{"id":"https://openalex.org/W7048126337","doi":null,"title":"Investigating the Effects of a Small-Molecule Allosteric Inhibitor of Core-Binding Factor Subunit Beta in Human Osteosarcoma","display_name":"Investigating the Effects of a Small-Molecule Allosteric Inhibitor of Core-Binding Factor Subunit Beta in Human Osteosarcoma","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W7048126337"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt1604w98d","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1604w98d","pdf_url":"https://escholarship.org/content/qt1604w98d/qt1604w98d.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/content/qt1604w98d/qt1604w98d.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008737769","display_name":"Dayn R. Godinez","orcid":"https://orcid.org/0000-0001-6072-368X","observed_orcids":["https://orcid.org/0000-0001-6072-368X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Godinez, Dayn Romero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008737769"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/core-binding-factor-beta","display_name":"core binding factor beta","score":0.7789999842643738},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/allosteric-inhibitors","display_name":"allosteric inhibitors","score":0.7879999876022339},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6809999942779541},{"id":"https://openalex.org/keywords/transcription-factor-heterodimer","display_name":"transcription factor heterodimer","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.46299999952316284},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.6019999980926514},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.621999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6769999861717224},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8119999766349792},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.7768999934196472},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.7360000014305115},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6848999857902527},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.678600013256073},{"id":"https://openalex.org/C2778220731","wikidata":"https://www.wikidata.org/wiki/Q5170186","display_name":"Core binding factor","level":4,"score":0.6592000126838684},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5706999897956848},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.47909998893737793},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46369999647140503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4404999911785126},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4293999969959259},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4189999997615814},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.40939998626708984},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3882000148296356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3693000078201294},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.365200012922287},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.32350000739097595},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3100000023841858},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C83730767","wikidata":"https://www.wikidata.org/wiki/Q24778884","display_name":"G alpha subunit","level":4,"score":0.2662000060081482},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2590999901294708},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.25290000438690186},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt1604w98d","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1604w98d","pdf_url":"https://escholarship.org/content/qt1604w98d/qt1604w98d.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt1604w98d","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1604w98d","pdf_url":"https://escholarship.org/content/qt1604w98d/qt1604w98d.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7048126337.pdf","grobid_xml":"https://content.openalex.org/works/W7048126337.grobid-xml"},"referenced_works_count":221,"referenced_works":["https://openalex.org/W186831022","https://openalex.org/W1504043030","https://openalex.org/W1546186502","https://openalex.org/W1547298604","https://openalex.org/W1557915648","https://openalex.org/W1562934832","https://openalex.org/W1586577566","https://openalex.org/W1637594623","https://openalex.org/W1709815505","https://openalex.org/W1963955574","https://openalex.org/W1964152102","https://openalex.org/W1967251768","https://openalex.org/W1971391892","https://openalex.org/W1972836732","https://openalex.org/W1977898942","https://openalex.org/W1979552083","https://openalex.org/W1980416049","https://openalex.org/W1982303400","https://openalex.org/W1983811810","https://openalex.org/W1984448141","https://openalex.org/W1984858176","https://openalex.org/W1985164472","https://openalex.org/W1987604182","https://openalex.org/W1987644911","https://openalex.org/W1992008830","https://openalex.org/W1992628946","https://openalex.org/W1993251792","https://openalex.org/W1994461451","https://openalex.org/W1997812904","https://openalex.org/W1997886758","https://openalex.org/W1999608828","https://openalex.org/W2000254314","https://openalex.org/W2000706451","https://openalex.org/W2003247578","https://openalex.org/W2003404796","https://openalex.org/W2003454650","https://openalex.org/W2003946870","https://openalex.org/W2004905158","https://openalex.org/W2007248571","https://openalex.org/W2009727781","https://openalex.org/W2013580179","https://openalex.org/W2016464448","https://openalex.org/W2019998985","https://openalex.org/W2020404858","https://openalex.org/W2021484300","https://openalex.org/W2028169159","https://openalex.org/W2030150987","https://openalex.org/W2030503662","https://openalex.org/W2033707323","https://openalex.org/W2046610941","https://openalex.org/W2048462242","https://openalex.org/W2051652408","https://openalex.org/W2052488462","https://openalex.org/W2053734323","https://openalex.org/W2057843847","https://openalex.org/W2058998284","https://openalex.org/W2071003879","https://openalex.org/W2077273625","https://openalex.org/W2080073306","https://openalex.org/W2081098333","https://openalex.org/W2085309186","https://openalex.org/W2086675262","https://openalex.org/W2090807626","https://openalex.org/W2096105973","https://openalex.org/W2097380204","https://openalex.org/W2097386768","https://openalex.org/W2098491485","https://openalex.org/W2099540110","https://openalex.org/W2100303227","https://openalex.org/W2100378516","https://openalex.org/W2103017472","https://openalex.org/W2105801209","https://openalex.org/W2107018762","https://openalex.org/W2111296429","https://openalex.org/W2112519107","https://openalex.org/W2120672212","https://openalex.org/W2123106337","https://openalex.org/W2123657323","https://openalex.org/W2124361787","https://openalex.org/W2125028197","https://openalex.org/W2127748864","https://openalex.org/W2130410032","https://openalex.org/W2132288466","https://openalex.org/W2132834292","https://openalex.org/W2137526110","https://openalex.org/W2141224543","https://openalex.org/W2144701866","https://openalex.org/W2146512944","https://openalex.org/W2147380886","https://openalex.org/W2148114118","https://openalex.org/W2154165826","https://openalex.org/W2155302632","https://openalex.org/W2156503775","https://openalex.org/W2156661861","https://openalex.org/W2156920440","https://openalex.org/W2157003991","https://openalex.org/W2159859242","https://openalex.org/W2161985793","https://openalex.org/W2162098634","https://openalex.org/W2169456326","https://openalex.org/W2214074259","https://openalex.org/W2235951706","https://openalex.org/W2292856360","https://openalex.org/W2317055602","https://openalex.org/W2317965794","https://openalex.org/W2334406698","https://openalex.org/W2337363956","https://openalex.org/W2342096321","https://openalex.org/W2343873789","https://openalex.org/W2399480124","https://openalex.org/W2418677774","https://openalex.org/W2473902344","https://openalex.org/W2512459060","https://openalex.org/W2593204081","https://openalex.org/W2617024351","https://openalex.org/W2623154658","https://openalex.org/W2738987172","https://openalex.org/W2751023845","https://openalex.org/W2762927830","https://openalex.org/W2789054899","https://openalex.org/W2790289324","https://openalex.org/W2790925099","https://openalex.org/W2793063263","https://openalex.org/W2799281626","https://openalex.org/W2804828062","https://openalex.org/W2811434284","https://openalex.org/W2883006170","https://openalex.org/W2890741641","https://openalex.org/W2891508711","https://openalex.org/W2909440457","https://openalex.org/W2913130244","https://openalex.org/W2913276036","https://openalex.org/W2936982636","https://openalex.org/W2937147758","https://openalex.org/W2941500297","https://openalex.org/W2943078804","https://openalex.org/W2943771149","https://openalex.org/W2948356525","https://openalex.org/W2952109315","https://openalex.org/W2965876955","https://openalex.org/W2967174732","https://openalex.org/W2969718750","https://openalex.org/W2979778527","https://openalex.org/W2981164020","https://openalex.org/W2981655388","https://openalex.org/W2988641336","https://openalex.org/W2990881755","https://openalex.org/W2995108535","https://openalex.org/W2996232679","https://openalex.org/W2996637491","https://openalex.org/W2999764612","https://openalex.org/W3002867676","https://openalex.org/W3010714573","https://openalex.org/W3012443934","https://openalex.org/W3015552325","https://openalex.org/W3021687736","https://openalex.org/W3024378081","https://openalex.org/W3039038988","https://openalex.org/W3039574079","https://openalex.org/W3049537661","https://openalex.org/W3083818914","https://openalex.org/W3084401096","https://openalex.org/W3087198975","https://openalex.org/W3103641075","https://openalex.org/W3110998212","https://openalex.org/W3112600195","https://openalex.org/W3119799492","https://openalex.org/W3136375955","https://openalex.org/W3138793515","https://openalex.org/W3150529164","https://openalex.org/W3159727437","https://openalex.org/W3162159726","https://openalex.org/W3165251159","https://openalex.org/W3171662715","https://openalex.org/W3173984402","https://openalex.org/W3176540806","https://openalex.org/W3183384356","https://openalex.org/W3191998012","https://openalex.org/W3193636802","https://openalex.org/W3194524617","https://openalex.org/W3199192392","https://openalex.org/W3199246615","https://openalex.org/W3202360414","https://openalex.org/W3203848352","https://openalex.org/W3215596355","https://openalex.org/W3215845635","https://openalex.org/W4200608463","https://openalex.org/W4206024274","https://openalex.org/W4210762403","https://openalex.org/W4211225392","https://openalex.org/W4214721375","https://openalex.org/W4221038703","https://openalex.org/W4223601055","https://openalex.org/W4223949287","https://openalex.org/W4224048998","https://openalex.org/W4281693500","https://openalex.org/W4283587154","https://openalex.org/W4283757418","https://openalex.org/W4285798115","https://openalex.org/W4294751350","https://openalex.org/W4294862129","https://openalex.org/W4295455964","https://openalex.org/W4296995699","https://openalex.org/W4307425304","https://openalex.org/W4308445935","https://openalex.org/W4313366903","https://openalex.org/W4313857047","https://openalex.org/W4319983173","https://openalex.org/W4320896752","https://openalex.org/W4321600870","https://openalex.org/W4327616128","https://openalex.org/W4327920776","https://openalex.org/W4379875529","https://openalex.org/W4381431441","https://openalex.org/W4383105860","https://openalex.org/W4383312745","https://openalex.org/W4385212135","https://openalex.org/W4386708615","https://openalex.org/W4386711796","https://openalex.org/W4386823765","https://openalex.org/W4389257684"],"related_works":["https://openalex.org/W4225411544","https://openalex.org/W2965876955","https://openalex.org/W7056160305","https://openalex.org/W4225402622","https://openalex.org/W4389227784","https://openalex.org/W2560379530","https://openalex.org/W2339403455","https://openalex.org/W2090316627","https://openalex.org/W2021720178","https://openalex.org/W2033498402"],"abstract_inverted_index":{"ABSTRACT":[0],"OF":[1],"DISSERTATIONInvestigating":[2],"the":[3,21,47,65,146,161,178,197,235,245,251,257,285,306,313,424,498,513,543,591,612,623,628,667,726,729,746,756,794,808,819,841,869,883,943,946,987,1003],"Effects":[4],"of":[5,10,68,80,96,140,148,181,199,215,247,253,256,312,322,343,383,389,482,515,520,558,577,588,637,653,670,702,710,722,779,783,791,800,843,871,945,955,957,990,1006,1016,1024],"a":[6,75,128,167,213,319,392,536,580,698,707,811,833],"Small-Molecule":[7],"Allosteric":[8],"Inhibitor":[9],"Core-Binding":[11],"Factor":[12,73,260],"Subunit":[13],"Beta":[14],"in":[15,28,42,58,112,131,170,192,204,300,310,325,331,370,418,423,570,602,627,629,635,651,677,713,725,731,745,755,771,793,807,882,902,921,928,937,960,996,1000,1022],"Human":[16],"Osteosarcoma":[17,18],"(OS)":[19],"is":[20,64,74,110,607,848],"most":[22,301],"common":[23],"primary":[24],"malignant":[25,179],"bone":[26,100,105],"tumor":[27],"humans,":[29],"however,":[30],"there":[31,951],"have":[32,894],"been":[33],"no":[34,386],"new":[35],"successful":[36,864],"therapies":[37],"that":[38,93,174,399,532,556,575,620,663,799,832,896,910,925,984,1012],"improve":[39],"long-term":[40],"survival":[41,887],"several":[43],"decades.":[44],"This":[45,133,740,846,949],"indicates":[46],"need":[48],"for":[49,54,453,690,748,860],"novel":[50],"therapeutics":[51],"and":[52,87,104,121,150,163,189,194,226,263,297,328,354,360,364,395,402,411,427,449,455,466,471,484,491,510,560,574,618,640,659,672,685,693,785,803,823,854,879,916,992,1020],"targets":[53],"treating":[55],"OS,":[56,961],"particularly":[57],"reducing":[59,153],"its":[60,767,1014],"metastatic":[61,674,813,880],"potential":[62,675],"which":[63,115,962],"leading":[66],"cause":[67],"osteosarcoma-related":[69],"deaths.":[70],"Core":[71,258],"Binding":[72,259],"heterodimeric":[76],"transcriptional":[77,504,538],"complex,":[78],"comprised":[79],"proteins":[81],"runt-related":[82],"transcription":[83,95,909],"factor":[84,89],"2":[85],"(RUNX2)":[86],"core-binding":[88],"subunit":[90],"beta":[91],"(CBFb),":[92],"promotes":[94],"genes":[97,619,654],"related":[98],"to":[99,117,144,156,159,243,337,501,511,542,611,798,830,857,964,972],"formation,":[101],"osteoblast":[102],"differentiation,":[103,123],"mineralization.":[106],"RUNX2":[107,149,154,164,223,469,578,606],"protein":[108],"expression":[109,478,568,585,652],"deregulated":[111],"OS":[113,183,217,904,931],"tumors":[114],"contributes":[116],"chemoresistance,":[118],"increased":[119],"proliferation,":[120],"defective":[122],"suggesting":[124,432],"it":[125],"could":[126,980],"be":[127,858,874,965,970,973],"therapeutic":[129],"target":[130,157,169,944],"OS.":[132,171,1025],"study":[134,847,979],"utilizes":[135],"small":[136],"molecule":[137],"allosteric":[138],"inhibitor":[139,508,516,522,533,1005],"CBFb,":[141,151,1007],"AI-14-":[142,290,340],"91,":[143],"disrupt":[145],"interaction":[147,165],"thereby":[152],"binding":[155],"genes,":[158],"evaluate":[160,502],"CBFb":[162,227,472,544,559,941],"as":[166,316,414,416,633,656,760],"pharmacological":[168],"We":[172],"hypothesized":[173],"AI-14-91":[175,248,276,304,346,452,565,592,671,705,723,792,838,872,897,926,991],"will":[176,855],"reduce":[177,196,840],"phenotype":[180],"human":[182,216,930],"cell":[184,200,218,229,273,302,307,314,323,366,419,430,474,546,638,642,718,821,905,932],"lines,":[185,274,431,906],"show":[186],"favorable":[187,918],"pharmacokinetic":[188,686,919],"pharmacodynamic":[190],"qualities":[191],"vivo,":[193],"effectively":[195],"development":[198,867],"line-derived":[201],"xenografts":[202],"(CDXs)":[203],"vivo.":[205,922],"In":[206,590],"vitro":[207,630,732],"cell-based":[208],"assays":[209,268,288],"were":[210,231,269,368,421,497,664,717,773,828,934],"performed":[211,270,440,500],"with":[212,221,271,318,349,357,447,462,518,564,609,775,837,886],"panel":[214],"lines":[219,230,315,547,933],"treated":[220,446,461,550],"AI-14-91.":[222],"knockout":[224,519],"(KO)":[225],"KO":[228,429,470,473,545],"also":[232,935],"generated":[233],"from":[234,280],"parental":[236,442],"U2OS":[237,371,403,425,443,458,571,678,938],"wild-type":[238],"(WT)":[239],"by":[240,345,374,379,507,648,876],"CRISPR/Cas9":[241],"editing,":[242],"compare":[244,512],"effects":[246,413,514,625,924],"treatment":[249,292,517,534,563,835],"versus":[250,593],"loss":[252,557,576,587],"each":[254],"component":[255],"complex.":[261],"Concentration-":[262],"time-":[264],"ii":[265],"dependent":[266],"proliferation":[267],"all":[272],"demonstrating":[275],"IC50":[277,733],"values":[278,689,734],"ranging":[279],"approximately":[281],"13-25":[282],"\u03bcM":[283,339,451,765],"across":[284],"panel.":[286],"Clonogenic":[287],"showed":[289,385,531,600],"91":[291],"significantly":[293],"reduced":[294,406,673],"colony":[295,298],"formation":[296],"size":[299],"lines.":[303,475],"disrupted":[305],"cycle":[308,420],"progression":[309],"some":[311],"well":[317,415],"significant":[320,387],"decrease":[321],"number":[324],"G0/G1":[326],"phase":[327,333],"an":[329,776],"increase":[330],"S":[332],"upon":[334],"48-hour":[335],"exposure":[336],"20":[338,450],"91.":[341],"Induction":[342],"apoptosis":[344],"was":[347,439,743,758,796],"quantified":[348],"caspase-3/-7":[350],"activity":[351],"fluorometric":[352],"assay":[353,397],"western":[355],"blotting":[356],"cleaved":[358,361],"caspase-3":[359],"PARP-1.":[362],"Apoptotic":[363],"necrotic":[365],"populations":[367],"evaluated":[369,875],"WT":[372,426,444,459,572,679],"cells":[373,404,445,460,573,939],"annexin":[375],"V/PI":[376],"staining":[377],"analyzed":[378],"flow":[380],"cytometry.":[381],"All":[382],"these":[384,891,913],"induction":[388],"apoptosis.":[390],"Lastly,":[391,681],"transwell":[393],"invasion":[394],"migration":[396,639],"demonstrated":[398,895],"AI-14-91-treated":[400],"LM7":[401,820],"had":[405,579],"invasive":[407],"ability.":[408],"These":[409,644,661],"anti-proliferative":[410],"-clonogenic":[412],"disruptions":[417],"seen":[422,626,676,744,774,936],"both":[428,691],"off-target":[433],"effects.":[434],"Batch":[435],"3\u2019":[436],"Tag-Seq":[437],"RNA-seq":[438,524],"on":[441,467,527,583],"5":[448],"6":[454],"48":[456],"hours,":[457],"DMSO":[463,549,595],"vehicle":[464],"control,":[465],"untreated":[468],"Differential":[476],"gene":[477,584,908],"(DGE),":[479],"Kyoto":[480],"Encyclopedia":[481],"Genes":[483],"Genomes":[485],"(KEGG)":[486],"pathway,":[487],"Gene":[488,492],"Ontology":[489],"(GO),":[490],"Set":[493],"Enrichment":[494],"Analysis":[495],"(GSEA)":[496],"analyses":[499],"pertinent":[503],"pathways":[505,604,634,662],"altered":[506,665],"treatment,":[509],"putative":[521],"targets.":[523],"data":[525],"plotted":[526],"multidimensional":[528],"scaling":[529],"plots":[530],"produced":[535,566],"unique":[537,567],"profile":[539],"when":[540],"compared":[541],"or":[548],"cells.":[551,680],"The":[552,752,789,923],"DGE":[553],"analysis":[554,599,615],"revealed":[555],"6-":[561],"hour":[562,750],"changes":[569,650],"smaller":[581],"effect":[582],"than":[586],"CBFb.":[589],"iii":[594],"comparison,":[596],"KEGG":[597],"pathway":[598],"enrichment":[601],"cancer":[603],"where":[605],"associated":[608],"metastasis":[610],"bone.":[613],"GO":[614],"highlighted":[616],"terms":[617],"would":[621,873,911],"support":[622,666,912],"anti-tumor":[624,668,900,1018],"experiments":[631],"such":[632,655],"regulation":[636],"mitotic":[641],"cycle.":[643],"are":[645,952],"further":[646,985,1010],"supported":[647],"specific":[649],"CDKN1C,":[657],"BRINP1":[658],"BMP4.":[660],"properties":[669,901,989],"we":[682,827,893],"determined":[683,730],"concentrations":[684,721],"(PK)":[687],"parameter":[688],"serum":[692,795],"lung":[694,757,884],"tissue":[695],"samples":[696],"after":[697],"single":[699],"intraperitoneal":[700],"injection":[701],"100":[703],"mg/kg":[704],"over":[706],"time":[708,778,853],"course":[709],"0-24":[711],"hours":[712,806],"nude":[714,815],"mice.":[715,1001],"There":[716],"line":[719,822],"growth-inhibiting":[720],"found":[724],"blood,":[727],"exceeding":[728],"(the":[735],"highest":[736],"being":[737],"23":[738],"\u03bcM).":[739],"effective":[741],"concentration":[742,754,772,781],"blood":[747],"1":[749],"post-injection.":[751],"measured":[753],"not":[759],"high":[761],"but":[762,968],"reached":[763],"10":[764,805],"at":[766,851],"peak.":[768],"Both":[769],"peaks":[770],"early":[777],"peak":[780],"(Tmax)":[782],"15":[784],"30":[786],"min,":[787],"respectively.":[788],"half-life":[790],"comparable":[797],"published":[801],"literature":[802],"exceeded":[804],"lung.":[809],"With":[810],"pulmonary":[812,997],"CDX":[814,844,861,866,998],"mouse":[816],"model":[817],"utilizing":[818],"live":[824],"bioluminescent":[825,877],"imaging,":[826],"unable":[829],"demonstrate":[831],"6-day":[834],"period":[836],"can":[839],"rate":[842],"growth.":[845],"still":[849],"ongoing":[850],"this":[852,958,977,994],"continue":[856],"monitored":[859],"development.":[862],"If":[863],"future":[865,982],"occurs,":[868],"efficacy":[870,1021],"signal":[878],"burden":[881],"along":[885],"curve":[888],"analysis.":[889],"Through":[890],"experiments,":[892],"has":[898,917],"desirable":[899],"multiple":[903,929],"alters":[907],"properties,":[914,1019],"iv":[915],"parameters":[920],"exerted":[927],"without":[940],"protein,":[942],"small-molecule":[947,1004],"inhibitor.":[948],"suggested":[950],"alternate":[953],"mechanisms":[954],"action":[956],"compound":[959,995],"began":[963],"investigated":[966],"here,":[967],"should":[969],"continued":[971],"expanded":[974],"upon.":[975],"Additionally,":[976],"PK":[978],"inform":[981],"studies":[983],"characterize":[986,1013],"ADMET":[988],"utilize":[993],"models":[999,1023],"Overall,":[1002],"AI-14-91,":[1008],"deserves":[1009],"investigations":[1011],"mechanism":[1015],"action,":[1017],"v":[1026]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
