{"id":"https://openalex.org/W7047837357","doi":null,"title":"Influence of structural variations on the catalytic properties of recombinant human ferritin","display_name":"Influence of structural variations on the catalytic properties of recombinant human ferritin","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W7047837357"},"language":"en","primary_location":{"id":"pmh:oai:dial.uclouvain.be:boreal:206413","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2078.1/206413","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078317182","display_name":"Louise Toussaint","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Toussaint, Louise","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078317182"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroxidase-activity","display_name":"ferroxidase activity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/metal-metal-distance","display_name":"metal-metal distance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/iron-incorporation","display_name":"iron incorporation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.6000000238418579},{"id":"https://openalex.org/keywords/iron-storage","display_name":"iron storage","score":0.46299999952316284},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.4309999942779541},{"id":"https://openalex.org/keywords/oxidation-of-organic-compounds","display_name":"organic oxidation","score":0.375}],"concepts":[{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.911899983882904},{"id":"https://openalex.org/C28452662","wikidata":"https://www.wikidata.org/wiki/Q422752","display_name":"Ceruloplasmin","level":2,"score":0.8353000283241272},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7063000202178955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5975000262260437},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5342000126838684},{"id":"https://openalex.org/C2776710925","wikidata":"https://www.wikidata.org/wiki/Q24777245","display_name":"Ferroportin","level":4,"score":0.429500013589859},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4104999899864197},{"id":"https://openalex.org/C17165728","wikidata":"https://www.wikidata.org/wiki/Q423350","display_name":"Metalloprotein","level":3,"score":0.3628000020980835},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.3601999878883362},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.35370001196861267},{"id":"https://openalex.org/C2780534640","wikidata":"https://www.wikidata.org/wiki/Q3233795","display_name":"Ferric","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C2780191927","wikidata":"https://www.wikidata.org/wiki/Q2250996","display_name":"Ferrihydrite","level":3,"score":0.319599986076355},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.29490000009536743},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C2779637800","wikidata":"https://www.wikidata.org/wiki/Q16969303","display_name":"Hydrous ferric oxides","level":4,"score":0.26409998536109924},{"id":"https://openalex.org/C2777697756","wikidata":"https://www.wikidata.org/wiki/Q721849","display_name":"Iron oxide","level":2,"score":0.25760000944137573}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:dial.uclouvain.be:boreal:206413","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2078.1/206413","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995803883","https://openalex.org/W2117523988","https://openalex.org/W4235017406","https://openalex.org/W2108816504","https://openalex.org/W2138551389","https://openalex.org/W4311968535","https://openalex.org/W2067430230","https://openalex.org/W2643238460","https://openalex.org/W2014991904","https://openalex.org/W3187486243"],"abstract_inverted_index":{"Ferritin":[0,47,137],"is":[1,15,21,189],"a":[2,31,49],"ubiquitous":[3],"intracellular":[4],"iron":[5,14,28,181],"storage":[6],"protein":[7,52,104],"consisting":[8],"of":[9,13,45,90,98,113,149,162,180,196],"24":[10],"subunits.":[11],"Storage":[12],"its":[16],"main":[17],"function":[18],"and":[19,54,70,157,172],"ferritin":[20,66],"able":[22],"to":[23,26,86,109],"store":[24],"up":[25],"4500":[27],"atoms":[29],"in":[30,143,151,177,191,212],"water-soluble,":[32],"non-toxic,":[33],"bioavailable":[34],"form":[35],"as":[36,201],"hydrated":[37],"ferric":[38],"oxide":[39],"mineral":[40],"core":[41],"with":[42,63,102,170],"various":[43],"amounts":[44],"phosphate.":[46],"has":[48],"very":[50],"stable":[51,204],"scaffold":[53],"exhibits":[55],"remarkable":[56],"stability":[57],"towards":[58,220],"denaturing":[59],"agents.":[60],"The":[61,124,140,208],"ease":[62],"which":[64],"recombinant":[65,134],"can":[67],"be":[68],"produced":[69],"purified":[71],"could":[72],"turn":[73],"it":[74],"into":[75,183],"attractive":[76],"tool":[77],"for":[78,216],"biocatalysis.":[79],"In":[80,100],"the":[81,88,91,95,111,117,121,144,152,159,163,174,203],"present":[82,125],"work,":[83],"we":[84,107],"want":[85,108],"study":[87],"importance":[89],"metal-metal":[92],"distance":[93],"within":[94],"diiron":[96,198],"site":[97],"ferritin.":[99,185,207],"conjunction":[101],"modern":[103],"engineering":[105],"strategies,":[106],"establish":[110],"consequences":[112],"iron-iron":[114],"elongation":[115],"inside":[116],"ferroxidase":[118,153,209],"centre":[119,154],"on":[120,133,158],"enzymatic":[122],"activity.":[123],"results":[126],"provide":[127],"more":[128],"rigorous":[129],"information":[130],"than":[131],"previous":[132],"Human":[135],"H":[136,206],"(HuHF)":[138],"structure.":[139],"metal-binding":[141],"sites":[142,195],"3-fold":[145],"channel":[146],"(entry":[147],"route":[148],"iron),":[150],"(iron":[155],"oxidation)":[156],"internal":[160],"surface":[161],"shell":[164],"(putative":[165],"nucleation":[166],"activity)":[167],"are":[168],"described":[169],"accuracy":[171],"constitute":[173],"important":[175],"points":[176],"our":[178,187],"understanding":[179],"incorporation":[182],"human":[184,205],"Moreover":[186],"laboratory":[188],"interested":[190],"mimicking":[192],"dinuclear":[193],"active":[194],"non-haem":[197],"proteins":[199],"using":[200],"support,":[202],"mutants":[210],"were":[211],"this":[213],"purpose":[214],"tested":[215],"an":[217,221],"oxidase":[218],"activity":[219],"organic":[222],"compound.":[223]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}