138],"Candida":[139,148,384],"Aspergillus":[141,166,386],"species":[142,149,167],"commonest":[145,389],"etiologic":[146,390],"agents.":[147,391],"accounted":[150,168],"87%":[152],"67,5":[159],"while":[165],"7%":[170],"17,5":[177],"infections.":[182],"Only":[183],"138":[184],"received":[186,193,326],"among":[190,312,322],"them":[191],"135":[192],"fluconazole":[194],"50":[196],"mg,":[197,210],"100":[198,259],"mg":[199,202,212,215,260],"or":[200,213,261,428],"200":[201],"daily;":[203],"amphotericin":[204],"B":[205],"was":[206,301,367],"given":[207],"10":[209],"25":[211],"daily.":[216],"Systemic":[217,392],"reduced":[220,264,395],"superficial":[224,280,401],"(15%":[225],"vs.":[226,234,244,296],"4%;":[227],"p":[228],"=":[229],"0,001)":[230],"(9%":[233],"3%;":[235],"p=0,019)and":[236],"therapy":[242],"(67%":[243],"23%;":[245],"p<":[246,298],"0,001),":[247],"but":[248,411],"it":[249],"showed":[250,412],"no":[251,302,413],"benefit":[252],"multivariate":[255,417],"analysis.":[256,418],"Fluconazole":[257],"lower":[262],"doses":[263],"early":[268],"mostly":[271],"due":[272],"decrease":[275],"when":[283],"compared":[284],"didn\u2019t":[288],"receive":[289],"any":[290],"kind":[291,420],"(3,2%":[295],"18,9%;":[297],"0,001).":[299],"There":[300,317],"difference":[303],"outcome":[305],"patient":[307],"regimens.":[316],"3":[319],"breakthroughs":[321],"prophylactic":[327],"fluconazole.":[328],"Significantly":[329],"associated":[330],"retransplantation":[342],"(OR":[343,351,360],"4,7;":[344],"CI":[345,353,362],"95%":[346,354,363],"2,0-11,3;":[347],"p<0,001),":[348],"colonization":[350,433],"20,6;":[352],"6,6-54,4;":[355],"p<0,001)":[356],"taking":[358,435],"metronidazole":[359,436],"4,8;":[361],"2,2-10,5;":[364],"p<0,001).Conclusions:":[365],"low":[369],"which":[375],"reflected":[376],"population":[378],"with":[379],"few":[381],"factors.":[383],"effect":[414],"No":[419],"regimen":[424],"affected":[425],"overall":[426],"mortality":[427],"loss.":[430],"Retransplantation,":[431],"identified":[439]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-10T00:00:00"}