{"id":"https://openalex.org/W7048959889","doi":null,"title":"Microengineering Aligned Collagen Substrates In Microfluidic Systems","display_name":"Microengineering Aligned Collagen Substrates In Microfluidic Systems","publication_year":2022,"publication_date":"2022-08-15","ids":{"openalex":"https://openalex.org/W7048959889"},"language":"en","primary_location":{"id":"pmh:oai:repository.rit.edu:theses-12418","doi":null,"is_oa":false,"landing_page_url":"https://repository.rit.edu/theses/11293","pdf_url":null,"source":{"id":"https://openalex.org/S4306402456","display_name":"RIT Scholar Works (Rochester Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155173764","host_organization_name":"Rochester Institute of Technology","host_organization_lineage":["https://openalex.org/I155173764"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ahmed, Adeel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ahmed, Adeel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.15700000524520874,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.8230000138282776},{"id":"https://openalex.org/keywords/fiber-alignment","display_name":"fiber alignment","score":0.7630000114440918},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.800000011920929},{"id":"https://openalex.org/keywords/microfluidic-cell-culture","display_name":"microfluidic cell culture","score":0.8769999742507935},{"id":"https://openalex.org/keywords/extensional-flow","display_name":"extensional flow","score":0.824999988079071},{"id":"https://openalex.org/keywords/biofabrication","display_name":"biofabrication","score":0.6930000185966492},{"id":"https://openalex.org/keywords/nanomembranes","display_name":"nanomembranes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tissue-barriers","display_name":"tissue barriers","score":0.9190000295639038},{"id":"https://openalex.org/keywords/in-vitro-tissue-models","display_name":"in vitro tissue models","score":0.6330000162124634},{"id":"https://openalex.org/keywords/cell-matrix-interactions","display_name":"cell-matrix interactions","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2780609957","wikidata":"https://www.wikidata.org/wiki/Q108887885","display_name":"Biofabrication","level":3,"score":0.8086000084877014},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7739999890327454},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6333000063896179},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5566999912261963},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5070000290870667},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4480000138282776},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.43549999594688416},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40400001406669617},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.34689998626708984},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C163688615","wikidata":"https://www.wikidata.org/wiki/Q15883629","display_name":"3D cell culture","level":3,"score":0.3400000035762787},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3240000009536743},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.3125},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29339998960494995},{"id":"https://openalex.org/C2993784607","wikidata":"https://www.wikidata.org/wiki/Q40397","display_name":"Native tissue","level":3,"score":0.28439998626708984},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C165932988","wikidata":"https://www.wikidata.org/wiki/Q7101746","display_name":"Organ-on-a-chip","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.267300009727478},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2653000056743622}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.rit.edu:theses-12418","doi":null,"is_oa":false,"landing_page_url":"https://repository.rit.edu/theses/11293","pdf_url":null,"source":{"id":"https://openalex.org/S4306402456","display_name":"RIT Scholar Works (Rochester Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155173764","host_organization_name":"Rochester Institute of Technology","host_organization_lineage":["https://openalex.org/I155173764"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses","raw_type":"text"},{"id":"pmh:oai:scholarworks.rit.edu:theses-12418","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.rit.edu/theses/11293","pdf_url":null,"source":{"id":"https://openalex.org/S4306402456","display_name":"RIT Scholar Works (Rochester Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155173764","host_organization_name":"Rochester Institute of Technology","host_organization_lineage":["https://openalex.org/I155173764"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4295094155","https://openalex.org/W1995256515","https://openalex.org/W4283332445","https://openalex.org/W3135154129","https://openalex.org/W3034605101","https://openalex.org/W4389859492","https://openalex.org/W2346261452","https://openalex.org/W257798240","https://openalex.org/W2012128059","https://openalex.org/W2040346056"],"abstract_inverted_index":{"Cells":[0],"in":[1,83,90,182,211,246],"vivo":[2],"are":[3],"surrounded":[4],"by":[5],"a":[6,87,100,134,141,183,241],"fibrous":[7],"matrix":[8,16],"of":[9,18,42,133],"proteins":[10],"and":[11,44,52,56,69,97,125,195,199,213,229],"macromolecules":[12],"called":[13],"the":[14,24,60,130,168,224,233],"extracellular":[15],"(ECM),":[17],"which":[19],"type":[20],"I":[21],"collagen":[22,33,152,177],"is":[23,86,221],"major":[25],"constituent.":[26],"During":[27],"tissue":[28,215],"development":[29],"or":[30],"cell-matrix":[31],"interactions,":[32],"fibers":[34,47,64,156],"organize":[35],"into":[36,157,236],"aligned":[37,63,155],"domains":[38],"with":[39,154,190,249],"defined":[40],"degrees":[41],"alignment":[43,79,96,132],"directionality.":[45],"Aligned":[46],"guide":[48,65],"stem":[49],"cell":[50,57,67,81,112,123],"differentiation":[51],"influence":[53],"cell-cell":[54],"communication":[55],"motility.":[58],"In":[59],"tumor":[61,66],"microenvironment,":[62],"invasion":[68],"have":[70,107],"been":[71,108],"linked":[72],"to":[73,93,115,149,192,204,231,243],"poor":[74],"patient":[75],"outcomes.":[76],"Since":[77],"fiber":[78,95,131],"instructs":[80],"behavior":[82],"vivo,":[84],"there":[85],"need":[88],"for":[89,103,167],"vitro":[91,247],"models":[92,248],"replicate":[94],"thus":[98],"provide":[99,116,240],"relevant":[101],"microenvironment":[102],"cells.":[104],"Microfluidic":[105],"systems":[106],"established":[109],"as":[110],"advanced":[111],"culture":[113],"platforms":[114,189],"precise":[117],"control":[118],"over":[119],"soluble":[120],"factor":[121],"concentration,":[122],"patterning,":[124],"fluid":[126],"flow.":[127],"However,":[128],"controlling":[129],"3D":[135,151,176,197],"material":[136],"within":[137],"them":[138],"has":[139],"remained":[140],"challenge.":[142],"This":[143],"work":[144,164],"addresses":[145],"existing":[146],"technological":[147],"challenges":[148],"integrate":[150],"matrices":[153,178,235],"microfluidic":[158,188,237],"platforms.":[159],"To":[160],"do":[161],"so,":[162],"this":[163],"i)":[165],"Demonstrates":[166],"first":[169],"time":[170],"that":[171,223],"extensional":[172],"flows":[173],"can":[174],"align":[175],"(250":[179],"\u00b5m":[180],"thick)":[181],"microchannel,":[184],"ii)":[185],"Develops":[186,201],"modular":[187],"capabilities":[191,203,228],"directly":[193],"access":[194],"perfuse":[196],"collagen,":[198],"iii)":[200],"biofabrication":[202],"create":[205,214],"interfaces":[206],"between":[207],"different":[208],"ECM":[209,226],"materials":[210],"3D,":[212],"barriers":[216],"using":[217],"ultrathin":[218],"nanomembranes.":[219],"It":[220],"anticipated":[222],"novel":[225],"microengineering":[227],"approach":[230],"integrating":[232],"engineered":[234,250],"devices":[238],"will":[239],"path":[242],"develop":[244],"tissue-specific":[245],"matrices.":[251]},"counts_by_year":[],"updated_date":"2026-09-02T18:50:13.731487","created_date":"2025-10-10T00:00:00"}