{"id":"https://openalex.org/W7043830652","doi":null,"title":"Triple combination of anti-CTLA-4, anti-PD-1 and anti-TNF in mouse melanoma models and advanced melanoma patients.","display_name":"Triple combination of anti-CTLA-4, anti-PD-1 and anti-TNF in mouse melanoma models and advanced melanoma patients.","publication_year":2023,"publication_date":"2023-05-09","ids":{"openalex":"https://openalex.org/W7043830652"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-04974544v1","doi":null,"is_oa":false,"landing_page_url":"https://ut3-toulouseinp.hal.science/hal-04974544","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EACR conferences \u201cDefence is the Best Attack: Immuno-Oncology Breakthroughs\u201d, Joan Seoane, May 2023, Barcelona, Spain","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038403474","display_name":"Bruno S\u00e9gui","orcid":"https://orcid.org/0000-0002-6119-1889","observed_orcids":["https://orcid.org/0000-0002-6119-1889"]},"institutions":[{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9gui, Bruno","raw_affiliation_strings":["CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","institution_ids":["https://openalex.org/I4210087620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033995803","display_name":"Anne Montfort","orcid":"https://orcid.org/0000-0002-2926-4902","observed_orcids":["https://orcid.org/0000-0002-2926-4902"]},"institutions":[{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Montfort, Anne","raw_affiliation_strings":["CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","institution_ids":["https://openalex.org/I4210087620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027023228","display_name":"Mathieu Virazels","orcid":"https://orcid.org/0000-0002-5026-0631","observed_orcids":["https://orcid.org/0000-0002-5026-0631"]},"institutions":[{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virazels, Mathieu","raw_affiliation_strings":["CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","institution_ids":["https://openalex.org/I4210087620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001685240","display_name":"Matthieu Genais","orcid":"https://orcid.org/0000-0003-1004-865X","observed_orcids":["https://orcid.org/0000-0003-1004-865X"]},"institutions":[{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Genais, Matthieu","raw_affiliation_strings":["CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","institution_ids":["https://openalex.org/I4210087620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015719789","display_name":"Am\u00e9lie Lusque","orcid":"https://orcid.org/0000-0001-9691-5536","observed_orcids":["https://orcid.org/0000-0001-9691-5536"]},"institutions":[{"id":"https://openalex.org/I4210128666","display_name":"Institut Claudius Regaud","ror":"https://ror.org/03pa87f90","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lusque, Am\u00e9lie","raw_affiliation_strings":["Oncopole Claudius Regaud (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncopole Claudius Regaud (France)","institution_ids":["https://openalex.org/I4210128666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003424696","display_name":"Thomas Filleron","orcid":"https://orcid.org/0000-0003-0724-0659","observed_orcids":["https://orcid.org/0000-0003-0724-0659"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210103698","display_name":"Centre de recherche en Epid\u00e9miologie et Sant\u00e9 des Populations","ror":"https://ror.org/01ed4t417","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210097159","https://openalex.org/I4210103698","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]},{"id":"https://openalex.org/I4210128666","display_name":"Institut Claudius Regaud","ror":"https://ror.org/03pa87f90","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Filleron, Thomas","raw_affiliation_strings":["CESP - Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)","Oncopole Claudius Regaud (France)","U1018 (\u00c9quipe 2) - Oncostat (Gustave Roussy.\r\n114 rue \u00c9douard Vaillant, 94805 Villejuif Cedex - France)","Universit\u00e9 Paris-Saclay (B\u00e2timent Br\u00e9guet, 3 Rue Joliot Curie 2e \u00e9t, 91190 Gif-sur-Yvette - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CESP - Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)","institution_ids":["https://openalex.org/I4210103698"]},{"raw_affiliation_string":"Oncopole Claudius Regaud (France)","institution_ids":["https://openalex.org/I4210128666"]},{"raw_affiliation_string":"U1018 (\u00c9quipe 2) - Oncostat (Gustave Roussy.\r\n114 rue \u00c9douard Vaillant, 94805 Villejuif Cedex - France)","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay (B\u00e2timent Br\u00e9guet, 3 Rue Joliot Curie 2e \u00e9t, 91190 Gif-sur-Yvette - France)","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068593388","display_name":"Clara\u2010Maria Scarlata","orcid":"https://orcid.org/0000-0003-3429-2825","observed_orcids":["https://orcid.org/0000-0003-3429-2825"]},"institutions":[{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Scarlata, Clara-Maria","raw_affiliation_strings":["CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","institution_ids":["https://openalex.org/I4210087620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079620095","display_name":"Maha Ayyoub","orcid":"https://orcid.org/0000-0003-2022-0898","observed_orcids":["https://orcid.org/0000-0003-2022-0898"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210128666","display_name":"Institut Claudius Regaud","ror":"https://ror.org/03pa87f90","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ayyoub, Maha","raw_affiliation_strings":["CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","Oncopole Claudius Regaud (France)","UT3 - Universit\u00e9 Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","institution_ids":["https://openalex.org/I4210087620"]},{"raw_affiliation_string":"Oncopole Claudius Regaud (France)","institution_ids":["https://openalex.org/I4210128666"]},{"raw_affiliation_string":"UT3 - Universit\u00e9 Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085268074","display_name":"C\u00e9line Colacios","orcid":"https://orcid.org/0000-0002-7509-0675","observed_orcids":["https://orcid.org/0000-0002-7509-0675"]},"institutions":[{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Colacios, C\u00e9line","raw_affiliation_strings":["CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","institution_ids":["https://openalex.org/I4210087620"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067794998","display_name":"Nicol\u00e1s Meyer","orcid":"https://orcid.org/0000-0003-4519-8666","observed_orcids":["https://orcid.org/0000-0003-4519-8666"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210127828","display_name":"H\u00f4pital Larrey","ror":"https://ror.org/03471w967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210127828"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Meyer, Nicolas","raw_affiliation_strings":["CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","Service Dermatologie [CHU Toulouse] (H\u00f4pital Larrey, \r\n24, chemin de Pouvourville - TSA 30030 - 31059 Toulouse cedex 9 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRCT - Centre de Recherches en Canc\u00e9rologie de Toulouse (Centre de Recherches en Canc\u00e9rologie de Toulouse\r\n2 Avenue Hubert Curien\r\n31037 Toulouse Cedex 1\r\nFRANCE - France)","institution_ids":["https://openalex.org/I4210087620"]},{"raw_affiliation_string":"Service Dermatologie [CHU Toulouse] (H\u00f4pital Larrey, \r\n24, chemin de Pouvourville - TSA 30030 - 31059 Toulouse cedex 9 - France)","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210127828"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54886405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-melanoma","display_name":"advanced melanoma","score":0.8330000042915344},{"id":"https://openalex.org/keywords/anti-ctla-4","display_name":"anti-CTLA-4","score":0.8560000061988831},{"id":"https://openalex.org/keywords/anti-pd-1-antibody","display_name":"anti-PD-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/triple-combination-therapy","display_name":"triple combination therapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.7099999785423279},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/certolizumab","display_name":"certolizumab","score":0.9139999747276306},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":1.0},{"id":"https://openalex.org/keywords/b16-ova-melanoma","display_name":"B16-OVA melanoma","score":0.8339999914169312},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6970000267028809},{"id":"https://openalex.org/keywords/drug-related-adverse-events","display_name":"drug-related adverse events","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.551800012588501},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5400000214576721},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.483599990606308},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2851000130176544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2655999958515167},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2485000044107437},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.24390000104904175},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.23600000143051147}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-04974544v1","doi":null,"is_oa":false,"landing_page_url":"https://ut3-toulouseinp.hal.science/hal-04974544","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EACR conferences \u201cDefence is the Best Attack: Immuno-Oncology Breakthroughs\u201d, Joan Seoane, May 2023, Barcelona, Spain","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4295817040","https://openalex.org/W7027369556","https://openalex.org/W4417308871","https://openalex.org/W7206525174","https://openalex.org/W7128928901","https://openalex.org/W4404064344","https://openalex.org/W3108454882","https://openalex.org/W2779658193","https://openalex.org/W4311386423","https://openalex.org/W3124047768"],"abstract_inverted_index":{"CTLA-4":[0],"and":[1,9,26,34,45,58,78,122,132,145,156,172,178,187,216,222,235,256,283],"PD-1":[2],"inhibitors":[3,24],"improve":[4],"Progression":[5],"Free":[6],"survival":[7],"(PFS)":[8],"Overall":[10],"Survival":[11],"(OS)":[12],"in":[13,31,47,98,111,152,158,183,189,230,262,270,279,288],"advanced":[14,112,271],"melanoma":[15,33,49,113,265,272],"patients.":[16],"TNF":[17],"production":[18],"is":[19,203,268],"increased":[20,54,71],"upon":[21],"immune":[22,72],"checkpoint":[23],"(ICI)":[25],"impedes":[27],"ICI":[28,97,260],"therapy":[29],"efficacy":[30,42,261],"preclinical":[32],"colon":[35],"cancer":[36],"models.":[37],"Herein,":[38],"anti-TNF":[39,70,95,257],"improved":[40],"the":[41,90,153,159,184,190,220,246,250,280,289],"of":[43,56,93,139,233,238,249,253],"anti-CTLA-4":[44,77],"anti-PD-1":[46,255],"B16-Ova":[48,66],"bearing":[50],"mice,":[51],"with":[52,76,96,115,208,274],"an":[53,102,225],"frequency":[55],"complete":[57],"long-term":[59],"responses.":[60],"Unbiased":[61],"RNA":[62],"Seq":[63],"analyses":[64],"from":[65,164],"tumours":[67],"indicated":[68],"that":[69,201,245],"responses":[73],"when":[74,206],"combined":[75,207],"anti-PD-1.":[79],"This":[80],"was":[81,128,173,228],"further":[82],"documented":[83],"by":[84],"flow":[85],"cytometry":[86],"analyses.":[87],"To":[88],"evaluate":[89,130],"putative":[91],"benefit":[92],"combining":[94],"patients,":[99,240,273],"we":[100],"conducted":[101],"open":[103],"label":[104],"phase":[105],"Ib":[106],"clinical":[107],"trial":[108],"TICIMEL":[109],"(NCT03293784)":[110],"patients":[114,148,182],"two":[116],"parallel":[117],"cohorts:":[118],"ipilimumab/nivolumab/certolizumab":[119],"(C":[120],"cohort)":[121],"ipilimumab/nivolumab/infliximab":[123],"(I":[124],"cohort).":[125],"The":[126],"objective":[127,226],"to":[129,133],"safety":[131,177],"screen":[134],"for":[135,176],"preliminary":[136],"anti-tumor":[137,179],"activity":[138],"these":[140],"triple":[141,251],"combinations.":[142],"Between":[143],"2018":[144],"2021,":[146],"33":[147],"were":[149,212],"included,":[150],"20":[151,234],"C":[154,185,221,281],"cohort":[155,166,186,192],"13":[157],"I":[160,165,191,223,290],"cohort.":[161,291],"One":[162],"patient":[163],"did":[167],"not":[168,174],"receive":[169],"any":[170],"treatment":[171],"evaluable":[175],"activity.":[180],"Fifteen":[181],"4":[188],"displayed":[193],"grade":[194],"3/4":[195],"drug-related":[196],"adverse":[197],"events":[198],"(AE),":[199],"indicating":[200],"infliximab":[202],"better":[204,285],"tolerated":[205],"ICI.":[209],"Drug-related":[210],"AE":[211],"mostly":[213],"hepatobiliary,":[214],"gastrointestinal":[215],"respiratory":[217],"disorders.":[218],"In":[219],"cohorts,":[224],"response":[227,277],"observed":[229],"12":[231,239],"out":[232,237],"6":[236],"respectively.":[241],"Our":[242],"study":[243],"shows":[244],"systemic":[247],"co-administration":[248],"combination":[252],"anti-CTLA-4,":[254],"(i)":[258],"improves":[259],"a":[263,275,284],"mouse":[264],"model,":[266],"(ii)":[267],"safe":[269],"promising":[276],"rate":[278],"cohort,":[282],"tolerability":[286],"profile":[287]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}