{"id":"https://openalex.org/W7048727250","doi":null,"title":"Mechanisms of Selective Vulnerability in Alzheimer\u2019s Disease and Stress Disorders","display_name":"Mechanisms of Selective Vulnerability in Alzheimer\u2019s Disease and Stress Disorders","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W7048727250"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt20h9n5hg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/20h9n5hg","pdf_url":"https://escholarship.org/content/qt20h9n5hg/qt20h9n5hg.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/content/qt20h9n5hg/qt20h9n5hg.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089194486","display_name":"Alexander J. Ehrenberg","orcid":"https://orcid.org/0000-0003-4334-9424","observed_orcids":["https://orcid.org/0000-0003-4334-9424"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ehrenberg, Alexander James","raw_affiliation_strings":["Doctor of Philosophy in Integrative Biology University of California , Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctor of Philosophy in Integrative Biology University of California , Berkeley","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089194486"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selective-vulnerability","display_name":"selective vulnerability","score":0.9129999876022339},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/stress-disorders","display_name":"stress disorders","score":0.8080000281333923},{"id":"https://openalex.org/keywords/social-isolation","display_name":"social isolation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/risk-factors-for-dementia","display_name":"dementia risk factors","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ras-gtpase","display_name":"Ras GTPase","score":0.6890000104904175},{"id":"https://openalex.org/keywords/rhes","display_name":"Rhes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/farnesyltransferase-inhibitors","display_name":"farnesyltransferase inhibitors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.621999979019165},{"id":"https://openalex.org/keywords/blood-brain-barrier-dysfunction","display_name":"blood-brain barrier dysfunction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/renal-structure","display_name":"renal structure","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9860000014305115},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7760999798774719},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7127000093460083},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7092000246047974},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.6179999709129333},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5224000215530396},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.5117999911308289},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.508400022983551},{"id":"https://openalex.org/C16634123","wikidata":"https://www.wikidata.org/wiki/Q7551393","display_name":"Social stress","level":2,"score":0.4702000021934509},{"id":"https://openalex.org/C2776893239","wikidata":"https://www.wikidata.org/wiki/Q1778765","display_name":"Social isolation","level":2,"score":0.45719999074935913},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.4108999967575073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3984000086784363},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.382999986410141},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.37709999084472656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3637999892234802},{"id":"https://openalex.org/C137176749","wikidata":"https://www.wikidata.org/wiki/Q4105337","display_name":"Psychological resilience","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C3017459112","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter systems","level":3,"score":0.3310000002384186},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.28360000252723694},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25209999084472656},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt20h9n5hg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/20h9n5hg","pdf_url":"https://escholarship.org/content/qt20h9n5hg/qt20h9n5hg.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt20h9n5hg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/20h9n5hg","pdf_url":"https://escholarship.org/content/qt20h9n5hg/qt20h9n5hg.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G140313323","display_name":null,"funder_award_id":"SFB-1436","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1408388370","display_name":"Central noradrenergic mechanisms of cerebrovascular pathology in Alzheimer's disease","funder_award_id":"R01AG060731","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1442296065","display_name":null,"funder_award_id":"681712","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G1824949478","display_name":"Linking tau proteostasis with neuronal activity in FTD","funder_award_id":"U54NS100717","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G282710236","display_name":null,"funder_award_id":"P50 AG023501","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G2915930666","display_name":null,"funder_award_id":"P30AG066515","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3097568876","display_name":null,"funder_award_id":"CRC 1436","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3368099204","display_name":"Impact of locus coeruleus-derived tau pathology in a rodent model of early Alzheimer's disease","funder_award_id":"R01AG062581","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G33726220","display_name":null,"funder_award_id":"CRC 1315","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3810827041","display_name":null,"funder_award_id":"P50AG023501","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3823167960","display_name":"Deciphering the dynamic neural basis of cognition and dementia","funder_award_id":"1193857","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G4554393869","display_name":"Novel Biomarkers Related to Sleep-Wake Alterations in Alzheimer\u2019s disease","funder_award_id":"AACSF-21-723056","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G5659667262","display_name":"Characterizing sleep-wake activity patterns to detect early Alzheimer's disease in normal older individuals","funder_award_id":"F32AG074625","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5819994080","display_name":"AMP-AD Brain Proteomic Network Enhancement, Validation, and Translation into CSF Biomarkers","funder_award_id":"U01AG061357","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G598330366","display_name":"Local and global consequences of hyperphosphorylated tau in the locus coeruleus in Alzheimer's Disease","funder_award_id":"F31AG069502","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6002919618","display_name":"NiPARK - Neuromelanin in Parkinson - Neuromelanin Imaging in Substantia Nigra und Locus Coeruleus","funder_award_id":"01ED2102B","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G6972686313","display_name":"Does the central noradrenergic system play a role in agitation in Alzheimer's disease?","funder_award_id":"MR/S021418/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7473646402","display_name":null,"funder_award_id":"P30AG066511","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7553336952","display_name":null,"funder_award_id":"P30AG072931","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G787013686","display_name":null,"funder_award_id":"P30AG072931","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8134286188","display_name":"GRK 2413: Die alternde Synapse  molekulare, zellul\u00e4re und verhaltensbiologische Mechanismen des kognitiven Leistungsabfalls","funder_award_id":"362321501","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8339569982","display_name":null,"funder_award_id":"R01AG025340","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8342502279","display_name":null,"funder_award_id":"P50 AG023501","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G8650669854","display_name":null,"funder_award_id":"F32AG074625","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G8653344385","display_name":"What determines amyloid beta aggregation and toxicity in Alzheimer\u2019s disease?","funder_award_id":"2018-02532","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8849727358","display_name":"Emotion-cognition interactions and aging","funder_award_id":"R01AG025340","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G896486012","display_name":"SFB 1436: Neuronale Ressourcen der Kognition","funder_award_id":"425899996","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G9000867437","display_name":"TREAT AD","funder_award_id":"U54AG065187","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000876459","display_name":"Michigan Alzheimer's Disease Research Center","funder_award_id":"P30AG072931","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000887811","display_name":"Neuropathological changes underlying clinical heterogeneity in Alzheimer dise","funder_award_id":"K24AG053435","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000894250","display_name":"Stanford Alzheimer's Disease Research Center","funder_award_id":"P30AG066515","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000918277","display_name":"Goizueta Alzheimer's Disease Research Center","funder_award_id":"P30AG066511","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G912028991","display_name":"New Approaches to Dementia Heterogeneity","funder_award_id":"P50AG023501","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320309697","display_name":"Alzheimer's Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74"},{"id":"https://openalex.org/F4320310045","display_name":"BioClinica","ror":"https://ror.org/03t95yr58"},{"id":"https://openalex.org/F4320314158","display_name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","ror":null},{"id":"https://openalex.org/F4320315806","display_name":"Global Brain Health Institute","ror":"https://ror.org/058pagg05"},{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320966","display_name":"University of Sydney","ror":"https://ror.org/0384j8v12"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320322168","display_name":"Hj\u00e4rnfonden","ror":"https://ror.org/014btj409"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323421","display_name":"G\u00f6teborgs Universitet","ror":"https://ror.org/01tm6cn81"},{"id":"https://openalex.org/F4320325247","display_name":"Alzheimerfonden","ror":"https://ror.org/027ey5735"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320336501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7048727250.pdf","grobid_xml":"https://content.openalex.org/works/W7048727250.grobid-xml"},"referenced_works_count":472,"referenced_works":["https://openalex.org/W170792860","https://openalex.org/W201050536","https://openalex.org/W292445073","https://openalex.org/W638243159","https://openalex.org/W1489255022","https://openalex.org/W1511517753","https://openalex.org/W1527739960","https://openalex.org/W1530282405","https://openalex.org/W1570458334","https://openalex.org/W1581119831","https://openalex.org/W1585581652","https://openalex.org/W1591850964","https://openalex.org/W1601100579","https://openalex.org/W1619082318","https://openalex.org/W1639328427","https://openalex.org/W1745700293","https://openalex.org/W1764202216","https://openalex.org/W1897972863","https://openalex.org/W1912893579","https://openalex.org/W1914747759","https://openalex.org/W1915842929","https://openalex.org/W1932385070","https://openalex.org/W1947166207","https://openalex.org/W1963903389","https://openalex.org/W1966557786","https://openalex.org/W1966720966","https://openalex.org/W1967823816","https://openalex.org/W1967922486","https://openalex.org/W1969866648","https://openalex.org/W1969969013","https://openalex.org/W1970709955","https://openalex.org/W1971916872","https://openalex.org/W1974244275","https://openalex.org/W1976491350","https://openalex.org/W1979637191","https://openalex.org/W1980129559","https://openalex.org/W1982064952","https://openalex.org/W1982959887","https://openalex.org/W1983633543","https://openalex.org/W1984064067","https://openalex.org/W1984841332","https://openalex.org/W1986900475","https://openalex.org/W1987815136","https://openalex.org/W1990378025","https://openalex.org/W1992926845","https://openalex.org/W1993023011","https://openalex.org/W1993571512","https://openalex.org/W1993790483","https://openalex.org/W1993888368","https://openalex.org/W1994285647","https://openalex.org/W1995176921","https://openalex.org/W1995761975","https://openalex.org/W1997438162","https://openalex.org/W1998689450","https://openalex.org/W1998717932","https://openalex.org/W1999385317","https://openalex.org/W1999631936","https://openalex.org/W2000019377","https://openalex.org/W2001556203","https://openalex.org/W2003156240","https://openalex.org/W2003490123","https://openalex.org/W2006526695","https://openalex.org/W2007838707","https://openalex.org/W2007960303","https://openalex.org/W2010033808","https://openalex.org/W2010254632","https://openalex.org/W2012275909","https://openalex.org/W2013241878","https://openalex.org/W2014601504","https://openalex.org/W2015603515","https://openalex.org/W2016204025","https://openalex.org/W2016268789","https://openalex.org/W2017745936","https://openalex.org/W2017963575","https://openalex.org/W2019993493","https://openalex.org/W2020639755","https://openalex.org/W2021075309","https://openalex.org/W2021181758","https://openalex.org/W2021505439","https://openalex.org/W2021556801","https://openalex.org/W2023055592","https://openalex.org/W2023341761","https://openalex.org/W2023586735","https://openalex.org/W2023604436","https://openalex.org/W2024153799","https://openalex.org/W2024318433","https://openalex.org/W2026833609","https://openalex.org/W2027953236","https://openalex.org/W2028796198","https://openalex.org/W2029638099","https://openalex.org/W2030325164","https://openalex.org/W2030341081","https://openalex.org/W2032221178","https://openalex.org/W2032416844","https://openalex.org/W2033263510","https://openalex.org/W2033541440","https://openalex.org/W2034156357","https://openalex.org/W2034253186","https://openalex.org/W2035086406","https://openalex.org/W2035473397","https://openalex.org/W2036082581","https://openalex.org/W2036362108","https://openalex.org/W2037199684","https://openalex.org/W2038440451","https://openalex.org/W2042250149","https://openalex.org/W2043291430","https://openalex.org/W2043446752","https://openalex.org/W2044964176","https://openalex.org/W2045194716","https://openalex.org/W2046209489","https://openalex.org/W2048505725","https://openalex.org/W2050385623","https://openalex.org/W2050591554","https://openalex.org/W2052742260","https://openalex.org/W2054765812","https://openalex.org/W2054847095","https://openalex.org/W2054914622","https://openalex.org/W2056046302","https://openalex.org/W2056456976","https://openalex.org/W2056645008","https://openalex.org/W2057249855","https://openalex.org/W2059313736","https://openalex.org/W2059829298","https://openalex.org/W2059834473","https://openalex.org/W2061829356","https://openalex.org/W2064841852","https://openalex.org/W2065680172","https://openalex.org/W2067772208","https://openalex.org/W2068508628","https://openalex.org/W2068744836","https://openalex.org/W2068793916","https://openalex.org/W2070372815","https://openalex.org/W2070558694","https://openalex.org/W2071068165","https://openalex.org/W2072296425","https://openalex.org/W2072857392","https://openalex.org/W2073449985","https://openalex.org/W2074608237","https://openalex.org/W2074726646","https://openalex.org/W2075829479","https://openalex.org/W2076677696","https://openalex.org/W2077126737","https://openalex.org/W2078285509","https://openalex.org/W2079110285","https://openalex.org/W2079472731","https://openalex.org/W2081533023","https://openalex.org/W2082056883","https://openalex.org/W2083633251","https://openalex.org/W2083657833","https://openalex.org/W2084691768","https://openalex.org/W2086143621","https://openalex.org/W2086257980","https://openalex.org/W2087157508","https://openalex.org/W2087674088","https://openalex.org/W2088073770","https://openalex.org/W2088435426","https://openalex.org/W2090598204","https://openalex.org/W2091173932","https://openalex.org/W2091265794","https://openalex.org/W2092198587","https://openalex.org/W2093374391","https://openalex.org/W2095272243","https://openalex.org/W2095706901","https://openalex.org/W2103451408","https://openalex.org/W2103717170","https://openalex.org/W2104227586","https://openalex.org/W2104434501","https://openalex.org/W2105106206","https://openalex.org/W2106623141","https://openalex.org/W2107554012","https://openalex.org/W2109742329","https://openalex.org/W2109762957","https://openalex.org/W2110363556","https://openalex.org/W2111710089","https://openalex.org/W2111963393","https://openalex.org/W2112765817","https://openalex.org/W2113460545","https://openalex.org/W2113661629","https://openalex.org/W2114104545","https://openalex.org/W2115694724","https://openalex.org/W2115999215","https://openalex.org/W2116487401","https://openalex.org/W2117724162","https://openalex.org/W2117842413","https://openalex.org/W2118414216","https://openalex.org/W2121642311","https://openalex.org/W2121794894","https://openalex.org/W2122022552","https://openalex.org/W2123106337","https://openalex.org/W2124490243","https://openalex.org/W2124793782","https://openalex.org/W2126712529","https://openalex.org/W2128228199","https://openalex.org/W2128613449","https://openalex.org/W2129181278","https://openalex.org/W2129579709","https://openalex.org/W2129928127","https://openalex.org/W2130410032","https://openalex.org/W2130788353","https://openalex.org/W2131271579","https://openalex.org/W2135607950","https://openalex.org/W2136195493","https://openalex.org/W2137493959","https://openalex.org/W2138207763","https://openalex.org/W2139191670","https://openalex.org/W2139581971","https://openalex.org/W2139919351","https://openalex.org/W2142340251","https://openalex.org/W2143197557","https://openalex.org/W2144744859","https://openalex.org/W2145846347","https://openalex.org/W2145875022","https://openalex.org/W2146279957","https://openalex.org/W2146288660","https://openalex.org/W2147270524","https://openalex.org/W2148920966","https://openalex.org/W2150523249","https://openalex.org/W2156751516","https://openalex.org/W2157479079","https://openalex.org/W2158499654","https://openalex.org/W2158625734","https://openalex.org/W2160929668","https://openalex.org/W2161418391","https://openalex.org/W2163465004","https://openalex.org/W2164907650","https://openalex.org/W2165243546","https://openalex.org/W2166578434","https://openalex.org/W2167369519","https://openalex.org/W2168142135","https://openalex.org/W2168451388","https://openalex.org/W2168784140","https://openalex.org/W2169438314","https://openalex.org/W2169456326","https://openalex.org/W2169482634","https://openalex.org/W2171250577","https://openalex.org/W2172007938","https://openalex.org/W2180270433","https://openalex.org/W2182763281","https://openalex.org/W2191292005","https://openalex.org/W2214074259","https://openalex.org/W2217184110","https://openalex.org/W2228408383","https://openalex.org/W2253073911","https://openalex.org/W2255905287","https://openalex.org/W2276238108","https://openalex.org/W2285334294","https://openalex.org/W2288973352","https://openalex.org/W2290722071","https://openalex.org/W2324304235","https://openalex.org/W2334692654","https://openalex.org/W2353483402","https://openalex.org/W2368834918","https://openalex.org/W2401296772","https://openalex.org/W2407468727","https://openalex.org/W2411933725","https://openalex.org/W2414029203","https://openalex.org/W2414917913","https://openalex.org/W2432513713","https://openalex.org/W2443970079","https://openalex.org/W2469116017","https://openalex.org/W2474981734","https://openalex.org/W2509946342","https://openalex.org/W2511854837","https://openalex.org/W2513816257","https://openalex.org/W2513968848","https://openalex.org/W2522090547","https://openalex.org/W2550583173","https://openalex.org/W2551360963","https://openalex.org/W2558106912","https://openalex.org/W2560490590","https://openalex.org/W2561827989","https://openalex.org/W2580595955","https://openalex.org/W2581791236","https://openalex.org/W2582711285","https://openalex.org/W2584715077","https://openalex.org/W2588166475","https://openalex.org/W2588578683","https://openalex.org/W2590862290","https://openalex.org/W2593272302","https://openalex.org/W2600914407","https://openalex.org/W2603438402","https://openalex.org/W2603512642","https://openalex.org/W2615683585","https://openalex.org/W2621105275","https://openalex.org/W2697566149","https://openalex.org/W2736307756","https://openalex.org/W2736518852","https://openalex.org/W2737320535","https://openalex.org/W2738201977","https://openalex.org/W2743510904","https://openalex.org/W2754334814","https://openalex.org/W2755335783","https://openalex.org/W2755781951","https://openalex.org/W2757253955","https://openalex.org/W2760256027","https://openalex.org/W2761165738","https://openalex.org/W2761403875","https://openalex.org/W2762703026","https://openalex.org/W2765541445","https://openalex.org/W2766574891","https://openalex.org/W2766710068","https://openalex.org/W2768574326","https://openalex.org/W2774853246","https://openalex.org/W2776518474","https://openalex.org/W2778870674","https://openalex.org/W2779463443","https://openalex.org/W2782386660","https://openalex.org/W2782426568","https://openalex.org/W2782964505","https://openalex.org/W2785757836","https://openalex.org/W2788231085","https://openalex.org/W2788239274","https://openalex.org/W2788770082","https://openalex.org/W2789744248","https://openalex.org/W2789785835","https://openalex.org/W2793496929","https://openalex.org/W2794213781","https://openalex.org/W2794902985","https://openalex.org/W2795307842","https://openalex.org/W2796338238","https://openalex.org/W2797148904","https://openalex.org/W2797850641","https://openalex.org/W2798054687","https://openalex.org/W2802894191","https://openalex.org/W2806938337","https://openalex.org/W2808672296","https://openalex.org/W2883286350","https://openalex.org/W2884982789","https://openalex.org/W2889670296","https://openalex.org/W2890722904","https://openalex.org/W2891083286","https://openalex.org/W2895292592","https://openalex.org/W2897833719","https://openalex.org/W2897964327","https://openalex.org/W2898978953","https://openalex.org/W2899315813","https://openalex.org/W2900969253","https://openalex.org/W2901628123","https://openalex.org/W2904433122","https://openalex.org/W2904608802","https://openalex.org/W2907061143","https://openalex.org/W2909437563","https://openalex.org/W2909720409","https://openalex.org/W2909727019","https://openalex.org/W2911487980","https://openalex.org/W2914406193","https://openalex.org/W2914978827","https://openalex.org/W2917353757","https://openalex.org/W2920879061","https://openalex.org/W2922673442","https://openalex.org/W2930394955","https://openalex.org/W2930696305","https://openalex.org/W2936761577","https://openalex.org/W2945016564","https://openalex.org/W2945672356","https://openalex.org/W2947261250","https://openalex.org/W2947548179","https://openalex.org/W2947686928","https://openalex.org/W2949287877","https://openalex.org/W2951101464","https://openalex.org/W2951632985","https://openalex.org/W2952571973","https://openalex.org/W2955273706","https://openalex.org/W2960000700","https://openalex.org/W2962856946","https://openalex.org/W2962866038","https://openalex.org/W2964104722","https://openalex.org/W2964207048","https://openalex.org/W2966365568","https://openalex.org/W2966973684","https://openalex.org/W2968114260","https://openalex.org/W2970598652","https://openalex.org/W2973222021","https://openalex.org/W2974165126","https://openalex.org/W2991594523","https://openalex.org/W2994094700","https://openalex.org/W2996576044","https://openalex.org/W2996856743","https://openalex.org/W2996924909","https://openalex.org/W2998707549","https://openalex.org/W2999565359","https://openalex.org/W2999676104","https://openalex.org/W2999746599","https://openalex.org/W3003229257","https://openalex.org/W3003649076","https://openalex.org/W3012115896","https://openalex.org/W3014452068","https://openalex.org/W3014634065","https://openalex.org/W3015939805","https://openalex.org/W3017272163","https://openalex.org/W3020271498","https://openalex.org/W3021718540","https://openalex.org/W3022036300","https://openalex.org/W3022217792","https://openalex.org/W3023302320","https://openalex.org/W3026387273","https://openalex.org/W3029222706","https://openalex.org/W3032994313","https://openalex.org/W3033976765","https://openalex.org/W3036273457","https://openalex.org/W3037385322","https://openalex.org/W3046275966","https://openalex.org/W3080123676","https://openalex.org/W3080585412","https://openalex.org/W3081941335","https://openalex.org/W3087653928","https://openalex.org/W3087918403","https://openalex.org/W3088697308","https://openalex.org/W3096204394","https://openalex.org/W3099862724","https://openalex.org/W3103859840","https://openalex.org/W3105079918","https://openalex.org/W3109942090","https://openalex.org/W3115671335","https://openalex.org/W3118272853","https://openalex.org/W3118587845","https://openalex.org/W3119202142","https://openalex.org/W3119674414","https://openalex.org/W3122490275","https://openalex.org/W3127198840","https://openalex.org/W3128414088","https://openalex.org/W3128463973","https://openalex.org/W3128594382","https://openalex.org/W3128971382","https://openalex.org/W3129061869","https://openalex.org/W3129272705","https://openalex.org/W3137160884","https://openalex.org/W3155821888","https://openalex.org/W3157539143","https://openalex.org/W3158474553","https://openalex.org/W3165690917","https://openalex.org/W3175286193","https://openalex.org/W3176015489","https://openalex.org/W3177020682","https://openalex.org/W3178776770","https://openalex.org/W3185007021","https://openalex.org/W3185155433","https://openalex.org/W3188845746","https://openalex.org/W3196018552","https://openalex.org/W3197493611","https://openalex.org/W3198144395","https://openalex.org/W3200392321","https://openalex.org/W3200931809","https://openalex.org/W3203440541","https://openalex.org/W3207033364","https://openalex.org/W3208259794","https://openalex.org/W3209164798","https://openalex.org/W3210549523","https://openalex.org/W3214337982","https://openalex.org/W4200607102","https://openalex.org/W4205640083","https://openalex.org/W4205971586","https://openalex.org/W4206015401","https://openalex.org/W4212983870","https://openalex.org/W4213182639","https://openalex.org/W4220785951","https://openalex.org/W4229925091","https://openalex.org/W4233641204","https://openalex.org/W4236773017","https://openalex.org/W4280537675","https://openalex.org/W4281615287","https://openalex.org/W4281790364","https://openalex.org/W4281857487","https://openalex.org/W4284675681","https://openalex.org/W4285132881","https://openalex.org/W4289766535","https://openalex.org/W4316371712","https://openalex.org/W4319078243","https://openalex.org/W4380152220","https://openalex.org/W4386214266","https://openalex.org/W4388728640","https://openalex.org/W4391575659"],"related_works":["https://openalex.org/W4407744924","https://openalex.org/W2042396829","https://openalex.org/W1823703999","https://openalex.org/W7153048349","https://openalex.org/W4383500582","https://openalex.org/W4386929608","https://openalex.org/W4409955334","https://openalex.org/W2998469511","https://openalex.org/W2714388496","https://openalex.org/W2148251113"],"abstract_inverted_index":{"To":[0],"date,":[1],"neurodegenerative":[2,294,323],"diseases":[3,83,324],"remain":[4],"with":[5,95,121,152],"lackluster":[6],"treatment":[7],"options.":[8],"Diseases":[9],"such":[10],"as":[11,56],"Alzheimer\u2019s":[12,245],"are":[13,114,124,137,241],"defined":[14],"based":[15],"on":[16,170,230,287,298,302],"proteinopathic":[17,154,193],"inclusions,":[18],"and":[19,80,104,129,203,247,255,265,296,325],"these":[20,35],"inclusions":[21,36,155,194],"have":[22],"been":[23],"the":[24,70,122,183,231,237,270,278,288,311],"targets":[25],"of":[26,73,141,160,172,210,236,252,318,328],"most":[27],"therapeutic":[28],"development.":[29],"The":[30,157],"premise":[31],"that":[32,135,182,214,274,320],"simply":[33],"addressing":[34],"will":[37],"be":[38],"sufficient":[39],"for":[40,78],"therapeutics":[41],"is":[42,165,187],"poorly":[43],"supported.":[44],"Here,":[45,179,257],"I":[46,68,133,144,180,223,258,283],"attempt":[47],"to":[48,59,110,262,269,292],"build":[49],"an":[50],"evidence":[51,317],"base":[52],"using":[53],"selective":[54,226,253,303],"vulnerability":[55,227,254,304],"a":[57,74,138,146,215,249,300],"substrate":[58],"work":[60,206],"towards":[61],"more":[62,279],"biologically":[63],"informed":[64],"disease-modifying":[65],"therapeutics.":[66,178],"First,":[67],"examine":[69,145],"physiological":[71],"underpinnings":[72],"potent":[75],"risk":[76],"factor":[77],"dementia":[79],"other":[81],"age-related":[82],"\u2013":[84],"social":[85,89,112,142],"isolation.":[86],"In":[87],"humans,":[88],"isolation":[90,113],"has":[91],"well-established":[92],"epidemiological":[93],"associations":[94],"dementia,":[96],"cardiovascular":[97],"disease,":[98],"immune":[99],"system":[100,240],"dysfunction,":[101],"metabolic":[102],"disorders,":[103],"mental":[105],"health":[106],"disorders.":[107,330],"Mice":[108],"exposed":[109],"long-term":[111],"studied":[115],"across":[116],"several":[117],"organ":[118],"systems.":[119],"Associations":[120],"stressor":[123],"detected":[125],"in":[126,163,189,195,201,204,208,221,244,310],"renal":[127],"structure":[128],"blood-brain-barrier":[130],"dysfunction;":[131],"however,":[132],"find":[134,181,259],"mice":[136],"poor":[139],"model":[140],"isolation.Next,":[143],"potential":[147],"mechanism":[148],"underlying":[149],"why":[150],"neurons":[151,190],"tau":[153,192],"die.":[156],"best":[158],"correlate":[159],"functional":[161],"decline":[162],"neurodegeneration":[164,220],"neuron":[166,173],"loss,":[167],"so":[168],"focusing":[169,229,286],"processes":[171],"loss":[174],"might":[175],"confer":[176],"better":[177],"Ras":[184],"GTPase,":[185],"Rhes,":[186],"dysregulated":[188],"harboring":[191],"sporadic":[196],"tauopathies.":[197,222],"This":[198],"study":[199,293],"reinforces":[200],"vitro":[202],"vivo":[205],"done":[207],"models":[209],"familial":[211],"tauopathy":[212],"demonstrating":[213],"farnesyltransferase":[216],"inhibitor":[217],"may":[218,305,321],"suppress":[219],"then":[224],"approach":[225],"by":[228,285],"neuromodulatory":[232,238],"subcortical":[233,239],"system.":[234],"Parts":[235],"affected":[242],"early":[243],"disease":[246,295],"feature":[248],"wide":[250],"gradient":[251],"resilience.":[256],"pathways":[260],"related":[261],"cholesterol":[263],"homeostasis":[264],"stress":[266,329],"hormone":[267],"signaling":[268],"noradrenergic":[271],"locus":[272],"coeruleus":[273],"differentiate":[275],"it":[276],"from":[277],"resilient":[280],"substantia":[281],"nigra.":[282],"close":[284],"epistemological":[289],"frameworks":[290],"used":[291],"comment":[297],"how":[299],"focus":[301],"drive":[306,322],"significant":[307],"paradigm":[308],"changes":[309],"field.":[312],"Overall,":[313],"this":[314],"dissertation":[315],"provides":[316],"pathophysiology":[319],"adverse":[326],"outcomes":[327]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
