{"id":"https://openalex.org/W7045153273","doi":null,"title":"Aberrant CpG Island Hypermethylation Profile in Malignant Brain Tumors","display_name":"Aberrant CpG Island Hypermethylation Profile in Malignant Brain Tumors","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W7045153273"},"language":"en","primary_location":{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/11477","doi":null,"is_oa":false,"landing_page_url":"http://kumel.medlib.dsmc.or.kr/handle/2015.oak/11477","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5145510343","display_name":"\uae40\uad11\ub82c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\uae40\uad11\ub82c","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5145510343"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.27149999141693115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpg-island-hypermethylation","display_name":"CpG island hypermethylation","score":0.968999981880188},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/malignant-brain-tumors","display_name":"malignant brain tumors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rassf1a","display_name":"RASSF1A","score":0.8880000114440918},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mgmt","display_name":"MGMT","score":0.9909999966621399},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p14","display_name":"p14","score":0.9480000138282776},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anaplastic-oligodendroglioma","display_name":"anaplastic oligodendroglioma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.6359999775886536},{"id":"https://openalex.org/keywords/methylation-profiles","display_name":"methylation profiles","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7545999884605408},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7214999794960022},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6674000024795532},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5900999903678894},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5716000199317932},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5618000030517578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5522000193595886},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5246000289916992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47859999537467957},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.47350001335144043},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.41200000047683716},{"id":"https://openalex.org/C2779083369","wikidata":"https://www.wikidata.org/wiki/Q486092","display_name":"Anaplastic astrocytoma","level":4,"score":0.3874000012874603},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.37389999628067017},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3626999855041504},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3174000084400177},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2750000059604645},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/11477","doi":null,"is_oa":false,"landing_page_url":"http://kumel.medlib.dsmc.or.kr/handle/2015.oak/11477","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2103807069","https://openalex.org/W2031135077","https://openalex.org/W2056529936","https://openalex.org/W2014319032","https://openalex.org/W1682181752","https://openalex.org/W2029655340","https://openalex.org/W7131962878","https://openalex.org/W2386456358","https://openalex.org/W2067367060","https://openalex.org/W1984014660"],"abstract_inverted_index":{"Aberrant":[0],"methylation":[1,58],"of":[2,16,23,46,60,77,90,102,113,162,180],"5'":[3],"CpG":[4],"islands":[5],"is":[6,30,144,169],"thought":[7],"to":[8,66,171,177],"play":[9,156],"an":[10],"important":[11],"role":[12,158],"in":[13,20,70,98,128,159],"the":[14,39,44,56,95,103,160],"inactivation":[15],"tumor":[17,47],"suppressor":[18],"genes":[19,34,174],"several":[21,33,61],"types":[22,76,179],"cancers.":[24],"In":[25,139],"malignant":[26,71,91,148,163,181],"brain":[27,72,92,149,164,182],"tumors,":[28,107,150],"it":[29],"known":[31],"that":[32,87,152],"are":[35,175],"frequently":[36,69,126],"methylated,":[37],"and":[38,48,74,123,136],"relationship":[40],"among":[41],"their":[42],"methylation,":[43],"development":[45,161],"its":[49],"clinical":[50],"features":[51],"has":[52],"been":[53],"studied.":[54],"So,":[55],"promoter":[57,96],"status":[59],"genes,":[62],"which":[63,173],"were":[64,125],"reported":[65],"be":[67],"methylated":[68,127],"tumors":[73,93],"other":[75],"cancers":[78],"was":[79],"analyzed":[80],"using":[81],"methylation-specific":[82],"PCR.":[83],"Our":[84],"result":[85],"showed":[86,110],"all":[88],"cases":[89],"represented":[94],"hypermethylation":[97,112,142],"at":[99],"least":[100],"one":[101],"genes.":[104,117],"Of":[105],"39":[106],"34":[108],"(87.18%)":[109],"concurrent":[111],"two":[114],"or":[115],"more":[116],"RASSF1A,":[118],"E-cadherin,":[119],"MGMT,":[120],"THBS1,":[121],"p14,":[122],"APC":[124],"high":[129],"grade":[130],"glioma":[131],"including":[132],"glioblastoma,":[133],"anaplastic":[134,137],"astrocytoma,":[135],"oligodendroglioma.":[138],"conclusion,":[140],"aberrant":[141],"profile":[143],"associated":[145],"with":[146],"various":[147],"suggesting":[151],"epigenetic":[153],"change":[154],"may":[155],"a":[157],"tumors.":[165,183],"A":[166],"further":[167],"study":[168],"necessary":[170],"find":[172],"related":[176],"specific":[178]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
