{"id":"https://openalex.org/W7043063013","doi":null,"title":"Regulation of miR-219 expression by experience and learning","display_name":"Regulation of miR-219 expression by experience and learning","publication_year":2018,"publication_date":"2018-10-17","ids":{"openalex":"https://openalex.org/W7043063013"},"language":"en","primary_location":{"id":"pmh:oai:etd.adm.unipi.it:etd-10022018-180344","doi":null,"is_oa":false,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-10022018-180344/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-10022018-180344/","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"BELLOTTI, CRISTINA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"BELLOTTI, CRISTINA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-219","display_name":"miR-219","score":1.0},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.8289999961853027},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.8040000200271606},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.996999979019165},{"id":"https://openalex.org/keywords/visual-experience","display_name":"visual experience","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dark-rearing","display_name":"dark rearing","score":0.8809999823570251},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.7110000252723694},{"id":"https://openalex.org/keywords/learning","display_name":"learning","score":0.6850000023841858},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.7239999771118164},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.8891000151634216},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.868399977684021},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.72079998254776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6640999913215637},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4876999855041504},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.48660001158714294},{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.39500001072883606},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.3598000109195709},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.35190001130104065},{"id":"https://openalex.org/C2908708501","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating Disorder","level":3,"score":0.3375999927520752},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3312999904155731},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.31690001487731934},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.31150001287460327},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.2818000018596649},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C2778531937","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating disease","level":3,"score":0.2630999982357025},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.2517000138759613}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:etd.adm.unipi.it:etd-10022018-180344","doi":null,"is_oa":false,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-10022018-180344/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-10022018-180344/","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2603769353","https://openalex.org/W2123661628","https://openalex.org/W2001810970","https://openalex.org/W2063653640","https://openalex.org/W7098643767","https://openalex.org/W2074103481","https://openalex.org/W2551266034","https://openalex.org/W2584443380","https://openalex.org/W2981059217","https://openalex.org/W3132726434"],"abstract_inverted_index":{"Oligodendrocyte":[0],"differentiation":[1,140],"and":[2,13,33,48,93,95,123,168,263,308,326,334,382],"myelin":[3,51,126,265],"formation":[4],"are":[5,8,53,70,137],"processes":[6,290],"that":[7,147,230,247,264,283],"fundamental":[9,103],"to":[10,40,72,88,114,118,125,179,190,238,281,354],"have":[11,184,191,267,362],"rapid":[12],"efficient":[14],"action":[15,198],"potential":[16],"propagation":[17],"in":[18,24,27,35,50,75,90,99,105,109,120,169,188,235,270,288,324,340,359,375],"the":[19,28,45,55,76,121,143,181,205,254,271,289,330,341,357],"CNS.":[20],"Myelin":[21],"maturation":[22],"happens":[23],"mice":[25,223,237,325],"mostly":[26],"first":[29,206],"weeks":[30],"of":[31,44,57,78,83,97,133,153,196,214,224,249,251,273,310,332,335,337,379],"life":[32],"defects":[34],"this":[36,134,186,203,215,315],"mechanism":[37],"can":[38],"bring":[39],"a":[41,102,151,192,240,268,311,351,376],"premature":[42],"death":[43],"animals.":[46],"Demyelination":[47],"failure":[49],"repair":[52,127],"at":[54,253],"base":[56],"severe":[58],"human":[59],"pathologies":[60],"such":[61,172],"as":[62,66,150,173],"Multiple":[63],"Sclerosis.":[64],"Acting":[65],"post-transciptional":[67],"regulators,":[68],"microRNAs":[69],"known":[71,131,246],"be":[73,115,286,304],"involved":[74,287],"modulation":[77,272],"many":[79],"biological":[80],"processes.":[81,107],"Several":[82],"these":[84,106,295],"small":[85],"molecules":[86],"seem":[87],"participate":[89],"oligodendrocyte":[91,139,154],"development":[92,167],"myelination,":[94],"one":[96],"them":[98],"particular":[100],"plays":[101],"role":[104,165],"miR-219,":[108],"fact,":[110],"has":[111],"been":[112],"demonstrated":[113],"both":[116],"necessary":[117,234],"myelination":[119,232,284,387],"CNS":[122],"sufficient":[124],"after":[128],"injury.":[129],"Among":[130],"targets":[132,339],"miRNA":[135,216],"there":[136],"several":[138],"inhibitors,":[141],"so":[142,277],"current":[144],"hypothesis":[145],"is":[146,233,244,256,279],"miR-219":[148,159,301,333,366,372],"act":[149],"promoter":[152],"lineage":[155],"progression.":[156],"Studies":[157],"on":[158,163,185,220,365,386],"until":[160],"now":[161],"focused":[162],"its":[164,197,338],"during":[166],"pathological":[170],"condition":[171],"demyelinating":[174],"injuries.":[175],"Our":[176],"objective":[177],"was":[178,210],"expand":[180],"knowledge":[182],"we":[183,208,297,316,328,349,369,383],"oligonucleotide":[187],"order":[189],"more":[193],"comprehensive":[194],"view":[195],"throughout":[199],"all":[200],"life.":[201],"For":[202,347],"reason,":[204],"thing":[207],"did":[209,317],"an":[211,257,363],"expression":[212,302,331,373],"study":[213],"via":[217],"real-time":[218,345],"PCR":[219],"explants":[221],"from":[222],"different":[225],"ages.":[226],"Recent":[227],"works":[228],"suggest":[229],"active":[231,380],"adult":[236],"learn":[239],"motor":[241],"task.":[242,312],"It":[243],"also":[245],"time":[248],"arrival":[250],"impulses":[252],"synapses":[255],"important":[258],"factor":[259],"for":[260],"synaptic":[261],"plasticity":[262],"sheaths":[266],"central":[269],"impulse":[274],"transmission":[275],"velocity,":[276],"it":[278],"reasonable":[280],"think":[282],"could":[285,303],"underlying":[291],"neural":[292],"plasticity.":[293],"Given":[294],"premises,":[296],"asked":[298],"ourselves":[299],"if":[300,356,371],"influenced":[305],"by":[306],"experience":[307,323,361],"learning":[309],"To":[313],"investigate":[314],"experiments":[318],"interfering":[319],"with":[320],"normal":[321],"visual":[322,342,360],"then":[327],"verified":[329],"some":[336],"cortex":[343],"through":[344],"PCR.":[346],"example,":[348],"utilized":[350],"dark-rearing":[352],"protocol":[353,378],"see":[355],"delay":[358],"effect":[364],"expression.":[367],"Successively,":[368],"tested":[370],"changes":[374],"behavioural":[377],"learning,":[381],"investigated":[384],"consequences":[385],"trough":[388],"immunohistochemistry.":[389]},"counts_by_year":[],"updated_date":"2026-09-14T07:18:48.979198","created_date":"2025-10-10T00:00:00"}
