{"id":"https://openalex.org/W7051929111","doi":null,"title":"Regulation of mitochondrial ROS production by JNK vs. JNK/PKC/p66Shc","display_name":"Regulation of mitochondrial ROS production by JNK vs. JNK/PKC/p66Shc","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W7051929111"},"language":"en","primary_location":{"id":"pmh:oai:diglib.uibk.ac.at/:6579499","doi":null,"is_oa":false,"landing_page_url":"https://resolver.obvsg.at/urn:nbn:at:at-ubi:1-95967","pdf_url":null,"source":{"id":"https://openalex.org/S4306401999","display_name":"Digital Library of the University of Innsbruck (University of Innsbruck)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143397708","host_organization_name":"Innsbruck Medical University","host_organization_lineage":["https://openalex.org/I143397708"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058960049","display_name":"Aleksandar Nikolajevic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nikolajevic, Aleksandar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058960049"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.24210000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.9470000267028809},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.8870000243186951},{"id":"https://openalex.org/keywords/p66shc","display_name":"p66Shc","score":0.925000011920929},{"id":"https://openalex.org/keywords/prkcb","display_name":"protein kinase C beta","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hyperosmotic-stress","display_name":"hyperosmotic stress","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sorbitol","display_name":"sorbitol","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mkk7","display_name":"MKK7","score":0.609000027179718},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7469000220298767},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7074000239372253},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6908000111579895},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6686000227928162},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.6679999828338623},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.44519999623298645},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4424999952316284},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4359999895095825},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.423799991607666},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4235000014305115},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4171999990940094},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.41110000014305115},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.40310001373291016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3946000039577484},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.37439998984336853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3714999854564667},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3580000102519989},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.351500004529953},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.29409998655319214},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.289900004863739},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.2669999897480011},{"id":"https://openalex.org/C3020761558","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Mitochondrial respiratory chain","level":3,"score":0.25850000977516174},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:diglib.uibk.ac.at/:6579499","doi":null,"is_oa":false,"landing_page_url":"https://resolver.obvsg.at/urn:nbn:at:at-ubi:1-95967","pdf_url":null,"source":{"id":"https://openalex.org/S4306401999","display_name":"Digital Library of the University of Innsbruck (University of Innsbruck)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143397708","host_organization_name":"Innsbruck Medical University","host_organization_lineage":["https://openalex.org/I143397708"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7066837887","https://openalex.org/W2032947455","https://openalex.org/W2253372330","https://openalex.org/W6986305071","https://openalex.org/W976106358","https://openalex.org/W2001006892","https://openalex.org/W164746271","https://openalex.org/W2062711706","https://openalex.org/W2379082489","https://openalex.org/W2520511949"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"are":[4,19,76,100],"important":[5],"signaling":[6],"molecules":[7],"in":[8,52,119,134],"normal":[9],"cell":[10,14,43,112],"physiology":[11],"that":[12],"promote":[13],"survival":[15],"and":[16,18,33,37,85,99],"proliferation":[17],"balanced":[20],"by":[21,60,71],"an":[22,129],"antioxidant":[23],"defense":[24],"system.":[25],"High":[26],"ROS":[27,56,93,161],"levels,":[28],"however,":[29],"exert":[30],"oxidative":[31],"stress":[32,188],"damage":[34],"proteins,":[35],"lipids,":[36],"DNA,":[38],"which":[39,108],"drives":[40,109],"cells":[41,90,98,185],"into":[42,111],"death.":[44,113],"The":[45],"MAPKs":[46],"JNK1/2":[47,208],"has":[48],"a":[49,105,116,135,149,225],"central":[50],"role":[51],"the":[53,63,74,78,120,126,141,144,170,177,221],"release":[54],"of":[55,62,80,122,128,137,143,172,179,198,211,224],"from":[57],"mitochondria,":[58],"either":[59],"phosphorylation":[61],"oxidoreductase":[64],"p66Shc":[65],"together":[66],"with":[67,181,200],"PKC\u03b2,":[68],"or":[69,157,176,214],"directly,":[70],"translocation":[72,171],"to":[73,96,104,153,174,186],"mitochondria.\\nROS":[75],"at":[77],"heart":[79],"many":[81],"pathologies":[82],"including":[83],"cancer":[84],"ischemia/reperfusion":[86],"injury":[87],"(IRI).":[88],"Cancer":[89],"exhibit":[91],"elevated":[92,206],"levels":[94,209],"compared":[95],"healthy":[97],"thus":[101],"more":[102],"susceptible":[103],"further":[106],"increase":[107,154],"them":[110],"IRI":[114],"is":[115],"major":[117],"problem":[118],"field":[121],"transplant":[123],"medicine":[124],"as":[125],"reperfusion":[127],"organ":[130],"after":[131],"ischemia":[132],"results":[133],"spike":[136],"ROS,":[138],"thereby":[139],"damaging":[140],"organ.\\nManipulation":[142],"JNK/p66Shc/PKC\u03b2":[145],"pathway":[146],"may":[147],"be":[148],"valuable":[150],"therapeutic":[151],"approach":[152],"(in":[155,159],"cancer)":[156],"decrease":[158],"IRI)":[160],"levels.\\nIn":[162],"this":[163],"thesis,":[164],"I":[165],"assessed":[166],"whether":[167],"PKC\u03b2":[168,201,212],"influenced":[169],"JNK":[173,180],"mitochondria":[175],"interaction":[178,196],"p66Shc.":[182],"Subjecting":[183],"HEK293T":[184],"hyperosmotic":[187],"via":[189],"sorbitol":[190],"had":[191,217],"no":[192,218],"effect":[193,219],"on":[194,220],"JNK-p66Shc":[195],"regardless":[197],"treatment":[199,204],"inhibitor.":[202],"Sorbitol":[203],"slightly":[205],"mitochondrial":[207],"independent":[210],"inhibition":[213],"activation":[215],"but":[216],"subcellular":[222],"localization":[223],"constitutively":[226],"active":[227],"MKK7-JNK":[228],"fusion":[229],"protein.":[230]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}