{"id":"https://openalex.org/W7043480128","doi":null,"title":"The structural response of Human Serum Albumin to oxidation: a biological buffer to local formation of hypochlorite","display_name":"The structural response of Human Serum Albumin to oxidation: a biological buffer to local formation of hypochlorite","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W7043480128"},"language":"en","primary_location":{"id":"pmh:oai:iris.uniroma1.it:11573/1417338","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1417338","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Del Giudice A","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Del Giudice A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dicko C","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dicko C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Galantini L","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galantini L","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Pavel N V","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pavel N V","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60003658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":1.0},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hypochlorite","display_name":"hypochlorite","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.7039999961853027},{"id":"https://openalex.org/keywords/alpha-helix-loss","display_name":"alpha-helix loss","score":0.7789999842643738},{"id":"https://openalex.org/keywords/protein-charge","display_name":"protein charge","score":0.5249999761581421},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8597999811172485},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.727400004863739},{"id":"https://openalex.org/C2776832558","wikidata":"https://www.wikidata.org/wiki/Q409049","display_name":"Hypochlorite","level":2,"score":0.5302000045776367},{"id":"https://openalex.org/C2994067411","wikidata":"https://www.wikidata.org/wiki/Q125264","display_name":"Molar ratio","level":3,"score":0.5056999921798706},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4970000088214874},{"id":"https://openalex.org/C184133267","wikidata":"https://www.wikidata.org/wiki/Q5090480","display_name":"Chemical modification","level":2,"score":0.47589999437332153},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47540000081062317},{"id":"https://openalex.org/C145018004","wikidata":"https://www.wikidata.org/wiki/Q4985944","display_name":"Buffer (optical fiber)","level":2,"score":0.42890000343322754},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4251999855041504},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42410001158714294},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.41620001196861267},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.41499999165534973},{"id":"https://openalex.org/C186399102","wikidata":"https://www.wikidata.org/wiki/Q903517","display_name":"Chemical stability","level":2,"score":0.38280001282691956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3752000033855438},{"id":"https://openalex.org/C175528265","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Chemical structure","level":2,"score":0.3693999946117401},{"id":"https://openalex.org/C2778117296","wikidata":"https://www.wikidata.org/wiki/Q208465","display_name":"Buffer solution","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.30869999527931213},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.30790001153945923},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C49271019","wikidata":"https://www.wikidata.org/wiki/Q1969120","display_name":"Structural change","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C2776776456","wikidata":"https://www.wikidata.org/wiki/Q407204","display_name":"Sodium hypochlorite","level":2,"score":0.2644999921321869}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:iris.uniroma1.it:11573/1417338","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1417338","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2554173838","https://openalex.org/W6996698365","https://openalex.org/W1997534177","https://openalex.org/W4391854595","https://openalex.org/W2736997544","https://openalex.org/W2063981291","https://openalex.org/W1553053557","https://openalex.org/W1514417416","https://openalex.org/W1970997459","https://openalex.org/W2959935924"],"abstract_inverted_index":{"The":[0,103],"most":[1],"abundant":[2],"plasma":[3],"protein,":[4],"human":[5],"serum":[6],"albumin":[7,146],"(HSA),":[8],"plays":[9],"a":[10,58,95,112,131,151],"key":[11],"part":[12],"in":[13,62,130],"the":[14,37,42,45,63,71,76,79,82,87,92,99,141,155],"body\u2019s":[15],"antioxidant":[16],"defense":[17],"against":[18],"reactive":[19],"species":[20],"[1].":[21],"This":[22,67],"study":[23],"was":[24],"aimed":[25],"at":[26],"correlating":[27],"oxidant-induced":[28],"chemical":[29,38,128],"and":[30,84,94],"structural":[31,59,114],"effects":[32],"on":[33],"HSA":[34],"[2].":[35],"\\nDespite":[36],"modification":[39,129],"induced":[40],"by":[41],"oxidant":[43],"hypochlorite,":[44],"native":[46],"shape":[47],"is":[48,105],"preserved":[49],"up":[50],"to":[51,86,123,143],"oxidant/HSA":[52],"molar":[53],"ratio":[54],"<80,":[55],"above":[56],"which":[57],"transition":[60,104],"occurs":[61],"critical":[64],"range":[65],"80\u2212120.":[66],"conformational":[68],"variation":[69],"involves":[70],"drifting":[72],"of":[73,75,81,89,91,98,117,127,158],"one":[74],"end-domains":[77],"from":[78],"rest":[80],"protein":[83,100],"corresponds":[85],"loss":[88],"one-third":[90],"\u03b1-helix":[93],"net":[96],"increase":[97],"negative":[101],"charge.":[102],"highly":[106],"reproducible":[107],"suggesting":[108],"that":[109],"it":[110],"represents":[111],"well-defined":[113],"response":[115],"typical":[116],"this":[118],"multidomain":[119],"protein.":[120],"\\nThe":[121],"ability":[122],"tolerate":[124],"high":[125],"levels":[126],"folded":[132],"or":[133],"only":[134],"partially":[135],"unfolded":[136],"state,":[137],"as":[138,140,150],"well":[139],"stability":[142],"aggregation,":[144],"provides":[145],"with":[147],"optimal":[148],"features":[149],"biological":[152],"buffer":[153],"for":[154],"local":[156],"formation":[157],"oxidants.":[159]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
