{"id":"https://openalex.org/W7045804773","doi":null,"title":"Characterization of human dermal macrophages in the context of aging","display_name":"Characterization of human dermal macrophages in the context of aging","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W7045804773"},"language":"en","primary_location":{"id":"pmh:oai:macau.uni-kiel.de:macau_mods_00003412","doi":null,"is_oa":true,"landing_page_url":"https://macau.uni-kiel.de/receive/macau_mods_00003412","pdf_url":"https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/macau_derivate_00004617/Thesis__LG_Druckversion.pdf","source":{"id":"https://openalex.org/S4306400664","display_name":"Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universit\u00e4t zu Kiel (Christian-Albrechts-Universit\u00e4t zu Kiel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151221077","host_organization_name":"Chung Yuan Christian University","host_organization_lineage":["https://openalex.org/I151221077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/macau_derivate_00004617/Thesis__LG_Druckversion.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081885886","display_name":"Leonie Gather","orcid":"https://orcid.org/0000-0002-0842-708X","observed_orcids":["https://orcid.org/0000-0002-0842-708X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gather, Leonie Katharina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081885886"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.36399999260902405,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.36399999260902405,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.3009999990463257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.20890000462532043,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dermal-macrophages","display_name":"dermal macrophages","score":0.9810000061988831},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.9940000176429749},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7580000162124634},{"id":"https://openalex.org/keywords/m1-macrophage-phenotype","display_name":"M1 macrophage phenotype","score":0.7960000038146973},{"id":"https://openalex.org/keywords/macrophage-heterogeneity","display_name":"macrophage heterogeneity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.7570000290870667},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.8197000026702881},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.705299973487854},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6547999978065491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6312999725341797},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6284000277519226},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5612000226974487},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5421000123023987},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5321999788284302},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.42160001397132874},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.352400004863739},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.35179999470710754},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.3346000015735626},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.32679998874664307},{"id":"https://openalex.org/C17675752","wikidata":"https://www.wikidata.org/wiki/Q12898553","display_name":"Adipose tissue macrophages","level":4,"score":0.3228999972343445},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32100000977516174},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.319599986076355},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3059000074863434},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C7244527","wikidata":"https://www.wikidata.org/wiki/Q6725501","display_name":"Macrophage-activating factor","level":4,"score":0.28110000491142273},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.28060001134872437},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2655999958515167}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:macau.uni-kiel.de:macau_mods_00003412","doi":null,"is_oa":true,"landing_page_url":"https://macau.uni-kiel.de/receive/macau_mods_00003412","pdf_url":"https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/macau_derivate_00004617/Thesis__LG_Druckversion.pdf","source":{"id":"https://openalex.org/S4306400664","display_name":"Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universit\u00e4t zu Kiel (Christian-Albrechts-Universit\u00e4t zu Kiel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151221077","host_organization_name":"Chung Yuan Christian University","host_organization_lineage":["https://openalex.org/I151221077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"}],"best_oa_location":{"id":"pmh:oai:macau.uni-kiel.de:macau_mods_00003412","doi":null,"is_oa":true,"landing_page_url":"https://macau.uni-kiel.de/receive/macau_mods_00003412","pdf_url":"https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/macau_derivate_00004617/Thesis__LG_Druckversion.pdf","source":{"id":"https://openalex.org/S4306400664","display_name":"Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universit\u00e4t zu Kiel (Christian-Albrechts-Universit\u00e4t zu Kiel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151221077","host_organization_name":"Chung Yuan Christian University","host_organization_lineage":["https://openalex.org/I151221077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7045804773.pdf","grobid_xml":"https://content.openalex.org/works/W7045804773.grobid-xml"},"referenced_works_count":163,"referenced_works":["https://openalex.org/W98461984","https://openalex.org/W1482873758","https://openalex.org/W1486303545","https://openalex.org/W1492593302","https://openalex.org/W1518095394","https://openalex.org/W1923917571","https://openalex.org/W1943705911","https://openalex.org/W1954606945","https://openalex.org/W1964937500","https://openalex.org/W1966217032","https://openalex.org/W1967069761","https://openalex.org/W1972580560","https://openalex.org/W1974139477","https://openalex.org/W1976134177","https://openalex.org/W1976333492","https://openalex.org/W1977168455","https://openalex.org/W1977631233","https://openalex.org/W1983426396","https://openalex.org/W1988086159","https://openalex.org/W1991272056","https://openalex.org/W1991601117","https://openalex.org/W1995830102","https://openalex.org/W2002220495","https://openalex.org/W2004273407","https://openalex.org/W2011848880","https://openalex.org/W2015163231","https://openalex.org/W2020744745","https://openalex.org/W2022168094","https://openalex.org/W2027042725","https://openalex.org/W2028402779","https://openalex.org/W2029331076","https://openalex.org/W2035182977","https://openalex.org/W2042194530","https://openalex.org/W2044341880","https://openalex.org/W2045363335","https://openalex.org/W2045475619","https://openalex.org/W2052101576","https://openalex.org/W2052388837","https://openalex.org/W2052616119","https://openalex.org/W2053402048","https://openalex.org/W2054020716","https://openalex.org/W2054259512","https://openalex.org/W2058743791","https://openalex.org/W2060130170","https://openalex.org/W2064441047","https://openalex.org/W2069376328","https://openalex.org/W2071419221","https://openalex.org/W2072172632","https://openalex.org/W2075021105","https://openalex.org/W2077590888","https://openalex.org/W2078096153","https://openalex.org/W2078958131","https://openalex.org/W2079822769","https://openalex.org/W2082402714","https://openalex.org/W2084855813","https://openalex.org/W2088566849","https://openalex.org/W2089573422","https://openalex.org/W2091191929","https://openalex.org/W2091487793","https://openalex.org/W2092427093","https://openalex.org/W2093668670","https://openalex.org/W2093705034","https://openalex.org/W2097353401","https://openalex.org/W2097671337","https://openalex.org/W2097861054","https://openalex.org/W2098514741","https://openalex.org/W2099290136","https://openalex.org/W2102622434","https://openalex.org/W2104908670","https://openalex.org/W2105225614","https://openalex.org/W2107277218","https://openalex.org/W2107531246","https://openalex.org/W2112815582","https://openalex.org/W2114216755","https://openalex.org/W2115852450","https://openalex.org/W2117423981","https://openalex.org/W2117692326","https://openalex.org/W2123204783","https://openalex.org/W2123226751","https://openalex.org/W2124841332","https://openalex.org/W2125248324","https://openalex.org/W2126525177","https://openalex.org/W2128337342","https://openalex.org/W2135568172","https://openalex.org/W2138258126","https://openalex.org/W2139654366","https://openalex.org/W2140147218","https://openalex.org/W2140316735","https://openalex.org/W2142480558","https://openalex.org/W2143177251","https://openalex.org/W2144402463","https://openalex.org/W2145045466","https://openalex.org/W2148438596","https://openalex.org/W2148596615","https://openalex.org/W2148651797","https://openalex.org/W2155585418","https://openalex.org/W2164428603","https://openalex.org/W2168448705","https://openalex.org/W2169758620","https://openalex.org/W2170352596","https://openalex.org/W2172085675","https://openalex.org/W2179438025","https://openalex.org/W2180997009","https://openalex.org/W2190545194","https://openalex.org/W2248565900","https://openalex.org/W2252882781","https://openalex.org/W2301038687","https://openalex.org/W2413888671","https://openalex.org/W2419520222","https://openalex.org/W2433067092","https://openalex.org/W2474593639","https://openalex.org/W2481379384","https://openalex.org/W2555524932","https://openalex.org/W2590317180","https://openalex.org/W2605292630","https://openalex.org/W2607434574","https://openalex.org/W2689866037","https://openalex.org/W2719931193","https://openalex.org/W2745237205","https://openalex.org/W2766698731","https://openalex.org/W2768033029","https://openalex.org/W2782929501","https://openalex.org/W2784164089","https://openalex.org/W2786195955","https://openalex.org/W2793605752","https://openalex.org/W2800438504","https://openalex.org/W2805291140","https://openalex.org/W2841660058","https://openalex.org/W2884081989","https://openalex.org/W2897273246","https://openalex.org/W2900976549","https://openalex.org/W2901552928","https://openalex.org/W2906988593","https://openalex.org/W2920712688","https://openalex.org/W2936868735","https://openalex.org/W2945926178","https://openalex.org/W2947124803","https://openalex.org/W2949177718","https://openalex.org/W2949237386","https://openalex.org/W2972011940","https://openalex.org/W2981568852","https://openalex.org/W2990706490","https://openalex.org/W2999893607","https://openalex.org/W3000597097","https://openalex.org/W3017440313","https://openalex.org/W3020212197","https://openalex.org/W3033290823","https://openalex.org/W3036265910","https://openalex.org/W3036810437","https://openalex.org/W3042406747","https://openalex.org/W3102558410","https://openalex.org/W3113258554","https://openalex.org/W3117139588","https://openalex.org/W3123653170","https://openalex.org/W3124296497","https://openalex.org/W3163579061","https://openalex.org/W3164692211","https://openalex.org/W3215796337","https://openalex.org/W4200613889","https://openalex.org/W4206384540","https://openalex.org/W4213413190","https://openalex.org/W4255785767","https://openalex.org/W4285414465"],"related_works":["https://openalex.org/W4285606743","https://openalex.org/W3163978705","https://openalex.org/W4415057437","https://openalex.org/W4213413190","https://openalex.org/W2894772070","https://openalex.org/W4393359136","https://openalex.org/W4312003516","https://openalex.org/W4284966906","https://openalex.org/W7212143512","https://openalex.org/W7116596592"],"abstract_inverted_index":{"Macrophages":[0,59],"are":[1,13,60],"the":[2,9,44,72,90,101,108,116,166,190,204,208,216,220,223,227,243,256,276],"most":[3],"abundant":[4],"immune":[5],"cell":[6],"population":[7,35],"in":[8,26,76,100,112,130,154,179,215,233,240,246,262],"human":[10,87,131,264],"dermis.":[11],"They":[12],"critical":[14],"regulators":[15],"of":[16,67,92,103,110,115,135,151,222,229,258,271,278],"tissue":[17,30,45,266],"homeostasis":[18],"and":[19,21,55,69,79,122,141,171,252,275],"regeneration":[20],"play":[22],"an":[23,184],"important":[24],"role":[25,109,221],"pathogen":[27],"defense.":[28],"Each":[29],"has":[31],"a":[32,37,146,211],"unique":[33],"macrophage":[34,77,127,231],"with":[36,157,196],"tissue-specific":[38],"phenotype":[39,80,150,214,232,245,274],"that":[40,126,168,203],"is":[41,49],"shaped":[42],"by":[43,51],"environment.":[46],"Skin":[47],"aging":[48,105],"accompanied":[50],"reduced":[52],"regenerative":[53],"capacity":[54],"chronic":[56],"low-grade":[57],"inflammation.":[58],"suggested":[61],"to":[62,64,96,106,160,165,187,189,210,269],"contribute":[63,268],"this":[65,93,119],"imbalance":[66],"pro-":[68],"anti-inflammatory":[70],"molecules,":[71],"inflammaging":[73],"process.":[74],"Alterations":[75],"number":[78],"have":[81],"not":[82],"yet":[83],"been":[84],"described":[85],"for":[86],"skin.":[88,117,133,217],"Therefore,":[89],"aim":[91],"thesis":[94],"was":[95,201],"study":[97],"dermal":[98,152,198],"macrophages":[99,111,144,153,174,209],"context":[102],"skin":[104,143,156,161,235,265,273,279],"reveal":[107],"age-dependent":[113],"disorders":[114],"In":[118,177],"study,":[120],"scRNA-seq":[121],"immunohistochemistry":[123],"analysis":[124],"demonstrated":[125],"numbers":[128],"increased":[129],"aged":[132,142,155,181,197,205,224,234,263,272],"Analysis":[134],"differentially":[136],"expressed":[137],"genes":[138],"between":[139],"young":[140],"revealed":[145],"more":[147,212],"pro-inflammatory":[148,213,259],"M1":[149,191,238,260],"high":[158],"resemblances":[159],"MDMs.":[162],"This":[163,218],"led":[164],"suggestion":[167],"MDMs":[169,182,239],"replace":[170],"supplement":[172],"skin-resident":[173],"over":[175],"time.":[176],"contrast,":[178],"vitro":[180],"had":[183],"impaired":[185],"ability":[186],"differentiate":[188],"phenotype.":[192],"Using":[193],"co-culture":[194],"experiments":[195],"fibroblast,":[199],"it":[200],"demonstrated,":[202],"microenvironment":[206,225],"polarizes":[207],"emphasizes":[219],"on":[226],"development":[228,277],"altered":[230],"tissue.":[236],"Pro-inflammatory":[237],"turn":[241],"impacted":[242],"fibroblast":[244],"its":[247],"metabolic":[248],"age,":[249],"ECM":[250],"remodeling":[251],"inflammatory":[253],"state.":[254],"Thus,":[255],"accumulation":[257],"found":[261],"could":[267],"alterations":[270],"disorders.":[280]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}