{"id":"https://openalex.org/W7051879689","doi":null,"title":"Pathogenetic mechanism of osteopenia in microgravity during space flight and its preventive/therapeutic measures","display_name":"Pathogenetic mechanism of osteopenia in microgravity during space flight and its preventive/therapeutic measures","publication_year":2001,"publication_date":"2001-12-25","ids":{"openalex":"https://openalex.org/W7051879689"},"language":"en","primary_location":{"id":"pmh:oai:repository.exst.jaxa.jp:a-is/39627","doi":null,"is_oa":false,"landing_page_url":"https://repository.exst.jaxa.jp/dspace/handle/a-is/39627","pdf_url":null,"source":{"id":"https://openalex.org/S4306400084","display_name":"JAXA Repository (JAXA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800865746","host_organization_name":"Japan Aerospace Exploration Agency","host_organization_lineage":["https://openalex.org/I2800865746"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Technical Report"},"volume":null,"type":"report","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038379833","display_name":"Yoshiki Seino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seino, Yoshiki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Matsumoto, Toshio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matsumoto, Toshio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Nakamura, Toshitaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nakamura, Toshitaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kato, Shigeaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kato, Shigeaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\u6e05\u91ce\u3000\u4f73\u7d00","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6e05\u91ce\u3000\u4f73\u7d00","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\u677e\u672c\u3000\u4fca\u592b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u677e\u672c\u3000\u4fca\u592b","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\u4e2d\u6751\u3000\u5229\u5b5d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4e2d\u6751\u3000\u5229\u5b5d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"\u52a0\u85e4\u3000\u8302\u660e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u52a0\u85e4\u3000\u8302\u660e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/spaceflight","display_name":"spaceflight","score":0.746999979019165},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.718999981880188},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9660000205039978},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.968999981880188},{"id":"https://openalex.org/keywords/osteoporosis-prevention","display_name":"osteoporosis prevention","score":0.6330000162124634},{"id":"https://openalex.org/keywords/osteoporosis-treatment","display_name":"osteoporosis treatment","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.8977000117301941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6367999911308289},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5496000051498413},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5263000130653381},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5033000111579895},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.436599999666214},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.3725000023841858},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.35350000858306885},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C37752432","wikidata":"https://www.wikidata.org/wiki/Q4299309","display_name":"Weightlessness","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C2911223091","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone Density Conservation Agents","level":4,"score":0.3073999881744385},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.26489999890327454},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2637999951839447},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25929999351501465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25780001282691956},{"id":"https://openalex.org/C2776169692","wikidata":"https://www.wikidata.org/wiki/Q4941552","display_name":"Bone disease","level":3,"score":0.2538999915122986},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repository.exst.jaxa.jp:a-is/39627","doi":null,"is_oa":false,"landing_page_url":"https://repository.exst.jaxa.jp/dspace/handle/a-is/39627","pdf_url":null,"source":{"id":"https://openalex.org/S4306400084","display_name":"JAXA Repository (JAXA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800865746","host_organization_name":"Japan Aerospace Exploration Agency","host_organization_lineage":["https://openalex.org/I2800865746"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Technical Report"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2283342841","https://openalex.org/W2145689197","https://openalex.org/W2373230753","https://openalex.org/W2419288115","https://openalex.org/W7015802094","https://openalex.org/W7099347230","https://openalex.org/W6997973503","https://openalex.org/W7097011407","https://openalex.org/W2065699183","https://openalex.org/W3141974255"],"abstract_inverted_index":{"Through":[0],"the":[1,17,66,83,108,111,129,138],"use":[2],"of":[3,19,36,58,68,85,113],"unloaded":[4],"hindlimb":[5],"models":[6],"in":[7,23],"which":[8],"mice":[9],"and":[10,30,46,99,119,133,136],"rats":[11],"were":[12,121],"suspended":[13],"by":[14,62],"their":[15,86],"tail,":[16],"effects":[18,112],"microgravity":[20],"on":[21,41],"bones":[22],"space":[24],"ware":[25],"investigated":[26],"to":[27,96],"develop":[28],"preventive":[29,98,132],"therapeutic":[31,100,134],"measures":[32,101],"for":[33,102],"osteopenia.":[34],"Pathogenesis":[35],"unloading-induced":[37],"osteopenia":[38,103],"is":[39,55,94,128],"based":[40],"early-stage":[42],"increased":[43],"bone":[44,49],"resorption":[45],"subsequent":[47],"decreased":[48],"formation.":[50],"In":[51,107],"other":[52],"words,":[53],"this":[54],"an":[56],"abnormality":[57],"cellular":[59],"differentiation":[60],"caused":[61],"information":[63],"transduction":[64],"via":[65],"mechanosensors":[67],"osteoblasts.":[69],"It":[70],"has":[71],"been":[72,90],"clarified":[73],"that":[74,126,137],"factors,":[75],"such":[76],"as":[77],"c-fos":[78],"gene,":[79],"are":[80,142],"involved,":[81],"but":[82],"details":[84],"involvement":[87],"have":[88],"not":[89],"clarified.":[91],"Furthermore,":[92],"it":[93],"imperative":[95],"establish":[97],"using":[104],"available":[105,140],"drugs.":[106],"present":[109],"study,":[110],"a":[114],"bisphosphonate":[115],"preparation,":[116],"IGF-I/IGFBP-3,":[117],"PTH":[118],"OCIF/OPG":[120,127],"investigated.":[122],"The":[123],"results":[124],"showed":[125],"most":[130],"promising":[131],"drug":[135],"currently":[139],"bisphosphonates":[141],"inadequate.":[143]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
